Plk2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plk2
Entrez Gene ID	83722
Full Name	polo-like kinase 2
Synonyms	Snk
General protein information	Preferred Names polo-like kinase 2 Names serine/threonine-protein kinase PLK2 PLK-2 polo-like kinase 1 serine/threonine-protein kinase SNK serum-inducible kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q14
Summary	binds Ca2+ and integrin-binding protein Cib; may phosphorylate proteins in the dendrites of activated neurons; may play a role in long term synaptic plasticity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031821.1	NP_114009.1	serine/threonine-protein kinase PLK2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PLK2	NP_006613.2
Bos taurus (cattle)	PLK2	NP_001179174.1
Mus musculus (house mouse)	Plk2	NP_690017.2
Xenopus tropicalis (tropical clawed frog)	plk2	NP_001096545.1
Rattus norvegicus (Norway rat)	Plk2	NP_114009.1
Macaca mulatta (Rhesus monkey)	PLK2	XP_001102885.2
Danio rerio (zebrafish)	plk2a	XP_003199325.1
Pan troglodytes (chimpanzee)	PLK2	XP_001140767.1
Gallus gallus (chicken)	PLK2	XP_424739.2
Canis lupus familiaris (dog)	PLK2	XP_535242.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.
Deng S, Wang H, Jia C, Zhu S, Chu X, Ma Q, Wei J, Chen E, Zhu W, Macon CJ, Jayaweera DT, Dykxhoorn DM, Dong C
Arteriosclerosis, thrombosis, and vascular biology37(2)280-290(2017 Feb)

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.
Zurnic I, Hütter S, Rzeha U, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann D
PLoS pathogens12(8)e1005860(2016 08)

miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction.
Pitzler L, Auler M, Probst K, Frie C, Bergmeier V, Holzer T, Belluoccio D, van den Bergen J, Etich J, Ehlen H, Zhou Z, Bielke W, Pöschl E, Paulsson M, Brachvogel B
Stem cells (Dayton, Ohio)34(5)1297-309(2016 05)

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.
Oueslati A, Schneider BL, Aebischer P, Lashuel HA
Proceedings of the National Academy of Sciences of the United States of America110(41)E3945-54(2013 Oct)

Targeted protein degradation and synapse remodeling by an inducible protein kinase.
Pak DT, Sheng M
Science (New York, N.Y.)302(5649)1368-73(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Plk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08816	NM_031821.1 Latest version!	Rattus norvegicus polo-like kinase 2 (Plk2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plk2 ( NM_031821.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114009.1 Rattus norvegicus polo-like kinase 2 (Plk2), mRNA.

