SPINT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPINT2
Entrez Gene ID	10653
Full Name	serine peptidase inhibitor, Kunitz type 2
Synonyms	DIAR3,HAI-2,HAI2,Kop,PB
General protein information	Preferred Names serine peptidase inhibitor, Kunitz type 2 Names kunitz-type protease inhibitor 2 hepatocyte growth factor activator inhibitor type 2 serine protease inhibitor, Kunitz type, 2 testicular tissue protein Li 183
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Disorder MIM:	605124
Disorder Html:	Diarrhea 3, secretory sodium, congenital, syndromic, 270420 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_021102.3	NP_066925.1	kunitz-type protease inhibitor 2 isoform a precursor
NM_001166103.2	NP_001159575.1	kunitz-type protease inhibitor 2 isoform b precursor
NM_001166103.1	NP_001159575.1	kunitz-type protease inhibitor 2 isoform b precursor
NM_021102.4	NP_066925.1	kunitz-type protease inhibitor 2 isoform a precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	SPINT2	XP_001106508.1
Mus musculus (house mouse)	Spint2	NP_035594.1
Xenopus tropicalis (tropical clawed frog)	spint2	NP_001039077.1
Bos taurus (cattle)	SPINT2	NP_001039436.1
Canis lupus familiaris (dog)	SPINT2	XP_853537.1
Rattus norvegicus (Norway rat)	Spint2	NP_001076018.1
Danio rerio (zebrafish)	spint2	NP_001070718.2
Homo sapiens (human)	SPINT2	NP_066925.1

Gene Ontology
Bibliography

Related articles in PubMed

HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasis.
Wu SR, Lin CH, Shih HP, Ko CJ, Lin HY, Lan SW, Lin HH, Tu HF, Ho CC, Huang HP, Lee MS
British journal of cancer120(5)499-511(2019 03)

Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas.
Fukushima T, Kawaguchi M, Yamamoto K, Yamashita F, Izumi A, Kaieda T, Takezaki Y, Itoh H, Takeshima H, Kataoka H
Cancer science109(9)2970-2979(2018 Sep)

Congenital sodium diarrhea and chorioretinal coloboma with optic disc coloboma in a patient with biallelic SPINT2 mutations, including p.(Tyr163Cys).
Hirabayashi KE, Moore AT, Mendelsohn BA, Taft RJ, Chawla A, Perry D, Henry D, Slavotinek A
American journal of medical genetics. Part A176(4)997-1000(2018 04)

Study on the methylation status of SPINT2 gene and its expression in cervical carcinoma.
Wang N, Che Y, Yin F, Yu F, Bi X, Wang Y
Cancer biomarkers : section A of Disease markers22(3)435-442(2018)

Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.
Murray AS, Varela FA, Hyland TE, Schoenbeck AJ, White JM, Tanabe LM, Todi SV, List K
The Journal of biological chemistry292(36)14867-14884(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SPINT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPINT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18521	NM_021102.4 Latest version!	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17602	NM_001166103.2 Latest version!	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu17602	NM_001166103.1	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu18521	NM_021102.3	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPINT2 ( NM_021102.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066925.1 Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu18521
Clone ID Related Accession (Same CDS sequence)	NM_021102.3 , NM_021102.4
Accession Version	NM_021102.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1510329600000
Organism	Homo sapiens(human)
Product	kunitz-type protease inhibitor 2 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI199013.1, BC001668.2 and AW275313.1. This sequence is a reference standard in the RefSeqGene project. On Oct 7, 2009 this sequence version replaced NM_021102.2. Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.235510.1, SRR1660807.121211.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGACTT CTGCCTGGTG 
TCGAAGGTGG TGGGCAGATG CCGGGCCTCC ATGCCTAGGT GGTGGTACAA TGTCACTGAC 
GGATCCTGCC AGCTGTTTGT GTATGGGGGC TGTGACGGAA ACAGCAATAA TTACCTGACC 
AAGGAGGAGT GCCTCAAGAA ATGTGCCACT GTCACAGAGA ATGCCACGGG TGACCTGGCC 
ACCAGCAGGA ATGCAGCGGA TTCCTCTGTC CCAAGTGCTC CCAGAAGGCA GGATTCTGAA 
GACCACTCCA GCGATATGTT CAACTATGAA GAATACTGCA CCGCCAACGC AGTCACTGGG 
CCTTGCCGTG CATCCTTCCC ACGCTGGTAC TTTGACGTGG AGAGGAACTC CTGCAATAAC 
TTCATCTATG GAGGCTGCCG GGGCAATAAG AACAGCTACC GCTCTGAGGA GGCCTGCATG 
CTCCGCTGCT TCCGCCAGCA GGAGAATCCT CCCCTGCCCC TTGGCTCAAA GGTGGTGGTT 
CTGGCGGGGC TGTTCGTGAT GGTGTTGATC CTCTTCCTGG GAGCCTCCAT GGTCTACCTG 
ATCCGGGTGG CACGGAGGAA CCAGGAGCGT GCCCTGCGCA CCGTCTGGAG CTCCGGAGAT 
GACAAGGAGC AGCTGGTGAA GAACACATAT GTCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066925.1
CDS	436..1194
Translation	MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

