| Gene Symbol | SOSTDC1 |
| Entrez Gene ID | 25928 |
| Full Name | sclerostin domain containing 1 |
| Synonyms | CDA019,DAND7,ECTODIN,USAG1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
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SOSTDC1 cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following SOSTDC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOSTDC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu10444 Clone ID Related Accession (Same CDS sequence) NM_015464.3 , XM_017011943.1 , NM_015464.2 Accession Version NM_015464.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 621bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1574611200000 Organism Homo sapiens(human) Product sclerostin domain-containing protein 1 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF361494.1, AI927000.1 and AI540640.1. On Nov 22, 2018 this sequence version replaced NM_015464.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF361494.1, SRR1660803.121045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307068.5/ ENSP00000304930.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481
541
601ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC
AGCAAGCACA GCATGAGTTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_056279.1 CDS 71..691 Translation 
Target ORF information:
RefSeq Version NM_015464.3 Organism Homo sapiens(human) Definition Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_015464.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC
AGCAAGCACA GCATGAGTTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu10444 Clone ID Related Accession (Same CDS sequence) NM_015464.3 , XM_017011943.1 , NM_015464.2 Accession Version NM_015464.2 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 621bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506787200000 Organism Homo sapiens(human) Product sclerostin domain-containing protein 1 precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF361494.1, AI927000.1 and AI540640.1. On May 25, 2006 this sequence version replaced NM_015464.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF361494.1, SRR1803613.182523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC
AGCAAGCACA GCATGAGTTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_056279.1 CDS 182..802 Translation
Target ORF information:
RefSeq Version NM_015464.2 Organism Homo sapiens(human) Definition Homo sapiens sclerostin domain containing 1 (SOSTDC1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_015464.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC
AGCAAGCACA GCATGAGTTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu10444 Clone ID Related Accession (Same CDS sequence) NM_015464.3 , XM_017011943.1 , NM_015464.2 Accession Version XM_017011943.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 621bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1465056000000 Organism Homo sapiens(human) Product sclerostin domain-containing protein 1 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541
601ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC
AGCAAGCACA GCATGAGTTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_016867432.1 CDS 324..944 Translation
Target ORF information:
RefSeq Version XM_017011943.1 Organism Homo sapiens(human) Definition Homo sapiens sclerostin domain containing 1 (SOSTDC1), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_017011943.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGCTTCCTC CTGCCATTCA TTTCTATCTC CTTCCCCTTG CATGCATCCT AATGAAAAGC
TGTTTGGCTT TTAAAAATGA TGCCACAGAA ATCCTTTATT CACATGTGGT TAAACCTGTT
CCAGCACACC CCAGCAGCAA CAGCACGTTG AATCAAGCCA GAAATGGAGG CAGGCATTTC
AGTAACACTG GACTGGATCG GAACACTCGG GTTCAAGTGG GTTGCCGGGA ACTGCGTTCC
ACCAAATACA TCTCTGATGG CCAGTGCACC AGCATCAGCC CTCTGAAGGA GCTGGTGTGT
GCTGGCGAGT GCTTGCCCCT GCCAGTGCTC CCTAACTGGA TTGGAGGAGG CTATGGAACA
AAGTACTGGA GCAGGAGGAG CTCCCAGGAG TGGCGGTGTG TCAATGACAA AACCCGTACC
CAGAGAATCC AGCTGCAGTG CCAAGATGGC AGCACACGCA CCTACAAAAT CACAGTAGTC
ACTGCCTGCA AGTGCAAGAG GTACACCCGG CAGCACAACG AGTCCAGTCA CAACTTTGAG
AGCATGTCAC CTGCCAAGCC AGTCCAGCAT CACAGAGAGC GGAAAAGAGC CAGCAAATCC
AGCAAGCACA GCATGAGTTA GThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Lack of association between PAX6/SOSTDC1/FAM20B gene polymorphisms and mesiodens.
BMC oral health19(1)90(2019 05)
Liu S,Li J,Xu J,Liao S,Chen Y,Zhang R,Tian R,Zhang K
SOSTDC1 inhibits bone metastasis in non-small cell lung cancer and may serve as a clinical therapeutic target.
International journal of molecular medicine42(6)3424-3436(2018 Dec)
Chen G,Gong H,Wang T,Wang J,Han Z,Bai G,Han S,Yang X,Zhou W,Liu T,Xiao J
Investigation of SOSTDC1 gene in non-syndromic patients with supernumerary teeth.
Medicina oral, patologia oral y cirugia bucal23(5)e531-e539(2018 Sep)
Arikan V,Cumaogullari O,Ozgul BM,Oz FT
SOSTDC1 inhibits follicular thyroid cancer cell proliferation, migration, and EMT via suppressing PI3K/Akt and MAPK/Erk signaling pathways.
Molecular and cellular biochemistry435(1-2)87-95(2017 Nov)
Zhou Q,Chen J,Feng J,Xu Y,Zheng W,Wang J
Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Oncotarget6(31)31780-91(2015 Oct)
Liang W,Guan H,He X,Ke W,Xu L,Liu L,Xiao H,Li Y
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