Price & Availability↑

CloneID	ORa08816
Clone ID Related Accession (Same CDS sequence)	NM_031821.1
Accession Version	NM_031821.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase PLK2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF136583.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF136583.1, BC070878.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTCC TGCGGACTAT CACCTACCAG CCGGCCGCCG GCACCAAGAT GTGCGAGCAG 
GCGCTGGGCA AAGCTTGCGG CGGGGACTCA AAGAAGAAGC GACCGCAGCA GCCTTCTGAA 
GACGGGCAGT CCCAAGCCCA GGTGACCCCG GCGGCCCCAC ACCACCATCA TCACCATTCT 
CACTCCGGAC CCGAGATCTC GCGGATTATA GTCGACCCCA CGACGGGGAA GCGCTACTGC 
CGGGGCAAAG TGCTGGGCAA GGGTGGATTT GCAAAGTGTT ACGAAATGAC AGATCTGACA 
AACAACAAAG TCTACGCTGC AAAAATTATC CCTCACAGCA GAGTAGCTAA ACCTCATCAA 
AGGGAAAAGA TCGACAAAGA AATTGAGCTT CACAGAATCC TGCACCATAA GCATGTAGTG 
CAGTTTTACC ACTACTTTGA AGACAAAGAA AACATTTACA TCCTCTTGGA GTACTGCAGT 
AGAAGGTCCA TGGCTCATAT CTTGAAAGCA AGAAAGGTGT TGACAGAGCC AGAAGTCCGA 
TACTACCTCA GGCAGATTGT GTCGGGACTC AAGTATCTTC ACGAACAAGA AATCTTGCAT 
AGGGATCTCA AGCTAGGGAA CTTTTTTATT AATGAGGCCA TGGAGCTGAA GGTTGGAGAC 
TTCGGCTTGG CTGCCAGACT GGAACCTTTG GAACACAGAA GGAGAACAAT ATGTGGAACC 
CCAAATTATC TCTCCCCTGA AGTCCTCAAC AAACAAGGAC ATGGCTGTGA ATCAGACATC 
TGGGCCTTAG GCTGTGTAAT GTATACAATG CTGCTAGGAA GACCTCCATT CGAAACAACA 
AATCTGAAAG AAACGTACAG GTGCATAAGA GAAGCAAGAT ATACAATGCC GTCTTCATTA 
CTGGCCCCCG CCAAGCACTT GATAGCCAGC ATGCTGTCCA AAAACCCAGA GGACCGCCCC 
AGTTTGGATG ACATCATTCG GCATGACTTC TTTCTGCAGG GCTTCACTCC AGACAGACTC 
TCTTCTAGCT GTTGCCACAC AGTTCCAGAC TTCCACTTGT CAAGCCCAGC TAAGAATTTC 
TTTAAGAAAG CTGCTGCCGC TCTTTTTGGT GGCAAAAAGG ACAAAGCAAG ATATAATGAC 
ACACACAATA AAGTGTCTAA GGAAGATGAA GACATCTACA AGCTTCGGCA TGATTTGAAG 
AAAACATCGA TAACCCAGCA ACCCAGCAAA CACAGAACAG ATGAGGAGCT CCAGCCTCCT 
CCAACTACCT TTGCCAAATC TGGGACATCC GCAGTGGAAA ACAAACAGCA GATTGGAGAT 
GCAATCCGGA TGATAGTTAG AGGGACGCTG GGCAGCTGCA GCAGCAGCAG TGAATGCCTT 
GAGGATAGCA CCATGGGAAG TGTTGCAGAC ACAGTGGCAA GAGTCCTTCG AGGGTGTCTA 
GAAAACATGC CTGAAGCTGA CTGTATTCCC AAAGAGCAGT TGAGCACGTC CTTTCAGTGG 
GTCACCAAAT GGGTCGACTA CTCCAACAAA TACGGCTTTG GATACCAGCT CTCAGACCAC 
ACTGTTGGAG TCCTTTTCAA CAACGGCGCT CACATGAGCC TCCTTCCAGA CAAAAAGACA 
GTTCACTATT ATGCGGAACT TGGCCAATGC TCTGTTTTCC CAGCAACAGA TGCCCCCGAA 
CAATTTATTA GTCAAGTGAC GGTGCTGAAA TACTTTTCCC ACTACATGGA GGAGAACCTC 
ATGGATGGTG GCGATCTCCC TAGTGTTACT GACATTCGAA GACCTCGGCT CTACCTCCTT 
CAGTGGTTAA AGTCTGATAA AGCCTTAATG ATGCTCTTCA ATGACGGCAC ATTTCAGGTG 
AATTTCTACC ACGATCATAC AAAGATAATT ATCTGTAACC AAAATGAAGA ATACCTTCTC 
ACATACATCA ACGAAGACAG GATATCTACA ACTTTCAGAC TGACGACCCT GTTGATGTCT 
GGCTGTTCGC TAGAATTGAA ACATCGAATG GAATACGCCC TGAACATGCT CTTGCAGAGA 
TGTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114009.1
CDS	132..2180
Translation	MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQSQAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPPTTFAKSGTSAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQNEEYLLTYINEDRISTTFRLTTLLMSGCSLELKHRMEYALNMLLQRCN

Target ORF information:

RefSeq Version	NM_031821.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus polo-like kinase 2 (Plk2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031821.1

ORF Insert Sequence:

ATGGAGCTCC TGCGGACTAT CACCTACCAG CCGGCCGCCG GCACCAAGAT GTGCGAGCAG 
GCGCTGGGCA AAGCTTGCGG CGGGGACTCA AAGAAGAAGC GACCGCAGCA GCCTTCTGAA 
GACGGGCAGT CCCAAGCCCA GGTGACCCCG GCGGCCCCAC ACCACCATCA TCACCATTCT 
CACTCCGGAC CCGAGATCTC GCGGATTATA GTCGACCCCA CGACGGGGAA GCGCTACTGC 
CGGGGCAAAG TGCTGGGCAA GGGTGGATTT GCAAAGTGTT ACGAAATGAC AGATCTGACA 
AACAACAAAG TCTACGCTGC AAAAATTATC CCTCACAGCA GAGTAGCTAA ACCTCATCAA 
AGGGAAAAGA TCGACAAAGA AATTGAGCTT CACAGAATCC TGCACCATAA GCATGTAGTG 
CAGTTTTACC ACTACTTTGA AGACAAAGAA AACATTTACA TCCTCTTGGA GTACTGCAGT 
AGAAGGTCCA TGGCTCATAT CTTGAAAGCA AGAAAGGTGT TGACAGAGCC AGAAGTCCGA 
TACTACCTCA GGCAGATTGT GTCGGGACTC AAGTATCTTC ACGAACAAGA AATCTTGCAT 
AGGGATCTCA AGCTAGGGAA CTTTTTTATT AATGAGGCCA TGGAGCTGAA GGTTGGAGAC 
TTCGGCTTGG CTGCCAGACT GGAACCTTTG GAACACAGAA GGAGAACAAT ATGTGGAACC 
CCAAATTATC TCTCCCCTGA AGTCCTCAAC AAACAAGGAC ATGGCTGTGA ATCAGACATC 
TGGGCCTTAG GCTGTGTAAT GTATACAATG CTGCTAGGAA GACCTCCATT CGAAACAACA 
AATCTGAAAG AAACGTACAG GTGCATAAGA GAAGCAAGAT ATACAATGCC GTCTTCATTA 
CTGGCCCCCG CCAAGCACTT GATAGCCAGC ATGCTGTCCA AAAACCCAGA GGACCGCCCC 
AGTTTGGATG ACATCATTCG GCATGACTTC TTTCTGCAGG GCTTCACTCC AGACAGACTC 
TCTTCTAGCT GTTGCCACAC AGTTCCAGAC TTCCACTTGT CAAGCCCAGC TAAGAATTTC 
TTTAAGAAAG CTGCTGCCGC TCTTTTTGGT GGCAAAAAGG ACAAAGCAAG ATATAATGAC 
ACACACAATA AAGTGTCTAA GGAAGATGAA GACATCTACA AGCTTCGGCA TGATTTGAAG 
AAAACATCGA TAACCCAGCA ACCCAGCAAA CACAGAACAG ATGAGGAGCT CCAGCCTCCT 
CCAACTACCT TTGCCAAATC TGGGACATCC GCAGTGGAAA ACAAACAGCA GATTGGAGAT 
GCAATCCGGA TGATAGTTAG AGGGACGCTG GGCAGCTGCA GCAGCAGCAG TGAATGCCTT 
GAGGATAGCA CCATGGGAAG TGTTGCAGAC ACAGTGGCAA GAGTCCTTCG AGGGTGTCTA 
GAAAACATGC CTGAAGCTGA CTGTATTCCC AAAGAGCAGT TGAGCACGTC CTTTCAGTGG 
GTCACCAAAT GGGTCGACTA CTCCAACAAA TACGGCTTTG GATACCAGCT CTCAGACCAC 
ACTGTTGGAG TCCTTTTCAA CAACGGCGCT CACATGAGCC TCCTTCCAGA CAAAAAGACA 
GTTCACTATT ATGCGGAACT TGGCCAATGC TCTGTTTTCC CAGCAACAGA TGCCCCCGAA 
CAATTTATTA GTCAAGTGAC GGTGCTGAAA TACTTTTCCC ACTACATGGA GGAGAACCTC 
ATGGATGGTG GCGATCTCCC TAGTGTTACT GACATTCGAA GACCTCGGCT CTACCTCCTT 
CAGTGGTTAA AGTCTGATAA AGCCTTAATG ATGCTCTTCA ATGACGGCAC ATTTCAGGTG 
AATTTCTACC ACGATCATAC AAAGATAATT ATCTGTAACC AAAATGAAGA ATACCTTCTC 
ACATACATCA ACGAAGACAG GATATCTACA ACTTTCAGAC TGACGACCCT GTTGATGTCT 
GGCTGTTCGC TAGAATTGAA ACATCGAATG GAATACGCCC TGAACATGCT CTTGCAGAGA 
TGTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.
Arteriosclerosis, thrombosis, and vascular biology37(2)280-290(2017 Feb)
Deng S,Wang H,Jia C,Zhu S,Chu X,Ma Q,Wei J,Chen E,Zhu W,Macon CJ,Jayaweera DT,Dykxhoorn DM,Dong C

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.
PLoS pathogens12(8)e1005860(2016 08)
Zurnic I,Hütter S,Rzeha U,Stanke N,Reh J,Müllers E,Hamann MV,Kern T,Gerresheim GK,Lindel F,Serrao E,Lesbats P,Engelman AN,Cherepanov P,Lindemann D

miR-126-3p Promotes Matrix-Dependent Perivascular Cell Attachment, Migration and Intercellular Interaction.
Stem cells (Dayton, Ohio)34(5)1297-309(2016 05)
Pitzler L,Auler M,Probst K,Frie C,Bergmeier V,Holzer T,Belluoccio D,van den Bergen J,Etich J,Ehlen H,Zhou Z,Bielke W,Pöschl E,Paulsson M,Brachvogel B

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.
Proceedings of the National Academy of Sciences of the United States of America110(41)E3945-54(2013 Oct)
Oueslati A,Schneider BL,Aebischer P,Lashuel HA

Targeted protein degradation and synapse remodeling by an inducible protein kinase.
Science (New York, N.Y.)302(5649)1368-73(2003 Nov)
Pak DT,Sheng M

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Plk2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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