atf6 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	atf6
Entrez Gene ID	558071
Full Name	activating transcription factor 6
Synonyms	fi12h10,si:ch211-199m3.9,si:ch211-260g14.1,wu:fi12h10
General protein information	Preferred Names activating transcription factor 6 Names cyclic AMP-dependent transcription factor ATF-6 alpha
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001110519.1	NP_001103989.1	cyclic AMP-dependent transcription factor ATF-6 alpha

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Atf6	NP_001074773.1
Gallus gallus (chicken)	ATF6	XP_422208.3
Danio rerio (zebrafish)	atf6	NP_001103989.1
Homo sapiens (human)	ATF6	NP_031374.2
Macaca mulatta (Rhesus monkey)	ATF6	XP_001118153.2
Bos taurus (cattle)	ATF6	XP_003585864.2
Xenopus tropicalis (tropical clawed frog)	atf6	XP_002933826.2
Pan troglodytes (chimpanzee)	ATF6	XP_001174215.1
Canis lupus familiaris (dog)	ATF6	XP_005640918.1
Rattus norvegicus (Norway rat)	Atf6	NP_001100666.1

Gene Ontology
Bibliography

Related articles in PubMed

Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway.
Jia ZL, Cen J, Wang JB, Zhang F, Xia Q, Wang X, Chen XQ, Wang RC, Hsiao CD, Liu KC, Zhang Y
Chemosphere227541-550(2019 Jul)

Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish.
Zhang Y, Cen J, Jia Z, Hsiao CD, Xia Q, Wang X, Chen X, Wang R, Jiang Z, Zhang L, Liu K
Antimicrobial agents and chemotherapy63(5)(2019 05)

3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish.
Park KH, Ye ZW, Zhang J, Hammad SM, Townsend DM, Rockey DC, Kim SH
Scientific reports9(1)1138(2019 Feb)

Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio).
Yang Y, Dong F, Liu X, Xu J, Wu X, Liu W, Zheng Y
Environmental pollution (Barking, Essex : 1987)243(Pt B)1904-1911(2018 Dec)

A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies.
Serafini PR, Feyder MJ, Hightower RM, Garcia-Perez D, Vieira NM, Lek A, Gibbs DE, Moukha-Chafiq O, Augelli-Szafran CE, Kawahara G, Widrick JJ, Kunkel LM, Alexander MS
JCI insight3(18)(2018 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following atf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the atf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa00698	NM_001110519.1 Latest version!	Danio rerio activating transcription factor 6 (atf6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

atf6 ( NM_001110519.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_001103989.1 Danio rerio activating transcription factor 6 (atf6), mRNA.

