FOSB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FOSB
Entrez Gene ID	2354
Full Name	FosB proto-oncogene, AP-1 transcription factor subunit
Synonyms	AP-1,G0S3,GOS3,GOSB
General protein information	Preferred Names FosB proto-oncogene, AP-1 transcription factor subunit Names protein fosB FBJ murine osteosarcoma viral oncogene homolog B FosB proto-oncogene, AP-1 trancription factor subunit G0/G1 switch regulatory protein 3 activator protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Summary	The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	164772

mRNA and Protein(s)

mRNA	Protein	Name
XM_005258691.1	XP_005258748.1	protein fosB isoform X1
NM_006732.3	NP_006723.2	protein fosB isoform 1
NM_001114171.1	NP_001107643.1	protein fosB isoform 2
NM_001114171.2	NP_001107643.1	protein fosB isoform 2
NM_006732.2	NP_006723.2	protein fosB isoform 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	FOSB	NP_001013866.1
Bos taurus (cattle)	FOSB	NP_001095718.1
Rattus norvegicus (Norway rat)	Fosb	NP_001243438.1
Mus musculus (house mouse)	Fosb	NP_032062.1
Danio rerio (zebrafish)	fosb	NP_001007313.1
Xenopus tropicalis (tropical clawed frog)	LOC100490871	XP_002932681.2
Homo sapiens (human)	FOSB	NP_006723.2

Gene Ontology
Bibliography

Related articles in PubMed

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.
Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, Kitajima Y, Nishiyama A, Izumi R, Morimoto S, Okada Y, Kamei T, Nishida M, Nogami M, Kaneda S, Ikeuchi Y, Mitsuhashi H, Nakayama K, Fujii T, Warita H, Okano H, Aoki M
EBioMedicine45362-378(2019 Jul)

Expanding the Spectrum of Genetic Alterations in Pseudomyogenic Hemangioendothelioma With Recurrent Novel ACTB-FOSB Gene Fusions.
Agaram NP, Zhang L, Cotzia P, Antonescu CR
The American journal of surgical pathology42(12)1653-1661(2018 12)

Recurrent rearrangements of FOS and FOSB define osteoblastoma.
Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC, Verfaillie A, Demeulemeester J, Zhang L, Berisha F, Tarabichi M, Young MD, Miranda E, Tarpey PS, Tirabosco R, Amary F, Grigoriadis AE, Stratton MR, Van Loo P, Antonescu CR, Campbell PJ, Flanagan AM, Behjati S
Nature communications9(1)2150(2018 06)

FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia).
Ortins-Pina A, Llamas-Velasco M, Turpin S, Soares-de-Almeida L, Filipe P, Kutzner H
Journal of cutaneous pathology45(6)395-402(2018 Jun)

Activator Protein-1: redox switch controlling structure and DNA-binding.
Yin Z, Machius M, Nestler EJ, Rudenko G
Nucleic acids research45(19)11425-11436(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FOSB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOSB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20171	NM_006732.3 Latest version!	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu20238	NM_001114171.2 Latest version!	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu52143	XM_005258691.1 Latest version!	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu20238	NM_001114171.1	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu20171	NM_006732.2	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FOSB ( NM_006732.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006723.2 Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20171
Clone ID Related Accession (Same CDS sequence)	NM_006732.3 , NM_006732.2
Accession Version	NM_006732.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577548800000
Organism	Homo sapiens(human)
Product	protein fosB isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA589470.1, DB275824.1, BC036724.1 and AC138128.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006732.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036724.1, L49169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000353609.8/ ENSP00000245919.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGCTC ACCCCAGAGG AAGAGGAGAA GCGAAGGGTG 
CGCCGGGAAC GAAATAAACT AGCAGCAGCT AAATGCAGGA ACCGGCGGAG GGAGCTGACC 
GACCGACTCC AGGCGGAGAC AGATCAGTTG GAGGAAGAAA AAGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TCCAAAAGGA GAAGGAACGT CTGGAGTTTG TGCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCCTACGA AGAGGGGCCC GGGCCGGGCC CGCTGGCGGA GGTGAGAGAT 
TTGCCGGGCT CAGCACCGGC TAAGGAAGAT GGCTTCAGCT GGCTGCTGCC GCCCCCGCCA 
CCACCGCCCC TGCCCTTCCA GACCAGCCAA GACGCACCCC CCAACCTGAC GGCTTCTCTC 
TTTACACACA GTGAAGTTCA AGTCCTCGGC GACCCCTTCC CCGTTGTTAA CCCTTCGTAC 
ACTTCTTCGT TTGTCCTCAC CTGCCCGGAG GTCTCCGCGT TCGCCGGCGC CCAACGCACC 
AGCGGCAGTG ACCAGCCTTC CGATCCCCTG AACTCGCCCT CCCTCCTCGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006723.2
CDS	592..1608
Translation	MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL

