Nrtn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nrtn
Entrez Gene ID	84423
Full Name	neurturin
General protein information	Preferred Names neurturin Names neurturin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12
Summary	a neurotrophic factor that is involved in neuronal cell protection and cell survival [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053399.1	NP_445851.1	neurturin precursor
XM_006244347.3	XP_006244409.1	neurturin isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nrtn	NP_032764.1
Homo sapiens (human)	NRTN	NP_004549.1
Canis lupus familiaris (dog)	NRTN	XP_005633060.1
Rattus norvegicus (Norway rat)	Nrtn	NP_445851.1
Macaca mulatta (Rhesus monkey)	NRTN	XP_001085705.1
Bos taurus (cattle)	NRTN	NP_001192848.1
Pan troglodytes (chimpanzee)	NRTN	XP_003316076.1

Gene Ontology
Bibliography

Related articles in PubMed

GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain.
Nencini S, Ringuet M, Kim DH, Greenhill C, Ivanusic JJ
The Journal of neuroscience : the official journal of the Society for Neuroscience38(21)4899-4911(2018 05)

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms.
Wan G, Zhou L, Lim Q', Wong YH, Too HP
Cellular signalling23(11)1727-37(2011 Nov)

Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Ramaswamy S, McBride JL, Herzog CD, Brandon E, Gasmi M, Bartus RT, Kordower JH
Neurobiology of disease26(2)375-84(2007 May)

The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons.
Zihlmann KB, Ducray AD, Schaller B, Huber AW, Krebs SH, Andres RH, Seiler RW, Meyer M, Widmer HR
Brain research bulletin68(1-2)42-53(2005 Dec)

Immunohistochemical expression of two members of the GDNF family of growth factors and their receptors in the olfactory system.
Maroldt H, Kaplinovsky T, Cunningham AM
Journal of neurocytology34(3-5)241-55(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nrtn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nrtn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09446	NM_053399.1 Latest version!	Rattus norvegicus neurturin (Nrtn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa09446	XM_006244347.3 Latest version!	Rattus norvegicus neurturin (Nrtn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nrtn ( NM_053399.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445851.1 Rattus norvegicus neurturin (Nrtn), mRNA.

Price & Availability↑

CloneID	ORa09446
Clone ID Related Accession (Same CDS sequence)	NM_053399.1 , XM_006244347.3
Accession Version	NM_053399.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572105600000
Organism	Rattus norvegicus(Norway rat)
Product	neurturin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY190603.1. On Jan 1, 2004 this sequence version replaced XM_343665.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY190603.1, BP482733.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGTGCT GGAAGGCGGC GGCCCTGGTG TCGCTCATCT GCAGCTCCCT GCTGTCTGTC 
TGGATGTGCC AGGAGGGTCT GCTCTTGGGT CACCGCCTGG GACCCGCGCT CGCTCCTCTG 
CGACGCCCTC CACGCACCCT GGACGCCCGC ATCGCCCGCC TGGCCCAGTA TCGCGCTCTG 
CTGCAGGGCG CCCCCGACGC GGTGGAGCTT CGAGAACTTT CTCCCTGGGT TGCCCGTCCC 
TCGGGGCCGC GCCGTCGAGC GGGTCCCCGG CGTCGGCGTG CGCGGCCAGG CTCGCGACCG 
TGCGGGCTGC GCGAGCTCGA GGTGCGTGTG AGCGAGCTGG GTCTGGGCTA CACGTCGGAC 
GAAACCGTCC TGTTCCGCTA CTGCGCAGGC GCGTGCGAGG CGGCCATACG CATCTACGAC 
CTGGGCCTGC GGCGCCTGCG CCAGCGACGA CGCGTGCGCA AAGAGCGGGT GCGAGCGCAC 
CCGTGCTGCC GCCCGACGGC CTACGAGGAC GAGGTGTCCT TCCTGGACGT ACACAGCCGC 
TACCACACGC TGCAAGAGCT GTCGGCGCGG GAGTGCGCGT GCGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445851.1
CDS	4..591
Translation	MRCWKAAALVSLICSSLLSVWMCQEGLLLGHRLGPALAPLRRPPRTLDARIARLAQYRALLQGAPDAVELRELSPWVARPSGPRRRAGPRRRRARPGSRPCGLRELEVRVSELGLGYTSDETVLFRYCAGACEAAIRIYDLGLRRLRQRRRVRKERVRAHPCCRPTAYEDEVSFLDVHSRYHTLQELSARECACV

Target ORF information:

RefSeq Version	NM_053399.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurturin (Nrtn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053399.1

ORF Insert Sequence:

ATGAGGTGCT GGAAGGCGGC GGCCCTGGTG TCGCTCATCT GCAGCTCCCT GCTGTCTGTC 
TGGATGTGCC AGGAGGGTCT GCTCTTGGGT CACCGCCTGG GACCCGCGCT CGCTCCTCTG 
CGACGCCCTC CACGCACCCT GGACGCCCGC ATCGCCCGCC TGGCCCAGTA TCGCGCTCTG 
CTGCAGGGCG CCCCCGACGC GGTGGAGCTT CGAGAACTTT CTCCCTGGGT TGCCCGTCCC 
TCGGGGCCGC GCCGTCGAGC GGGTCCCCGG CGTCGGCGTG CGCGGCCAGG CTCGCGACCG 
TGCGGGCTGC GCGAGCTCGA GGTGCGTGTG AGCGAGCTGG GTCTGGGCTA CACGTCGGAC 
GAAACCGTCC TGTTCCGCTA CTGCGCAGGC GCGTGCGAGG CGGCCATACG CATCTACGAC 
CTGGGCCTGC GGCGCCTGCG CCAGCGACGA CGCGTGCGCA AAGAGCGGGT GCGAGCGCAC 
CCGTGCTGCC GCCCGACGGC CTACGAGGAC GAGGTGTCCT TCCTGGACGT ACACAGCCGC 
TACCACACGC TGCAAGAGCT GTCGGCGCGG GAGTGCGCGT GCGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nrtn ( XM_006244347.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006244409.1 Rattus norvegicus neurturin (Nrtn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09446
Clone ID Related Accession (Same CDS sequence)	NM_053399.1 , XM_006244347.3
Accession Version	XM_006244347.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	neurturin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006244347.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGTGCT GGAAGGCGGC GGCCCTGGTG TCGCTCATCT GCAGCTCCCT GCTGTCTGTC 
TGGATGTGCC AGGAGGGTCT GCTCTTGGGT CACCGCCTGG GACCCGCGCT CGCTCCTCTG 
CGACGCCCTC CACGCACCCT GGACGCCCGC ATCGCCCGCC TGGCCCAGTA TCGCGCTCTG 
CTGCAGGGCG CCCCCGACGC GGTGGAGCTT CGAGAACTTT CTCCCTGGGT TGCCCGTCCC 
TCGGGGCCGC GCCGTCGAGC GGGTCCCCGG CGTCGGCGTG CGCGGCCAGG CTCGCGACCG 
TGCGGGCTGC GCGAGCTCGA GGTGCGTGTG AGCGAGCTGG GTCTGGGCTA CACGTCGGAC 
GAAACCGTCC TGTTCCGCTA CTGCGCAGGC GCGTGCGAGG CGGCCATACG CATCTACGAC 
CTGGGCCTGC GGCGCCTGCG CCAGCGACGA CGCGTGCGCA AAGAGCGGGT GCGAGCGCAC 
CCGTGCTGCC GCCCGACGGC CTACGAGGAC GAGGTGTCCT TCCTGGACGT ACACAGCCGC 
TACCACACGC TGCAAGAGCT GTCGGCGCGG GAGTGCGCGT GCGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006244409.1
CDS	776..1363
Translation	MRCWKAAALVSLICSSLLSVWMCQEGLLLGHRLGPALAPLRRPPRTLDARIARLAQYRALLQGAPDAVELRELSPWVARPSGPRRRAGPRRRRARPGSRPCGLRELEVRVSELGLGYTSDETVLFRYCAGACEAAIRIYDLGLRRLRQRRRVRKERVRAHPCCRPTAYEDEVSFLDVHSRYHTLQELSARECACV

Target ORF information:

RefSeq Version	XM_006244347.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neurturin (Nrtn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006244347.3

ORF Insert Sequence:

ATGAGGTGCT GGAAGGCGGC GGCCCTGGTG TCGCTCATCT GCAGCTCCCT GCTGTCTGTC 
TGGATGTGCC AGGAGGGTCT GCTCTTGGGT CACCGCCTGG GACCCGCGCT CGCTCCTCTG 
CGACGCCCTC CACGCACCCT GGACGCCCGC ATCGCCCGCC TGGCCCAGTA TCGCGCTCTG 
CTGCAGGGCG CCCCCGACGC GGTGGAGCTT CGAGAACTTT CTCCCTGGGT TGCCCGTCCC 
TCGGGGCCGC GCCGTCGAGC GGGTCCCCGG CGTCGGCGTG CGCGGCCAGG CTCGCGACCG 
TGCGGGCTGC GCGAGCTCGA GGTGCGTGTG AGCGAGCTGG GTCTGGGCTA CACGTCGGAC 
GAAACCGTCC TGTTCCGCTA CTGCGCAGGC GCGTGCGAGG CGGCCATACG CATCTACGAC 
CTGGGCCTGC GGCGCCTGCG CCAGCGACGA CGCGTGCGCA AAGAGCGGGT GCGAGCGCAC 
CCGTGCTGCC GCCCGACGGC CTACGAGGAC GAGGTGTCCT TCCTGGACGT ACACAGCCGC 
TACCACACGC TGCAAGAGCT GTCGGCGCGG GAGTGCGCGT GCGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience38(21)4899-4911(2018 05)
Nencini S,Ringuet M,Kim DH,Greenhill C,Ivanusic JJ

Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms.
Cellular signalling23(11)1727-37(2011 Nov)
Wan G,Zhou L,Lim Q',Wong YH,Too HP

Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.
Neurobiology of disease26(2)375-84(2007 May)
Ramaswamy S,McBride JL,Herzog CD,Brandon E,Gasmi M,Bartus RT,Kordower JH

The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons.
Brain research bulletin68(1-2)42-53(2005 Dec)
Zihlmann KB,Ducray AD,Schaller B,Huber AW,Krebs SH,Andres RH,Seiler RW,Meyer M,Widmer HR

Immunohistochemical expression of two members of the GDNF family of growth factors and their receptors in the olfactory system.
Journal of neurocytology34(3-5)241-55(2005 Sep)
Maroldt H,Kaplinovsky T,Cunningham AM