Gfral cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gfral
Entrez Gene ID	501023
Full Name	GDNF family receptor alpha like
Synonyms	RGD1565220
General protein information	Preferred Names GDNF family receptor alpha like Names GDNF family receptor alpha-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243416.3	XP_006243478.1	GDNF family receptor alpha-like isoform X1
NM_001191998.1	NP_001178927.1	GDNF family receptor alpha-like precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GFRAL	XP_002697218.1
Rattus norvegicus (Norway rat)	Gfral	NP_001178927.1
Homo sapiens (human)	GFRAL	NP_997293.2
Gallus gallus (chicken)	GFRAL	XP_419904.4
Macaca mulatta (Rhesus monkey)	GFRAL	XP_001104929.1
Canis lupus familiaris (dog)	GFRAL	XP_538972.3
Mus musculus (house mouse)	Gfral	NP_995316.2
Xenopus tropicalis (tropical clawed frog)	gfral	XP_002934908.2
Pan troglodytes (chimpanzee)	GFRAL	XP_001157000.1

Gene Ontology
Bibliography

Related articles in PubMed

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkjær SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, Nørgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, Jørgensen SB
Nature medicine23(10)1158-1166(2017 Oct)

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X
Nature medicine23(10)1215-1219(2017 Oct)

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Mullican SE, Lin-Schmidt X, Chin CN, Chavez JA, Furman JL, Armstrong AA, Beck SC, South VJ, Dinh TQ, Cash-Mason TD, Cavanaugh CR, Nelson S, Huang C, Hunter MJ, Rangwala SM
Nature medicine23(10)1150-1157(2017 Oct)

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB
Nature550(7675)255-259(2017 10)

Identification, expression and functional characterization of the GRAL gene.
Li Z, Wang B, Wu X, Cheng SY, Paraoan L, Zhou J
Journal of neurochemistry95(2)361-76(2005 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gfral gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gfral cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08292	NM_001191998.1 Latest version!	Rattus norvegicus GDNF family receptor alpha like (Gfral), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa31385	XM_006243416.3 Latest version!	Rattus norvegicus GDNF family receptor alpha like (Gfral), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gfral ( NM_001191998.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178927.1 Rattus norvegicus GDNF family receptor alpha like (Gfral), mRNA.

Price & Availability↑

CloneID	ORa08292
Clone ID Related Accession (Same CDS sequence)	NM_001191998.1
Accession Version	NM_001191998.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555516800000
Organism	Rattus norvegicus(Norway rat)
Product	GDNF family receptor alpha-like precursor
Comment	Comment: INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from AABR07070760.1 and AABR07070759.1. On Jul 17, 2010 this sequence version replaced XM_576432.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2689595, SAMEA2689604 [ECO:0000350] ##Evidence-Data-END##