Target ORF information:

RefSeq Version	NM_006732.3
Organism	Homo sapiens(human)
Definition	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006732.3

ORF Insert Sequence:

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGCTC ACCCCAGAGG AAGAGGAGAA GCGAAGGGTG 
CGCCGGGAAC GAAATAAACT AGCAGCAGCT AAATGCAGGA ACCGGCGGAG GGAGCTGACC 
GACCGACTCC AGGCGGAGAC AGATCAGTTG GAGGAAGAAA AAGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TCCAAAAGGA GAAGGAACGT CTGGAGTTTG TGCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCCTACGA AGAGGGGCCC GGGCCGGGCC CGCTGGCGGA GGTGAGAGAT 
TTGCCGGGCT CAGCACCGGC TAAGGAAGAT GGCTTCAGCT GGCTGCTGCC GCCCCCGCCA 
CCACCGCCCC TGCCCTTCCA GACCAGCCAA GACGCACCCC CCAACCTGAC GGCTTCTCTC 
TTTACACACA GTGAAGTTCA AGTCCTCGGC GACCCCTTCC CCGTTGTTAA CCCTTCGTAC 
ACTTCTTCGT TTGTCCTCAC CTGCCCGGAG GTCTCCGCGT TCGCCGGCGC CCAACGCACC 
AGCGGCAGTG ACCAGCCTTC CGATCCCCTG AACTCGCCCT CCCTCCTCGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOSB ( NM_006732.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006723.2 Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20171
Clone ID Related Accession (Same CDS sequence)	NM_006732.3 , NM_006732.2
Accession Version	NM_006732.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514649600000
Organism	Homo sapiens(human)
Product	protein fosB isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA589470.1, DB275824.1, BC036724.1 and AC138128.1. This sequence is a reference standard in the RefSeqGene project. On Feb 6, 2008 this sequence version replaced NM_006732.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L49169.1, AK292720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGCTC ACCCCAGAGG AAGAGGAGAA GCGAAGGGTG 
CGCCGGGAAC GAAATAAACT AGCAGCAGCT AAATGCAGGA ACCGGCGGAG GGAGCTGACC 
GACCGACTCC AGGCGGAGAC AGATCAGTTG GAGGAAGAAA AAGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TCCAAAAGGA GAAGGAACGT CTGGAGTTTG TGCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCCTACGA AGAGGGGCCC GGGCCGGGCC CGCTGGCGGA GGTGAGAGAT 
TTGCCGGGCT CAGCACCGGC TAAGGAAGAT GGCTTCAGCT GGCTGCTGCC GCCCCCGCCA 
CCACCGCCCC TGCCCTTCCA GACCAGCCAA GACGCACCCC CCAACCTGAC GGCTTCTCTC 
TTTACACACA GTGAAGTTCA AGTCCTCGGC GACCCCTTCC CCGTTGTTAA CCCTTCGTAC 
ACTTCTTCGT TTGTCCTCAC CTGCCCGGAG GTCTCCGCGT TCGCCGGCGC CCAACGCACC 
AGCGGCAGTG ACCAGCCTTC CGATCCCCTG AACTCGCCCT CCCTCCTCGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006723.2
CDS	593..1609
Translation	MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL

Target ORF information:

RefSeq Version	NM_006732.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006732.2

ORF Insert Sequence:

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGCTC ACCCCAGAGG AAGAGGAGAA GCGAAGGGTG 
CGCCGGGAAC GAAATAAACT AGCAGCAGCT AAATGCAGGA ACCGGCGGAG GGAGCTGACC 
GACCGACTCC AGGCGGAGAC AGATCAGTTG GAGGAAGAAA AAGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TCCAAAAGGA GAAGGAACGT CTGGAGTTTG TGCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCCTACGA AGAGGGGCCC GGGCCGGGCC CGCTGGCGGA GGTGAGAGAT 
TTGCCGGGCT CAGCACCGGC TAAGGAAGAT GGCTTCAGCT GGCTGCTGCC GCCCCCGCCA 
CCACCGCCCC TGCCCTTCCA GACCAGCCAA GACGCACCCC CCAACCTGAC GGCTTCTCTC 
TTTACACACA GTGAAGTTCA AGTCCTCGGC GACCCCTTCC CCGTTGTTAA CCCTTCGTAC 
ACTTCTTCGT TTGTCCTCAC CTGCCCGGAG GTCTCCGCGT TCGCCGGCGC CCAACGCACC 
AGCGGCAGTG ACCAGCCTTC CGATCCCCTG AACTCGCCCT CCCTCCTCGC TCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOSB ( NM_001114171.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001107643.1 Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20238
Clone ID Related Accession (Same CDS sequence)	NM_001114171.1 , NM_001114171.2
Accession Version	NM_001114171.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1545408000000
Organism	Homo sapiens(human)
Product	protein fosB isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA589470.1, DB275824.1, EU178109.1 and AC138128.1. Transcript Variant: This variant (2) lacks an inframe coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU178109.1, BC063042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGGAG ACAGATCAGT TGGAGGAAGA AAAAGCAGAG 
CTGGAGTCGG AGATCGCCGA GCTCCAAAAG GAGAAGGAAC GTCTGGAGTT TGTGCTGGTG 
GCCCACAAAC CGGGCTGCAA GATCCCCTAC GAAGAGGGGC CCGGGCCGGG CCCGCTGGCG 
GAGGTGAGAG ATTTGCCGGG CTCAGCACCG GCTAAGGAAG ATGGCTTCAG CTGGCTGCTG 
CCGCCCCCGC CACCACCGCC CCTGCCCTTC CAGACCAGCC AAGACGCACC CCCCAACCTG 
ACGGCTTCTC TCTTTACACA CAGTGAAGTT CAAGTCCTCG GCGACCCCTT CCCCGTTGTT 
AACCCTTCGT ACACTTCTTC GTTTGTCCTC ACCTGCCCGG AGGTCTCCGC GTTCGCCGGC 
GCCCAACGCA CCAGCGGCAG TGACCAGCCT TCCGATCCCC TGAACTCGCC CTCCCTCCTC 
GCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001107643.1
CDS	593..1501
Translation	MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL

Target ORF information:

RefSeq Version	NM_001114171.1
Organism	Homo sapiens(human)
Definition	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114171.1

ORF Insert Sequence:

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGGAG ACAGATCAGT TGGAGGAAGA AAAAGCAGAG 
CTGGAGTCGG AGATCGCCGA GCTCCAAAAG GAGAAGGAAC GTCTGGAGTT TGTGCTGGTG 
GCCCACAAAC CGGGCTGCAA GATCCCCTAC GAAGAGGGGC CCGGGCCGGG CCCGCTGGCG 
GAGGTGAGAG ATTTGCCGGG CTCAGCACCG GCTAAGGAAG ATGGCTTCAG CTGGCTGCTG 
CCGCCCCCGC CACCACCGCC CCTGCCCTTC CAGACCAGCC AAGACGCACC CCCCAACCTG 
ACGGCTTCTC TCTTTACACA CAGTGAAGTT CAAGTCCTCG GCGACCCCTT CCCCGTTGTT 
AACCCTTCGT ACACTTCTTC GTTTGTCCTC ACCTGCCCGG AGGTCTCCGC GTTCGCCGGC 
GCCCAACGCA CCAGCGGCAG TGACCAGCCT TCCGATCCCC TGAACTCGCC CTCCCTCCTC 
GCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOSB ( NM_001114171.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001107643.1 Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20238
Clone ID Related Accession (Same CDS sequence)	NM_001114171.1 , NM_001114171.2
Accession Version	NM_001114171.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	protein fosB isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA589470.1, DB275824.1, EU178109.1 and AC138128.1. On May 31, 2019 this sequence version replaced NM_001114171.1. Transcript Variant: This variant (2) lacks an inframe coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU178109.1, BC063042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGGAG ACAGATCAGT TGGAGGAAGA AAAAGCAGAG 
CTGGAGTCGG AGATCGCCGA GCTCCAAAAG GAGAAGGAAC GTCTGGAGTT TGTGCTGGTG 
GCCCACAAAC CGGGCTGCAA GATCCCCTAC GAAGAGGGGC CCGGGCCGGG CCCGCTGGCG 
GAGGTGAGAG ATTTGCCGGG CTCAGCACCG GCTAAGGAAG ATGGCTTCAG CTGGCTGCTG 
CCGCCCCCGC CACCACCGCC CCTGCCCTTC CAGACCAGCC AAGACGCACC CCCCAACCTG 
ACGGCTTCTC TCTTTACACA CAGTGAAGTT CAAGTCCTCG GCGACCCCTT CCCCGTTGTT 
AACCCTTCGT ACACTTCTTC GTTTGTCCTC ACCTGCCCGG AGGTCTCCGC GTTCGCCGGC 
GCCCAACGCA CCAGCGGCAG TGACCAGCCT TCCGATCCCC TGAACTCGCC CTCCCTCCTC 
GCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001107643.1
CDS	592..1500
Translation	MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL

Target ORF information:

RefSeq Version	NM_001114171.2
Organism	Homo sapiens(human)
Definition	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001114171.2

ORF Insert Sequence:

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGGAG ACAGATCAGT TGGAGGAAGA AAAAGCAGAG 
CTGGAGTCGG AGATCGCCGA GCTCCAAAAG GAGAAGGAAC GTCTGGAGTT TGTGCTGGTG 
GCCCACAAAC CGGGCTGCAA GATCCCCTAC GAAGAGGGGC CCGGGCCGGG CCCGCTGGCG 
GAGGTGAGAG ATTTGCCGGG CTCAGCACCG GCTAAGGAAG ATGGCTTCAG CTGGCTGCTG 
CCGCCCCCGC CACCACCGCC CCTGCCCTTC CAGACCAGCC AAGACGCACC CCCCAACCTG 
ACGGCTTCTC TCTTTACACA CAGTGAAGTT CAAGTCCTCG GCGACCCCTT CCCCGTTGTT 
AACCCTTCGT ACACTTCTTC GTTTGTCCTC ACCTGCCCGG AGGTCTCCGC GTTCGCCGGC 
GCCCAACGCA CCAGCGGCAG TGACCAGCCT TCCGATCCCC TGAACTCGCC CTCCCTCCTC 
GCTCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FOSB ( XM_005258691.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005258748.1 Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant X1, mRNA.