Price & Availability↑

CloneID	ODa00698
Clone ID Related Accession (Same CDS sequence)	NM_001110519.1
Accession Version	NM_001110519.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1962bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576771200000
Organism	Danio rerio(zebrafish)
Product	cyclic AMP-dependent transcription factor ATF-6 alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX296562.4 and BX571790.8. On Nov 16, 2007 this sequence version replaced XM_681241.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GDQH01000451.1, GDQQ01001017.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGTCGTCGA ATTTAATGTT AGATTTAATG AATCCTTCGA TGAGTAGTAA GGAAGTGGGA 
GATATTTCCA TCGACCAGGA TGGAGAGTGG GACATCAGTT TGTTTGATGA GCTGGAGGAT 
CTTGGAGATG CTGATGAGCT TCTGGAGGCG CTGGTGAAAA GTGTAGGCTA TGACACATCT 
GTTCCTGACC TGAACTTTGG CACTGAGCAA CCAGCATGGA GCTCAGATGG ATGGAGAGAA 
ACCAGCAGCC CTCGATCAGA TGGGGATGTA ACTGTGGACT CACTGTCACC AAACCACACA 
TTCAGTTCAG TGTCATCACC AGCGTCAGTG GAGCCTCAGT CACCGTACTC CACACATGAT 
GAGGCACTGT CTCCAGACTC GTGGCGTTCC CATCCCTCTC CGCTGTCCGT CTGCTCTGAC 
TCCAGTGGAT TTACTGAGGC ACCTAATGAG AAGAAGCCAT CTAAGAGGAC CAATCAGACA 
AAAGCCAAAC CTCTCCAACC AGCAAAAAGA CCCATCCAGG TGTGCCCCAA GGTTTCCATT 
CAGCCTAAAC CAATCATTAC AGCTGTTCCC ATCTCCCGTC CGGCAGCCCC TCTTCAAACC 
AAGATCATCA TCCAGCCGCT TCAGGCCACA GTTCTGCCTG TGGTGAAACC TCCACCTGTC 
ACTATTCAAC CAGCGCCCCC TACAGGTCAG CTAATGCAGC TTCCTCAGCC CACTCAGGTT 
CTCCAGCTTC AGACGCCTCA GTCAATGCCC ACGCGTGTAG TCACTATGCC TGCACTGGCA 
CAGGACAGAC CCATCTCTCT TGTTGCTCCG GTAACAACAT CTCCTGTGGT CACCATGACA 
CTGCAAAATT CCACGCCTGA CGATGATTCA AATGCGTCTC GGAGACAGCA GCGCATGATA 
AAGAACAGAG AGTCAGCTTC TCTCTCCCGG AAGAAAAAAA AGGAGTATTT AATGACACTG 
GAGACCCGTC TGAAGTTAGC GCTGACAGAA AATGAGAAGC TGAAGAATGA AAATGGCACA 
