DIS3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DIS3
Entrez Gene ID	22894
Full Name	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Synonyms	2810028N01Rik,EXOSC11,KIAA1008,RRP44,dis3p
General protein information	Preferred Names DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Names exosome complex exonuclease RRP44 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease DIS3 mitotic control homolog exosome component 11 mitotic control protein dis3 homolog ribosomal RNA-processing protein 44
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q21.33
Disorder MIM:	607533

mRNA and Protein(s)

mRNA	Protein	Name
NM_001322349.2	NP_001309278.1	exosome complex exonuclease RRP44 isoform d
NM_001322349.1	NP_001309278.1	exosome complex exonuclease RRP44 isoform d
NM_001128226.2	NP_001121698.1	exosome complex exonuclease RRP44 isoform b
NM_001128226.3	NP_001121698.1	exosome complex exonuclease RRP44 isoform b
NM_014953.5	NP_055768.3	exosome complex exonuclease RRP44 isoform a
NM_014953.4	NP_055768.3	exosome complex exonuclease RRP44 isoform a
NM_001322348.1	NP_001309277.1	exosome complex exonuclease RRP44 isoform c
NM_001322348.2	NP_001309277.1	exosome complex exonuclease RRP44 isoform c

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DIS3	XP_542610.3
Magnaporthe oryzae (rice blast fungus)	MGG_00193	XP_003718924.1
Xenopus tropicalis (tropical clawed frog)	dis3	NP_001120564.1
Arabidopsis thaliana (thale cress)	EMB2763	NP_001189541.1
Eremothecium gossypii	AGOS_AEL031C	NP_984830.1
Neurospora crassa	NCU03065	XP_963787.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005191	XP_314089.3
Pan troglodytes (chimpanzee)	DIS3	XP_509678.2
Bos taurus (cattle)	DIS3	XP_002691932.2
Mus musculus (house mouse)	Dis3	NP_082591.2
Gallus gallus (chicken)	DIS3	XP_417016.3
Caenorhabditis elegans (roundworm)	dis-3	NP_501835.2
Oryza sativa (rice)	Os03g0129200	NP_001048846.1
Saccharomyces cerevisiae (baker's yeast)	DIS3	NP_014621.1
Kluyveromyces lactis	KLLA0A10835g	XP_451472.1
Homo sapiens (human)	DIS3	NP_055768.3
Macaca mulatta (Rhesus monkey)	DIS3	XP_001083933.1
Rattus norvegicus (Norway rat)	Dis3	NP_001120955.1
Drosophila melanogaster (fruit fly)	Dis3	NP_001262910.1
Schizosaccharomyces pombe (fission yeast)	dis3	NP_596653.1
Danio rerio (zebrafish)	dis3	XP_001336850.2

Gene Ontology
Bibliography

Related articles in PubMed

Post-transcriptional negative feedback regulation of proteostasis through the Dis3 ribonuclease and its disruption by polyQ-expanded Huntingtin.
Kong KE, Hung TF, Man PM, Wong TN, Cheng T, Jin DY
Nucleic acids research47(19)10040-10058(2019 11)

Elimination of 01/A'-A0 pre-rRNA processing by-product in human cells involves cooperative action of two nuclear exosome-associated nucleases: RRP6 and DIS3.
Kobyłecki K, Drążkowska K, Kuliński TM, Dziembowski A, Tomecki R
RNA (New York, N.Y.)24(12)1677-1692(2018 12)

Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
Gerlach P, Schuller JM, Bonneau F, Basquin J, Reichelt P, Falk S, Conti E
eLife7(2018 07)

DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers.
Robinson SR, Viegas SC, Matos RG, Domingues S, Bedir M, Stewart HJS, Chevassut TJ, Oliver AW, Arraiano CM, Newbury SF
The Biochemical journal475(12)2091-2105(2018 06)

Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression.
Hoskins JW, Ibrahim A, Emmanuel MA, Manmiller SM, Wu Y, O'Neill M, Jia J, Collins I, Zhang M, Thomas JV, Rost LM, Das S, Parikh H, Haake JM, Matters GL, Kurtz RC, Bamlet WR, Klein A, Stolzenberg-Solomon R, Wolpin BM, Yarden R, Wang Z, Smith J, Olson SH, Andresson T, Petersen GM, Amundadottir LT
Human molecular genetics25(21)4726-4738(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DIS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DIS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14985	NM_001128226.3 Latest version!	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu47098	NM_001322348.2 Latest version!	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu47099	NM_001322349.2 Latest version!	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu15178	NM_014953.5 Latest version!	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$510.30 $729.00
View Old Accession Versions >>
OHu47099	NM_001322349.1	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OHu14985	NM_001128226.2	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu15178	NM_014953.4	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$510.30 $729.00
OHu47098	NM_001322348.1	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DIS3 ( NM_001128226.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121698.1 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 2, mRNA.

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CloneID	OHu14985
Clone ID Related Accession (Same CDS sequence)	NM_001128226.2 , NM_001128226.3
Accession Version	NM_001128226.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2787bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB075344.1, AB023225.1, AL832266.1, AL080158.1, AL138695.13 and U79246.1. On Nov 13, 2013 this sequence version replaced NM_001128226.1. Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.79112.1, AB023225.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGTAAGTGCC 
TGGAGGCCGG GGACCTGGGC TTCTGTGGCC TCCAGCCTGC GACTCCCAGG CAGCTTAGAA 
ACCTATGTAG AACAAGAACA GGGAGAAAAT GCTAATGACA GGAATGATAG AGCGATTCGA 
GTAGCAGCAA AATGGTACAA TGAACATTTG AAAAAAATGT CAGCAGACAA CCAGCTGCAA 
GTTATCTTCA TAACAAATGA CAGGAGAAAC AAAGAGAAAG CCATAGAAGA AGGAATACCA 
GCTTTCACTT GTGAAGAATA TGTAAAGAGC CTAACTGCTA ACCCCGAACT CATAGATCGT 
CTTGCTTGTT TGTCTGAAGA AGGGAATGAA ATAGAAAGTG GAAAAATAAT ATTTTCAGAG 
CATCTTCCCT TAAGTAAGCT ACAGCAAGGC ATAAAATCTG GTACATACCT TCAAGGAACA 
TTTAGAGCTA GCAGGGAAAA TTACTTGGAA GCTACAGTAT GGATTCATGG CGACAATGAA 
GAAAATAAAG AGATAATCTT ACAGGGACTT AAACATTTAA ACAGAGCTGT TCACGAAGAT 
ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT CAGTGGGTAG CACCATCTTC TGTGGTTTTA 
CATGATGAAG GTCAAAATGA AGAAGATGTG GAGAAAGAAG AAGAGACAGA ACGAATGCTT 
AAGACTGCTG TAAGCGAGAA AATGTTGAAG CCTACAGGTA GAGTTGTAGG AATAATAAAA 
AGGAATTGGA GACCATATTG TGGCATGCTT TCCAAGTCTG ACATTAAGGA GTCAAGAAGA 
CATCTCTTTA CACCTGCTGA TAAGAGAATC CCTCGAATTC GCATAGAAAC CAGACAGGCT 
TCCACATTAG AAGGACGGAG AATTATTGTT GCTATTGATG GTTGGCCCAG AAATTCCAGA 
TATCCAAATG GACACTTTGT GAGAAATTTA GGTGATGTTG GAGAGAAAGA GACTGAAACA 
GAAGTTTTGT TACTTGAACA CGATGTTCCC CATCAGCCTT TTTCACAGGC TGTTCTTAGT 
TTTCTGCCAA AGATGCCCTG GAGCATTACT GAAAAGGACA TGAAAAACCG AGAAGACCTG 
AGGCATCTGT GTATTTGTAG TGTAGACCCA CCAGGATGTA CTGATATAGA CGATGCTCTA 
CATTGTCGAG AACTCGAAAA TGGAAATTTG GAGGTTGGTG TTCATATTGC TGATGTGAGC 
CATTTTATTA GGCCAGGAAA TGCCTTGGAT CAAGAATCAG CCAGAAGAGG AACAACTGTG 
TATCTTTGTG AAAAGAGGAT TGACATGGTT CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC 
TTAAAATGTG ACGTGGACAG GCTGGCATTT TCATGTATTT GGGAAATGAA TCACAATGCT 
GAAATCTTAA AAACGAAGTT TACCAAAAGT GTTATTAATT CAAAGGCATC TCTGACGTAT 
GCTGAAGCTC AGTTGAGAAT TGATTCAGCA AACATGAATG ATGATATTAC CACTAGTCTC 
CGTGGACTGA ATAAACTAGC CAAAATTCTG AAGAAAAGAA GGATTGAAAA AGGGGCTTTG 
ACTCTATCCT CTCCTGAAGT TCGATTCCAC ATGGACAGTG AAACTCACGA TCCTATAGAT 
CTGCAGACCA AGGAACTTAG GGAAACAAAT TCCATGGTTG AAGAATTTAT GTTACTTGCC 
AATATTTCTG TTGCAAAAAA AATTCATGAG GAATTTTCTG AACATGCTCT GCTTCGAAAA 
CATCCTGCTC CACCTCCATC AAATTATGAA ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT 
TTGGAAATTA AGACTGATAC AGCCAAGTCT TTGGCTGAGT CTTTGGATCA GGCCGAATCT 
CCTACTTTTC CATATCTAAA CACTCTGTTG AGAATATTAG CCACTCGCTG TATGATGCAA 
GCTGTGTACT TCTGTTCTGG AATGGATAAT GATTTTCATC ACTATGGCTT AGCGTCTCCA 
ATATACACAC ATTTTACTTC ACCCATTAGA AGATACGCAG ATGTCATTGT TCATCGGCTT 
TTGGCTGTGG CTATTGGGGC TGACTGTACT TATCCAGAGT TGACAGACAA ACACAAGCTT 
GCAGATATAT GTAAAAATCT AAATTTCCGG CACAAAATGG CTCAATATGC CCAACGTGCA 
TCAGTGGCTT TTCATACCCA GTTATTCTTC AAAAGCAAAG GAATAGTAAG TGAAGAAGCC 
TATATTTTAT TTGTAAGAAA GAATGCCATT GTGGTATTAA TTCCAAAGTA TGGTTTAGAA 
GGGACAGTCT TTTTTGAAGA AAAGGACAAA CCAAACCCAC AGCTTATTTA TGATGATGAG 
ATACCCTCAC TTAAAATAGA AGATACAGTG TTCCATGTAT TTGATAAAGT TAAAGTGAAA 
ATCATGTTAG ACTCATCTAA TCTTCAACAT CAGAAGATCC GAATGTCCCT GGTAGAACCA 
CAGATACCAG GAATAAGCAT TCCTACTGAT ACTTCAAACA TGGACCTTAA TGGACCAAAG 
AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121698.1
CDS	297..3083
Translation	MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIVSAWRPGTWASVASSLRLPGSLETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_001128226.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128226.2

ORF Insert Sequence:

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGTAAGTGCC 
TGGAGGCCGG GGACCTGGGC TTCTGTGGCC TCCAGCCTGC GACTCCCAGG CAGCTTAGAA 
ACCTATGTAG AACAAGAACA GGGAGAAAAT GCTAATGACA GGAATGATAG AGCGATTCGA 
GTAGCAGCAA AATGGTACAA TGAACATTTG AAAAAAATGT CAGCAGACAA CCAGCTGCAA 
GTTATCTTCA TAACAAATGA CAGGAGAAAC AAAGAGAAAG CCATAGAAGA AGGAATACCA 
GCTTTCACTT GTGAAGAATA TGTAAAGAGC CTAACTGCTA ACCCCGAACT CATAGATCGT 
CTTGCTTGTT TGTCTGAAGA AGGGAATGAA ATAGAAAGTG GAAAAATAAT ATTTTCAGAG 
CATCTTCCCT TAAGTAAGCT ACAGCAAGGC ATAAAATCTG GTACATACCT TCAAGGAACA 
TTTAGAGCTA GCAGGGAAAA TTACTTGGAA GCTACAGTAT GGATTCATGG CGACAATGAA 
GAAAATAAAG AGATAATCTT ACAGGGACTT AAACATTTAA ACAGAGCTGT TCACGAAGAT 
ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT CAGTGGGTAG CACCATCTTC TGTGGTTTTA 
CATGATGAAG GTCAAAATGA AGAAGATGTG GAGAAAGAAG AAGAGACAGA ACGAATGCTT 
AAGACTGCTG TAAGCGAGAA AATGTTGAAG CCTACAGGTA GAGTTGTAGG AATAATAAAA 
AGGAATTGGA GACCATATTG TGGCATGCTT TCCAAGTCTG ACATTAAGGA GTCAAGAAGA 
CATCTCTTTA CACCTGCTGA TAAGAGAATC CCTCGAATTC GCATAGAAAC CAGACAGGCT 
TCCACATTAG AAGGACGGAG AATTATTGTT GCTATTGATG GTTGGCCCAG AAATTCCAGA 
TATCCAAATG GACACTTTGT GAGAAATTTA GGTGATGTTG GAGAGAAAGA GACTGAAACA 
GAAGTTTTGT TACTTGAACA CGATGTTCCC CATCAGCCTT TTTCACAGGC TGTTCTTAGT 
TTTCTGCCAA AGATGCCCTG GAGCATTACT GAAAAGGACA TGAAAAACCG AGAAGACCTG 
AGGCATCTGT GTATTTGTAG TGTAGACCCA CCAGGATGTA CTGATATAGA CGATGCTCTA 
CATTGTCGAG AACTCGAAAA TGGAAATTTG GAGGTTGGTG TTCATATTGC TGATGTGAGC 
CATTTTATTA GGCCAGGAAA TGCCTTGGAT CAAGAATCAG CCAGAAGAGG AACAACTGTG 
TATCTTTGTG AAAAGAGGAT TGACATGGTT CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC 
TTAAAATGTG ACGTGGACAG GCTGGCATTT TCATGTATTT GGGAAATGAA TCACAATGCT 
GAAATCTTAA AAACGAAGTT TACCAAAAGT GTTATTAATT CAAAGGCATC TCTGACGTAT 
GCTGAAGCTC AGTTGAGAAT TGATTCAGCA AACATGAATG ATGATATTAC CACTAGTCTC 
CGTGGACTGA ATAAACTAGC CAAAATTCTG AAGAAAAGAA GGATTGAAAA AGGGGCTTTG 
ACTCTATCCT CTCCTGAAGT TCGATTCCAC ATGGACAGTG AAACTCACGA TCCTATAGAT 
CTGCAGACCA AGGAACTTAG GGAAACAAAT TCCATGGTTG AAGAATTTAT GTTACTTGCC 
AATATTTCTG TTGCAAAAAA AATTCATGAG GAATTTTCTG AACATGCTCT GCTTCGAAAA 
CATCCTGCTC CACCTCCATC AAATTATGAA ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT 
TTGGAAATTA AGACTGATAC AGCCAAGTCT TTGGCTGAGT CTTTGGATCA GGCCGAATCT 
CCTACTTTTC CATATCTAAA CACTCTGTTG AGAATATTAG CCACTCGCTG TATGATGCAA 
GCTGTGTACT TCTGTTCTGG AATGGATAAT GATTTTCATC ACTATGGCTT AGCGTCTCCA 
ATATACACAC ATTTTACTTC ACCCATTAGA AGATACGCAG ATGTCATTGT TCATCGGCTT 
TTGGCTGTGG CTATTGGGGC TGACTGTACT TATCCAGAGT TGACAGACAA ACACAAGCTT 
GCAGATATAT GTAAAAATCT AAATTTCCGG CACAAAATGG CTCAATATGC CCAACGTGCA 
TCAGTGGCTT TTCATACCCA GTTATTCTTC AAAAGCAAAG GAATAGTAAG TGAAGAAGCC 
TATATTTTAT TTGTAAGAAA GAATGCCATT GTGGTATTAA TTCCAAAGTA TGGTTTAGAA 
GGGACAGTCT TTTTTGAAGA AAAGGACAAA CCAAACCCAC AGCTTATTTA TGATGATGAG 
ATACCCTCAC TTAAAATAGA AGATACAGTG TTCCATGTAT TTGATAAAGT TAAAGTGAAA 
ATCATGTTAG ACTCATCTAA TCTTCAACAT CAGAAGATCC GAATGTCCCT GGTAGAACCA 
CAGATACCAG GAATAAGCAT TCCTACTGAT ACTTCAAACA TGGACCTTAA TGGACCAAAG 
AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIS3 ( NM_001128226.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001121698.1 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14985
Clone ID Related Accession (Same CDS sequence)	NM_001128226.2 , NM_001128226.3
Accession Version	NM_001128226.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2787bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AB023225.1, AL832266.1, AL080158.1, AL138695.13 and U79246.1. On Jun 1, 2019 this sequence version replaced NM_001128226.2. Transcript Variant: This variant (2) lacks an exon and contains an alternate exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.244984.1, SRR1803611.79112.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGTAAGTGCC 
TGGAGGCCGG GGACCTGGGC TTCTGTGGCC TCCAGCCTGC GACTCCCAGG CAGCTTAGAA 
ACCTATGTAG AACAAGAACA GGGAGAAAAT GCTAATGACA GGAATGATAG AGCGATTCGA 
GTAGCAGCAA AATGGTACAA TGAACATTTG AAAAAAATGT CAGCAGACAA CCAGCTGCAA 
GTTATCTTCA TAACAAATGA CAGGAGAAAC AAAGAGAAAG CCATAGAAGA AGGAATACCA 
GCTTTCACTT GTGAAGAATA TGTAAAGAGC CTAACTGCTA ACCCCGAACT CATAGATCGT 
CTTGCTTGTT TGTCTGAAGA AGGGAATGAA ATAGAAAGTG GAAAAATAAT ATTTTCAGAG 
CATCTTCCCT TAAGTAAGCT ACAGCAAGGC ATAAAATCTG GTACATACCT TCAAGGAACA 
TTTAGAGCTA GCAGGGAAAA TTACTTGGAA GCTACAGTAT GGATTCATGG CGACAATGAA 
GAAAATAAAG AGATAATCTT ACAGGGACTT AAACATTTAA ACAGAGCTGT TCACGAAGAT 
ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT CAGTGGGTAG CACCATCTTC TGTGGTTTTA 
CATGATGAAG GTCAAAATGA AGAAGATGTG GAGAAAGAAG AAGAGACAGA ACGAATGCTT 
AAGACTGCTG TAAGCGAGAA AATGTTGAAG CCTACAGGTA GAGTTGTAGG AATAATAAAA 
AGGAATTGGA GACCATATTG TGGCATGCTT TCCAAGTCTG ACATTAAGGA GTCAAGAAGA 
CATCTCTTTA CACCTGCTGA TAAGAGAATC CCTCGAATTC GCATAGAAAC CAGACAGGCT 
TCCACATTAG AAGGACGGAG AATTATTGTT GCTATTGATG GTTGGCCCAG AAATTCCAGA 
TATCCAAATG GACACTTTGT GAGAAATTTA GGTGATGTTG GAGAGAAAGA GACTGAAACA 
GAAGTTTTGT TACTTGAACA CGATGTTCCC CATCAGCCTT TTTCACAGGC TGTTCTTAGT 
TTTCTGCCAA AGATGCCCTG GAGCATTACT GAAAAGGACA TGAAAAACCG AGAAGACCTG 
AGGCATCTGT GTATTTGTAG TGTAGACCCA CCAGGATGTA CTGATATAGA CGATGCTCTA 
CATTGTCGAG AACTCGAAAA TGGAAATTTG GAGGTTGGTG TTCATATTGC TGATGTGAGC 
CATTTTATTA GGCCAGGAAA TGCCTTGGAT CAAGAATCAG CCAGAAGAGG AACAACTGTG 
TATCTTTGTG AAAAGAGGAT TGACATGGTT CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC 
TTAAAATGTG ACGTGGACAG GCTGGCATTT TCATGTATTT GGGAAATGAA TCACAATGCT 
GAAATCTTAA AAACGAAGTT TACCAAAAGT GTTATTAATT CAAAGGCATC TCTGACGTAT 
GCTGAAGCTC AGTTGAGAAT TGATTCAGCA AACATGAATG ATGATATTAC CACTAGTCTC 
CGTGGACTGA ATAAACTAGC CAAAATTCTG AAGAAAAGAA GGATTGAAAA AGGGGCTTTG 
ACTCTATCCT CTCCTGAAGT TCGATTCCAC ATGGACAGTG AAACTCACGA TCCTATAGAT 
CTGCAGACCA AGGAACTTAG GGAAACAAAT TCCATGGTTG AAGAATTTAT GTTACTTGCC 
AATATTTCTG TTGCAAAAAA AATTCATGAG GAATTTTCTG AACATGCTCT GCTTCGAAAA 
CATCCTGCTC CACCTCCATC AAATTATGAA ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT 
TTGGAAATTA AGACTGATAC AGCCAAGTCT TTGGCTGAGT CTTTGGATCA GGCCGAATCT 
CCTACTTTTC CATATCTAAA CACTCTGTTG AGAATATTAG CCACTCGCTG TATGATGCAA 
GCTGTGTACT TCTGTTCTGG AATGGATAAT GATTTTCATC ACTATGGCTT AGCGTCTCCA 
ATATACACAC ATTTTACTTC ACCCATTAGA AGATACGCAG ATGTCATTGT TCATCGGCTT 
TTGGCTGTGG CTATTGGGGC TGACTGTACT TATCCAGAGT TGACAGACAA ACACAAGCTT 
GCAGATATAT GTAAAAATCT AAATTTCCGG CACAAAATGG CTCAATATGC CCAACGTGCA 
TCAGTGGCTT TTCATACCCA GTTATTCTTC AAAAGCAAAG GAATAGTAAG TGAAGAAGCC 
TATATTTTAT TTGTAAGAAA GAATGCCATT GTGGTATTAA TTCCAAAGTA TGGTTTAGAA 
GGGACAGTCT TTTTTGAAGA AAAGGACAAA CCAAACCCAC AGCTTATTTA TGATGATGAG 
ATACCCTCAC TTAAAATAGA AGATACAGTG TTCCATGTAT TTGATAAAGT TAAAGTGAAA 
ATCATGTTAG ACTCATCTAA TCTTCAACAT CAGAAGATCC GAATGTCCCT GGTAGAACCA 
CAGATACCAG GAATAAGCAT TCCTACTGAT ACTTCAAACA TGGACCTTAA TGGACCAAAG 
AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121698.1
CDS	69..2855
Translation	MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIVSAWRPGTWASVASSLRLPGSLETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_001128226.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001128226.3

ORF Insert Sequence:

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGTAAGTGCC 
TGGAGGCCGG GGACCTGGGC TTCTGTGGCC TCCAGCCTGC GACTCCCAGG CAGCTTAGAA 
ACCTATGTAG AACAAGAACA GGGAGAAAAT GCTAATGACA GGAATGATAG AGCGATTCGA 
GTAGCAGCAA AATGGTACAA TGAACATTTG AAAAAAATGT CAGCAGACAA CCAGCTGCAA 
GTTATCTTCA TAACAAATGA CAGGAGAAAC AAAGAGAAAG CCATAGAAGA AGGAATACCA 
GCTTTCACTT GTGAAGAATA TGTAAAGAGC CTAACTGCTA ACCCCGAACT CATAGATCGT 
CTTGCTTGTT TGTCTGAAGA AGGGAATGAA ATAGAAAGTG GAAAAATAAT ATTTTCAGAG 
CATCTTCCCT TAAGTAAGCT ACAGCAAGGC ATAAAATCTG GTACATACCT TCAAGGAACA 
TTTAGAGCTA GCAGGGAAAA TTACTTGGAA GCTACAGTAT GGATTCATGG CGACAATGAA 
GAAAATAAAG AGATAATCTT ACAGGGACTT AAACATTTAA ACAGAGCTGT TCACGAAGAT 
ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT CAGTGGGTAG CACCATCTTC TGTGGTTTTA 
CATGATGAAG GTCAAAATGA AGAAGATGTG GAGAAAGAAG AAGAGACAGA ACGAATGCTT 
AAGACTGCTG TAAGCGAGAA AATGTTGAAG CCTACAGGTA GAGTTGTAGG AATAATAAAA 
AGGAATTGGA GACCATATTG TGGCATGCTT TCCAAGTCTG ACATTAAGGA GTCAAGAAGA 
CATCTCTTTA CACCTGCTGA TAAGAGAATC CCTCGAATTC GCATAGAAAC CAGACAGGCT 
TCCACATTAG AAGGACGGAG AATTATTGTT GCTATTGATG GTTGGCCCAG AAATTCCAGA 
TATCCAAATG GACACTTTGT GAGAAATTTA GGTGATGTTG GAGAGAAAGA GACTGAAACA 
GAAGTTTTGT TACTTGAACA CGATGTTCCC CATCAGCCTT TTTCACAGGC TGTTCTTAGT 
TTTCTGCCAA AGATGCCCTG GAGCATTACT GAAAAGGACA TGAAAAACCG AGAAGACCTG 
AGGCATCTGT GTATTTGTAG TGTAGACCCA CCAGGATGTA CTGATATAGA CGATGCTCTA 
CATTGTCGAG AACTCGAAAA TGGAAATTTG GAGGTTGGTG TTCATATTGC TGATGTGAGC 
CATTTTATTA GGCCAGGAAA TGCCTTGGAT CAAGAATCAG CCAGAAGAGG AACAACTGTG 
TATCTTTGTG AAAAGAGGAT TGACATGGTT CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC 
TTAAAATGTG ACGTGGACAG GCTGGCATTT TCATGTATTT GGGAAATGAA TCACAATGCT 
GAAATCTTAA AAACGAAGTT TACCAAAAGT GTTATTAATT CAAAGGCATC TCTGACGTAT 
GCTGAAGCTC AGTTGAGAAT TGATTCAGCA AACATGAATG ATGATATTAC CACTAGTCTC 
CGTGGACTGA ATAAACTAGC CAAAATTCTG AAGAAAAGAA GGATTGAAAA AGGGGCTTTG 
ACTCTATCCT CTCCTGAAGT TCGATTCCAC ATGGACAGTG AAACTCACGA TCCTATAGAT 
CTGCAGACCA AGGAACTTAG GGAAACAAAT TCCATGGTTG AAGAATTTAT GTTACTTGCC 
AATATTTCTG TTGCAAAAAA AATTCATGAG GAATTTTCTG AACATGCTCT GCTTCGAAAA 
CATCCTGCTC CACCTCCATC AAATTATGAA ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT 
TTGGAAATTA AGACTGATAC AGCCAAGTCT TTGGCTGAGT CTTTGGATCA GGCCGAATCT 
CCTACTTTTC CATATCTAAA CACTCTGTTG AGAATATTAG CCACTCGCTG TATGATGCAA 
GCTGTGTACT TCTGTTCTGG AATGGATAAT GATTTTCATC ACTATGGCTT AGCGTCTCCA 
ATATACACAC ATTTTACTTC ACCCATTAGA AGATACGCAG ATGTCATTGT TCATCGGCTT 
TTGGCTGTGG CTATTGGGGC TGACTGTACT TATCCAGAGT TGACAGACAA ACACAAGCTT 
GCAGATATAT GTAAAAATCT AAATTTCCGG CACAAAATGG CTCAATATGC CCAACGTGCA 
TCAGTGGCTT TTCATACCCA GTTATTCTTC AAAAGCAAAG GAATAGTAAG TGAAGAAGCC 
TATATTTTAT TTGTAAGAAA GAATGCCATT GTGGTATTAA TTCCAAAGTA TGGTTTAGAA 
GGGACAGTCT TTTTTGAAGA AAAGGACAAA CCAAACCCAC AGCTTATTTA TGATGATGAG 
ATACCCTCAC TTAAAATAGA AGATACAGTG TTCCATGTAT TTGATAAAGT TAAAGTGAAA 
ATCATGTTAG ACTCATCTAA TCTTCAACAT CAGAAGATCC GAATGTCCCT GGTAGAACCA 
CAGATACCAG GAATAAGCAT TCCTACTGAT ACTTCAAACA TGGACCTTAA TGGACCAAAG 
AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIS3 ( NM_001322348.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309277.1 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu47098
Clone ID Related Accession (Same CDS sequence)	NM_001322348.1 , NM_001322348.2
Accession Version	NM_001322348.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2508bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL391384.18 and AL138695.13. On Apr 11, 2016 this sequence version replaced XM_006719778.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.19089.1, SRR1803613.146240.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTGTTACT GCACCAGAGA AACCTATGTA GAACAAGAAC AGGGAGAAAA TGCTAATGAC 
AGGAATGATA GAGCGATTCG AGTAGCAGCA AAATGGTACA ATGAACATTT GAAAAAAATG 
TCAGCAGACA ACCAGCTGCA AGTTATCTTC ATAACAAATG ACAGGAGAAA CAAAGAGAAA 
GCCATAGAAG AAGGAATACC AGCTTTCACT TGTGAAGAAT ATGTAAAGAG CCTAACTGCT 
AACCCCGAAC TCATAGATCG TCTTGCTTGT TTGTCTGAAG AAGGGAATGA AATAGAAAGT 
GGAAAAATAA TATTTTCAGA GCATCTTCCC TTAAGTAAGC TACAGCAAGG CATAAAATCT 
GGTACATACC TTCAAGGAAC ATTTAGAGCT AGCAGGGAAA ATTACTTGGA AGCTACAGTA 
TGGATTCATG GCGACAATGA AGAAAATAAA GAGATAATCT TACAGGGACT TAAACATTTA 
AACAGAGCTG TTCACGAAGA TATTGTGGCT GTGGAGCTTC TCCCCAAGAG TCAGTGGGTA 
GCACCATCTT CTGTGGTTTT ACATGATGAA GGTCAAAATG AAGAAGATGT GGAGAAAGAA 
GAAGAGACAG AACGAATGCT TAAGACTGCT GTAAGCGAGA AAATGTTGAA GCCTACAGGT 
AGAGTTGTAG GAATAATAAA AAGGAATTGG AGACCATATT GTGGCATGCT TTCCAAGTCT 
GACATTAAGG AGTCAAGAAG ACATCTCTTT ACACCTGCTG ATAAGAGAAT CCCTCGAATT 
CGCATAGAAA CCAGACAGGC TTCCACATTA GAAGGACGGA GAATTATTGT TGCTATTGAT 
GGTTGGCCCA GAAATTCCAG ATATCCAAAT GGACACTTTG TGAGAAATTT AGGTGATGTT 
GGAGAGAAAG AGACTGAAAC AGAAGTTTTG TTACTTGAAC ACGATGTTCC CCATCAGCCT 
TTTTCACAGG CTGTTCTTAG TTTTCTGCCA AAGATGCCCT GGAGCATTAC TGAAAAGGAC 
ATGAAAAACC GAGAAGACCT GAGGCATCTG TGTATTTGTA GTGTAGACCC ACCAGGATGT 
ACTGATATAG ACGATGCTCT ACATTGTCGA GAACTCGAAA ATGGAAATTT GGAGGTTGGT 
GTTCATATTG CTGATGTGAG CCATTTTATT AGGCCAGGAA ATGCCTTGGA TCAAGAATCA 
GCCAGAAGAG GAACAACTGT GTATCTTTGT GAAAAGAGGA TTGACATGGT TCCAGAGTTG 
CTTAGCTCTA ACTTGTGTTC CTTAAAATGT GACGTGGACA GGCTGGCATT TTCATGTATT 
TGGGAAATGA ATCACAATGC TGAAATCTTA AAAACGAAGT TTACCAAAAG TGTTATTAAT 
TCAAAGGCAT CTCTGACGTA TGCTGAAGCT CAGTTGAGAA TTGATTCAGC AAACATGAAT 
GATGATATTA CCACTAGTCT CCGTGGACTG AATAAACTAG CCAAAATTCT GAAGAAAAGA 
AGGATTGAAA AAGGGGCTTT GACTCTATCC TCTCCTGAAG TTCGATTCCA CATGGACAGT 
GAAACTCACG ATCCTATAGA TCTGCAGACC AAGGAACTTA GGGAAACAAA TTCCATGGTT 
GAAGAATTTA TGTTACTTGC CAATATTTCT GTTGCAAAAA AAATTCATGA GGAATTTTCT 
GAACATGCTC TGCTTCGAAA ACATCCTGCT CCACCTCCAT CAAATTATGA AATTCTTGTT 
AAGGCAGCCA GGTCAAGGAA TTTGGAAATT AAGACTGATA CAGCCAAGTC TTTGGCTGAG 
TCTTTGGATC AGGCCGAATC TCCTACTTTT CCATATCTAA ACACTCTGTT GAGAATATTA 
GCCACTCGCT GTATGATGCA AGCTGTGTAC TTCTGTTCTG GAATGGATAA TGATTTTCAT 
CACTATGGCT TAGCGTCTCC AATATACACA CATTTTACTT CACCCATTAG AAGATACGCA 
GATGTCATTG TTCATCGGCT TTTGGCTGTG GCTATTGGGG CTGACTGTAC TTATCCAGAG 
TTGACAGACA AACACAAGCT TGCAGATATA TGTAAAAATC TAAATTTCCG GCACAAAATG 
GCTCAATATG CCCAACGTGC ATCAGTGGCT TTTCATACCC AGTTATTCTT CAAAAGCAAA 
GGAATAGTAA GTGAAGAAGC CTATATTTTA TTTGTAAGAA AGAATGCCAT TGTGGTATTA 
ATTCCAAAGT ATGGTTTAGA AGGGACAGTC TTTTTTGAAG AAAAGGACAA ACCAAACCCA 
CAGCTTATTT ATGATGATGA GATACCCTCA CTTAAAATAG AAGATACAGT GTTCCATGTA 
TTTGATAAAG TTAAAGTGAA AATCATGTTA GACTCATCTA ATCTTCAACA TCAGAAGATC 
CGAATGTCCC TGGTAGAACC ACAGATACCA GGAATAAGCA TTCCTACTGA TACTTCAAAC 
ATGGACCTTA ATGGACCAAA GAAAAAGAAG ATGAAGCTTG GAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309277.1
CDS	508..3015
Translation	MCYCTRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_001322348.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322348.1

ORF Insert Sequence:

ATGTGTTACT GCACCAGAGA AACCTATGTA GAACAAGAAC AGGGAGAAAA TGCTAATGAC 
AGGAATGATA GAGCGATTCG AGTAGCAGCA AAATGGTACA ATGAACATTT GAAAAAAATG 
TCAGCAGACA ACCAGCTGCA AGTTATCTTC ATAACAAATG ACAGGAGAAA CAAAGAGAAA 
GCCATAGAAG AAGGAATACC AGCTTTCACT TGTGAAGAAT ATGTAAAGAG CCTAACTGCT 
AACCCCGAAC TCATAGATCG TCTTGCTTGT TTGTCTGAAG AAGGGAATGA AATAGAAAGT 
GGAAAAATAA TATTTTCAGA GCATCTTCCC TTAAGTAAGC TACAGCAAGG CATAAAATCT 
GGTACATACC TTCAAGGAAC ATTTAGAGCT AGCAGGGAAA ATTACTTGGA AGCTACAGTA 
TGGATTCATG GCGACAATGA AGAAAATAAA GAGATAATCT TACAGGGACT TAAACATTTA 
AACAGAGCTG TTCACGAAGA TATTGTGGCT GTGGAGCTTC TCCCCAAGAG TCAGTGGGTA 
GCACCATCTT CTGTGGTTTT ACATGATGAA GGTCAAAATG AAGAAGATGT GGAGAAAGAA 
GAAGAGACAG AACGAATGCT TAAGACTGCT GTAAGCGAGA AAATGTTGAA GCCTACAGGT 
AGAGTTGTAG GAATAATAAA AAGGAATTGG AGACCATATT GTGGCATGCT TTCCAAGTCT 
GACATTAAGG AGTCAAGAAG ACATCTCTTT ACACCTGCTG ATAAGAGAAT CCCTCGAATT 
CGCATAGAAA CCAGACAGGC TTCCACATTA GAAGGACGGA GAATTATTGT TGCTATTGAT 
GGTTGGCCCA GAAATTCCAG ATATCCAAAT GGACACTTTG TGAGAAATTT AGGTGATGTT 
GGAGAGAAAG AGACTGAAAC AGAAGTTTTG TTACTTGAAC ACGATGTTCC CCATCAGCCT 
TTTTCACAGG CTGTTCTTAG TTTTCTGCCA AAGATGCCCT GGAGCATTAC TGAAAAGGAC 
ATGAAAAACC GAGAAGACCT GAGGCATCTG TGTATTTGTA GTGTAGACCC ACCAGGATGT 
ACTGATATAG ACGATGCTCT ACATTGTCGA GAACTCGAAA ATGGAAATTT GGAGGTTGGT 
GTTCATATTG CTGATGTGAG CCATTTTATT AGGCCAGGAA ATGCCTTGGA TCAAGAATCA 
GCCAGAAGAG GAACAACTGT GTATCTTTGT GAAAAGAGGA TTGACATGGT TCCAGAGTTG 
CTTAGCTCTA ACTTGTGTTC CTTAAAATGT GACGTGGACA GGCTGGCATT TTCATGTATT 
TGGGAAATGA ATCACAATGC TGAAATCTTA AAAACGAAGT TTACCAAAAG TGTTATTAAT 
TCAAAGGCAT CTCTGACGTA TGCTGAAGCT CAGTTGAGAA TTGATTCAGC AAACATGAAT 
GATGATATTA CCACTAGTCT CCGTGGACTG AATAAACTAG CCAAAATTCT GAAGAAAAGA 
AGGATTGAAA AAGGGGCTTT GACTCTATCC TCTCCTGAAG TTCGATTCCA CATGGACAGT 
GAAACTCACG ATCCTATAGA TCTGCAGACC AAGGAACTTA GGGAAACAAA TTCCATGGTT 
GAAGAATTTA TGTTACTTGC CAATATTTCT GTTGCAAAAA AAATTCATGA GGAATTTTCT 
GAACATGCTC TGCTTCGAAA ACATCCTGCT CCACCTCCAT CAAATTATGA AATTCTTGTT 
AAGGCAGCCA GGTCAAGGAA TTTGGAAATT AAGACTGATA CAGCCAAGTC TTTGGCTGAG 
TCTTTGGATC AGGCCGAATC TCCTACTTTT CCATATCTAA ACACTCTGTT GAGAATATTA 
GCCACTCGCT GTATGATGCA AGCTGTGTAC TTCTGTTCTG GAATGGATAA TGATTTTCAT 
CACTATGGCT TAGCGTCTCC AATATACACA CATTTTACTT CACCCATTAG AAGATACGCA 
GATGTCATTG TTCATCGGCT TTTGGCTGTG GCTATTGGGG CTGACTGTAC TTATCCAGAG 
TTGACAGACA AACACAAGCT TGCAGATATA TGTAAAAATC TAAATTTCCG GCACAAAATG 
GCTCAATATG CCCAACGTGC ATCAGTGGCT TTTCATACCC AGTTATTCTT CAAAAGCAAA 
GGAATAGTAA GTGAAGAAGC CTATATTTTA TTTGTAAGAA AGAATGCCAT TGTGGTATTA 
ATTCCAAAGT ATGGTTTAGA AGGGACAGTC TTTTTTGAAG AAAAGGACAA ACCAAACCCA 
CAGCTTATTT ATGATGATGA GATACCCTCA CTTAAAATAG AAGATACAGT GTTCCATGTA 
TTTGATAAAG TTAAAGTGAA AATCATGTTA GACTCATCTA ATCTTCAACA TCAGAAGATC 
CGAATGTCCC TGGTAGAACC ACAGATACCA GGAATAAGCA TTCCTACTGA TACTTCAAAC 
ATGGACCTTA ATGGACCAAA GAAAAAGAAG ATGAAGCTTG GAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIS3 ( NM_001322348.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309277.1 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu47098
Clone ID Related Accession (Same CDS sequence)	NM_001322348.1 , NM_001322348.2
Accession Version	NM_001322348.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2508bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577980800000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform c
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL391384.18 and AL138695.13. On May 31, 2019 this sequence version replaced NM_001322348.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.146240.1, SRR1660807.53450.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTGTTACT GCACCAGAGA AACCTATGTA GAACAAGAAC AGGGAGAAAA TGCTAATGAC 
AGGAATGATA GAGCGATTCG AGTAGCAGCA AAATGGTACA ATGAACATTT GAAAAAAATG 
TCAGCAGACA ACCAGCTGCA AGTTATCTTC ATAACAAATG ACAGGAGAAA CAAAGAGAAA 
GCCATAGAAG AAGGAATACC AGCTTTCACT TGTGAAGAAT ATGTAAAGAG CCTAACTGCT 
AACCCCGAAC TCATAGATCG TCTTGCTTGT TTGTCTGAAG AAGGGAATGA AATAGAAAGT 
GGAAAAATAA TATTTTCAGA GCATCTTCCC TTAAGTAAGC TACAGCAAGG CATAAAATCT 
GGTACATACC TTCAAGGAAC ATTTAGAGCT AGCAGGGAAA ATTACTTGGA AGCTACAGTA 
TGGATTCATG GCGACAATGA AGAAAATAAA GAGATAATCT TACAGGGACT TAAACATTTA 
AACAGAGCTG TTCACGAAGA TATTGTGGCT GTGGAGCTTC TCCCCAAGAG TCAGTGGGTA 
GCACCATCTT CTGTGGTTTT ACATGATGAA GGTCAAAATG AAGAAGATGT GGAGAAAGAA 
GAAGAGACAG AACGAATGCT TAAGACTGCT GTAAGCGAGA AAATGTTGAA GCCTACAGGT 
AGAGTTGTAG GAATAATAAA AAGGAATTGG AGACCATATT GTGGCATGCT TTCCAAGTCT 
GACATTAAGG AGTCAAGAAG ACATCTCTTT ACACCTGCTG ATAAGAGAAT CCCTCGAATT 
CGCATAGAAA CCAGACAGGC TTCCACATTA GAAGGACGGA GAATTATTGT TGCTATTGAT 
GGTTGGCCCA GAAATTCCAG ATATCCAAAT GGACACTTTG TGAGAAATTT AGGTGATGTT 
GGAGAGAAAG AGACTGAAAC AGAAGTTTTG TTACTTGAAC ACGATGTTCC CCATCAGCCT 
TTTTCACAGG CTGTTCTTAG TTTTCTGCCA AAGATGCCCT GGAGCATTAC TGAAAAGGAC 
ATGAAAAACC GAGAAGACCT GAGGCATCTG TGTATTTGTA GTGTAGACCC ACCAGGATGT 
ACTGATATAG ACGATGCTCT ACATTGTCGA GAACTCGAAA ATGGAAATTT GGAGGTTGGT 
GTTCATATTG CTGATGTGAG CCATTTTATT AGGCCAGGAA ATGCCTTGGA TCAAGAATCA 
GCCAGAAGAG GAACAACTGT GTATCTTTGT GAAAAGAGGA TTGACATGGT TCCAGAGTTG 
CTTAGCTCTA ACTTGTGTTC CTTAAAATGT GACGTGGACA GGCTGGCATT TTCATGTATT 
TGGGAAATGA ATCACAATGC TGAAATCTTA AAAACGAAGT TTACCAAAAG TGTTATTAAT 
TCAAAGGCAT CTCTGACGTA TGCTGAAGCT CAGTTGAGAA TTGATTCAGC AAACATGAAT 
GATGATATTA CCACTAGTCT CCGTGGACTG AATAAACTAG CCAAAATTCT GAAGAAAAGA 
AGGATTGAAA AAGGGGCTTT GACTCTATCC TCTCCTGAAG TTCGATTCCA CATGGACAGT 
GAAACTCACG ATCCTATAGA TCTGCAGACC AAGGAACTTA GGGAAACAAA TTCCATGGTT 
GAAGAATTTA TGTTACTTGC CAATATTTCT GTTGCAAAAA AAATTCATGA GGAATTTTCT 
GAACATGCTC TGCTTCGAAA ACATCCTGCT CCACCTCCAT CAAATTATGA AATTCTTGTT 
AAGGCAGCCA GGTCAAGGAA TTTGGAAATT AAGACTGATA CAGCCAAGTC TTTGGCTGAG 
TCTTTGGATC AGGCCGAATC TCCTACTTTT CCATATCTAA ACACTCTGTT GAGAATATTA 
GCCACTCGCT GTATGATGCA AGCTGTGTAC TTCTGTTCTG GAATGGATAA TGATTTTCAT 
CACTATGGCT TAGCGTCTCC AATATACACA CATTTTACTT CACCCATTAG AAGATACGCA 
GATGTCATTG TTCATCGGCT TTTGGCTGTG GCTATTGGGG CTGACTGTAC TTATCCAGAG 
TTGACAGACA AACACAAGCT TGCAGATATA TGTAAAAATC TAAATTTCCG GCACAAAATG 
GCTCAATATG CCCAACGTGC ATCAGTGGCT TTTCATACCC AGTTATTCTT CAAAAGCAAA 
GGAATAGTAA GTGAAGAAGC CTATATTTTA TTTGTAAGAA AGAATGCCAT TGTGGTATTA 
ATTCCAAAGT ATGGTTTAGA AGGGACAGTC TTTTTTGAAG AAAAGGACAA ACCAAACCCA 
CAGCTTATTT ATGATGATGA GATACCCTCA CTTAAAATAG AAGATACAGT GTTCCATGTA 
TTTGATAAAG TTAAAGTGAA AATCATGTTA GACTCATCTA ATCTTCAACA TCAGAAGATC 
CGAATGTCCC TGGTAGAACC ACAGATACCA GGAATAAGCA TTCCTACTGA TACTTCAAAC 
ATGGACCTTA ATGGACCAAA GAAAAAGAAG ATGAAGCTTG GAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309277.1
CDS	280..2787
Translation	MCYCTRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_001322348.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322348.2

ORF Insert Sequence:

ATGTGTTACT GCACCAGAGA AACCTATGTA GAACAAGAAC AGGGAGAAAA TGCTAATGAC 
AGGAATGATA GAGCGATTCG AGTAGCAGCA AAATGGTACA ATGAACATTT GAAAAAAATG 
TCAGCAGACA ACCAGCTGCA AGTTATCTTC ATAACAAATG ACAGGAGAAA CAAAGAGAAA 
GCCATAGAAG AAGGAATACC AGCTTTCACT TGTGAAGAAT ATGTAAAGAG CCTAACTGCT 
AACCCCGAAC TCATAGATCG TCTTGCTTGT TTGTCTGAAG AAGGGAATGA AATAGAAAGT 
GGAAAAATAA TATTTTCAGA GCATCTTCCC TTAAGTAAGC TACAGCAAGG CATAAAATCT 
GGTACATACC TTCAAGGAAC ATTTAGAGCT AGCAGGGAAA ATTACTTGGA AGCTACAGTA 
TGGATTCATG GCGACAATGA AGAAAATAAA GAGATAATCT TACAGGGACT TAAACATTTA 
AACAGAGCTG TTCACGAAGA TATTGTGGCT GTGGAGCTTC TCCCCAAGAG TCAGTGGGTA 
GCACCATCTT CTGTGGTTTT ACATGATGAA GGTCAAAATG AAGAAGATGT GGAGAAAGAA 
GAAGAGACAG AACGAATGCT TAAGACTGCT GTAAGCGAGA AAATGTTGAA GCCTACAGGT 
AGAGTTGTAG GAATAATAAA AAGGAATTGG AGACCATATT GTGGCATGCT TTCCAAGTCT 
GACATTAAGG AGTCAAGAAG ACATCTCTTT ACACCTGCTG ATAAGAGAAT CCCTCGAATT 
CGCATAGAAA CCAGACAGGC TTCCACATTA GAAGGACGGA GAATTATTGT TGCTATTGAT 
GGTTGGCCCA GAAATTCCAG ATATCCAAAT GGACACTTTG TGAGAAATTT AGGTGATGTT 
GGAGAGAAAG AGACTGAAAC AGAAGTTTTG TTACTTGAAC ACGATGTTCC CCATCAGCCT 
TTTTCACAGG CTGTTCTTAG TTTTCTGCCA AAGATGCCCT GGAGCATTAC TGAAAAGGAC 
ATGAAAAACC GAGAAGACCT GAGGCATCTG TGTATTTGTA GTGTAGACCC ACCAGGATGT 
ACTGATATAG ACGATGCTCT ACATTGTCGA GAACTCGAAA ATGGAAATTT GGAGGTTGGT 
GTTCATATTG CTGATGTGAG CCATTTTATT AGGCCAGGAA ATGCCTTGGA TCAAGAATCA 
GCCAGAAGAG GAACAACTGT GTATCTTTGT GAAAAGAGGA TTGACATGGT TCCAGAGTTG 
CTTAGCTCTA ACTTGTGTTC CTTAAAATGT GACGTGGACA GGCTGGCATT TTCATGTATT 
TGGGAAATGA ATCACAATGC TGAAATCTTA AAAACGAAGT TTACCAAAAG TGTTATTAAT 
TCAAAGGCAT CTCTGACGTA TGCTGAAGCT CAGTTGAGAA TTGATTCAGC AAACATGAAT 
GATGATATTA CCACTAGTCT CCGTGGACTG AATAAACTAG CCAAAATTCT GAAGAAAAGA 
AGGATTGAAA AAGGGGCTTT GACTCTATCC TCTCCTGAAG TTCGATTCCA CATGGACAGT 
GAAACTCACG ATCCTATAGA TCTGCAGACC AAGGAACTTA GGGAAACAAA TTCCATGGTT 
GAAGAATTTA TGTTACTTGC CAATATTTCT GTTGCAAAAA AAATTCATGA GGAATTTTCT 
GAACATGCTC TGCTTCGAAA ACATCCTGCT CCACCTCCAT CAAATTATGA AATTCTTGTT 
AAGGCAGCCA GGTCAAGGAA TTTGGAAATT AAGACTGATA CAGCCAAGTC TTTGGCTGAG 
TCTTTGGATC AGGCCGAATC TCCTACTTTT CCATATCTAA ACACTCTGTT GAGAATATTA 
GCCACTCGCT GTATGATGCA AGCTGTGTAC TTCTGTTCTG GAATGGATAA TGATTTTCAT 
CACTATGGCT TAGCGTCTCC AATATACACA CATTTTACTT CACCCATTAG AAGATACGCA 
GATGTCATTG TTCATCGGCT TTTGGCTGTG GCTATTGGGG CTGACTGTAC TTATCCAGAG 
TTGACAGACA AACACAAGCT TGCAGATATA TGTAAAAATC TAAATTTCCG GCACAAAATG 
GCTCAATATG CCCAACGTGC ATCAGTGGCT TTTCATACCC AGTTATTCTT CAAAAGCAAA 
GGAATAGTAA GTGAAGAAGC CTATATTTTA TTTGTAAGAA AGAATGCCAT TGTGGTATTA 
ATTCCAAAGT ATGGTTTAGA AGGGACAGTC TTTTTTGAAG AAAAGGACAA ACCAAACCCA 
CAGCTTATTT ATGATGATGA GATACCCTCA CTTAAAATAG AAGATACAGT GTTCCATGTA 
TTTGATAAAG TTAAAGTGAA AATCATGTTA GACTCATCTA ATCTTCAACA TCAGAAGATC 
CGAATGTCCC TGGTAGAACC ACAGATACCA GGAATAAGCA TTCCTACTGA TACTTCAAAC 
ATGGACCTTA ATGGACCAAA GAAAAAGAAG ATGAAGCTTG GAAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIS3 ( NM_001322349.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309278.1 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu47099
Clone ID Related Accession (Same CDS sequence)	NM_001322349.2 , NM_001322349.1
Accession Version	NM_001322349.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform d
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL391384.18 and AL138695.13. On May 31, 2019 this sequence version replaced NM_001322349.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.145364.1, SRR1803616.80575.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCAGCAG ACAACCAGCT GCAAGTTATC TTCATAACAA ATGACAGGAG AAACAAAGAG 
AAAGCCATAG AAGAAGGAAT ACCAGCTTTC ACTTGTGAAG AATATGTAAA GAGCCTAACT 
GCTAACCCCG AACTCATAGA TCGTCTTGCT TGTTTGTCTG AAGAAGGGAA TGAAATAGAA 
AGTGGAAAAA TAATATTTTC AGAGCATCTT CCCTTAAGTA AGCTACAGCA AGGCATAAAA 
TCTGGTACAT ACCTTCAAGG AACATTTAGA GCTAGCAGGG AAAATTACTT GGAAGCTACA 
GTATGGATTC ATGGCGACAA TGAAGAAAAT AAAGAGATAA TCTTACAGGG ACTTAAACAT 
TTAAACAGAG CTGTTCACGA AGATATTGTG GCTGTGGAGC TTCTCCCCAA GAGTCAGTGG 
GTAGCACCAT CTTCTGTGGT TTTACATGAT GAAGGTCAAA ATGAAGAAGA TGTGGAGAAA 
GAAGAAGAGA CAGAACGAAT GCTTAAGACT GCTGTAAGCG AGAAAATGTT GAAGCCTACA 
GGTAGAGTTG TAGGAATAAT AAAAAGGAAT TGGAGACCAT ATTGTGGCAT GCTTTCCAAG 
TCTGACATTA AGGAGTCAAG AAGACATCTC TTTACACCTG CTGATAAGAG AATCCCTCGA 
ATTCGCATAG AAACCAGACA GGCTTCCACA TTAGAAGGAC GGAGAATTAT TGTTGCTATT 
GATGGTTGGC CCAGAAATTC CAGATATCCA AATGGACACT TTGTGAGAAA TTTAGGTGAT 
GTTGGAGAGA AAGAGACTGA AACAGAAGTT TTGTTACTTG AACACGATGT TCCCCATCAG 
CCTTTTTCAC AGGCTGTTCT TAGTTTTCTG CCAAAGATGC CCTGGAGCAT TACTGAAAAG 
GACATGAAAA ACCGAGAAGA CCTGAGGCAT CTGTGTATTT GTAGTGTAGA CCCACCAGGA 
TGTACTGATA TAGACGATGC TCTACATTGT CGAGAACTCG AAAATGGAAA TTTGGAGGTT 
GGTGTTCATA TTGCTGATGT GAGCCATTTT ATTAGGCCAG GAAATGCCTT GGATCAAGAA 
TCAGCCAGAA GAGGAACAAC TGTGTATCTT TGTGAAAAGA GGATTGACAT GGTTCCAGAG 
TTGCTTAGCT CTAACTTGTG TTCCTTAAAA TGTGACGTGG ACAGGCTGGC ATTTTCATGT 
ATTTGGGAAA TGAATCACAA TGCTGAAATC TTAAAAACGA AGTTTACCAA AAGTGTTATT 
AATTCAAAGG CATCTCTGAC GTATGCTGAA GCTCAGTTGA GAATTGATTC AGCAAACATG 
AATGATGATA TTACCACTAG TCTCCGTGGA CTGAATAAAC TAGCCAAAAT TCTGAAGAAA 
AGAAGGATTG AAAAAGGGGC TTTGACTCTA TCCTCTCCTG AAGTTCGATT CCACATGGAC 
AGTGAAACTC ACGATCCTAT AGATCTGCAG ACCAAGGAAC TTAGGGAAAC AAATTCCATG 
GTTGAAGAAT TTATGTTACT TGCCAATATT TCTGTTGCAA AAAAAATTCA TGAGGAATTT 
TCTGAACATG CTCTGCTTCG AAAACATCCT GCTCCACCTC CATCAAATTA TGAAATTCTT 
GTTAAGGCAG CCAGGTCAAG GAATTTGGAA ATTAAGACTG ATACAGCCAA GTCTTTGGCT 
GAGTCTTTGG ATCAGGCCGA ATCTCCTACT TTTCCATATC TAAACACTCT GTTGAGAATA 
TTAGCCACTC GCTGTATGAT GCAAGCTGTG TACTTCTGTT CTGGAATGGA TAATGATTTT 
CATCACTATG GCTTAGCGTC TCCAATATAC ACACATTTTA CTTCACCCAT TAGAAGATAC 
GCAGATGTCA TTGTTCATCG GCTTTTGGCT GTGGCTATTG GGGCTGACTG TACTTATCCA 
GAGTTGACAG ACAAACACAA GCTTGCAGAT ATATGTAAAA ATCTAAATTT CCGGCACAAA 
ATGGCTCAAT ATGCCCAACG TGCATCAGTG GCTTTTCATA CCCAGTTATT CTTCAAAAGC 
AAAGGAATAG TAAGTGAAGA AGCCTATATT TTATTTGTAA GAAAGAATGC CATTGTGGTA 
TTAATTCCAA AGTATGGTTT AGAAGGGACA GTCTTTTTTG AAGAAAAGGA CAAACCAAAC 
CCACAGCTTA TTTATGATGA TGAGATACCC TCACTTAAAA TAGAAGATAC AGTGTTCCAT 
GTATTTGATA AAGTTAAAGT GAAAATCATG TTAGACTCAT CTAATCTTCA ACATCAGAAG 
ATCCGAATGT CCCTGGTAGA ACCACAGATA CCAGGAATAA GCATTCCTAC TGATACTTCA 
AACATGGACC TTAATGGACC AAAGAAAAAG AAGATGAAGC TTGGAAAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309278.1
CDS	623..3013
Translation	MSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_001322349.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322349.2

ORF Insert Sequence:

ATGTCAGCAG ACAACCAGCT GCAAGTTATC TTCATAACAA ATGACAGGAG AAACAAAGAG 
AAAGCCATAG AAGAAGGAAT ACCAGCTTTC ACTTGTGAAG AATATGTAAA GAGCCTAACT 
GCTAACCCCG AACTCATAGA TCGTCTTGCT TGTTTGTCTG AAGAAGGGAA TGAAATAGAA 
AGTGGAAAAA TAATATTTTC AGAGCATCTT CCCTTAAGTA AGCTACAGCA AGGCATAAAA 
TCTGGTACAT ACCTTCAAGG AACATTTAGA GCTAGCAGGG AAAATTACTT GGAAGCTACA 
GTATGGATTC ATGGCGACAA TGAAGAAAAT AAAGAGATAA TCTTACAGGG ACTTAAACAT 
TTAAACAGAG CTGTTCACGA AGATATTGTG GCTGTGGAGC TTCTCCCCAA GAGTCAGTGG 
GTAGCACCAT CTTCTGTGGT TTTACATGAT GAAGGTCAAA ATGAAGAAGA TGTGGAGAAA 
GAAGAAGAGA CAGAACGAAT GCTTAAGACT GCTGTAAGCG AGAAAATGTT GAAGCCTACA 
GGTAGAGTTG TAGGAATAAT AAAAAGGAAT TGGAGACCAT ATTGTGGCAT GCTTTCCAAG 
TCTGACATTA AGGAGTCAAG AAGACATCTC TTTACACCTG CTGATAAGAG AATCCCTCGA 
ATTCGCATAG AAACCAGACA GGCTTCCACA TTAGAAGGAC GGAGAATTAT TGTTGCTATT 
GATGGTTGGC CCAGAAATTC CAGATATCCA AATGGACACT TTGTGAGAAA TTTAGGTGAT 
GTTGGAGAGA AAGAGACTGA AACAGAAGTT TTGTTACTTG AACACGATGT TCCCCATCAG 
CCTTTTTCAC AGGCTGTTCT TAGTTTTCTG CCAAAGATGC CCTGGAGCAT TACTGAAAAG 
GACATGAAAA ACCGAGAAGA CCTGAGGCAT CTGTGTATTT GTAGTGTAGA CCCACCAGGA 
TGTACTGATA TAGACGATGC TCTACATTGT CGAGAACTCG AAAATGGAAA TTTGGAGGTT 
GGTGTTCATA TTGCTGATGT GAGCCATTTT ATTAGGCCAG GAAATGCCTT GGATCAAGAA 
TCAGCCAGAA GAGGAACAAC TGTGTATCTT TGTGAAAAGA GGATTGACAT GGTTCCAGAG 
TTGCTTAGCT CTAACTTGTG TTCCTTAAAA TGTGACGTGG ACAGGCTGGC ATTTTCATGT 
ATTTGGGAAA TGAATCACAA TGCTGAAATC TTAAAAACGA AGTTTACCAA AAGTGTTATT 
AATTCAAAGG CATCTCTGAC GTATGCTGAA GCTCAGTTGA GAATTGATTC AGCAAACATG 
AATGATGATA TTACCACTAG TCTCCGTGGA CTGAATAAAC TAGCCAAAAT TCTGAAGAAA 
AGAAGGATTG AAAAAGGGGC TTTGACTCTA TCCTCTCCTG AAGTTCGATT CCACATGGAC 
AGTGAAACTC ACGATCCTAT AGATCTGCAG ACCAAGGAAC TTAGGGAAAC AAATTCCATG 
GTTGAAGAAT TTATGTTACT TGCCAATATT TCTGTTGCAA AAAAAATTCA TGAGGAATTT 
TCTGAACATG CTCTGCTTCG AAAACATCCT GCTCCACCTC CATCAAATTA TGAAATTCTT 
GTTAAGGCAG CCAGGTCAAG GAATTTGGAA ATTAAGACTG ATACAGCCAA GTCTTTGGCT 
GAGTCTTTGG ATCAGGCCGA ATCTCCTACT TTTCCATATC TAAACACTCT GTTGAGAATA 
TTAGCCACTC GCTGTATGAT GCAAGCTGTG TACTTCTGTT CTGGAATGGA TAATGATTTT 
CATCACTATG GCTTAGCGTC TCCAATATAC ACACATTTTA CTTCACCCAT TAGAAGATAC 
GCAGATGTCA TTGTTCATCG GCTTTTGGCT GTGGCTATTG GGGCTGACTG TACTTATCCA 
GAGTTGACAG ACAAACACAA GCTTGCAGAT ATATGTAAAA ATCTAAATTT CCGGCACAAA 
ATGGCTCAAT ATGCCCAACG TGCATCAGTG GCTTTTCATA CCCAGTTATT CTTCAAAAGC 
AAAGGAATAG TAAGTGAAGA AGCCTATATT TTATTTGTAA GAAAGAATGC CATTGTGGTA 
TTAATTCCAA AGTATGGTTT AGAAGGGACA GTCTTTTTTG AAGAAAAGGA CAAACCAAAC 
CCACAGCTTA TTTATGATGA TGAGATACCC TCACTTAAAA TAGAAGATAC AGTGTTCCAT 
GTATTTGATA AAGTTAAAGT GAAAATCATG TTAGACTCAT CTAATCTTCA ACATCAGAAG 
ATCCGAATGT CCCTGGTAGA ACCACAGATA CCAGGAATAA GCATTCCTAC TGATACTTCA 
AACATGGACC TTAATGGACC AAAGAAAAAG AAGATGAAGC TTGGAAAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIS3 ( NM_001322349.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001309278.1 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu47099
Clone ID Related Accession (Same CDS sequence)	NM_001322349.2 , NM_001322349.1
Accession Version	NM_001322349.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform d
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL391384.18 and AL138695.13. On Apr 11, 2016 this sequence version replaced XM_005266294.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.128354.1, SRR1803616.80575.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCAGCAG ACAACCAGCT GCAAGTTATC TTCATAACAA ATGACAGGAG AAACAAAGAG 
AAAGCCATAG AAGAAGGAAT ACCAGCTTTC ACTTGTGAAG AATATGTAAA GAGCCTAACT 
GCTAACCCCG AACTCATAGA TCGTCTTGCT TGTTTGTCTG AAGAAGGGAA TGAAATAGAA 
AGTGGAAAAA TAATATTTTC AGAGCATCTT CCCTTAAGTA AGCTACAGCA AGGCATAAAA 
TCTGGTACAT ACCTTCAAGG AACATTTAGA GCTAGCAGGG AAAATTACTT GGAAGCTACA 
GTATGGATTC ATGGCGACAA TGAAGAAAAT AAAGAGATAA TCTTACAGGG ACTTAAACAT 
TTAAACAGAG CTGTTCACGA AGATATTGTG GCTGTGGAGC TTCTCCCCAA GAGTCAGTGG 
GTAGCACCAT CTTCTGTGGT TTTACATGAT GAAGGTCAAA ATGAAGAAGA TGTGGAGAAA 
GAAGAAGAGA CAGAACGAAT GCTTAAGACT GCTGTAAGCG AGAAAATGTT GAAGCCTACA 
GGTAGAGTTG TAGGAATAAT AAAAAGGAAT TGGAGACCAT ATTGTGGCAT GCTTTCCAAG 
TCTGACATTA AGGAGTCAAG AAGACATCTC TTTACACCTG CTGATAAGAG AATCCCTCGA 
ATTCGCATAG AAACCAGACA GGCTTCCACA TTAGAAGGAC GGAGAATTAT TGTTGCTATT 
GATGGTTGGC CCAGAAATTC CAGATATCCA AATGGACACT TTGTGAGAAA TTTAGGTGAT 
GTTGGAGAGA AAGAGACTGA AACAGAAGTT TTGTTACTTG AACACGATGT TCCCCATCAG 
CCTTTTTCAC AGGCTGTTCT TAGTTTTCTG CCAAAGATGC CCTGGAGCAT TACTGAAAAG 
GACATGAAAA ACCGAGAAGA CCTGAGGCAT CTGTGTATTT GTAGTGTAGA CCCACCAGGA 
TGTACTGATA TAGACGATGC TCTACATTGT CGAGAACTCG AAAATGGAAA TTTGGAGGTT 
GGTGTTCATA TTGCTGATGT GAGCCATTTT ATTAGGCCAG GAAATGCCTT GGATCAAGAA 
TCAGCCAGAA GAGGAACAAC TGTGTATCTT TGTGAAAAGA GGATTGACAT GGTTCCAGAG 
TTGCTTAGCT CTAACTTGTG TTCCTTAAAA TGTGACGTGG ACAGGCTGGC ATTTTCATGT 
ATTTGGGAAA TGAATCACAA TGCTGAAATC TTAAAAACGA AGTTTACCAA AAGTGTTATT 
AATTCAAAGG CATCTCTGAC GTATGCTGAA GCTCAGTTGA GAATTGATTC AGCAAACATG 
AATGATGATA TTACCACTAG TCTCCGTGGA CTGAATAAAC TAGCCAAAAT TCTGAAGAAA 
AGAAGGATTG AAAAAGGGGC TTTGACTCTA TCCTCTCCTG AAGTTCGATT CCACATGGAC 
AGTGAAACTC ACGATCCTAT AGATCTGCAG ACCAAGGAAC TTAGGGAAAC AAATTCCATG 
GTTGAAGAAT TTATGTTACT TGCCAATATT TCTGTTGCAA AAAAAATTCA TGAGGAATTT 
TCTGAACATG CTCTGCTTCG AAAACATCCT GCTCCACCTC CATCAAATTA TGAAATTCTT 
GTTAAGGCAG CCAGGTCAAG GAATTTGGAA ATTAAGACTG ATACAGCCAA GTCTTTGGCT 
GAGTCTTTGG ATCAGGCCGA ATCTCCTACT TTTCCATATC TAAACACTCT GTTGAGAATA 
TTAGCCACTC GCTGTATGAT GCAAGCTGTG TACTTCTGTT CTGGAATGGA TAATGATTTT 
CATCACTATG GCTTAGCGTC TCCAATATAC ACACATTTTA CTTCACCCAT TAGAAGATAC 
GCAGATGTCA TTGTTCATCG GCTTTTGGCT GTGGCTATTG GGGCTGACTG TACTTATCCA 
GAGTTGACAG ACAAACACAA GCTTGCAGAT ATATGTAAAA ATCTAAATTT CCGGCACAAA 
ATGGCTCAAT ATGCCCAACG TGCATCAGTG GCTTTTCATA CCCAGTTATT CTTCAAAAGC 
AAAGGAATAG TAAGTGAAGA AGCCTATATT TTATTTGTAA GAAAGAATGC CATTGTGGTA 
TTAATTCCAA AGTATGGTTT AGAAGGGACA GTCTTTTTTG AAGAAAAGGA CAAACCAAAC 
CCACAGCTTA TTTATGATGA TGAGATACCC TCACTTAAAA TAGAAGATAC AGTGTTCCAT 
GTATTTGATA AAGTTAAAGT GAAAATCATG TTAGACTCAT CTAATCTTCA ACATCAGAAG 
ATCCGAATGT CCCTGGTAGA ACCACAGATA CCAGGAATAA GCATTCCTAC TGATACTTCA 
AACATGGACC TTAATGGACC AAAGAAAAAG AAGATGAAGC TTGGAAAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309278.1
CDS	851..3241
Translation	MSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_001322349.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322349.1

ORF Insert Sequence:

ATGTCAGCAG ACAACCAGCT GCAAGTTATC TTCATAACAA ATGACAGGAG AAACAAAGAG 
AAAGCCATAG AAGAAGGAAT ACCAGCTTTC ACTTGTGAAG AATATGTAAA GAGCCTAACT 
GCTAACCCCG AACTCATAGA TCGTCTTGCT TGTTTGTCTG AAGAAGGGAA TGAAATAGAA 
AGTGGAAAAA TAATATTTTC AGAGCATCTT CCCTTAAGTA AGCTACAGCA AGGCATAAAA 
TCTGGTACAT ACCTTCAAGG AACATTTAGA GCTAGCAGGG AAAATTACTT GGAAGCTACA 
GTATGGATTC ATGGCGACAA TGAAGAAAAT AAAGAGATAA TCTTACAGGG ACTTAAACAT 
TTAAACAGAG CTGTTCACGA AGATATTGTG GCTGTGGAGC TTCTCCCCAA GAGTCAGTGG 
GTAGCACCAT CTTCTGTGGT TTTACATGAT GAAGGTCAAA ATGAAGAAGA TGTGGAGAAA 
GAAGAAGAGA CAGAACGAAT GCTTAAGACT GCTGTAAGCG AGAAAATGTT GAAGCCTACA 
GGTAGAGTTG TAGGAATAAT AAAAAGGAAT TGGAGACCAT ATTGTGGCAT GCTTTCCAAG 
TCTGACATTA AGGAGTCAAG AAGACATCTC TTTACACCTG CTGATAAGAG AATCCCTCGA 
ATTCGCATAG AAACCAGACA GGCTTCCACA TTAGAAGGAC GGAGAATTAT TGTTGCTATT 
GATGGTTGGC CCAGAAATTC CAGATATCCA AATGGACACT TTGTGAGAAA TTTAGGTGAT 
GTTGGAGAGA AAGAGACTGA AACAGAAGTT TTGTTACTTG AACACGATGT TCCCCATCAG 
CCTTTTTCAC AGGCTGTTCT TAGTTTTCTG CCAAAGATGC CCTGGAGCAT TACTGAAAAG 
GACATGAAAA ACCGAGAAGA CCTGAGGCAT CTGTGTATTT GTAGTGTAGA CCCACCAGGA 
TGTACTGATA TAGACGATGC TCTACATTGT CGAGAACTCG AAAATGGAAA TTTGGAGGTT 
GGTGTTCATA TTGCTGATGT GAGCCATTTT ATTAGGCCAG GAAATGCCTT GGATCAAGAA 
TCAGCCAGAA GAGGAACAAC TGTGTATCTT TGTGAAAAGA GGATTGACAT GGTTCCAGAG 
TTGCTTAGCT CTAACTTGTG TTCCTTAAAA TGTGACGTGG ACAGGCTGGC ATTTTCATGT 
ATTTGGGAAA TGAATCACAA TGCTGAAATC TTAAAAACGA AGTTTACCAA AAGTGTTATT 
AATTCAAAGG CATCTCTGAC GTATGCTGAA GCTCAGTTGA GAATTGATTC AGCAAACATG 
AATGATGATA TTACCACTAG TCTCCGTGGA CTGAATAAAC TAGCCAAAAT TCTGAAGAAA 
AGAAGGATTG AAAAAGGGGC TTTGACTCTA TCCTCTCCTG AAGTTCGATT CCACATGGAC 
AGTGAAACTC ACGATCCTAT AGATCTGCAG ACCAAGGAAC TTAGGGAAAC AAATTCCATG 
GTTGAAGAAT TTATGTTACT TGCCAATATT TCTGTTGCAA AAAAAATTCA TGAGGAATTT 
TCTGAACATG CTCTGCTTCG AAAACATCCT GCTCCACCTC CATCAAATTA TGAAATTCTT 
GTTAAGGCAG CCAGGTCAAG GAATTTGGAA ATTAAGACTG ATACAGCCAA GTCTTTGGCT 
GAGTCTTTGG ATCAGGCCGA ATCTCCTACT TTTCCATATC TAAACACTCT GTTGAGAATA 
TTAGCCACTC GCTGTATGAT GCAAGCTGTG TACTTCTGTT CTGGAATGGA TAATGATTTT 
CATCACTATG GCTTAGCGTC TCCAATATAC ACACATTTTA CTTCACCCAT TAGAAGATAC 
GCAGATGTCA TTGTTCATCG GCTTTTGGCT GTGGCTATTG GGGCTGACTG TACTTATCCA 
GAGTTGACAG ACAAACACAA GCTTGCAGAT ATATGTAAAA ATCTAAATTT CCGGCACAAA 
ATGGCTCAAT ATGCCCAACG TGCATCAGTG GCTTTTCATA CCCAGTTATT CTTCAAAAGC 
AAAGGAATAG TAAGTGAAGA AGCCTATATT TTATTTGTAA GAAAGAATGC CATTGTGGTA 
TTAATTCCAA AGTATGGTTT AGAAGGGACA GTCTTTTTTG AAGAAAAGGA CAAACCAAAC 
CCACAGCTTA TTTATGATGA TGAGATACCC TCACTTAAAA TAGAAGATAC AGTGTTCCAT 
GTATTTGATA AAGTTAAAGT GAAAATCATG TTAGACTCAT CTAATCTTCA ACATCAGAAG 
ATCCGAATGT CCCTGGTAGA ACCACAGATA CCAGGAATAA GCATTCCTAC TGATACTTCA 
AACATGGACC TTAATGGACC AAAGAAAAAG AAGATGAAGC TTGGAAAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIS3 ( NM_014953.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055768.3 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15178
Clone ID Related Accession (Same CDS sequence)	NM_014953.5 , NM_014953.4
Accession Version	NM_014953.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2877bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC056143.1, AL832266.1, AL080158.1, AL138695.13 and U79246.1. On Nov 23, 2018 this sequence version replaced NM_014953.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF330044.1, SRR1803612.30007.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377767.9/ ENSP00000366997.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGATGTTCTT 
GAGGACCCTG CCATCAGGAA TGTAATTGTG CTACAAACAG TTCTTCAAGA AGTGAGAAAT 
CGCAGTGCCC CCGTATATAA ACGCATCCGA GATGTGACTA ATAACCAAGA GAAGCATTTC 
TATACTTTCA CTAATGAGCA CCATAGAGAA ACCTATGTAG AACAAGAACA GGGAGAAAAT 
GCTAATGACA GGAATGATAG AGCGATTCGA GTAGCAGCAA AATGGTACAA TGAACATTTG 
AAAAAAATGT CAGCAGACAA CCAGCTGCAA GTTATCTTCA TAACAAATGA CAGGAGAAAC 
AAAGAGAAAG CCATAGAAGA AGGAATACCA GCTTTCACTT GTGAAGAATA TGTAAAGAGC 
CTAACTGCTA ACCCCGAACT CATAGATCGT CTTGCTTGTT TGTCTGAAGA AGGGAATGAA 
ATAGAAAGTG GAAAAATAAT ATTTTCAGAG CATCTTCCCT TAAGTAAGCT ACAGCAAGGC 
ATAAAATCTG GTACATACCT TCAAGGAACA TTTAGAGCTA GCAGGGAAAA TTACTTGGAA 
GCTACAGTAT GGATTCATGG CGACAATGAA GAAAATAAAG AGATAATCTT ACAGGGACTT 
AAACATTTAA ACAGAGCTGT TCACGAAGAT ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT 
CAGTGGGTAG CACCATCTTC TGTGGTTTTA CATGATGAAG GTCAAAATGA AGAAGATGTG 
GAGAAAGAAG AAGAGACAGA ACGAATGCTT AAGACTGCTG TAAGCGAGAA AATGTTGAAG 
CCTACAGGTA GAGTTGTAGG AATAATAAAA AGGAATTGGA GACCATATTG TGGCATGCTT 
TCCAAGTCTG ACATTAAGGA GTCAAGAAGA CATCTCTTTA CACCTGCTGA TAAGAGAATC 
CCTCGAATTC GCATAGAAAC CAGACAGGCT TCCACATTAG AAGGACGGAG AATTATTGTT 
GCTATTGATG GTTGGCCCAG AAATTCCAGA TATCCAAATG GACACTTTGT GAGAAATTTA 
GGTGATGTTG GAGAGAAAGA GACTGAAACA GAAGTTTTGT TACTTGAACA CGATGTTCCC 
CATCAGCCTT TTTCACAGGC TGTTCTTAGT TTTCTGCCAA AGATGCCCTG GAGCATTACT 
GAAAAGGACA TGAAAAACCG AGAAGACCTG AGGCATCTGT GTATTTGTAG TGTAGACCCA 
CCAGGATGTA CTGATATAGA CGATGCTCTA CATTGTCGAG AACTCGAAAA TGGAAATTTG 
GAGGTTGGTG TTCATATTGC TGATGTGAGC CATTTTATTA GGCCAGGAAA TGCCTTGGAT 
CAAGAATCAG CCAGAAGAGG AACAACTGTG TATCTTTGTG AAAAGAGGAT TGACATGGTT 
CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC TTAAAATGTG ACGTGGACAG GCTGGCATTT 
TCATGTATTT GGGAAATGAA TCACAATGCT GAAATCTTAA AAACGAAGTT TACCAAAAGT 
GTTATTAATT CAAAGGCATC TCTGACGTAT GCTGAAGCTC AGTTGAGAAT TGATTCAGCA 
AACATGAATG ATGATATTAC CACTAGTCTC CGTGGACTGA ATAAACTAGC CAAAATTCTG 
AAGAAAAGAA GGATTGAAAA AGGGGCTTTG ACTCTATCCT CTCCTGAAGT TCGATTCCAC 
ATGGACAGTG AAACTCACGA TCCTATAGAT CTGCAGACCA AGGAACTTAG GGAAACAAAT 
TCCATGGTTG AAGAATTTAT GTTACTTGCC AATATTTCTG TTGCAAAAAA AATTCATGAG 
GAATTTTCTG AACATGCTCT GCTTCGAAAA CATCCTGCTC CACCTCCATC AAATTATGAA 
ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT TTGGAAATTA AGACTGATAC AGCCAAGTCT 
TTGGCTGAGT CTTTGGATCA GGCCGAATCT CCTACTTTTC CATATCTAAA CACTCTGTTG 
AGAATATTAG CCACTCGCTG TATGATGCAA GCTGTGTACT TCTGTTCTGG AATGGATAAT 
GATTTTCATC ACTATGGCTT AGCGTCTCCA ATATACACAC ATTTTACTTC ACCCATTAGA 
AGATACGCAG ATGTCATTGT TCATCGGCTT TTGGCTGTGG CTATTGGGGC TGACTGTACT 
TATCCAGAGT TGACAGACAA ACACAAGCTT GCAGATATAT GTAAAAATCT AAATTTCCGG 
CACAAAATGG CTCAATATGC CCAACGTGCA TCAGTGGCTT TTCATACCCA GTTATTCTTC 
AAAAGCAAAG GAATAGTAAG TGAAGAAGCC TATATTTTAT TTGTAAGAAA GAATGCCATT 
GTGGTATTAA TTCCAAAGTA TGGTTTAGAA GGGACAGTCT TTTTTGAAGA AAAGGACAAA 
CCAAACCCAC AGCTTATTTA TGATGATGAG ATACCCTCAC TTAAAATAGA AGATACAGTG 
TTCCATGTAT TTGATAAAGT TAAAGTGAAA ATCATGTTAG ACTCATCTAA TCTTCAACAT 
CAGAAGATCC GAATGTCCCT GGTAGAACCA CAGATACCAG GAATAAGCAT TCCTACTGAT 
ACTTCAAACA TGGACCTTAA TGGACCAAAG AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055768.3
CDS	69..2945
Translation	MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_014953.5
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014953.5

