ADAMTS5 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAMTS5
Entrez Gene ID	286805
Full Name	ADAM metallopeptidase with thrombospondin type 1 motif 5
General protein information	Preferred Names ADAM metallopeptidase with thrombospondin type 1 motif 5 Names A disintegrin and metalloproteinase with thrombospondin motifs 5 ADAM-TS 5 ADAM-TS5 ADAMTS-5 ADMP-2 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 aggrecanase-2
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001166515.1	NP_001159987.1	A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor
XM_024993812.1	XP_024849580.1	A disintegrin and metalloproteinase with thrombospondin motifs 5 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Adamts5	NP_035912.2
Canis lupus familiaris (dog)	ADAMTS5	XP_851118.2
Bos taurus (cattle)	ADAMTS5	NP_001159987.1
Gallus gallus (chicken)	ADAMTS5	XP_425541.4
Xenopus tropicalis (tropical clawed frog)	adamts5	XP_002935740.1
Pan troglodytes (chimpanzee)	ADAMTS5	XP_531407.2
Danio rerio (zebrafish)	adamts5	XP_693454.6
Homo sapiens (human)	ADAMTS5	NP_008969.2
Macaca mulatta (Rhesus monkey)	ADAMTS5	XP_001103439.1
Rattus norvegicus (Norway rat)	Adamts5	NP_942056.1

Gene Ontology
Bibliography

Related articles in PubMed

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
Durigova M, Nagase H, Mort JS, Roughley PJ
Matrix biology : journal of the International Society for Matrix Biology30(2)145-53(2011 Mar)

Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
Lee JH, Fitzgerald JB, DiMicco MA, Cheng DM, Flannery CR, Sandy JD, Plaas AH, Grodzinsky AJ
Archives of biochemistry and biophysics489(1-2)118-26(2009 Sep)

Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
Miwa HE, Gerken TA, Huynh TD, Duesler LR, Cotter M, Hering TM
Biochimica et biophysica acta1790(3)161-72(2009 Mar)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marçais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM
The Journal of biological chemistry279(17)17554-61(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADAMTS5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAMTS5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa44534	NM_001166515.1 Latest version!	Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OBa45512	XM_024993812.1 Latest version!	Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAMTS5 ( NM_001166515.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001159987.1 Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), mRNA.