ATGCTAGTGT TCATTTTCCT GGCCGTGAGG CTAAGCTCAG AAAACGAATC CTCTTCCCAA 
ACAAATGATT GTGCATATTT CATGCGGCAA TGCTTGACTG ATACAGATGG CTGTAAGCAG 
TCATGGAGAT CAATGGAAGA CGCCTGCCTT GTCTCAGGTG ACTCCTGCAA GATAAATAAT 
CCATTGCCTT GTAACCTGAG TATCCAGTCT TTGGTGGAAA AACATTTTCA ATTTAAAGGG 
TGTCTTTGCA CTGATGATCT CCACTGTACA GTAAACAAAA TTTTTGGAAA AAAGTGCACC 
AATAAGACAG ATAGCATGAA AAAAGATAAT AAATACAAAC GGAATCTAAC TACTCCTTTA 
TATCATGATA CAGGATTCAA ACAGATGCAG TCTTGTTTGG AAGTGACAGA GGCGTGTGTA 
GGGGATGTGG TTTGTAATGC ACAGTTGGCC CTTTACCTTA AAGCATGCAC AGCAAATGGA 
AATCTGTGTG ATGTGAAACA CTGCCAAGCG GCCATACGGT TCTTCTATCA AAATATGCCT 
TTTAACACTG CCCAGATGTT GGCTTTTTGT GACTGTGCTC AATCTGATAT ACCCTGTCAA 
CAATCCAAAG AAACTCTTCA CAGCAAGCCA TGTGCACTGA ACGTAGTTCC ACCCCCCACT 
TGCCTCAGTG TAATTCACAC TTGCCGAAAT GATGAATTAT GCAGGACATA CTACCGAACA 
TTCCAGACAG AATGCTGGCC CCATGTGGCT GGGAAGTGTC GTGAAGATGA GACCTGCATT 
AGTATGCTGG GCAAGCAAGA CCTTACTTGT TCTGGGAGTG ACAGCTGCAG GGCAGCCTAC 
CTAGGAACCT TCGGGACAGT CCTTCAGGTG CCGTGTGCTT GCAGAAGCAT CACACAGGGT 
GAAGAACCCT TGTGCATGGC TTTCCAGCAC ATGCTTCACA GCAAATCATG TTTCAATTAC 
CCAACTCCTA ATGTCAAAGA CATTTCCTCA TATGAAAGAA AGCATTCAAA AGAAATTACC 
CTGACTGGAT TCAATTCTCC CTTCAGTGGA GAACTAATCT ATGTTGTTGT GTGCATGGTA 
GTTACCAGCG GGATTCTTTC CTTGGTGATG CTCAAGCTAA GGATACCTAG TAAGAAAAGA 
GACCCCGCGC CCATCGAAAT AGCTGGAGCT GTCATCATTC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178927.1
CDS	1..1185
Translation	MLVFIFLAVRLSSENESSSQTNDCAYFMRQCLTDTDGCKQSWRSMEDACLVSGDSCKINNPLPCNLSIQSLVEKHFQFKGCLCTDDLHCTVNKIFGKKCTNKTDSMKKDNKYKRNLTTPLYHDTGFKQMQSCLEVTEACVGDVVCNAQLALYLKACTANGNLCDVKHCQAAIRFFYQNMPFNTAQMLAFCDCAQSDIPCQQSKETLHSKPCALNVVPPPTCLSVIHTCRNDELCRTYYRTFQTECWPHVAGKCREDETCISMLGKQDLTCSGSDSCRAAYLGTFGTVLQVPCACRSITQGEEPLCMAFQHMLHSKSCFNYPTPNVKDISSYERKHSKEITLTGFNSPFSGELIYVVVCMVVTSGILSLVMLKLRIPSKKRDPAPIEIAGAVIIQ

Target ORF information:

RefSeq Version	NM_001191998.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GDNF family receptor alpha like (Gfral), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191998.1

ORF Insert Sequence:

ATGCTAGTGT TCATTTTCCT GGCCGTGAGG CTAAGCTCAG AAAACGAATC CTCTTCCCAA 
ACAAATGATT GTGCATATTT CATGCGGCAA TGCTTGACTG ATACAGATGG CTGTAAGCAG 
TCATGGAGAT CAATGGAAGA CGCCTGCCTT GTCTCAGGTG ACTCCTGCAA GATAAATAAT 
CCATTGCCTT GTAACCTGAG TATCCAGTCT TTGGTGGAAA AACATTTTCA ATTTAAAGGG 
TGTCTTTGCA CTGATGATCT CCACTGTACA GTAAACAAAA TTTTTGGAAA AAAGTGCACC 
AATAAGACAG ATAGCATGAA AAAAGATAAT AAATACAAAC GGAATCTAAC TACTCCTTTA 
TATCATGATA CAGGATTCAA ACAGATGCAG TCTTGTTTGG AAGTGACAGA GGCGTGTGTA 
GGGGATGTGG TTTGTAATGC ACAGTTGGCC CTTTACCTTA AAGCATGCAC AGCAAATGGA 
AATCTGTGTG ATGTGAAACA CTGCCAAGCG GCCATACGGT TCTTCTATCA AAATATGCCT 
TTTAACACTG CCCAGATGTT GGCTTTTTGT GACTGTGCTC AATCTGATAT ACCCTGTCAA 
CAATCCAAAG AAACTCTTCA CAGCAAGCCA TGTGCACTGA ACGTAGTTCC ACCCCCCACT 
TGCCTCAGTG TAATTCACAC TTGCCGAAAT GATGAATTAT GCAGGACATA CTACCGAACA 
TTCCAGACAG AATGCTGGCC CCATGTGGCT GGGAAGTGTC GTGAAGATGA GACCTGCATT 
AGTATGCTGG GCAAGCAAGA CCTTACTTGT TCTGGGAGTG ACAGCTGCAG GGCAGCCTAC 
CTAGGAACCT TCGGGACAGT CCTTCAGGTG CCGTGTGCTT GCAGAAGCAT CACACAGGGT 
GAAGAACCCT TGTGCATGGC TTTCCAGCAC ATGCTTCACA GCAAATCATG TTTCAATTAC 
CCAACTCCTA ATGTCAAAGA CATTTCCTCA TATGAAAGAA AGCATTCAAA AGAAATTACC 
CTGACTGGAT TCAATTCTCC CTTCAGTGGA GAACTAATCT ATGTTGTTGT GTGCATGGTA 
GTTACCAGCG GGATTCTTTC CTTGGTGATG CTCAAGCTAA GGATACCTAG TAAGAAAAGA 
GACCCCGCGC CCATCGAAAT AGCTGGAGCT GTCATCATTC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gfral ( XM_006243416.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243478.1 Rattus norvegicus GDNF family receptor alpha like (Gfral), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31385
Clone ID Related Accession (Same CDS sequence)	XM_006243416.3
Accession Version	XM_006243416.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	GDNF family receptor alpha-like isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243416.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCTTAG GAAGCAAAAG CAGACACGGA ACCATTTATT CAGGAATTTC AGTCGGGATG 
TTGGTCGGTG TCAGTTCATC TGCCTTTCTC CCAGGTGACC AGCTCCAGTT GGCCAACATG 
CTAGTGTTCA TTTTCCTGGC CGTGAGGCTA AGCTCAGAAA ACGAATCCTC TTCCCAAACA 
AATGATTGTG CATATTTCAT GCGGCAATGC TTGACTGATA CAGATGGCTG TAAGCAGTCA 
TGGAGATCAA TGGAAGACGC CTGCCTTGTC TCAGTGCGCC CTCCCAGTGT TGACTCAGCG 
TTTGGGGGAC AAAAGACAGG ACTTCTTTGG AGATCTCTGA GGAAATTAAG GACCAAGGGG 
