| Gene Symbol | IDO1 |
| Entrez Gene ID | 3620 |
| Full Name | indoleamine 2,3-dioxygenase 1 |
| Synonyms | IDO,IDO-1,INDO |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]. |
| Disorder MIM: |
- REAGENT SERVICES Hot!
-
PRODUCTS
-
Most Popular Reagents
-
Instruments
-
Antibodies
-
ELISA Kits
-
Protein Electrophoresis and Blotting
-
Protein and Antibody Purification
-
Recombinant Proteins
-
Molecular Biology
-
Stable Cell Lines
-
Cell Isolation and Activation
-
IVD Raw Materials
-
Therapy Applications
-
Resources
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Anti-Camelid VHH]()
MonoRab™ Anti-VHH Antibodies
-
![ELISA Kits]()
ELISA Kits
-
![Precast Gels]()
SurePAGE™ Precast Gels
-
![Quatro ProAb Automated Protein and Antibody Purification System]()
AmMag™ Quatro ProAb Automated Protein and Antibody Purification System
-
![Target Proteins]()
Target Proteins
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Stable Cell Lines]()
Stable Cell Lines
-
![Cell Isolation and Activation]()
Cell Isolation and Activation
-
![Quick
Order]()
Quick Order
-
![Quick
Order]()
Quick Order
- APPLICATIONS
- RESOURCES
- ABOUT US
IDO1 cDNA ORF clone, Homo sapiens(human)
-
Gene
-
Clones
gRNAs
The following IDO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IDO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
-
Reference Sequences (Refseq)
CloneID OHu20074 
Clone ID Related Accession (Same CDS sequence) NM_002164.5 , NM_002164.6 Accession Version NM_002164.5 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1212bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1510416000000 Organism Homo sapiens(human) Product indoleamine 2,3-dioxygenase 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU137351.1, BC027882.1, CD366252.1 and BF094375.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2011 this sequence version replaced NM_002164.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027882.1, X17668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGGCACACG CTATGGAAAA CTCCTGGACA ATCAGTAAAG AGTACCATAT TGATGAAGAA
GTGGGCTTTG CTCTGCCAAA TCCACAGGAA AATCTACCTG ATTTTTATAA TGACTGGATG
TTCATTGCTA AACATCTGCC TGATCTCATA GAGTCTGGCC AGCTTCGAGA AAGAGTTGAG
AAGTTAAACA TGCTCAGCAT TGATCATCTC ACAGACCACA AGTCACAGCG CCTTGCACGT
CTAGTTCTGG GATGCATCAC CATGGCATAT GTGTGGGGCA AAGGTCATGG AGATGTCCGT
AAGGTCTTGC CAAGAAATAT TGCTGTTCCT TACTGCCAAC TCTCCAAGAA ACTGGAACTG
CCTCCTATTT TGGTTTATGC AGACTGTGTC TTGGCAAACT GGAAGAAAAA GGATCCTAAT
AAGCCCCTGA CTTATGAGAA CATGGACGTT TTGTTCTCAT TTCGTGATGG AGACTGCAGT
AAAGGATTCT TCCTGGTCTC TCTATTGGTG GAAATAGCAG CTGCTTCTGC AATCAAAGTA