Price & Availability↑

CloneID	OBa44534
Clone ID Related Accession (Same CDS sequence)	NM_001166515.1
Accession Version	NM_001166515.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2805bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Bos taurus(cattle)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from NKLS02000001.1. On Oct 27, 2009 this sequence version replaced XM_589193.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03145422, SAMN03145425 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC 
GGCCCCACCG CGGCACCTGC CCAGGATAAA GCCGGGCAGC CTCGGGCTGC TGCTGTGGCT 
GCGGCCGCCC AGCCCCGTGG GCGGCGGGGG GAGGAGGCGC AGGAGCCGGC CGAGCCTCCG 
GGCCACCCGC ACCCCCTGGC GCCGCAGCGC GGGAGCCGCG GGCTCGTGCA GAACATCGAC 
CAGCTCTACT CCGGCGGCGG CAAGGTGGGC TACCTCGTCT ACGCGGGAGG TCGGCGGTTC 
CTCTTGGACT TGGAAAGGGA CGATTCGGTG GGCGCCGCTG GCTTGGTGCC CGCAGGAGGC 
GGGCCGAACG CGACCCGGCG CCACCGGGGC CACTGCTTCT ATCGGGGCAC GGTGGACGGC 
AGCCCGCGCT CGCTGGCAGT CTTTGACCTC TGCGGCGGCC TCGACGGCTT TTTCGCGGTC 
AAGCGCGCGC GCTACACCCT GCAGCCGCTG CTGCGCGGTC CCTGGGCAGA GGCGGAGGGC 
GATGCGCGAG TCTACGGGGA CGAGTCCGCG CGAATCCTGC ACGTCTATAC CCGCGAGGGT 
TTCAGCTTTG AGGCTCTGCC TCCTCGCACC AGCTGCGAGA CCCACGCGTC CCCGCCAGGC 
GCCCGCGAGC GCCCCCCGGC GCCCAGCCGC CCGGACGGAC GCTGGGCTCT GGCCCCGCAG 
CAGCTCCCGG GCCAGTCGGC TCCCTCGTCC GACGGGAGTC AGGGACCACG GACGTGGTGG 
CGGCGGCGGC GCCGCTCAAT CTCCCGGGCC CGCCAGGTGG AGCTGCTCCT AGTGGCCGAC 
GCATCCATGG CGCGGATGTA CGGCCGGGGC CTCCAGCATT ACCTACTGAC CCTGGCCTCC 
ATCGCCAACA AGCTGTACAG CCACGCCAGC ATCGAGAACC ACATCCGCCT GGTCGTGGTG 
AAGGTGGTGG TGCTGGGCGA TAAGGACAAG AGCCTGGAGG TGAGCAAGAA CGCGGCCACC 
ACGCTCAAGA ACTTCTGCAA GTGGCAGCAC CAGCACAACC AGCTAGGGGA TGATCACGAG 
GAGCACTATG ACGCGGCCAT CCTGTTTACT CGGGAGGATT TATGTGGGCA TCATTCCTGC 
GACACCCTGG GAATGGCAGA CGTTGGGACC ATATGCTCTC CTGAGCGCAG CTGTGCGGTG 
ATTGAAGACG ATGGCCTCCA TGCAGCCTTC ACCGTGGCTC ACGAAATTGG ACATCTGCTT 
GGCCTCTCCC ATGACGATTC CAAGTTCTGT GAAGAAAATT TCGGCTCCAC GGAAGATAAG 
CGCTTAATGT CTTCCATCCT CACCAGCATT GACGCATCCA AACCCTGGTC CAAATGCACC 
TCAGCCACCA TCACAGAATT TCTGGATGAT GGTCACGGTA ACTGTTTGCT GGACCTACCA 
CGAAAACAGA TTCCCGGGCC CGAGGAGCTC CCAGGCCAGA CCTACGATGC CAGCCAGCAG 
TGCAACCTGA CCTTCGGGCC AGAGTACTCG GTGTGTCCCG GCATGGACGT GTGTGCCCGC 
