Ido1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ido1
Entrez Gene ID	66029
Full Name	indoleamine 2,3-dioxygenase 1
Synonyms	Ido,Indo
General protein information	Preferred Names indoleamine 2,3-dioxygenase 1 Names indoleamine 2,3-dioxygenase 1 IDO-1 indoleamine 23-dioxygenase indoleamine-pyrrole 2,3-dioxygenase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5
Summary	enzyme which catalyzes degradation of L-tryptophan to N-formylkynurenine; human homolog is induced by gamma-interferon and is believed to be involved in that agent's tumor antiproliferative effects [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_023973.1	NP_076463.1	indoleamine 2,3-dioxygenase 1

Pathways from BioSystems

Homologies

Neurospora crassa	NCU05752	XP_959727.1
Canis lupus familiaris (dog)	IDO1	XP_532793.1
Bos taurus (cattle)	IDO1	NP_001095336.1
Magnaporthe oryzae (rice blast fungus)	MGG_13773	XP_003710825.1
Homo sapiens (human)	IDO1	NP_002155.1
Saccharomyces cerevisiae (baker's yeast)	BNA2	NP_012612.3
Pan troglodytes (chimpanzee)	IDO1	XP_001137531.1
Macaca mulatta (Rhesus monkey)	IDO1	NP_001070951.1
Eremothecium gossypii	AGOS_ACR188C	NP_983590.1
Mus musculus (house mouse)	Ido1	NP_032350.1
Rattus norvegicus (Norway rat)	Ido1	NP_076463.1

Gene Ontology
Bibliography

Related articles in PubMed

IDO, COX and iNOS have an important role in the proliferation of Neospora caninum in neuron/glia co-cultures.
Jesus LB, Santos AB, Jesus EEV, Santos RGD, Grangeiro MS, Bispo-da-Silva A, Arruda MR, Argolo DS, Pinheiro AM, El-Bachá RS, Costa SL, Costa MFD
Veterinary parasitology26696-102(2019 Feb)

Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism.
Li Y, Hu N, Yang D, Oxenkrug G, Yang Q
The FEBS journal284(6)948-966(2017 03)

Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.
Moretti S, Menicali E, Nucci N, Voce P, Colella R, Melillo RM, Liotti F, Morelli S, Fallarino F, Macchiarulo A, Santoro M, Avenia N, Puxeddu E
The Journal of biological chemistry292(5)1785-1797(2017 02)

Infliximab ameliorating depression-like behavior through inhibiting the activation of the IDO-HAAO pathway mediated by tumor necrosis factor-α in a rat model.
Fu XY, Li HY, Jiang QS, Cui T, Jiang XH, Zhou QX, Qiu HM
Neuroreport27(13)953-9(2016 09)

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus.
Lam CS, Tipoe GL, Wong JK, Youdim MB, Fung ML
PloS one11(11)e0166966(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ido1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ido1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06679	NM_023973.1 Latest version!	Rattus norvegicus indoleamine 2,3-dioxygenase 1 (Ido1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ido1 ( NM_023973.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_076463.1 Rattus norvegicus indoleamine 2,3-dioxygenase 1 (Ido1), mRNA.

Price & Availability↑

CloneID	ORa06679
Clone ID Related Accession (Same CDS sequence)	NM_023973.1
Accession Version	NM_023973.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1224bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576857600000
Organism	Rattus norvegicus(Norway rat)
Product	indoleamine 2,3-dioxygenase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF312699.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF312699.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689596, SAMEA2689599 [ECO:0000350] ##Evidence-Data-END##

