CPB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CPB1
Entrez Gene ID	1360
Full Name	carboxypeptidase B1
Synonyms	CPB,PASP,PCPB
General protein information	Preferred Names carboxypeptidase B1 Names carboxypeptidase B carboxypeptidase B1 (tissue) pancreas-specific protein pancreatic carboxypeptidase B procarboxypeptidase B protaminase tissue carboxypeptidase B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q24
Summary	Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008].
Disorder MIM:	114852

mRNA and Protein(s)

mRNA	Protein	Name
NM_001871.3	NP_001862.2	carboxypeptidase B preproprotein
XM_005247124.2	XP_005247181.1	carboxypeptidase B isoform X1
XM_011512436.1	XP_011510738.1	carboxypeptidase B isoform X1
NM_001871.2	NP_001862.2	carboxypeptidase B preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CPB1	NP_001098820.1
Rattus norvegicus (Norway rat)	Cpb1	NP_036665.1
Pan troglodytes (chimpanzee)	CPB1	XP_516808.2
Macaca mulatta (Rhesus monkey)	CPB1	XP_001110220.1
Danio rerio (zebrafish)	cpb1	NP_001103491.1
Xenopus tropicalis (tropical clawed frog)	LOC100494117	XP_002937383.2
Mus musculus (house mouse)	Cpb1	NP_083982.1
Gallus gallus (chicken)	CPB1	NP_001264374.1
Homo sapiens (human)	CPB1	NP_001862.2
Canis lupus familiaris (dog)	CPB1	NP_001003005.1
Drosophila melanogaster (fruit fly)	CG4017	NP_609309.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in the pancreatic secretory enzymes
Tamura K, Yu J, Hata T, Suenaga M, Shindo K, Abe T, MacGregor-Das A, Borges M, Wolfgang CL, Weiss MJ, He J, Canto MI, Petersen GM, Gallinger S, Syngal S, Brand RE, Rustgi A, Olson SH, Stoffel E, Cote ML, Zogopoulos G, Potash JB, Goes FS, McCombie RW, Zandi PP, Pirooznia M, Kramer M, Parla J, Eshleman JR, Roberts NJ, Hruban RH, Klein AP, Goggins M
Proceedings of the National Academy of Sciences of the United States of America115(18)4767-4772(2018 05)

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H
American journal of physiology. Gastrointestinal and liver physiology309(8)G688-94(2015 Oct)

Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer.
Bouchal P, Dvořáková M, Roumeliotis T, Bortlíček Z, Ihnatová I, Procházková I, Ho JT, Maryáš J, Imrichová H, Budinská E, Vyzula R, Garbis SD, Vojtěšek B, Nenutil R
Molecular & cellular proteomics : MCP14(7)1814-30(2015 Jul)

The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B.
Pantoja-Uceda D, Arolas JL, García P, López-Hernández E, Padró D, Aviles FX, Blanco FJ
Biochemistry47(27)7066-78(2008 Jul)

TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cells.
Guimarães AH, Laurens N, Weijers EM, Koolwijk P, van Hinsbergh VW, Rijken DC
Arteriosclerosis, thrombosis, and vascular biology27(10)2157-62(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CPB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CPB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29236	NM_001871.3 Latest version!	Homo sapiens carboxypeptidase B1 (CPB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu29236	XM_011512436.1 Latest version!	Homo sapiens carboxypeptidase B1 (tissue) (CPB1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OHu29236	XM_005247124.2 Latest version!	Homo sapiens carboxypeptidase B1 (tissue) (CPB1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
View Old Accession Versions >>
OHu29236	NM_001871.2	Homo sapiens carboxypeptidase B1 (CPB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CPB1 ( NM_001871.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001862.2 Homo sapiens carboxypeptidase B1 (CPB1), mRNA.

Price & Availability↑

CloneID	OHu29236
Clone ID Related Accession (Same CDS sequence)	NM_001871.3 , XM_005247124.2 , XM_011512436.1 , NM_001871.2
Accession Version	NM_001871.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569427200000
Organism	Homo sapiens(human)
Product	carboxypeptidase B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI770145.1 and BC015338.1. On Nov 24, 2018 this sequence version replaced NM_001871.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.55850.1, M81057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000282957.9/ ENSP00000282957.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001862.2
CDS	14..1267
Translation	MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY

Target ORF information:

RefSeq Version	NM_001871.3
Organism	Homo sapiens(human)
Definition	Homo sapiens carboxypeptidase B1 (CPB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001871.3

ORF Insert Sequence:

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CPB1 ( NM_001871.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001862.2 Homo sapiens carboxypeptidase B1 (CPB1), mRNA.

Price & Availability↑

CloneID	OHu29236
Clone ID Related Accession (Same CDS sequence)	NM_001871.3 , XM_005247124.2 , XM_011512436.1 , NM_001871.2
Accession Version	NM_001871.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506700800000
Organism	Homo sapiens(human)
Product	carboxypeptidase B preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI770145.1 and BC015338.1. On Oct 23, 2004 this sequence version replaced NM_001871.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015338.1, M81057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001862.2
CDS	24..1277
Translation	MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY

Target ORF information:

RefSeq Version	NM_001871.2
Organism	Homo sapiens(human)
Definition	Homo sapiens carboxypeptidase B1 (CPB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001871.2

ORF Insert Sequence:

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CPB1 ( XM_005247124.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005247181.1 Homo sapiens carboxypeptidase B1 (tissue) (CPB1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu29236
Clone ID Related Accession (Same CDS sequence)	NM_001871.3 , XM_005247124.2 , XM_011512436.1 , NM_001871.2
Accession Version	XM_005247124.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	carboxypeptidase B isoform X1
Comment

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_005247181.1

Translation

MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY

Target ORF information:

RefSeq Version	XM_005247124.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens carboxypeptidase B1 (tissue) (CPB1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005247124.2

ORF Insert Sequence:

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CPB1 ( XM_011512436.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011510738.1 Homo sapiens carboxypeptidase B1 (tissue) (CPB1), transcript variant X2, mRNA.