CCTGGTGACT CCTGCAAGAT AAATAATCCA TTGCCTTGTA ACCTGAGTAT CCAGTCTTTG 
GTGGAAAAAC ATTTTCAATT TAAAGGGTGT CTTTGCACTG ATGATCTCCA CTGTACAGTA 
AACAAAATTT TTGGAAAAAA GTGCACCAAT AAGACAGAAG ACTCACCACT GCCCTCCAAT 
CTGGCGCCAA GGTCAAATGT TCCCCGATGG TTCCCAAGGA GAGATTCGTC TTCACTGGCT 
GTAAGGAAGG CTGACTGCGT CGCGGCTGCC GAGGCCTGCC AGGAATCGGA GCACTGCGCA 
CTGCTCCATG AGAACTTTAA GAACGCCTGT GACACAGGAA CAGCTCAGTG TCGCACTCTT 
AGCGGCCGAC TGAAGTGTGT GGGCCTAAGA CAGCGCCTGA GACAGACGGT CCTGTGGGAG 
TGTCGCTGCG GTCTCCCTTT AGAAAAAGAC TGCGTTCAGA TTAGGAAAAG CCTGTTTGGA 
GACATTTGCG TACAGGATGC TCAAATGGAA CAAATTCCCA CCTTCAGTCA AGACAACCAA 
GATGGATTCA AGGAGGACGT TGCTTCAGGA TTCAAACAGA TGCAGTCTTG TTTGGAAGTG 
ACAGAGGCGT GTGTAGGGGA TGTGGTTTGT AATGCACAGT TGGCCCTTTA CCTTAAAGCA 
TGCACAGCAA ATGGAAATCT GTGTGATGTG AAACACTGCC AAGCGGCCAT ACGGTTCTTC 
TATCAAAATA TGCCTTTTAA CACTGCCCAG ATGTTGGCTT TTTGTGACTG TGCTCAATCT 
GATATACCCT GTCAACAATC CAAAGAAACT CTTCACAGCA AGCCATGTGC ACTGAACGTA 
GTTCCACCCC CCACTTGCCT CAGTGTAATT CACACTTGCC GAAATGATGA ATTATGCAGG 
ACATACTACC GAACATTCCA GACAGAATGC TGGCCCCATG TGGCTGGGAA GTGTCGTGAA 
GATGAGACCT GCATTAGTAT GCTGGGCAAG CAAGACCTTA CTTGTTCTGG GAGTGACAGC 
TGCAGGGCAG CCTACCTAGG AACCTTCGGG ACAGTCCTTC AGGTGCCGTG TGCTTGCAGA 
AGCATCACAC AGGGTGAAGA ACCCTTGTGC ATGGCTTTCC AGCACATGCT TCACAGCAAA 
TCATGTTTCA ATTACCCAAC TCCTAATGTC AAAGACATTT CCTCATATGA AAGAAAGCAT 
TCAAAAGAAA TTACCCTGAC TGGATTCAAT TCTCCCTTCA GTGGAGAACT AATCTATGTT 
GTTGTGTGCA TGGTAGTTAC CAGCGGGATT CTTTCCTTGG TGATGCTCAA GCTAAGGATA 
CCTAGTAAGA AAAGAGACCC CGCGCCCATC GAAATAGCTG GAGCTGTCAT CATTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243478.1
CDS	1631..3370
Translation	MLLGSKSRHGTIYSGISVGMLVGVSSSAFLPGDQLQLANMLVFIFLAVRLSSENESSSQTNDCAYFMRQCLTDTDGCKQSWRSMEDACLVSVRPPSVDSAFGGQKTGLLWRSLRKLRTKGPGDSCKINNPLPCNLSIQSLVEKHFQFKGCLCTDDLHCTVNKIFGKKCTNKTEDSPLPSNLAPRSNVPRWFPRRDSSSLAVRKADCVAAAEACQESEHCALLHENFKNACDTGTAQCRTLSGRLKCVGLRQRLRQTVLWECRCGLPLEKDCVQIRKSLFGDICVQDAQMEQIPTFSQDNQDGFKEDVASGFKQMQSCLEVTEACVGDVVCNAQLALYLKACTANGNLCDVKHCQAAIRFFYQNMPFNTAQMLAFCDCAQSDIPCQQSKETLHSKPCALNVVPPPTCLSVIHTCRNDELCRTYYRTFQTECWPHVAGKCREDETCISMLGKQDLTCSGSDSCRAAYLGTFGTVLQVPCACRSITQGEEPLCMAFQHMLHSKSCFNYPTPNVKDISSYERKHSKEITLTGFNSPFSGELIYVVVCMVVTSGILSLVMLKLRIPSKKRDPAPIEIAGAVIIQ