TTAAAAAGAC AAGTGGAAGG CCTAATGAGT GAGAACTCTG TGCTGAAAGC AACTGCTCCA 
AAACGGAGGG CTGTGTGTCT TATGGTTGTC CTGGTCTTCT TGGTTGTCAA CTTGGGTCCA 
ATGAGTTTGC TTGGAGGAGA CAGAGGGTCT GCCTTTCCTG CTACCCCTGT GTTCAATGGC 
AGACACCTGC TGGGATTTTC TCCTGAGTCA GAGAGAAACT TGGACAAGCC TCAGACTGAC 
CCATCTAACA CTGTGGACAG GTTGGAGGAG GGGGTTTCAG AGCAGAAGGC ATTGATGGTG 
GTCAAGGATC CTCTGTATTT CAGAACTCCA CCCCCCTGCC AGCCACCTGT CAACAGGACC 
AAGTGCATAA AGATAGCACA TGAGCTGAGA GGATGGGTGC ATCGGCATGA GGTTGAGCGG 
ACCAAAACTC GCCGCATGAG CAACACTCAG CACAGAGGCA GAACCTTCAT GAAAGCGTCA 
AGTAAACAAG CTGACGTACC ACAGATAATG TCACAGATCC AGTACACAGA CTCCTCTGAA 
AAGAATCCCG GCAGTGAACT GCAGGTGTAT TACGCTCCTC ACCGAACCTA CAATGACTTC 
TTTGATGAGC TCAACCGAAG AGGGGACACT TTCTACGTGA TCTCTTTCCG CCGGGATCAC 
CTCCTGCTTC CCGCCACTAA CCACAACAAA GGCAGTCGCC CCAAGATGTC AGTGGTCCTG 
CCAGCTATGA ATTACAATGA GAGCATCATT AAAGACAAGG ATTATGAGGT GATGATGCAG 
ATCGACTGTG AGGTCATGGA CACCAAAATC CTCCACATCA AATCGTCCAG TATCCCCCCT 
ATCCTGCGGG TCAATCAGAC GGAGACAAGC TCTTTTTATC ACGCCACCCC CAGCAATAAC 
CAACCCGCCG CCCCTGTTGG AGTCCTCGTG GGCTCTTCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001103989.1
CDS	1..1962
Translation	MSSNLMLDLMNPSMSSKEVGDISIDQDGEWDISLFDELEDLGDADELLEALVKSVGYDTSVPDLNFGTEQPAWSSDGWRETSSPRSDGDVTVDSLSPNHTFSSVSSPASVEPQSPYSTHDEALSPDSWRSHPSPLSVCSDSSGFTEAPNEKKPSKRTNQTKAKPLQPAKRPIQVCPKVSIQPKPIITAVPISRPAAPLQTKIIIQPLQATVLPVVKPPPVTIQPAPPTGQLMQLPQPTQVLQLQTPQSMPTRVVTMPALAQDRPISLVAPVTTSPVVTMTLQNSTPDDDSNASRRQQRMIKNRESASLSRKKKKEYLMTLETRLKLALTENEKLKNENGTLKRQVEGLMSENSVLKATAPKRRAVCLMVVLVFLVVNLGPMSLLGGDRGSAFPATPVFNGRHLLGFSPESERNLDKPQTDPSNTVDRLEEGVSEQKALMVVKDPLYFRTPPPCQPPVNRTKCIKIAHELRGWVHRHEVERTKTRRMSNTQHRGRTFMKASSKQADVPQIMSQIQYTDSSEKNPGSELQVYYAPHRTYNDFFDELNRRGDTFYVISFRRDHLLLPATNHNKGSRPKMSVVLPAMNYNESIIKDKDYEVMMQIDCEVMDTKILHIKSSSIPPILRVNQTETSSFYHATPSNNQPAAPVGVLVGSS