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CloneID	OHu29236
Clone ID Related Accession (Same CDS sequence)	NM_001871.3 , XM_005247124.2 , XM_011512436.1 , NM_001871.2
Accession Version	XM_011512436.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426003200000
Organism	Homo sapiens(Human)
Product	carboxypeptidase B isoform X1
Comment

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011510738.1

Translation

MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQIKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGGSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY

Target ORF information:

RefSeq Version	XM_011512436.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens carboxypeptidase B1 (tissue) (CPB1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011512436.1

ORF Insert Sequence:

ATGTTGGCAC TCTTGGTTCT GGTGACTGTG GCCCTGGCAT CTGCTCATCA TGGTGGTGAG 
CACTTTGAAG GCGAGAAGGT GTTCCGTGTT AACGTTGAAG ATGAAAATCA CATTAACATA 
ATCCGCGAGT TGGCCAGCAC GACCCAGATT GACTTCTGGA AGCCAGATTC TGTCACACAA 
ATCAAACCTC ACAGTACAGT TGACTTCCGT GTTAAAGCAG AAGATACTGT CACTGTGGAG 
AATGTTCTAA AGCAGAATGA ACTACAATAC AAGGTACTGA TAAGCAACCT GAGAAATGTG 
GTGGAGGCTC AGTTTGATAG CCGGGTTCGT GCAACAGGAC ACAGTTATGA GAAGTACAAC 
AAGTGGGAAA CGATAGAGGC TTGGACTCAA CAAGTCGCCA CTGAGAATCC AGCCCTCATC 
TCTCGCAGTG TTATCGGAAC CACATTTGAG GGACGCGCTA TTTACCTCCT GAAGGTTGGC 
AAAGCTGGAC AAAATAAGCC TGCCATTTTC ATGGACTGTG GTTTCCATGC CAGAGAGTGG 
ATTTCTCCTG CATTCTGCCA GTGGTTTGTA AGAGAGGCTG TTCGTACCTA TGGACGTGAG 
ATCCAAGTGA CAGAGCTTCT CGACAAGTTA GACTTTTATG TCCTGCCTGT GCTCAATATT 
GATGGCTACA TCTACACCTG GACCAAGAGC CGATTTTGGA GAAAGACTCG CTCCACCCAT 
ACTGGATCTA GCTGCATTGG CACAGACCCC AACAGAAATT TTGATGCTGG TTGGTGTGAA 
ATTGGAGCCT CTCGAAACCC CTGTGATGAA ACTTACTGTG GACCTGCCGC AGAGTCTGAA 
AAGGAGACCA AGGCCCTGGC TGATTTCATC CGCAACAAAC TCTCTTCCAT CAAGGCATAT 
CTGACAATCC ACTCGTACTC CCAAATGATG ATCTACCCTT ACTCATATGC TTACAAACTC 
GGTGAGAACA ATGCTGAGTT GAATGCCCTG GCTAAAGCTA CTGTGAAAGA ACTTGCCTCA 
CTGCACGGCA CCAAGTACAC ATATGGCCCG GGAGCTACAA CAATCTATCC TGCTGCTGGG 
GGCTCTGACG ACTGGGCTTA TGACCAAGGA ATCAGATATT CCTTCACCTT TGAACTTCGA 
GATACAGGCA GATATGGCTT TCTCCTTCCA GAATCCCAGA TCCGGGCTAC CTGCGAGGAG 
ACCTTCCTGG CAATCAAGTA TGTTGCCAGC TACGTCCTGG AACACCTGTA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in the pancreatic secretory enzymes
Proceedings of the National Academy of Sciences of the United States of America115(18)4767-4772(2018 05)
Tamura K,Yu J,Hata T,Suenaga M,Shindo K,Abe T,MacGregor-Das A,Borges M,Wolfgang CL,Weiss MJ,He J,Canto MI,Petersen GM,Gallinger S,Syngal S,Brand RE,Rustgi A,Olson SH,Stoffel E,Cote ML,Zogopoulos G,Potash JB,Goes FS,McCombie RW,Zandi PP,Pirooznia M,Kramer M,Parla J,Eshleman JR,Roberts NJ,Hruban RH,Klein AP,Goggins M

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology309(8)G688-94(2015 Oct)
Nakano E,Geisz A,Masamune A,Niihori T,Hamada S,Kume K,Kakuta Y,Aoki Y,Matsubara Y,Ebert K,Ludwig M,Braun M,Groneberg DA,Shimosegawa T,Sahin-Tóth M,Witt H

Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer.
Molecular & cellular proteomics : MCP14(7)1814-30(2015 Jul)
Bouchal P,Dvořáková M,Roumeliotis T,Bortlíček Z,Ihnatová I,Procházková I,Ho JT,Maryáš J,Imrichová H,Budinská E,Vyzula R,Garbis SD,Vojtěšek B,Nenutil R

The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B.
Biochemistry47(27)7066-78(2008 Jul)
Pantoja-Uceda D,Arolas JL,García P,López-Hernández E,Padró D,Aviles FX,Blanco FJ

TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology27(10)2157-62(2007 Oct)
Guimarães AH,Laurens N,Weijers EM,Koolwijk P,van Hinsbergh VW,Rijken DC

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CPB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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