Target ORF information:

RefSeq Version	NM_021102.3
Organism	Homo sapiens(human)
Definition	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021102.3

ORF Insert Sequence:

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGACTT CTGCCTGGTG 
TCGAAGGTGG TGGGCAGATG CCGGGCCTCC ATGCCTAGGT GGTGGTACAA TGTCACTGAC 
GGATCCTGCC AGCTGTTTGT GTATGGGGGC TGTGACGGAA ACAGCAATAA TTACCTGACC 
AAGGAGGAGT GCCTCAAGAA ATGTGCCACT GTCACAGAGA ATGCCACGGG TGACCTGGCC 
ACCAGCAGGA ATGCAGCGGA TTCCTCTGTC CCAAGTGCTC CCAGAAGGCA GGATTCTGAA 
GACCACTCCA GCGATATGTT CAACTATGAA GAATACTGCA CCGCCAACGC AGTCACTGGG 
CCTTGCCGTG CATCCTTCCC ACGCTGGTAC TTTGACGTGG AGAGGAACTC CTGCAATAAC 
TTCATCTATG GAGGCTGCCG GGGCAATAAG AACAGCTACC GCTCTGAGGA GGCCTGCATG 
CTCCGCTGCT TCCGCCAGCA GGAGAATCCT CCCCTGCCCC TTGGCTCAAA GGTGGTGGTT 
CTGGCGGGGC TGTTCGTGAT GGTGTTGATC CTCTTCCTGG GAGCCTCCAT GGTCTACCTG 
ATCCGGGTGG CACGGAGGAA CCAGGAGCGT GCCCTGCGCA CCGTCTGGAG CTCCGGAGAT 
GACAAGGAGC AGCTGGTGAA GAACACATAT GTCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPINT2 ( NM_021102.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066925.1 Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant a, mRNA.

Price & Availability↑

CloneID	OHu18521
Clone ID Related Accession (Same CDS sequence)	NM_021102.3 , NM_021102.4
Accession Version	NM_021102.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 759bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576339200000
Organism	Homo sapiens(human)
Product	kunitz-type protease inhibitor 2 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001668.2, AW275313.1 and AC011479.7. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_021102.3. Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.531412.1, SRR3476690.1133047.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301244.12/ ENSP00000301244.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGACTT CTGCCTGGTG 
TCGAAGGTGG TGGGCAGATG CCGGGCCTCC ATGCCTAGGT GGTGGTACAA TGTCACTGAC 
GGATCCTGCC AGCTGTTTGT GTATGGGGGC TGTGACGGAA ACAGCAATAA TTACCTGACC 
AAGGAGGAGT GCCTCAAGAA ATGTGCCACT GTCACAGAGA ATGCCACGGG TGACCTGGCC 
ACCAGCAGGA ATGCAGCGGA TTCCTCTGTC CCAAGTGCTC CCAGAAGGCA GGATTCTGAA 
GACCACTCCA GCGATATGTT CAACTATGAA GAATACTGCA CCGCCAACGC AGTCACTGGG 
CCTTGCCGTG CATCCTTCCC ACGCTGGTAC TTTGACGTGG AGAGGAACTC CTGCAATAAC 
TTCATCTATG GAGGCTGCCG GGGCAATAAG AACAGCTACC GCTCTGAGGA GGCCTGCATG 
CTCCGCTGCT TCCGCCAGCA GGAGAATCCT CCCCTGCCCC TTGGCTCAAA GGTGGTGGTT 
CTGGCGGGGC TGTTCGTGAT GGTGTTGATC CTCTTCCTGG GAGCCTCCAT GGTCTACCTG 
ATCCGGGTGG CACGGAGGAA CCAGGAGCGT GCCCTGCGCA CCGTCTGGAG CTCCGGAGAT 
GACAAGGAGC AGCTGGTGAA GAACACATAT GTCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066925.1
CDS	321..1079
Translation	MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

Target ORF information:

RefSeq Version	NM_021102.4
Organism	Homo sapiens(human)
Definition	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021102.4

ORF Insert Sequence:

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGACTT CTGCCTGGTG 
TCGAAGGTGG TGGGCAGATG CCGGGCCTCC ATGCCTAGGT GGTGGTACAA TGTCACTGAC 
GGATCCTGCC AGCTGTTTGT GTATGGGGGC TGTGACGGAA ACAGCAATAA TTACCTGACC 
AAGGAGGAGT GCCTCAAGAA ATGTGCCACT GTCACAGAGA ATGCCACGGG TGACCTGGCC 
ACCAGCAGGA ATGCAGCGGA TTCCTCTGTC CCAAGTGCTC CCAGAAGGCA GGATTCTGAA 
GACCACTCCA GCGATATGTT CAACTATGAA GAATACTGCA CCGCCAACGC AGTCACTGGG 
CCTTGCCGTG CATCCTTCCC ACGCTGGTAC TTTGACGTGG AGAGGAACTC CTGCAATAAC 
TTCATCTATG GAGGCTGCCG GGGCAATAAG AACAGCTACC GCTCTGAGGA GGCCTGCATG 
CTCCGCTGCT TCCGCCAGCA GGAGAATCCT CCCCTGCCCC TTGGCTCAAA GGTGGTGGTT 
CTGGCGGGGC TGTTCGTGAT GGTGTTGATC CTCTTCCTGG GAGCCTCCAT GGTCTACCTG 
ATCCGGGTGG CACGGAGGAA CCAGGAGCGT GCCCTGCGCA CCGTCTGGAG CTCCGGAGAT 
GACAAGGAGC AGCTGGTGAA GAACACATAT GTCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPINT2 ( NM_001166103.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159575.1 Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu17602
Clone ID Related Accession (Same CDS sequence)	NM_001166103.2 , NM_001166103.1
Accession Version	NM_001166103.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576339200000
Organism	Homo sapiens(human)
Product	kunitz-type protease inhibitor 2 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI199013.1, AK297154.1, AW275313.1 and AC011479.7. On May 31, 2019 this sequence version replaced NM_001166103.1. Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a. The resulting isoform (b) lacks an internal segment near the N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.673547.1, SRR7346977.85048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGAGAA TGCCACGGGT 
GACCTGGCCA CCAGCAGGAA TGCAGCGGAT TCCTCTGTCC CAAGTGCTCC CAGAAGGCAG 
GATTCTGAAG ACCACTCCAG CGATATGTTC AACTATGAAG AATACTGCAC CGCCAACGCA 
GTCACTGGGC CTTGCCGTGC ATCCTTCCCA CGCTGGTACT TTGACGTGGA GAGGAACTCC 
TGCAATAACT TCATCTATGG AGGCTGCCGG GGCAATAAGA ACAGCTACCG CTCTGAGGAG 
GCCTGCATGC TCCGCTGCTT CCGCCAGCAG GAGAATCCTC CCCTGCCCCT TGGCTCAAAG 
GTGGTGGTTC TGGCGGGGCT GTTCGTGATG GTGTTGATCC TCTTCCTGGG AGCCTCCATG 
GTCTACCTGA TCCGGGTGGC ACGGAGGAAC CAGGAGCGTG CCCTGCGCAC CGTCTGGAGC 
TCCGGAGATG ACAAGGAGCA GCTGGTGAAG AACACATATG TCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159575.1
CDS	321..908
Translation	MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

Target ORF information:

RefSeq Version	NM_001166103.2
Organism	Homo sapiens(human)
Definition	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166103.2

ORF Insert Sequence:

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGAGAA TGCCACGGGT 
GACCTGGCCA CCAGCAGGAA TGCAGCGGAT TCCTCTGTCC CAAGTGCTCC CAGAAGGCAG 
GATTCTGAAG ACCACTCCAG CGATATGTTC AACTATGAAG AATACTGCAC CGCCAACGCA 
GTCACTGGGC CTTGCCGTGC ATCCTTCCCA CGCTGGTACT TTGACGTGGA GAGGAACTCC 
TGCAATAACT TCATCTATGG AGGCTGCCGG GGCAATAAGA ACAGCTACCG CTCTGAGGAG 
GCCTGCATGC TCCGCTGCTT CCGCCAGCAG GAGAATCCTC CCCTGCCCCT TGGCTCAAAG 
GTGGTGGTTC TGGCGGGGCT GTTCGTGATG GTGTTGATCC TCTTCCTGGG AGCCTCCATG 
GTCTACCTGA TCCGGGTGGC ACGGAGGAAC CAGGAGCGTG CCCTGCGCAC CGTCTGGAGC 
TCCGGAGATG ACAAGGAGCA GCTGGTGAAG AACACATATG TCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPINT2 ( NM_001166103.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159575.1 Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant b, mRNA.