ATGCCTCACA GTCAAATATC TCCTGCAGAA GGCTCTAGAA GGATCCTTGA AGAATACCAC 
ATAGATGAAG ATGTGGGCTT TGCTCTACCA CATCCACTGG AGGAGCTGCC TGATACGTAC 
AGACCTTGGA TCCTTGTGGC TAGAAATCTG CCTAAGCTGA TTGAGAATGG GAAGCTCCGA 
GAAGAAGTCG AGAAGCTGCC CACACTGCGC ACCGAAGAAC TGAGGGGACA CAGGTTACAG 
CGCCTGGCAC ATTTGGCCCT GGGGTACATC ACCATGGCGT ATGTGTGGAA CCGAGGGGAT 
GATGATATTC GAAAGGTGCT GCCCCGCAAT CTTGCCGTTC CCTACTGCGA GCTCTCGGAG 
AAGCTGGGGC TGCCTCCCAT TCTGTCTTAC GCAGACTGCG TCCTGGCAAA CTGGAAGAAA 
AAGGACCCCA ATGGGCCCAT GACATACGAG AACATGGACA TTCTGTTCTC GTTTCCTGGT 
GGGGACTGCG ATAAAGGCTT CTTCCTGGTC TCTCTAATGG TGGAAATCGC AGCTTCTCCT 
GCAATCAAAG CAATTCCTAC TGTATCCAGT GCAGTAGAGC ATCAAGACCC GAAAGCACTG 
GAGAAGGCAC TGTGTAGTAT AGCTGCCAGT CTGGAGAAAG CCAAGGAAAT TTTTAAGAGG 
ATGCGTGACT TCGTGGATCC AGACACCTTT TTCCACGTTC TTCGCATATA TTTGTCTGGT 
TGGAAGGGCA ACCCTAAGCT GCCGGAGGGT CTGCTGTACG AGGGCGTCTG GGACACCCCC 
AAAAAATTTT CAGGGGGCAG TGCAGGCCAG AGCAGCATCT TTCAGAGTCT TGATGTCCTT 
CTGGGAATAA AGCATGACGT TGGTGAAGGA TCTGCTGCAG AATTCCTCCA GGAAATGAGA 
GAGTACATGC CTCCAGCCCA CCGGAACTTC CTCTCCTCCT TAGAGTCAGC TCCCCCAGTC 
CGTGAGTTTG TCATTTTAAG ACGCAATGAA GACTTGAAGG AGGCTTATAA TGAGTGTGTG 
AATGGCCTGG TCTCCCTCAG AATGTTCCAC CTCTCGATAG TAGATACTTA CATTGTGAAG 
CCTTCGAAGC AGAAGCCCAT GGGTGGCCAC AAGTCAGAAG AGCCCTCAAA CACGGAAAAC 
AGAGGGACTG GGGGTACTGA CGTCATGAAT TTCCTGAGGA GTGTGAAAGA TACAACCAAG 
AAAGCCCTTC TGAGTTGGCC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076463.1
CDS	1..1224
Translation	MPHSQISPAEGSRRILEEYHIDEDVGFALPHPLEELPDTYRPWILVARNLPKLIENGKLREEVEKLPTLRTEELRGHRLQRLAHLALGYITMAYVWNRGDDDIRKVLPRNLAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLMVEIAASPAIKAIPTVSSAVEHQDPKALEKALCSIAASLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKGNPKLPEGLLYEGVWDTPKKFSGGSAGQSSIFQSLDVLLGIKHDVGEGSAAEFLQEMREYMPPAHRNFLSSLESAPPVREFVILRRNEDLKEAYNECVNGLVSLRMFHLSIVDTYIVKPSKQKPMGGHKSEEPSNTENRGTGGTDVMNFLRSVKDTTKKALLSWP

Target ORF information:

RefSeq Version	NM_023973.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus indoleamine 2,3-dioxygenase 1 (Ido1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023973.1

ORF Insert Sequence:

ATGCCTCACA GTCAAATATC TCCTGCAGAA GGCTCTAGAA GGATCCTTGA AGAATACCAC 
ATAGATGAAG ATGTGGGCTT TGCTCTACCA CATCCACTGG AGGAGCTGCC TGATACGTAC 
AGACCTTGGA TCCTTGTGGC TAGAAATCTG CCTAAGCTGA TTGAGAATGG GAAGCTCCGA 
GAAGAAGTCG AGAAGCTGCC CACACTGCGC ACCGAAGAAC TGAGGGGACA CAGGTTACAG 
CGCCTGGCAC ATTTGGCCCT GGGGTACATC ACCATGGCGT ATGTGTGGAA CCGAGGGGAT 
GATGATATTC GAAAGGTGCT GCCCCGCAAT CTTGCCGTTC CCTACTGCGA GCTCTCGGAG 
AAGCTGGGGC TGCCTCCCAT TCTGTCTTAC GCAGACTGCG TCCTGGCAAA CTGGAAGAAA 
AAGGACCCCA ATGGGCCCAT GACATACGAG AACATGGACA TTCTGTTCTC GTTTCCTGGT 
GGGGACTGCG ATAAAGGCTT CTTCCTGGTC TCTCTAATGG TGGAAATCGC AGCTTCTCCT 
GCAATCAAAG CAATTCCTAC TGTATCCAGT GCAGTAGAGC ATCAAGACCC GAAAGCACTG 
GAGAAGGCAC TGTGTAGTAT AGCTGCCAGT CTGGAGAAAG CCAAGGAAAT TTTTAAGAGG 
ATGCGTGACT TCGTGGATCC AGACACCTTT TTCCACGTTC TTCGCATATA TTTGTCTGGT 
TGGAAGGGCA ACCCTAAGCT GCCGGAGGGT CTGCTGTACG AGGGCGTCTG GGACACCCCC 
AAAAAATTTT CAGGGGGCAG TGCAGGCCAG AGCAGCATCT TTCAGAGTCT TGATGTCCTT 
CTGGGAATAA AGCATGACGT TGGTGAAGGA TCTGCTGCAG AATTCCTCCA GGAAATGAGA 
GAGTACATGC CTCCAGCCCA CCGGAACTTC CTCTCCTCCT TAGAGTCAGC TCCCCCAGTC 
CGTGAGTTTG TCATTTTAAG ACGCAATGAA GACTTGAAGG AGGCTTATAA TGAGTGTGTG 
AATGGCCTGG TCTCCCTCAG AATGTTCCAC CTCTCGATAG TAGATACTTA CATTGTGAAG 
CCTTCGAAGC AGAAGCCCAT GGGTGGCCAC AAGTCAGAAG AGCCCTCAAA CACGGAAAAC 
AGAGGGACTG GGGGTACTGA CGTCATGAAT TTCCTGAGGA GTGTGAAAGA TACAACCAAG 
AAAGCCCTTC TGAGTTGGCC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

IDO, COX and iNOS have an important role in the proliferation of Neospora caninum in neuron/glia co-cultures.
Veterinary parasitology26696-102(2019 Feb)
Jesus LB,Santos AB,Jesus EEV,Santos RGD,Grangeiro MS,Bispo-da-Silva A,Arruda MR,Argolo DS,Pinheiro AM,El-Bachá RS,Costa SL,Costa MFD

Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism.
The FEBS journal284(6)948-966(2017 03)
Li Y,Hu N,Yang D,Oxenkrug G,Yang Q

Signal Transducer and Activator of Transcription 1 Plays a Pivotal Role in RET/PTC3 Oncogene-induced Expression of Indoleamine 2,3-Dioxygenase 1.
The Journal of biological chemistry292(5)1785-1797(2017 02)
Moretti S,Menicali E,Nucci N,Voce P,Colella R,Melillo RM,Liotti F,Morelli S,Fallarino F,Macchiarulo A,Santoro M,Avenia N,Puxeddu E

Infliximab ameliorating depression-like behavior through inhibiting the activation of the IDO-HAAO pathway mediated by tumor necrosis factor-α in a rat model.
Neuroreport27(13)953-9(2016 09)
Fu XY,Li HY,Jiang QS,Cui T,Jiang XH,Zhou QX,Qiu HM

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus.
PloS one11(11)e0166966(2016)
Lam CS,Tipoe GL,Wong JK,Youdim MB,Fung ML