CTCTGGTGTG CCGTGGTGCG CCAGGGCCAG ATGGTGTGTC TGACCAAGAA GCTGCCGGCC 
GTGGAAGGAA CACCATGTGG GAAAGGGAGG ATCTGCCTGC AGGGCAAGTG TGTGGACAAA 
ACCAAGAAAA AATATTATTC GACATCAAGC CACGGCAACT GGGGGTCCTG GGGGTCCTGG 
GGCCAGTGTT CTCGCTCGTG TGGGGGCGGA GTGCAGTTTG CCTACCGCCA CTGCAATAAC 
CCAGCGCCCA GGAACAACGG CCGCTATTGC ACAGGGAAGA GGGCTATCTA CCGCTCCTGC 
AGCGTCACGC CCTGCCCAGC TAACGGTAAA TCTTTTCGTC ATGAGCAGTG TGAGGCCAAA 
AATGGATATC AGTCTGATGC AAAAGGAGTC AAAACGTTTG TGGAATGGGT TCCCAAATAT 
GCTGGTGTCC TGCCCGGAGA CGTGTGCAAA CTGACCTGCA GAGCTAAGGG CACTGGCTAC 
TACGTGGTGT TCTCTCCAAA GGTGACCGAT GGGACAGAGT GCAGGCCATA CAGCAATTCC 
GTGTGTGTCC GGGGGAAGTG TGTGCGGACA GGCTGTGACG GCATCATTGG CTCGAAGCTG 
CAGTATGACA AATGTGGCGT CTGTGGAGGA GACAACTCCA GTTGCACAAA GGTGGTCGGA 
ACCTTCAATA AAAAAAGTAA GGGTTACACT GACGTCGTGA GGATCCCCGA AGGGGCGACT 
CACATAAAAG TCCGCCAGTT CAAGGCCAAG GACCAGACCA GATTCACTGC CTACTTAGCC 
CTGAAGAAGA AAAACGGTGA GTACTTGATC AATGGCAAGT ACATGATCTC CACTTCAGAA 
ACCATCATCG ACATCAACGG GACCGTCATG AACTACAGCG GTTGGAGCCA CAGGGACGAC 
TTCTTGCACG GGATGGGCTA CTCAGCCACC AAGGAAATTC TCATCGTGCA GATTCTTGCC 
ACAGACCCCA CGAAAGCCCT TGATGTCCGC TACAGCTTCT TCGTTCCCAA GAAGTCGGCT 
CCAAAAGCAA ACTCTGTCAC CAGCCAGGGC AGCAATAAAG TGGGCTCGCC CACCCCGCAG 
CTGCAGTGGG TGACGGGCCC CTGGCTTGCC TGTTCGCGAA CCTGTGACAC GGGCTGGCAC 
ACCAGGACGG TGCAGTGCCA GGACGGGAAT CGGAAGCTGG CGAAGGGATG TCTCCTCTCC 
CAGAGGCCTT CCGCGTTTAA GCAGTGTTTT CAGAAGAAGT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159987.1
CDS	1..2805
Translation	MLLGWAALMLCALRLPPVAAGPTAAPAQDKAGQPRAAAVAAAAQPRGRRGEEAQEPAEPPGHPHPLAPQRGSRGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDSVGAAGLVPAGGGPNATRRHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKRARYTLQPLLRGPWAEAEGDARVYGDESARILHVYTREGFSFEALPPRTSCETHASPPGARERPPAPSRPDGRWALAPQQLPGQSAPSSDGSQGPRTWWRRRRRSISRARQVELLLVADASMARMYGRGLQHYLLTLASIANKLYSHASIENHIRLVVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQIPGPEELPGQTYDASQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSVTPCPANGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPGDVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKVVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKSAPKANSVTSQGSNKVGSPTPQLQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCLLSQRPSAFKQCFQKKC

Target ORF information:

RefSeq Version	NM_001166515.1
Organism	Bos taurus(cattle)
Definition	Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166515.1

ORF Insert Sequence:

ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC 
GGCCCCACCG CGGCACCTGC CCAGGATAAA GCCGGGCAGC CTCGGGCTGC TGCTGTGGCT 
GCGGCCGCCC AGCCCCGTGG GCGGCGGGGG GAGGAGGCGC AGGAGCCGGC CGAGCCTCCG 
GGCCACCCGC ACCCCCTGGC GCCGCAGCGC GGGAGCCGCG GGCTCGTGCA GAACATCGAC 
CAGCTCTACT CCGGCGGCGG CAAGGTGGGC TACCTCGTCT ACGCGGGAGG TCGGCGGTTC 
CTCTTGGACT TGGAAAGGGA CGATTCGGTG GGCGCCGCTG GCTTGGTGCC CGCAGGAGGC 
GGGCCGAACG CGACCCGGCG CCACCGGGGC CACTGCTTCT ATCGGGGCAC GGTGGACGGC 
AGCCCGCGCT CGCTGGCAGT CTTTGACCTC TGCGGCGGCC TCGACGGCTT TTTCGCGGTC 
AAGCGCGCGC GCTACACCCT GCAGCCGCTG CTGCGCGGTC CCTGGGCAGA GGCGGAGGGC 
GATGCGCGAG TCTACGGGGA CGAGTCCGCG CGAATCCTGC ACGTCTATAC CCGCGAGGGT 
TTCAGCTTTG AGGCTCTGCC TCCTCGCACC AGCTGCGAGA CCCACGCGTC CCCGCCAGGC 
GCCCGCGAGC GCCCCCCGGC GCCCAGCCGC CCGGACGGAC GCTGGGCTCT GGCCCCGCAG 
CAGCTCCCGG GCCAGTCGGC TCCCTCGTCC GACGGGAGTC AGGGACCACG GACGTGGTGG 
CGGCGGCGGC GCCGCTCAAT CTCCCGGGCC CGCCAGGTGG AGCTGCTCCT AGTGGCCGAC 
GCATCCATGG CGCGGATGTA CGGCCGGGGC CTCCAGCATT ACCTACTGAC CCTGGCCTCC 
ATCGCCAACA AGCTGTACAG CCACGCCAGC ATCGAGAACC ACATCCGCCT GGTCGTGGTG 
AAGGTGGTGG TGCTGGGCGA TAAGGACAAG AGCCTGGAGG TGAGCAAGAA CGCGGCCACC 
ACGCTCAAGA ACTTCTGCAA GTGGCAGCAC CAGCACAACC AGCTAGGGGA TGATCACGAG 
GAGCACTATG ACGCGGCCAT CCTGTTTACT CGGGAGGATT TATGTGGGCA TCATTCCTGC 
GACACCCTGG GAATGGCAGA CGTTGGGACC ATATGCTCTC CTGAGCGCAG CTGTGCGGTG 
ATTGAAGACG ATGGCCTCCA TGCAGCCTTC ACCGTGGCTC ACGAAATTGG ACATCTGCTT 
GGCCTCTCCC ATGACGATTC CAAGTTCTGT GAAGAAAATT TCGGCTCCAC GGAAGATAAG 
CGCTTAATGT CTTCCATCCT CACCAGCATT GACGCATCCA AACCCTGGTC CAAATGCACC 
TCAGCCACCA TCACAGAATT TCTGGATGAT GGTCACGGTA ACTGTTTGCT GGACCTACCA 
CGAAAACAGA TTCCCGGGCC CGAGGAGCTC CCAGGCCAGA CCTACGATGC CAGCCAGCAG 
TGCAACCTGA CCTTCGGGCC AGAGTACTCG GTGTGTCCCG GCATGGACGT GTGTGCCCGC 
CTCTGGTGTG CCGTGGTGCG CCAGGGCCAG ATGGTGTGTC TGACCAAGAA GCTGCCGGCC 
GTGGAAGGAA CACCATGTGG GAAAGGGAGG ATCTGCCTGC AGGGCAAGTG TGTGGACAAA 
ACCAAGAAAA AATATTATTC GACATCAAGC CACGGCAACT GGGGGTCCTG GGGGTCCTGG 
GGCCAGTGTT CTCGCTCGTG TGGGGGCGGA GTGCAGTTTG CCTACCGCCA CTGCAATAAC 
CCAGCGCCCA GGAACAACGG CCGCTATTGC ACAGGGAAGA GGGCTATCTA CCGCTCCTGC 
AGCGTCACGC CCTGCCCAGC TAACGGTAAA TCTTTTCGTC ATGAGCAGTG TGAGGCCAAA 