ATTCCTACTG TATTCAAGGC AATGCAAATG CAAGAACGGG ACACTTTGCT AAAGGCGCTG
TTGGAAATAG CTTCTTGCTT GGAGAAAGCC CTTCAAGTGT TTCACCAAAT CCACGATCAT
GTGAACCCAA AAGCATTTTT CAGTGTTCTT CGCATATATT TGTCTGGCTG GAAAGGCAAC
CCCCAGCTAT CAGACGGTCT GGTGTATGAA GGGTTCTGGG AAGACCCAAA GGAGTTTGCA
GGGGGCAGTG CAGGCCAAAG CAGCGTCTTT CAGTGCTTTG ACGTCCTGCT GGGCATCCAG
CAGACTGCTG GTGGAGGACA TGCTGCTCAG TTCCTCCAGG ACATGAGAAG ATATATGCCA
CCAGCTCACA GGAACTTCCT GTGCTCATTA GAGTCAAATC CCTCAGTCCG TGAGTTTGTC
CTTTCAAAAG GTGATGCTGG CCTGCGGGAA GCTTATGACG CCTGTGTGAA AGCTCTGGTC
TCCCTGAGGA GCTACCATCT GCAAATCGTG ACTAAGTACA TCCTGATTCC TGCAAGCCAG
CAGCCAAAGG AGAATAAGAC CTCTGAAGAC CCTTCAAAAC TGGAAGCCAA AGGAACTGGA
GGCACTGATT TAATGAATTT CCTGAAGACT GTAAGAAGTA CAACTGAGAA ATCCCTTTTG
AAGGAAGGTT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_002155.1 CDS 115..1326 Translation 
Target ORF information:
RefSeq Version NM_002164.5 Organism Homo sapiens(human) Definition Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_002164.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGGCACACG CTATGGAAAA CTCCTGGACA ATCAGTAAAG AGTACCATAT TGATGAAGAA
GTGGGCTTTG CTCTGCCAAA TCCACAGGAA AATCTACCTG ATTTTTATAA TGACTGGATG
TTCATTGCTA AACATCTGCC TGATCTCATA GAGTCTGGCC AGCTTCGAGA AAGAGTTGAG
AAGTTAAACA TGCTCAGCAT TGATCATCTC ACAGACCACA AGTCACAGCG CCTTGCACGT
CTAGTTCTGG GATGCATCAC CATGGCATAT GTGTGGGGCA AAGGTCATGG AGATGTCCGT
AAGGTCTTGC CAAGAAATAT TGCTGTTCCT TACTGCCAAC TCTCCAAGAA ACTGGAACTG
CCTCCTATTT TGGTTTATGC AGACTGTGTC TTGGCAAACT GGAAGAAAAA GGATCCTAAT
AAGCCCCTGA CTTATGAGAA CATGGACGTT TTGTTCTCAT TTCGTGATGG AGACTGCAGT
AAAGGATTCT TCCTGGTCTC TCTATTGGTG GAAATAGCAG CTGCTTCTGC AATCAAAGTA
ATTCCTACTG TATTCAAGGC AATGCAAATG CAAGAACGGG ACACTTTGCT AAAGGCGCTG
TTGGAAATAG CTTCTTGCTT GGAGAAAGCC CTTCAAGTGT TTCACCAAAT CCACGATCAT
GTGAACCCAA AAGCATTTTT CAGTGTTCTT CGCATATATT TGTCTGGCTG GAAAGGCAAC
CCCCAGCTAT CAGACGGTCT GGTGTATGAA GGGTTCTGGG AAGACCCAAA GGAGTTTGCA
GGGGGCAGTG CAGGCCAAAG CAGCGTCTTT CAGTGCTTTG ACGTCCTGCT GGGCATCCAG
CAGACTGCTG GTGGAGGACA TGCTGCTCAG TTCCTCCAGG ACATGAGAAG ATATATGCCA
CCAGCTCACA GGAACTTCCT GTGCTCATTA GAGTCAAATC CCTCAGTCCG TGAGTTTGTC
CTTTCAAAAG GTGATGCTGG CCTGCGGGAA GCTTATGACG CCTGTGTGAA AGCTCTGGTC
TCCCTGAGGA GCTACCATCT GCAAATCGTG ACTAAGTACA TCCTGATTCC TGCAAGCCAG
CAGCCAAAGG AGAATAAGAC CTCTGAAGAC CCTTCAAAAC TGGAAGCCAA AGGAACTGGA
GGCACTGATT TAATGAATTT CCTGAAGACT GTAAGAAGTA CAACTGAGAA ATCCCTTTTG