Target ORF information:

RefSeq Version	XM_006243416.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GDNF family receptor alpha like (Gfral), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243416.3

ORF Insert Sequence:

ATGCTCTTAG GAAGCAAAAG CAGACACGGA ACCATTTATT CAGGAATTTC AGTCGGGATG 
TTGGTCGGTG TCAGTTCATC TGCCTTTCTC CCAGGTGACC AGCTCCAGTT GGCCAACATG 
CTAGTGTTCA TTTTCCTGGC CGTGAGGCTA AGCTCAGAAA ACGAATCCTC TTCCCAAACA 
AATGATTGTG CATATTTCAT GCGGCAATGC TTGACTGATA CAGATGGCTG TAAGCAGTCA 
TGGAGATCAA TGGAAGACGC CTGCCTTGTC TCAGTGCGCC CTCCCAGTGT TGACTCAGCG 
TTTGGGGGAC AAAAGACAGG ACTTCTTTGG AGATCTCTGA GGAAATTAAG GACCAAGGGG 
CCTGGTGACT CCTGCAAGAT AAATAATCCA TTGCCTTGTA ACCTGAGTAT CCAGTCTTTG 
GTGGAAAAAC ATTTTCAATT TAAAGGGTGT CTTTGCACTG ATGATCTCCA CTGTACAGTA 
AACAAAATTT TTGGAAAAAA GTGCACCAAT AAGACAGAAG ACTCACCACT GCCCTCCAAT 
CTGGCGCCAA GGTCAAATGT TCCCCGATGG TTCCCAAGGA GAGATTCGTC TTCACTGGCT 
GTAAGGAAGG CTGACTGCGT CGCGGCTGCC GAGGCCTGCC AGGAATCGGA GCACTGCGCA 
CTGCTCCATG AGAACTTTAA GAACGCCTGT GACACAGGAA CAGCTCAGTG TCGCACTCTT 
AGCGGCCGAC TGAAGTGTGT GGGCCTAAGA CAGCGCCTGA GACAGACGGT CCTGTGGGAG 
TGTCGCTGCG GTCTCCCTTT AGAAAAAGAC TGCGTTCAGA TTAGGAAAAG CCTGTTTGGA 
GACATTTGCG TACAGGATGC TCAAATGGAA CAAATTCCCA CCTTCAGTCA AGACAACCAA 
GATGGATTCA AGGAGGACGT TGCTTCAGGA TTCAAACAGA TGCAGTCTTG TTTGGAAGTG 
ACAGAGGCGT GTGTAGGGGA TGTGGTTTGT AATGCACAGT TGGCCCTTTA CCTTAAAGCA 
TGCACAGCAA ATGGAAATCT GTGTGATGTG AAACACTGCC AAGCGGCCAT ACGGTTCTTC 
TATCAAAATA TGCCTTTTAA CACTGCCCAG ATGTTGGCTT TTTGTGACTG TGCTCAATCT 
GATATACCCT GTCAACAATC CAAAGAAACT CTTCACAGCA AGCCATGTGC ACTGAACGTA 
GTTCCACCCC CCACTTGCCT CAGTGTAATT CACACTTGCC GAAATGATGA ATTATGCAGG 
ACATACTACC GAACATTCCA GACAGAATGC TGGCCCCATG TGGCTGGGAA GTGTCGTGAA 
GATGAGACCT GCATTAGTAT GCTGGGCAAG CAAGACCTTA CTTGTTCTGG GAGTGACAGC 
TGCAGGGCAG CCTACCTAGG AACCTTCGGG ACAGTCCTTC AGGTGCCGTG TGCTTGCAGA 
AGCATCACAC AGGGTGAAGA ACCCTTGTGC ATGGCTTTCC AGCACATGCT TCACAGCAAA 
TCATGTTTCA ATTACCCAAC TCCTAATGTC AAAGACATTT CCTCATATGA AAGAAAGCAT 
TCAAAAGAAA TTACCCTGAC TGGATTCAAT TCTCCCTTCA GTGGAGAACT AATCTATGTT 
GTTGTGTGCA TGGTAGTTAC CAGCGGGATT CTTTCCTTGG TGATGCTCAA GCTAAGGATA 
CCTAGTAAGA AAAGAGACCC CGCGCCCATC GAAATAGCTG GAGCTGTCAT CATTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Nature medicine23(10)1158-1166(2017 Oct)
Yang L,Chang CC,Sun Z,Madsen D,Zhu H,Padkjær SB,Wu X,Huang T,Hultman K,Paulsen SJ,Wang J,Bugge A,Frantzen JB,Nørgaard P,Jeppesen JF,Yang Z,Secher A,Chen H,Li X,John LM,Shan B,He Z,Gao X,Su J,Hansen KT,Yang W,Jørgensen SB

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.
Nature medicine23(10)1215-1219(2017 Oct)
Emmerson PJ,Wang F,Du Y,Liu Q,Pickard RT,Gonciarz MD,Coskun T,Hamang MJ,Sindelar DK,Ballman KK,Foltz LA,Muppidi A,Alsina-Fernandez J,Barnard GC,Tang JX,Liu X,Mao X,Siegel R,Sloan JH,Mitchell PJ,Zhang BB,Gimeno RE,Shan B,Wu X

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.
Nature medicine23(10)1150-1157(2017 Oct)
Mullican SE,Lin-Schmidt X,Chin CN,Chavez JA,Furman JL,Armstrong AA,Beck SC,South VJ,Dinh TQ,Cash-Mason TD,Cavanaugh CR,Nelson S,Huang C,Hunter MJ,Rangwala SM

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature550(7675)255-259(2017 10)
Hsu JY,Crawley S,Chen M,Ayupova DA,Lindhout DA,Higbee J,Kutach A,Joo W,Gao Z,Fu D,To C,Mondal K,Li B,Kekatpure A,Wang M,Laird T,Horner G,Chan J,McEntee M,Lopez M,Lakshminarasimhan D,White A,Wang SP,Yao J,Yie J,Matern H,Solloway M,Haldankar R,Parsons T,Tang J,Shen WD,Alice Chen Y,Tian H,Allan BB

Identification, expression and functional characterization of the GRAL gene.
Journal of neurochemistry95(2)361-76(2005 Oct)
Li Z,Wang B,Wu X,Cheng SY,Paraoan L,Zhou J

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Gfral cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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