ORF Insert Sequence:

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGATGTTCTT 
GAGGACCCTG CCATCAGGAA TGTAATTGTG CTACAAACAG TTCTTCAAGA AGTGAGAAAT 
CGCAGTGCCC CCGTATATAA ACGCATCCGA GATGTGACTA ATAACCAAGA GAAGCATTTC 
TATACTTTCA CTAATGAGCA CCATAGAGAA ACCTATGTAG AACAAGAACA GGGAGAAAAT 
GCTAATGACA GGAATGATAG AGCGATTCGA GTAGCAGCAA AATGGTACAA TGAACATTTG 
AAAAAAATGT CAGCAGACAA CCAGCTGCAA GTTATCTTCA TAACAAATGA CAGGAGAAAC 
AAAGAGAAAG CCATAGAAGA AGGAATACCA GCTTTCACTT GTGAAGAATA TGTAAAGAGC 
CTAACTGCTA ACCCCGAACT CATAGATCGT CTTGCTTGTT TGTCTGAAGA AGGGAATGAA 
ATAGAAAGTG GAAAAATAAT ATTTTCAGAG CATCTTCCCT TAAGTAAGCT ACAGCAAGGC 
ATAAAATCTG GTACATACCT TCAAGGAACA TTTAGAGCTA GCAGGGAAAA TTACTTGGAA 
GCTACAGTAT GGATTCATGG CGACAATGAA GAAAATAAAG AGATAATCTT ACAGGGACTT 
AAACATTTAA ACAGAGCTGT TCACGAAGAT ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT 
CAGTGGGTAG CACCATCTTC TGTGGTTTTA CATGATGAAG GTCAAAATGA AGAAGATGTG 
GAGAAAGAAG AAGAGACAGA ACGAATGCTT AAGACTGCTG TAAGCGAGAA AATGTTGAAG 
CCTACAGGTA GAGTTGTAGG AATAATAAAA AGGAATTGGA GACCATATTG TGGCATGCTT 
TCCAAGTCTG ACATTAAGGA GTCAAGAAGA CATCTCTTTA CACCTGCTGA TAAGAGAATC 
CCTCGAATTC GCATAGAAAC CAGACAGGCT TCCACATTAG AAGGACGGAG AATTATTGTT 
GCTATTGATG GTTGGCCCAG AAATTCCAGA TATCCAAATG GACACTTTGT GAGAAATTTA 
GGTGATGTTG GAGAGAAAGA GACTGAAACA GAAGTTTTGT TACTTGAACA CGATGTTCCC 
CATCAGCCTT TTTCACAGGC TGTTCTTAGT TTTCTGCCAA AGATGCCCTG GAGCATTACT 
GAAAAGGACA TGAAAAACCG AGAAGACCTG AGGCATCTGT GTATTTGTAG TGTAGACCCA 
CCAGGATGTA CTGATATAGA CGATGCTCTA CATTGTCGAG AACTCGAAAA TGGAAATTTG 
GAGGTTGGTG TTCATATTGC TGATGTGAGC CATTTTATTA GGCCAGGAAA TGCCTTGGAT 
CAAGAATCAG CCAGAAGAGG AACAACTGTG TATCTTTGTG AAAAGAGGAT TGACATGGTT 
CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC TTAAAATGTG ACGTGGACAG GCTGGCATTT 
TCATGTATTT GGGAAATGAA TCACAATGCT GAAATCTTAA AAACGAAGTT TACCAAAAGT 
GTTATTAATT CAAAGGCATC TCTGACGTAT GCTGAAGCTC AGTTGAGAAT TGATTCAGCA 
AACATGAATG ATGATATTAC CACTAGTCTC CGTGGACTGA ATAAACTAGC CAAAATTCTG 
AAGAAAAGAA GGATTGAAAA AGGGGCTTTG ACTCTATCCT CTCCTGAAGT TCGATTCCAC 
ATGGACAGTG AAACTCACGA TCCTATAGAT CTGCAGACCA AGGAACTTAG GGAAACAAAT 
TCCATGGTTG AAGAATTTAT GTTACTTGCC AATATTTCTG TTGCAAAAAA AATTCATGAG 
GAATTTTCTG AACATGCTCT GCTTCGAAAA CATCCTGCTC CACCTCCATC AAATTATGAA 
ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT TTGGAAATTA AGACTGATAC AGCCAAGTCT 
TTGGCTGAGT CTTTGGATCA GGCCGAATCT CCTACTTTTC CATATCTAAA CACTCTGTTG 
AGAATATTAG CCACTCGCTG TATGATGCAA GCTGTGTACT TCTGTTCTGG AATGGATAAT 
GATTTTCATC ACTATGGCTT AGCGTCTCCA ATATACACAC ATTTTACTTC ACCCATTAGA 
AGATACGCAG ATGTCATTGT TCATCGGCTT TTGGCTGTGG CTATTGGGGC TGACTGTACT 
TATCCAGAGT TGACAGACAA ACACAAGCTT GCAGATATAT GTAAAAATCT AAATTTCCGG 
CACAAAATGG CTCAATATGC CCAACGTGCA TCAGTGGCTT TTCATACCCA GTTATTCTTC 
AAAAGCAAAG GAATAGTAAG TGAAGAAGCC TATATTTTAT TTGTAAGAAA GAATGCCATT 
GTGGTATTAA TTCCAAAGTA TGGTTTAGAA GGGACAGTCT TTTTTGAAGA AAAGGACAAA 
CCAAACCCAC AGCTTATTTA TGATGATGAG ATACCCTCAC TTAAAATAGA AGATACAGTG 
TTCCATGTAT TTGATAAAGT TAAAGTGAAA ATCATGTTAG ACTCATCTAA TCTTCAACAT 
CAGAAGATCC GAATGTCCCT GGTAGAACCA CAGATACCAG GAATAAGCAT TCCTACTGAT 
ACTTCAAACA TGGACCTTAA TGGACCAAAG AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DIS3 ( NM_014953.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055768.3 Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu15178
Clone ID Related Accession (Same CDS sequence)	NM_014953.5 , NM_014953.4
Accession Version	NM_014953.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2877bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1504886400000
Organism	Homo sapiens(human)
Product	exosome complex exonuclease RRP44 isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB075344.1, BC056143.1, AL832266.1, AL080158.1, AL138695.13 and U79246.1. On Nov 13, 2013 this sequence version replaced NM_014953.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF330044.1, SRR1803612.30007.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGATGTTCTT 
GAGGACCCTG CCATCAGGAA TGTAATTGTG CTACAAACAG TTCTTCAAGA AGTGAGAAAT 
CGCAGTGCCC CCGTATATAA ACGCATCCGA GATGTGACTA ATAACCAAGA GAAGCATTTC 
TATACTTTCA CTAATGAGCA CCATAGAGAA ACCTATGTAG AACAAGAACA GGGAGAAAAT 
GCTAATGACA GGAATGATAG AGCGATTCGA GTAGCAGCAA AATGGTACAA TGAACATTTG 
AAAAAAATGT CAGCAGACAA CCAGCTGCAA GTTATCTTCA TAACAAATGA CAGGAGAAAC 
AAAGAGAAAG CCATAGAAGA AGGAATACCA GCTTTCACTT GTGAAGAATA TGTAAAGAGC 
CTAACTGCTA ACCCCGAACT CATAGATCGT CTTGCTTGTT TGTCTGAAGA AGGGAATGAA 
ATAGAAAGTG GAAAAATAAT ATTTTCAGAG CATCTTCCCT TAAGTAAGCT ACAGCAAGGC 
ATAAAATCTG GTACATACCT TCAAGGAACA TTTAGAGCTA GCAGGGAAAA TTACTTGGAA 
GCTACAGTAT GGATTCATGG CGACAATGAA GAAAATAAAG AGATAATCTT ACAGGGACTT 
AAACATTTAA ACAGAGCTGT TCACGAAGAT ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT 
CAGTGGGTAG CACCATCTTC TGTGGTTTTA CATGATGAAG GTCAAAATGA AGAAGATGTG 
GAGAAAGAAG AAGAGACAGA ACGAATGCTT AAGACTGCTG TAAGCGAGAA AATGTTGAAG 
CCTACAGGTA GAGTTGTAGG AATAATAAAA AGGAATTGGA GACCATATTG TGGCATGCTT 
TCCAAGTCTG ACATTAAGGA GTCAAGAAGA CATCTCTTTA CACCTGCTGA TAAGAGAATC 
CCTCGAATTC GCATAGAAAC CAGACAGGCT TCCACATTAG AAGGACGGAG AATTATTGTT 
GCTATTGATG GTTGGCCCAG AAATTCCAGA TATCCAAATG GACACTTTGT GAGAAATTTA 
GGTGATGTTG GAGAGAAAGA GACTGAAACA GAAGTTTTGT TACTTGAACA CGATGTTCCC 
CATCAGCCTT TTTCACAGGC TGTTCTTAGT TTTCTGCCAA AGATGCCCTG GAGCATTACT 
GAAAAGGACA TGAAAAACCG AGAAGACCTG AGGCATCTGT GTATTTGTAG TGTAGACCCA 
CCAGGATGTA CTGATATAGA CGATGCTCTA CATTGTCGAG AACTCGAAAA TGGAAATTTG 
GAGGTTGGTG TTCATATTGC TGATGTGAGC CATTTTATTA GGCCAGGAAA TGCCTTGGAT 
CAAGAATCAG CCAGAAGAGG AACAACTGTG TATCTTTGTG AAAAGAGGAT TGACATGGTT 
CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC TTAAAATGTG ACGTGGACAG GCTGGCATTT 
TCATGTATTT GGGAAATGAA TCACAATGCT GAAATCTTAA AAACGAAGTT TACCAAAAGT 
GTTATTAATT CAAAGGCATC TCTGACGTAT GCTGAAGCTC AGTTGAGAAT TGATTCAGCA 
AACATGAATG ATGATATTAC CACTAGTCTC CGTGGACTGA ATAAACTAGC CAAAATTCTG 
AAGAAAAGAA GGATTGAAAA AGGGGCTTTG ACTCTATCCT CTCCTGAAGT TCGATTCCAC 
ATGGACAGTG AAACTCACGA TCCTATAGAT CTGCAGACCA AGGAACTTAG GGAAACAAAT 
TCCATGGTTG AAGAATTTAT GTTACTTGCC AATATTTCTG TTGCAAAAAA AATTCATGAG 
GAATTTTCTG AACATGCTCT GCTTCGAAAA CATCCTGCTC CACCTCCATC AAATTATGAA 
ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT TTGGAAATTA AGACTGATAC AGCCAAGTCT 
TTGGCTGAGT CTTTGGATCA GGCCGAATCT CCTACTTTTC CATATCTAAA CACTCTGTTG 
AGAATATTAG CCACTCGCTG TATGATGCAA GCTGTGTACT TCTGTTCTGG AATGGATAAT 
GATTTTCATC ACTATGGCTT AGCGTCTCCA ATATACACAC ATTTTACTTC ACCCATTAGA 
AGATACGCAG ATGTCATTGT TCATCGGCTT TTGGCTGTGG CTATTGGGGC TGACTGTACT 
TATCCAGAGT TGACAGACAA ACACAAGCTT GCAGATATAT GTAAAAATCT AAATTTCCGG 
CACAAAATGG CTCAATATGC CCAACGTGCA TCAGTGGCTT TTCATACCCA GTTATTCTTC 
AAAAGCAAAG GAATAGTAAG TGAAGAAGCC TATATTTTAT TTGTAAGAAA GAATGCCATT 
GTGGTATTAA TTCCAAAGTA TGGTTTAGAA GGGACAGTCT TTTTTGAAGA AAAGGACAAA 
CCAAACCCAC AGCTTATTTA TGATGATGAG ATACCCTCAC TTAAAATAGA AGATACAGTG 
TTCCATGTAT TTGATAAAGT TAAAGTGAAA ATCATGTTAG ACTCATCTAA TCTTCAACAT 
CAGAAGATCC GAATGTCCCT GGTAGAACCA CAGATACCAG GAATAAGCAT TCCTACTGAT 
ACTTCAAACA TGGACCTTAA TGGACCAAAG AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055768.3
CDS	297..3173
Translation	MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