AAGGAAGGTT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu20074 Clone ID Related Accession (Same CDS sequence) NM_002164.5 , NM_002164.6 Accession Version NM_002164.6 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1212bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577548800000 Organism Homo sapiens(human) Product indoleamine 2,3-dioxygenase 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC027882.1, CD366252.1 and BF094375.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002164.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027882.1, X17668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000518237.6/ ENSP00000430950.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGGCACACG CTATGGAAAA CTCCTGGACA ATCAGTAAAG AGTACCATAT TGATGAAGAA
GTGGGCTTTG CTCTGCCAAA TCCACAGGAA AATCTACCTG ATTTTTATAA TGACTGGATG
TTCATTGCTA AACATCTGCC TGATCTCATA GAGTCTGGCC AGCTTCGAGA AAGAGTTGAG
AAGTTAAACA TGCTCAGCAT TGATCATCTC ACAGACCACA AGTCACAGCG CCTTGCACGT
CTAGTTCTGG GATGCATCAC CATGGCATAT GTGTGGGGCA AAGGTCATGG AGATGTCCGT
AAGGTCTTGC CAAGAAATAT TGCTGTTCCT TACTGCCAAC TCTCCAAGAA ACTGGAACTG
CCTCCTATTT TGGTTTATGC AGACTGTGTC TTGGCAAACT GGAAGAAAAA GGATCCTAAT
AAGCCCCTGA CTTATGAGAA CATGGACGTT TTGTTCTCAT TTCGTGATGG AGACTGCAGT
AAAGGATTCT TCCTGGTCTC TCTATTGGTG GAAATAGCAG CTGCTTCTGC AATCAAAGTA
ATTCCTACTG TATTCAAGGC AATGCAAATG CAAGAACGGG ACACTTTGCT AAAGGCGCTG
TTGGAAATAG CTTCTTGCTT GGAGAAAGCC CTTCAAGTGT TTCACCAAAT CCACGATCAT
GTGAACCCAA AAGCATTTTT CAGTGTTCTT CGCATATATT TGTCTGGCTG GAAAGGCAAC
CCCCAGCTAT CAGACGGTCT GGTGTATGAA GGGTTCTGGG AAGACCCAAA GGAGTTTGCA
GGGGGCAGTG CAGGCCAAAG CAGCGTCTTT CAGTGCTTTG ACGTCCTGCT GGGCATCCAG
CAGACTGCTG GTGGAGGACA TGCTGCTCAG TTCCTCCAGG ACATGAGAAG ATATATGCCA
CCAGCTCACA GGAACTTCCT GTGCTCATTA GAGTCAAATC CCTCAGTCCG TGAGTTTGTC
CTTTCAAAAG GTGATGCTGG CCTGCGGGAA GCTTATGACG CCTGTGTGAA AGCTCTGGTC
TCCCTGAGGA GCTACCATCT GCAAATCGTG ACTAAGTACA TCCTGATTCC TGCAAGCCAG
CAGCCAAAGG AGAATAAGAC CTCTGAAGAC CCTTCAAAAC TGGAAGCCAA AGGAACTGGA
GGCACTGATT TAATGAATTT CCTGAAGACT GTAAGAAGTA CAACTGAGAA ATCCCTTTTG
AAGGAAGGTT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_002155.1 CDS 33..1244 Translation
Target ORF information:
RefSeq Version NM_002164.6 Organism Homo sapiens(human) Definition Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_002164.6
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201ATGGCACACG CTATGGAAAA CTCCTGGACA ATCAGTAAAG AGTACCATAT TGATGAAGAA
GTGGGCTTTG CTCTGCCAAA TCCACAGGAA AATCTACCTG ATTTTTATAA TGACTGGATG
TTCATTGCTA AACATCTGCC TGATCTCATA GAGTCTGGCC AGCTTCGAGA AAGAGTTGAG
AAGTTAAACA TGCTCAGCAT TGATCATCTC ACAGACCACA AGTCACAGCG CCTTGCACGT
CTAGTTCTGG GATGCATCAC CATGGCATAT GTGTGGGGCA AAGGTCATGG AGATGTCCGT
AAGGTCTTGC CAAGAAATAT TGCTGTTCCT TACTGCCAAC TCTCCAAGAA ACTGGAACTG
CCTCCTATTT TGGTTTATGC AGACTGTGTC TTGGCAAACT GGAAGAAAAA GGATCCTAAT
AAGCCCCTGA CTTATGAGAA CATGGACGTT TTGTTCTCAT TTCGTGATGG AGACTGCAGT