Price & Availability↑

CloneID	OHu17602
Clone ID Related Accession (Same CDS sequence)	NM_001166103.2 , NM_001166103.1
Accession Version	NM_001166103.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1551542400000
Organism	Homo sapiens(human)
Product	kunitz-type protease inhibitor 2 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI199013.1, AK297154.1 and AW275313.1. Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a. The resulting isoform (b) lacks an internal segment near the N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM794606.2, AK297154.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGAGAA TGCCACGGGT 
GACCTGGCCA CCAGCAGGAA TGCAGCGGAT TCCTCTGTCC CAAGTGCTCC CAGAAGGCAG 
GATTCTGAAG ACCACTCCAG CGATATGTTC AACTATGAAG AATACTGCAC CGCCAACGCA 
GTCACTGGGC CTTGCCGTGC ATCCTTCCCA CGCTGGTACT TTGACGTGGA GAGGAACTCC 
TGCAATAACT TCATCTATGG AGGCTGCCGG GGCAATAAGA ACAGCTACCG CTCTGAGGAG 
GCCTGCATGC TCCGCTGCTT CCGCCAGCAG GAGAATCCTC CCCTGCCCCT TGGCTCAAAG 
GTGGTGGTTC TGGCGGGGCT GTTCGTGATG GTGTTGATCC TCTTCCTGGG AGCCTCCATG 
GTCTACCTGA TCCGGGTGGC ACGGAGGAAC CAGGAGCGTG CCCTGCGCAC CGTCTGGAGC 
TCCGGAGATG ACAAGGAGCA GCTGGTGAAG AACACATATG TCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159575.1
CDS	436..1023
Translation	MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

Target ORF information:

RefSeq Version	NM_001166103.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serine peptidase inhibitor, Kunitz type 2 (SPINT2), transcript variant b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166103.1

ORF Insert Sequence:

ATGGCGCAGC TGTGCGGGCT GAGGCGGAGC CGGGCGTTTC TCGCCCTGCT GGGATCGCTG 
CTCCTCTCTG GGGTCCTGGC GGCCGACCGA GAACGCAGCA TCCACGAGAA TGCCACGGGT 
GACCTGGCCA CCAGCAGGAA TGCAGCGGAT TCCTCTGTCC CAAGTGCTCC CAGAAGGCAG 
GATTCTGAAG ACCACTCCAG CGATATGTTC AACTATGAAG AATACTGCAC CGCCAACGCA 
GTCACTGGGC CTTGCCGTGC ATCCTTCCCA CGCTGGTACT TTGACGTGGA GAGGAACTCC 
TGCAATAACT TCATCTATGG AGGCTGCCGG GGCAATAAGA ACAGCTACCG CTCTGAGGAG 
GCCTGCATGC TCCGCTGCTT CCGCCAGCAG GAGAATCCTC CCCTGCCCCT TGGCTCAAAG 
GTGGTGGTTC TGGCGGGGCT GTTCGTGATG GTGTTGATCC TCTTCCTGGG AGCCTCCATG 
GTCTACCTGA TCCGGGTGGC ACGGAGGAAC CAGGAGCGTG CCCTGCGCAC CGTCTGGAGC 
TCCGGAGATG ACAAGGAGCA GCTGGTGAAG AACACATATG TCCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasis.
British journal of cancer120(5)499-511(2019 03)
Wu SR,Lin CH,Shih HP,Ko CJ,Lin HY,Lan SW,Lin HH,Tu HF,Ho CC,Huang HP,Lee MS

Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas.
Cancer science109(9)2970-2979(2018 Sep)
Fukushima T,Kawaguchi M,Yamamoto K,Yamashita F,Izumi A,Kaieda T,Takezaki Y,Itoh H,Takeshima H,Kataoka H

Congenital sodium diarrhea and chorioretinal coloboma with optic disc coloboma in a patient with biallelic SPINT2 mutations, including p.(Tyr163Cys).
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Hirabayashi KE,Moore AT,Mendelsohn BA,Taft RJ,Chawla A,Perry D,Henry D,Slavotinek A

Study on the methylation status of SPINT2 gene and its expression in cervical carcinoma.
Cancer biomarkers : section A of Disease markers22(3)435-442(2018)
Wang N,Che Y,Yin F,Yu F,Bi X,Wang Y

Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.
The Journal of biological chemistry292(36)14867-14884(2017 09)
Murray AS,Varela FA,Hyland TE,Schoenbeck AJ,White JM,Tanabe LM,Todi SV,List K

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SPINT2 cDNA ORF clone, Homo sapiens(human)

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