Target ORF information:

RefSeq Version	NM_014953.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014953.4

ORF Insert Sequence:

ATGCTCAAGT CCAAGACGTT CTTAAAAAAG ACCCGGGCGG GCGGCGTGAT GAAGATCGTG 
CGCGAGCACT ACCTGCGAGA CGACATCGGC TGCGGTGCGC CCGGGTGCGC AGCGTGTGGA 
GGGGCGCACG AGGGGCCGGC CCTGGAGCCG CAGCCCCAGG ACCCGGCGAG CAGCGTCTGC 
CCGCAACCGC ACTACTTGCT GCCCGACACT AATGTGTTAC TGCACCAGAT TGATGTTCTT 
GAGGACCCTG CCATCAGGAA TGTAATTGTG CTACAAACAG TTCTTCAAGA AGTGAGAAAT 
CGCAGTGCCC CCGTATATAA ACGCATCCGA GATGTGACTA ATAACCAAGA GAAGCATTTC 
TATACTTTCA CTAATGAGCA CCATAGAGAA ACCTATGTAG AACAAGAACA GGGAGAAAAT 
GCTAATGACA GGAATGATAG AGCGATTCGA GTAGCAGCAA AATGGTACAA TGAACATTTG 
AAAAAAATGT CAGCAGACAA CCAGCTGCAA GTTATCTTCA TAACAAATGA CAGGAGAAAC 
AAAGAGAAAG CCATAGAAGA AGGAATACCA GCTTTCACTT GTGAAGAATA TGTAAAGAGC 
CTAACTGCTA ACCCCGAACT CATAGATCGT CTTGCTTGTT TGTCTGAAGA AGGGAATGAA 
ATAGAAAGTG GAAAAATAAT ATTTTCAGAG CATCTTCCCT TAAGTAAGCT ACAGCAAGGC 
ATAAAATCTG GTACATACCT TCAAGGAACA TTTAGAGCTA GCAGGGAAAA TTACTTGGAA 
GCTACAGTAT GGATTCATGG CGACAATGAA GAAAATAAAG AGATAATCTT ACAGGGACTT 
AAACATTTAA ACAGAGCTGT TCACGAAGAT ATTGTGGCTG TGGAGCTTCT CCCCAAGAGT 
CAGTGGGTAG CACCATCTTC TGTGGTTTTA CATGATGAAG GTCAAAATGA AGAAGATGTG 
GAGAAAGAAG AAGAGACAGA ACGAATGCTT AAGACTGCTG TAAGCGAGAA AATGTTGAAG 
CCTACAGGTA GAGTTGTAGG AATAATAAAA AGGAATTGGA GACCATATTG TGGCATGCTT 
TCCAAGTCTG ACATTAAGGA GTCAAGAAGA CATCTCTTTA CACCTGCTGA TAAGAGAATC 
CCTCGAATTC GCATAGAAAC CAGACAGGCT TCCACATTAG AAGGACGGAG AATTATTGTT 
GCTATTGATG GTTGGCCCAG AAATTCCAGA TATCCAAATG GACACTTTGT GAGAAATTTA 
GGTGATGTTG GAGAGAAAGA GACTGAAACA GAAGTTTTGT TACTTGAACA CGATGTTCCC 
CATCAGCCTT TTTCACAGGC TGTTCTTAGT TTTCTGCCAA AGATGCCCTG GAGCATTACT 
GAAAAGGACA TGAAAAACCG AGAAGACCTG AGGCATCTGT GTATTTGTAG TGTAGACCCA 
CCAGGATGTA CTGATATAGA CGATGCTCTA CATTGTCGAG AACTCGAAAA TGGAAATTTG 
GAGGTTGGTG TTCATATTGC TGATGTGAGC CATTTTATTA GGCCAGGAAA TGCCTTGGAT 
CAAGAATCAG CCAGAAGAGG AACAACTGTG TATCTTTGTG AAAAGAGGAT TGACATGGTT 
CCAGAGTTGC TTAGCTCTAA CTTGTGTTCC TTAAAATGTG ACGTGGACAG GCTGGCATTT 
TCATGTATTT GGGAAATGAA TCACAATGCT GAAATCTTAA AAACGAAGTT TACCAAAAGT 
GTTATTAATT CAAAGGCATC TCTGACGTAT GCTGAAGCTC AGTTGAGAAT TGATTCAGCA 
AACATGAATG ATGATATTAC CACTAGTCTC CGTGGACTGA ATAAACTAGC CAAAATTCTG 
AAGAAAAGAA GGATTGAAAA AGGGGCTTTG ACTCTATCCT CTCCTGAAGT TCGATTCCAC 
ATGGACAGTG AAACTCACGA TCCTATAGAT CTGCAGACCA AGGAACTTAG GGAAACAAAT 
TCCATGGTTG AAGAATTTAT GTTACTTGCC AATATTTCTG TTGCAAAAAA AATTCATGAG 
GAATTTTCTG AACATGCTCT GCTTCGAAAA CATCCTGCTC CACCTCCATC AAATTATGAA 
ATTCTTGTTA AGGCAGCCAG GTCAAGGAAT TTGGAAATTA AGACTGATAC AGCCAAGTCT 
TTGGCTGAGT CTTTGGATCA GGCCGAATCT CCTACTTTTC CATATCTAAA CACTCTGTTG 
AGAATATTAG CCACTCGCTG TATGATGCAA GCTGTGTACT TCTGTTCTGG AATGGATAAT 
GATTTTCATC ACTATGGCTT AGCGTCTCCA ATATACACAC ATTTTACTTC ACCCATTAGA 
AGATACGCAG ATGTCATTGT TCATCGGCTT TTGGCTGTGG CTATTGGGGC TGACTGTACT 
TATCCAGAGT TGACAGACAA ACACAAGCTT GCAGATATAT GTAAAAATCT AAATTTCCGG 
CACAAAATGG CTCAATATGC CCAACGTGCA TCAGTGGCTT TTCATACCCA GTTATTCTTC 
AAAAGCAAAG GAATAGTAAG TGAAGAAGCC TATATTTTAT TTGTAAGAAA GAATGCCATT 
GTGGTATTAA TTCCAAAGTA TGGTTTAGAA GGGACAGTCT TTTTTGAAGA AAAGGACAAA 
CCAAACCCAC AGCTTATTTA TGATGATGAG ATACCCTCAC TTAAAATAGA AGATACAGTG 
TTCCATGTAT TTGATAAAGT TAAAGTGAAA ATCATGTTAG ACTCATCTAA TCTTCAACAT 
CAGAAGATCC GAATGTCCCT GGTAGAACCA CAGATACCAG GAATAAGCAT TCCTACTGAT 
ACTTCAAACA TGGACCTTAA TGGACCAAAG AAAAAGAAGA TGAAGCTTGG AAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Post-transcriptional negative feedback regulation of proteostasis through the Dis3 ribonuclease and its disruption by polyQ-expanded Huntingtin.
Nucleic acids research47(19)10040-10058(2019 11)
Kong KE,Hung TF,Man PM,Wong TN,Cheng T,Jin DY

Elimination of 01/A'-A0 pre-rRNA processing by-product in human cells involves cooperative action of two nuclear exosome-associated nucleases: RRP6 and DIS3.
RNA (New York, N.Y.)24(12)1677-1692(2018 12)
Kobyłecki K,Drążkowska K,Kuliński TM,Dziembowski A,Tomecki R

Distinct and evolutionary conserved structural features of the human nuclear exosome complex.
eLife7(2018 07)
Gerlach P,Schuller JM,Bonneau F,Basquin J,Reichelt P,Falk S,Conti E

DIS3 isoforms vary in their endoribonuclease activity and are differentially expressed within haematological cancers.
The Biochemical journal475(12)2091-2105(2018 06)
Robinson SR,Viegas SC,Matos RG,Domingues S,Bedir M,Stewart HJS,Chevassut TJ,Oliver AW,Arraiano CM,Newbury SF

Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression.
Human molecular genetics25(21)4726-4738(2016 11)
Hoskins JW,Ibrahim A,Emmanuel MA,Manmiller SM,Wu Y,O'Neill M,Jia J,Collins I,Zhang M,Thomas JV,Rost LM,Das S,Parikh H,Haake JM,Matters GL,Kurtz RC,Bamlet WR,Klein A,Stolzenberg-Solomon R,Wolpin BM,Yarden R,Wang Z,Smith J,Olson SH,Andresson T,Petersen GM,Amundadottir LT

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DIS3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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