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CloneID	OHu52143
Clone ID Related Accession (Same CDS sequence)	XM_005258691.1
Accession Version	XM_005258691.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 714bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	protein fosB isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGCTC ACCCCAGAGG AAGAGGAGAA GCGAAGGGTG 
CGCCGGGAAC GAAATAAACT AGCAGCAGCT AAATGCAGGA ACCGGCGGAG GGAGCTGACC 
GACCGACTCC AGGCGGAGAC AGATCAGTTG GAGGAAGAAA AAGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TCCAAAAGGA GAAGGAACGT CTGGAGTTTG TGCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCCTACGA AGAGGGGCCC GGGCCGGGCC CGCTGGCGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005258748.1
CDS	592..1305
Translation	MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAE

Target ORF information:

RefSeq Version	XM_005258691.1
Organism	Homo sapiens(human)
Definition	Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit (FOSB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005258691.1

ORF Insert Sequence:

ATGTTTCAGG CTTTCCCCGG AGACTACGAC TCCGGCTCCC GGTGCAGCTC CTCACCCTCT 
GCCGAGTCTC AATATCTGTC TTCGGTGGAC TCCTTCGGCA GTCCACCCAC CGCCGCCGCC 
TCCCAGGAGT GCGCCGGTCT CGGGGAAATG CCCGGTTCCT TCGTGCCCAC GGTCACCGCG 
ATCACAACCA GCCAGGACCT CCAGTGGCTT GTGCAACCCA CCCTCATCTC TTCCATGGCC 
CAGTCCCAGG GGCAGCCACT GGCCTCCCAG CCCCCGGTCG TCGACCCCTA CGACATGCCG 
GGAACCAGCT ACTCCACACC AGGCATGAGT GGCTACAGCA GTGGCGGAGC GAGTGGCAGT 
GGTGGGCCTT CCACCAGCGG AACTACCAGT GGGCCTGGGC CTGCCCGCCC AGCCCGAGCC 
CGGCCTAGGA GACCCCGAGA GGAGACGCTC ACCCCAGAGG AAGAGGAGAA GCGAAGGGTG 
CGCCGGGAAC GAAATAAACT AGCAGCAGCT AAATGCAGGA ACCGGCGGAG GGAGCTGACC 
GACCGACTCC AGGCGGAGAC AGATCAGTTG GAGGAAGAAA AAGCAGAGCT GGAGTCGGAG 
ATCGCCGAGC TCCAAAAGGA GAAGGAACGT CTGGAGTTTG TGCTGGTGGC CCACAAACCG 
GGCTGCAAGA TCCCCTACGA AGAGGGGCCC GGGCCGGGCC CGCTGGCGGA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.
EBioMedicine45362-378(2019 Jul)
Akiyama T,Suzuki N,Ishikawa M,Fujimori K,Sone T,Kawada J,Funayama R,Fujishima F,Mitsuzawa S,Ikeda K,Ono H,Shijo T,Osana S,Shirota M,Nakagawa T,Kitajima Y,Nishiyama A,Izumi R,Morimoto S,Okada Y,Kamei T,Nishida M,Nogami M,Kaneda S,Ikeuchi Y,Mitsuhashi H,Nakayama K,Fujii T,Warita H,Okano H,Aoki M

Expanding the Spectrum of Genetic Alterations in Pseudomyogenic Hemangioendothelioma With Recurrent Novel ACTB-FOSB Gene Fusions.
The American journal of surgical pathology42(12)1653-1661(2018 12)
Agaram NP,Zhang L,Cotzia P,Antonescu CR

Recurrent rearrangements of FOS and FOSB define osteoblastoma.
Nature communications9(1)2150(2018 06)
Fittall MW,Mifsud W,Pillay N,Ye H,Strobl AC,Verfaillie A,Demeulemeester J,Zhang L,Berisha F,Tarabichi M,Young MD,Miranda E,Tarpey PS,Tirabosco R,Amary F,Grigoriadis AE,Stratton MR,Van Loo P,Antonescu CR,Campbell PJ,Flanagan AM,Behjati S

FOSB immunoreactivity in endothelia of epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia).
Journal of cutaneous pathology45(6)395-402(2018 Jun)
Ortins-Pina A,Llamas-Velasco M,Turpin S,Soares-de-Almeida L,Filipe P,Kutzner H

Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic acids research45(19)11425-11436(2017 Nov)
Yin Z,Machius M,Nestler EJ,Rudenko G

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FOSB cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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