AAAGGATTCT TCCTGGTCTC TCTATTGGTG GAAATAGCAG CTGCTTCTGC AATCAAAGTA
ATTCCTACTG TATTCAAGGC AATGCAAATG CAAGAACGGG ACACTTTGCT AAAGGCGCTG
TTGGAAATAG CTTCTTGCTT GGAGAAAGCC CTTCAAGTGT TTCACCAAAT CCACGATCAT
GTGAACCCAA AAGCATTTTT CAGTGTTCTT CGCATATATT TGTCTGGCTG GAAAGGCAAC
CCCCAGCTAT CAGACGGTCT GGTGTATGAA GGGTTCTGGG AAGACCCAAA GGAGTTTGCA
GGGGGCAGTG CAGGCCAAAG CAGCGTCTTT CAGTGCTTTG ACGTCCTGCT GGGCATCCAG
CAGACTGCTG GTGGAGGACA TGCTGCTCAG TTCCTCCAGG ACATGAGAAG ATATATGCCA
CCAGCTCACA GGAACTTCCT GTGCTCATTA GAGTCAAATC CCTCAGTCCG TGAGTTTGTC
CTTTCAAAAG GTGATGCTGG CCTGCGGGAA GCTTATGACG CCTGTGTGAA AGCTCTGGTC
TCCCTGAGGA GCTACCATCT GCAAATCGTG ACTAAGTACA TCCTGATTCC TGCAAGCCAG
CAGCCAAAGG AGAATAAGAC CTCTGAAGAC CCTTCAAAAC TGGAAGCCAA AGGAACTGGA
GGCACTGATT TAATGAATTT CCTGAAGACT GTAAGAAGTA CAACTGAGAA ATCCCTTTTG
AAGGAAGGTT AAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota.
Gastroenterology157(4)1093-1108.e11(2019 10)
Alvarado DM,Chen B,Iticovici M,Thaker AI,Dai N,VanDussen KL,Shaikh N,Lim CK,Guillemin GJ,Tarr PI,Ciorba MA
Indoleamine 2, 3-dioxygenase 1 promoter hypomethylation is associated with poor prognosis in patients with esophageal cancer.
Cancer science110(6)1863-1871(2019 Jun)
Kiyozumi Y,Baba Y,Okadome K,Yagi T,Ogata Y,Eto K,Hiyoshi Y,Ishimoto T,Iwatsuki M,Iwagami S,Miyamoto Y,Yoshida N,Watanabe M,Baba H
IDO and intra-tumoral neutrophils were independent prognostic factors for overall survival for hepatocellular carcinoma.
Journal of clinical laboratory analysis33(5)e22872(2019 Jun)
Wang Y,Yao R,Zhang L,Xie X,Chen R,Ren Z
hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye.
International journal of molecular sciences20(4)(2019 Feb)
Spekker-Bosker K,Ufermann CM,Maywald M,Zimmermann A,Domröse A,Woite C,Däubener W,Eller SK
Co-expression of IDO1 and PD-L1 in lung squamous cell carcinoma: Potential targets of novel combination therapy.
Lung cancer (Amsterdam, Netherlands)12826-32(2019 02)
Takada K,Kohashi K,Shimokawa M,Haro A,Osoegawa A,Tagawa T,Seto T,Oda Y,Maehara Y
-
-
Most Popular Services
-
Services & Products
-
News & Blogs
- CRISPR treatment prevents hearing loss in mice with genetic deafness
- Using Next Generation Sequencing, Scientist have Discovered an Answer to a 4,000 Year Old Mummy Mystery
- Microprotein plays key role in modulating UPR in response to ER stress
- Real Life Mockingjays: How Songbirds Learn New Songs
- Novel Cas9 enzyme expands CRISPR genome editing capability
- Novel Trispecific Antibody Shows Promising Therapeutic Effects for Multiple Myeloma
- Broad HIV Neutralization – The Long-Standing Goal Is Achieved
- Has Western Blot Become Obsolete?
-
-
-
PubMed
-