AATGGATATC AGTCTGATGC AAAAGGAGTC AAAACGTTTG TGGAATGGGT TCCCAAATAT 
GCTGGTGTCC TGCCCGGAGA CGTGTGCAAA CTGACCTGCA GAGCTAAGGG CACTGGCTAC 
TACGTGGTGT TCTCTCCAAA GGTGACCGAT GGGACAGAGT GCAGGCCATA CAGCAATTCC 
GTGTGTGTCC GGGGGAAGTG TGTGCGGACA GGCTGTGACG GCATCATTGG CTCGAAGCTG 
CAGTATGACA AATGTGGCGT CTGTGGAGGA GACAACTCCA GTTGCACAAA GGTGGTCGGA 
ACCTTCAATA AAAAAAGTAA GGGTTACACT GACGTCGTGA GGATCCCCGA AGGGGCGACT 
CACATAAAAG TCCGCCAGTT CAAGGCCAAG GACCAGACCA GATTCACTGC CTACTTAGCC 
CTGAAGAAGA AAAACGGTGA GTACTTGATC AATGGCAAGT ACATGATCTC CACTTCAGAA 
ACCATCATCG ACATCAACGG GACCGTCATG AACTACAGCG GTTGGAGCCA CAGGGACGAC 
TTCTTGCACG GGATGGGCTA CTCAGCCACC AAGGAAATTC TCATCGTGCA GATTCTTGCC 
ACAGACCCCA CGAAAGCCCT TGATGTCCGC TACAGCTTCT TCGTTCCCAA GAAGTCGGCT 
CCAAAAGCAA ACTCTGTCAC CAGCCAGGGC AGCAATAAAG TGGGCTCGCC CACCCCGCAG 
CTGCAGTGGG TGACGGGCCC CTGGCTTGCC TGTTCGCGAA CCTGTGACAC GGGCTGGCAC 
ACCAGGACGG TGCAGTGCCA GGACGGGAAT CGGAAGCTGG CGAAGGGATG TCTCCTCTCC 
CAGAGGCCTT CCGCGTTTAA GCAGTGTTTT CAGAAGAAGT GTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS5 ( XM_024993812.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024849580.1 Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa45512
Clone ID Related Accession (Same CDS sequence)	XM_024993812.1
Accession Version	XM_024993812.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2268bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1525536000000
Organism	Bos taurus(cattle)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037328.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC 
GGCCCCACCG CGGCACCTGC CCAGGATAAA GCCGGGCAGC CTCGGGCTGC TGCTGTGGCT 
GCGGCCGCCC AGCCCCGTGG GCGGCGGGGG GAGGAGGCGC AGGAGCCGGC CGAGCCTCCG 
GGCCACCCGC ACCCCCTGGC GCCGCAGCGC GGGAGCCGCG GGCTCGTGCA GAACATCGAC 
CAGCTCTACT CCGGCGGCGG CAAGGTGGGC TACCTCGTCT ACGCGGGAGG TCGGCGGTTC 
CTCTTGGACT TGGAAAGGGA CGATTCGGTG GGCGCCGCTG GCTTGGTGCC CGCAGGAGGC 
GGGCCGAACG CGACCCGGCG CCACCGGGGC CACTGCTTCT ATCGGGGCAC GGTGGACGGC 
AGCCCGCGCT CGCTGGCAGT CTTTGACCTC TGCGGCGGCC TCGACGGCTT TTTCGCGGTC 
AAGCGCGCGC GCTACACCCT GCAGCCGCTG CTGCGCGGTC CCTGGGCAGA GGCGGAGGGC 
GATGCGCGAG TCTACGGGGA CGAGTCCGCG CGAATCCTGC ACGTCTATAC CCGCGAGGGT 
TTCAGCTTTG AGGCTCTGCC TCCTCGCACC AGCTGCGAGA CCCACGCGTC CCCGCCAGGC 
GCCCGCGAGC GCCCCCCGGC GCCCAGCCGC CCGGACGGAC GCTGGGCTCT GGCCCCGCAG 
CAGCTCCCGG GCCAGTCGGC TCCCTCGTCC GACGGGAGTC AGGGACCACG GACGTGGTGG 