Target ORF information:

RefSeq Version	NM_001110519.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio activating transcription factor 6 (atf6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001110519.1

ORF Insert Sequence:

ATGTCGTCGA ATTTAATGTT AGATTTAATG AATCCTTCGA TGAGTAGTAA GGAAGTGGGA 
GATATTTCCA TCGACCAGGA TGGAGAGTGG GACATCAGTT TGTTTGATGA GCTGGAGGAT 
CTTGGAGATG CTGATGAGCT TCTGGAGGCG CTGGTGAAAA GTGTAGGCTA TGACACATCT 
GTTCCTGACC TGAACTTTGG CACTGAGCAA CCAGCATGGA GCTCAGATGG ATGGAGAGAA 
ACCAGCAGCC CTCGATCAGA TGGGGATGTA ACTGTGGACT CACTGTCACC AAACCACACA 
TTCAGTTCAG TGTCATCACC AGCGTCAGTG GAGCCTCAGT CACCGTACTC CACACATGAT 
GAGGCACTGT CTCCAGACTC GTGGCGTTCC CATCCCTCTC CGCTGTCCGT CTGCTCTGAC 
TCCAGTGGAT TTACTGAGGC ACCTAATGAG AAGAAGCCAT CTAAGAGGAC CAATCAGACA 
AAAGCCAAAC CTCTCCAACC AGCAAAAAGA CCCATCCAGG TGTGCCCCAA GGTTTCCATT 
CAGCCTAAAC CAATCATTAC AGCTGTTCCC ATCTCCCGTC CGGCAGCCCC TCTTCAAACC 
AAGATCATCA TCCAGCCGCT TCAGGCCACA GTTCTGCCTG TGGTGAAACC TCCACCTGTC 
ACTATTCAAC CAGCGCCCCC TACAGGTCAG CTAATGCAGC TTCCTCAGCC CACTCAGGTT 
CTCCAGCTTC AGACGCCTCA GTCAATGCCC ACGCGTGTAG TCACTATGCC TGCACTGGCA 
CAGGACAGAC CCATCTCTCT TGTTGCTCCG GTAACAACAT CTCCTGTGGT CACCATGACA 
CTGCAAAATT CCACGCCTGA CGATGATTCA AATGCGTCTC GGAGACAGCA GCGCATGATA 
AAGAACAGAG AGTCAGCTTC TCTCTCCCGG AAGAAAAAAA AGGAGTATTT AATGACACTG 
GAGACCCGTC TGAAGTTAGC GCTGACAGAA AATGAGAAGC TGAAGAATGA AAATGGCACA 
TTAAAAAGAC AAGTGGAAGG CCTAATGAGT GAGAACTCTG TGCTGAAAGC AACTGCTCCA 
AAACGGAGGG CTGTGTGTCT TATGGTTGTC CTGGTCTTCT TGGTTGTCAA CTTGGGTCCA 
ATGAGTTTGC TTGGAGGAGA CAGAGGGTCT GCCTTTCCTG CTACCCCTGT GTTCAATGGC 
AGACACCTGC TGGGATTTTC TCCTGAGTCA GAGAGAAACT TGGACAAGCC TCAGACTGAC 
CCATCTAACA CTGTGGACAG GTTGGAGGAG GGGGTTTCAG AGCAGAAGGC ATTGATGGTG 
GTCAAGGATC CTCTGTATTT CAGAACTCCA CCCCCCTGCC AGCCACCTGT CAACAGGACC 
AAGTGCATAA AGATAGCACA TGAGCTGAGA GGATGGGTGC ATCGGCATGA GGTTGAGCGG 
ACCAAAACTC GCCGCATGAG CAACACTCAG CACAGAGGCA GAACCTTCAT GAAAGCGTCA 
AGTAAACAAG CTGACGTACC ACAGATAATG TCACAGATCC AGTACACAGA CTCCTCTGAA 
AAGAATCCCG GCAGTGAACT GCAGGTGTAT TACGCTCCTC ACCGAACCTA CAATGACTTC 
TTTGATGAGC TCAACCGAAG AGGGGACACT TTCTACGTGA TCTCTTTCCG CCGGGATCAC 
CTCCTGCTTC CCGCCACTAA CCACAACAAA GGCAGTCGCC CCAAGATGTC AGTGGTCCTG 
CCAGCTATGA ATTACAATGA GAGCATCATT AAAGACAAGG ATTATGAGGT GATGATGCAG 
ATCGACTGTG AGGTCATGGA CACCAAAATC CTCCACATCA AATCGTCCAG TATCCCCCCT 
ATCCTGCGGG TCAATCAGAC GGAGACAAGC TCTTTTTATC ACGCCACCCC CAGCAATAAC 
CAACCCGCCG CCCCTGTTGG AGTCCTCGTG GGCTCTTCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway.
Chemosphere227541-550(2019 Jul)
Jia ZL,Cen J,Wang JB,Zhang F,Xia Q,Wang X,Chen XQ,Wang RC,Hsiao CD,Liu KC,Zhang Y

Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish.
Antimicrobial agents and chemotherapy63(5)(2019 05)
Zhang Y,Cen J,Jia Z,Hsiao CD,Xia Q,Wang X,Chen X,Wang R,Jiang Z,Zhang L,Liu K

3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish.
Scientific reports9(1)1138(2019 Feb)
Park KH,Ye ZW,Zhang J,Hammad SM,Townsend DM,Rockey DC,Kim SH

Crosstalk of oxidative damage, apoptosis, and autophagy under endoplasmic reticulum (ER) stress involved in thifluzamide-induced liver damage in zebrafish (Danio rerio).
Environmental pollution (Barking, Essex : 1987)243(Pt B)1904-1911(2018 Dec)
Yang Y,Dong F,Liu X,Xu J,Wu X,Liu W,Zheng Y

A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies.
JCI insight3(18)(2018 09)
Serafini PR,Feyder MJ,Hightower RM,Garcia-Perez D,Vieira NM,Lek A,Gibbs DE,Moukha-Chafiq O,Augelli-Szafran CE,Kawahara G,Widrick JJ,Kunkel LM,Alexander MS

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atf6 cDNA ORF clone, Danio rerio(zebrafish)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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