gene Related Biological Terms

The movement of genes from one population to another by way of interbreeding of individuals in the two populations.

The accidental joining of DNA of two genes, such as can occur in a translocation or inversion. gene fusions can give rise to hybrid Proteins or to the misregulation of the transcription of one gene by the cis regulatory elements (enhancers) of another. A gene fusion is a hybrid gene formed from two separated genes.

a device for transforming Cells with foreign DNA that works by propelling small metal spheres covered with a DNA molecule into living Cells.

The collaboration of several different genes in the production of one phenotypic character (or related group of characters).

See genomic library.

The hereditary association of genes located on the same chromosome.

The specific place on a chromosome where a gene is located.

1. A linear designation of mutant sites within a gene, based upon the various frequencies of interallelic (intragenic) recombination. 2. The DNA sequence of a gene annotated with sites of regulatory elements, Introns, Exons and mutations.

Gene mapping is the methodology used to assign a gene its location and position relative to other genes within a chromosome. There are two main gene mapping strategies, including physical and genetic linkage mapping. Physical mapping relies on molecular biology methods, such as Next-Generation Sequencing, to determine the gene location based on nucleotide sequence. Genetic linkage mapping identifies a gene’s location by evaluating unique sequences or genetic markers along the genome, such as identifiable sequences (e.g., Restriction fragment length polymorphisms, Simple sequence length polymorphisms, and Single nucleotide polymorphisms), which are generated through recombination within a chromosome or between chromosomes (cross-over). Gene mapping is used to identify and establish the genetic bases of rare diseases, such as Angelman Syndrome and Amyotrophic Lateral Sclerosis .

The chemical repair of a gene's defective DNA sequence.