CGGCGGCGGC GCCGCTCAAT CTCCCGGGCC CGCCAGGTGG AGCTGCTCCT AGTGGCCGAC 
GCATCCATGG CGCGGATGTA CGGCCGGGGC CTCCAGCATT ACCTACTGAC CCTGGCCTCC 
ATCGCCAACA AGCTGTACAG CCACGCCAGC ATCGAGAACC ACATCCGCCT GGTCGTGGTG 
AAGGTGGTGG TGCTGGGCGA TAAGGACAAG AGCCTGGAGG TGAGCAAGAA CGCGGCCACC 
ACGCTCAAGA ACTTCTGCAA GTGGCAGCAC CAGCACAACC AGCTAGGGGA TGATCACGAG 
GAGCACTATG ACGCGGCCAT CCTGTTTACT CGGGAGGATT TATGTGGGCA TCATTCCTGC 
GACACCCTGG GAATGGCAGA CGTTGGGACC ATATGCTCTC CTGAGCGCAG CTGTGCGGTG 
ATTGAAGACG ATGGCCTCCA TGCAGCCTTC ACCGTGGCTC ACGAAATTGG ACATCTGCTT 
GGCCTCTCCC ATGACGATTC CAAGTTCTGT GAAGAAAATT TCGGCTCCAC GGAAGATAAG 
CGCTTAATGT CTTCCATCCT CACCAGCATT GACGCATCCA AACCCTGGTC CAAATGCACC 
TCAGCCACCA TCACAGAATT TCTGGATGAT GGTCACGGTA ACTGTTTGCT GGACCTACCA 
CGAAAACAGA TTCCCGGGCC CGAGGAGCTC CCAGGCCAGA CCTACGATGC CAGCCAGCAG 
TGCAACCTGA CCTTCGGGCC AGAGTACTCG GTGTGTCCCG GCATGGACGT GTGTGCCCGC 
CTCTGGTGTG CCGTGGTGCG CCAGGGCCAG ATGGTGTGTC TGACCAAGAA GCTGCCGGCC 
GTGGAAGGAA CACCATGTGG GAAAGGGAGG ATCTGCCTGC AGGGCAAGTG TGTGGACAAA 
ACCAAGAAAA AATATTATTC GACATCAAGC CACGGCAACT GGGGGTCCTG GGGGTCCTGG 
GGCCAGTGTT CTCGCTCGTG TGGGGGCGGA GTGCAGTTTG CCTACCGCCA CTGCAATAAC 
CCAGCGCCCA GGAACAACGG CCGCTATTGC ACAGGGAAGA GGGCTATCTA CCGCTCCTGC 
AGCGTCACGC CCTGCCCAGC TAACGGTAAA TCTTTTCGTC ATGAGCAGTG TGAGGCCAAA 
AATGGATATC AGTCTGATGC AAAAGGAGTC AAAACGTTTG TGGAATGGGT TCCCAAATAT 
GCTGGTGTCC TGCCCGGAGA CGTGTGCAAA CTGACCTGCA GAGCTAAGGG CACTGGCTAC 
TACGTGGTGT TCTCTCCAAA GGTGACCGAT GGGACAGAGT GCAGGCCATA CAGCAATTCC 
GTGTGTGTCC GGGGGAAGTG TGTGCGGACA GGCTGTGACG GCATCATTGG CTCGAAGCTG 
CAGTATGACA AATGTGGCGT CTGTGGAGGA GACAACTCCA GTTGCACAAA GGTGGTCGGA 
ACCTTCAATA AAAAAAGACT ACCCTTATGC TATGTGGTAT TGGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024849580.1
CDS	829..3096
Translation	MLLGWAALMLCALRLPPVAAGPTAAPAQDKAGQPRAAAVAAAAQPRGRRGEEAQEPAEPPGHPHPLAPQRGSRGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDSVGAAGLVPAGGGPNATRRHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKRARYTLQPLLRGPWAEAEGDARVYGDESARILHVYTREGFSFEALPPRTSCETHASPPGARERPPAPSRPDGRWALAPQQLPGQSAPSSDGSQGPRTWWRRRRRSISRARQVELLLVADASMARMYGRGLQHYLLTLASIANKLYSHASIENHIRLVVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQIPGPEELPGQTYDASQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSVTPCPANGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPGDVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKVVGTFNKKRLPLCYVVLV

Target ORF information:

RefSeq Version	XM_024993812.1
Organism	Bos taurus(cattle)
Definition	Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024993812.1

ORF Insert Sequence:

ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC 
GGCCCCACCG CGGCACCTGC CCAGGATAAA GCCGGGCAGC CTCGGGCTGC TGCTGTGGCT 
GCGGCCGCCC AGCCCCGTGG GCGGCGGGGG GAGGAGGCGC AGGAGCCGGC CGAGCCTCCG 
GGCCACCCGC ACCCCCTGGC GCCGCAGCGC GGGAGCCGCG GGCTCGTGCA GAACATCGAC 
CAGCTCTACT CCGGCGGCGG CAAGGTGGGC TACCTCGTCT ACGCGGGAGG TCGGCGGTTC 
CTCTTGGACT TGGAAAGGGA CGATTCGGTG GGCGCCGCTG GCTTGGTGCC CGCAGGAGGC 
GGGCCGAACG CGACCCGGCG CCACCGGGGC CACTGCTTCT ATCGGGGCAC GGTGGACGGC 
AGCCCGCGCT CGCTGGCAGT CTTTGACCTC TGCGGCGGCC TCGACGGCTT TTTCGCGGTC 
AAGCGCGCGC GCTACACCCT GCAGCCGCTG CTGCGCGGTC CCTGGGCAGA GGCGGAGGGC 
GATGCGCGAG TCTACGGGGA CGAGTCCGCG CGAATCCTGC ACGTCTATAC CCGCGAGGGT 
TTCAGCTTTG AGGCTCTGCC TCCTCGCACC AGCTGCGAGA CCCACGCGTC CCCGCCAGGC 
GCCCGCGAGC GCCCCCCGGC GCCCAGCCGC CCGGACGGAC GCTGGGCTCT GGCCCCGCAG 
CAGCTCCCGG GCCAGTCGGC TCCCTCGTCC GACGGGAGTC AGGGACCACG GACGTGGTGG 
CGGCGGCGGC GCCGCTCAAT CTCCCGGGCC CGCCAGGTGG AGCTGCTCCT AGTGGCCGAC 
GCATCCATGG CGCGGATGTA CGGCCGGGGC CTCCAGCATT ACCTACTGAC CCTGGCCTCC 
ATCGCCAACA AGCTGTACAG CCACGCCAGC ATCGAGAACC ACATCCGCCT GGTCGTGGTG 
AAGGTGGTGG TGCTGGGCGA TAAGGACAAG AGCCTGGAGG TGAGCAAGAA CGCGGCCACC 
ACGCTCAAGA ACTTCTGCAA GTGGCAGCAC CAGCACAACC AGCTAGGGGA TGATCACGAG 
GAGCACTATG ACGCGGCCAT CCTGTTTACT CGGGAGGATT TATGTGGGCA TCATTCCTGC 
GACACCCTGG GAATGGCAGA CGTTGGGACC ATATGCTCTC CTGAGCGCAG CTGTGCGGTG 
ATTGAAGACG ATGGCCTCCA TGCAGCCTTC ACCGTGGCTC ACGAAATTGG ACATCTGCTT 
GGCCTCTCCC ATGACGATTC CAAGTTCTGT GAAGAAAATT TCGGCTCCAC GGAAGATAAG 
CGCTTAATGT CTTCCATCCT CACCAGCATT GACGCATCCA AACCCTGGTC CAAATGCACC 
TCAGCCACCA TCACAGAATT TCTGGATGAT GGTCACGGTA ACTGTTTGCT GGACCTACCA 
CGAAAACAGA TTCCCGGGCC CGAGGAGCTC CCAGGCCAGA CCTACGATGC CAGCCAGCAG 
TGCAACCTGA CCTTCGGGCC AGAGTACTCG GTGTGTCCCG GCATGGACGT GTGTGCCCGC 
CTCTGGTGTG CCGTGGTGCG CCAGGGCCAG ATGGTGTGTC TGACCAAGAA GCTGCCGGCC 
GTGGAAGGAA CACCATGTGG GAAAGGGAGG ATCTGCCTGC AGGGCAAGTG TGTGGACAAA 
ACCAAGAAAA AATATTATTC GACATCAAGC CACGGCAACT GGGGGTCCTG GGGGTCCTGG 
GGCCAGTGTT CTCGCTCGTG TGGGGGCGGA GTGCAGTTTG CCTACCGCCA CTGCAATAAC 
CCAGCGCCCA GGAACAACGG CCGCTATTGC ACAGGGAAGA GGGCTATCTA CCGCTCCTGC 
AGCGTCACGC CCTGCCCAGC TAACGGTAAA TCTTTTCGTC ATGAGCAGTG TGAGGCCAAA 
AATGGATATC AGTCTGATGC AAAAGGAGTC AAAACGTTTG TGGAATGGGT TCCCAAATAT 
GCTGGTGTCC TGCCCGGAGA CGTGTGCAAA CTGACCTGCA GAGCTAAGGG CACTGGCTAC 
TACGTGGTGT TCTCTCCAAA GGTGACCGAT GGGACAGAGT GCAGGCCATA CAGCAATTCC 
GTGTGTGTCC GGGGGAAGTG TGTGCGGACA GGCTGTGACG GCATCATTGG CTCGAAGCTG 
CAGTATGACA AATGTGGCGT CTGTGGAGGA GACAACTCCA GTTGCACAAA GGTGGTCGGA 
ACCTTCAATA AAAAAAGACT ACCCTTATGC TATGTGGTAT TGGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
Matrix biology : journal of the International Society for Matrix Biology30(2)145-53(2011 Mar)
Durigova M,Nagase H,Mort JS,Roughley PJ

Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
Archives of biochemistry and biophysics489(1-2)118-26(2009 Sep)
Lee JH,Fitzgerald JB,DiMicco MA,Cheng DM,Flannery CR,Sandy JD,Plaas AH,Grodzinsky AJ

Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
Biochimica et biophysica acta1790(3)161-72(2009 Mar)
Miwa HE,Gerken TA,Huynh TD,Duesler LR,Cotter M,Hering TM

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Marçais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
The Journal of biological chemistry279(17)17554-61(2004 Apr)
Tortorella MD,Arner EC,Hills R,Easton A,Korte-Sarfaty J,Fok K,Wittwer AJ,Liu RQ,Malfait AM

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ADAMTS5 cDNA ORF clone, Bos taurus(cattle)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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