Plk2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plk2
Entrez Gene ID	20620
Full Name	polo like kinase 2
Synonyms	Snk
General protein information	Preferred Names polo like kinase 2 Names serine/threonine-protein kinase PLK2 PLK-2 serine/threonine-protein kinase SNK serum-inducible kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 D2.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_152804.2	NP_690017.2	serine/threonine-protein kinase PLK2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PLK2	NP_006613.2
Bos taurus (cattle)	PLK2	NP_001179174.1
Mus musculus (house mouse)	Plk2	NP_690017.2
Xenopus tropicalis (tropical clawed frog)	plk2	NP_001096545.1
Rattus norvegicus (Norway rat)	Plk2	NP_114009.1
Macaca mulatta (Rhesus monkey)	PLK2	XP_001102885.2
Danio rerio (zebrafish)	plk2a	XP_003199325.1
Pan troglodytes (chimpanzee)	PLK2	XP_001140767.1
Gallus gallus (chicken)	PLK2	XP_424739.2
Canis lupus familiaris (dog)	PLK2	XP_535242.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice.
Lee JS, Lee Y, André EA, Lee KJ, Nguyen T, Feng Y, Jia N, Harris BT, Burns MP, Pak DTS
PloS one14(7)e0219691(2019)

Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production.
Kofoed RH, Zheng J, Ferreira N, Lykke-Andersen S, Salvi M, Betzer C, Reimer L, Jensen TH, Fog K, Jensen PH
Neurobiology of disease10649-62(2017 Oct)

Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells.
Mochizuki M, Lorenz V, Ivanek R, Della Verde G, Gaudiello E, Marsano A, Pfister O, Kuster GM
Journal of the American Heart Association6(10)(2017 Oct)

Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S
Proceedings of the National Academy of Sciences of the United States of America114(30)8029-8034(2017 07)

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.
Deng S, Wang H, Jia C, Zhu S, Chu X, Ma Q, Wei J, Chen E, Zhu W, Macon CJ, Jayaweera DT, Dykxhoorn DM, Dong C
Arteriosclerosis, thrombosis, and vascular biology37(2)280-290(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Plk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22818	NM_152804.2 Latest version!	Mus musculus polo like kinase 2 (Plk2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plk2 ( NM_152804.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_690017.2 Mus musculus polo like kinase 2 (Plk2), mRNA.

Price & Availability↑

CloneID	OMu22818
Clone ID Related Accession (Same CDS sequence)	NM_152804.2
Accession Version	NM_152804.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2049bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566230400000
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase PLK2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ063842.1, BM947259.1, AK164365.1, AK160441.1 and BP765662.1. On Jan 18, 2008 this sequence version replaced NM_152804.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034513.1, AK133962.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTCC TGCGGACTAT CACCTACCAG CCGGCCGCCG GCACCAAGAT GTGCGAGCAG 
GCTCTGGGCA AAGCTTGCGG CGGGGACTCA AAGAAGAAGC GACCGCAGCA GCCTTCTGAA 
GATGGGCAGC CCCAAGCCCA GGTGACCCCG GCGGCCCCGC ACCACCATCA CCACCATTCC 
CACTCGGGAC CCGAGATCTC GCGGATTATA GTCGACCCCA CGACGGGGAA GCGCTACTGC 
CGGGGCAAAG TGCTGGGCAA GGGTGGATTT GCAAAGTGTT ACGAAATGAC AGATCTGACA 
AACAACAAAG TCTACGCTGC AAAAATTATT CCTCACAGCA GAGTAGCTAA ACCTCATCAG 
AGGGAAAAGA TCGACAAAGA AATCGAGCTT CACAGACTAC TGCACCATAA GCATGTCGTG 
CAGTTTTACC ACTACTTTGA AGACAAAGAA AACATTTACA TTCTCTTGGA ATACTGCAGT 
AGAAGGTCCA TGGCTCACAT CTTGAAAGCA AGAAAGGTGT TGACAGAGCC AGAAGTCCGA 
TACTACCTCA GGCAGATTGT GTCAGGACTC AAGTATCTTC ACGAACAAGA AATCTTGCAC 
AGGGATCTCA AGCTAGGGAA CTTTTTTATT AATGAAGCCA TGGAGCTGAA GGTGGGAGAC 
TTTGGTTTGG CAGCCAGACT GGAACCACTG GAACACAGAA GGAGAACAAT ATGTGGAACC 
CCAAATTATC TCTCCCCCGA AGTCCTCAAC AAACAAGGAC ACGGCTGTGA ATCAGACATC 
TGGGCCTTAG GCTGTGTAAT GTATACGATG CTGCTAGGAA GACCTCCATT CGAAACCACA 
AATCTGAAAG AAACGTACAG GTGCATAAGG GAAGCAAGGT ATACCATGCC ATCCTCATTG 
CTGGCCCCTG CTAAGCACTT GATAGCTAGC ATGCTGTCCA AAAACCCAGA GGACCGCCCC 
AGTTTGGATG ACATCATTCG GCATGACTTC TTCCTGCAGG GTTTCACTCC GGACAGACTC 
TCTTCCAGCT GTTGCCACAC AGTTCCAGAT TTCCACTTGT CAAGCCCAGC CAAGAATTTC 
TTTAAGAAAG CCGCAGCCGC TCTTTTTGGT GGCAAGAAGG ACAAAGCAAG ATATAACGAC 
ACACACAATA AGGTGTCTAA GGAAGATGAA GACATTTACA AGCTTCGGCA TGATTTGAAG 
AAAGTGTCGA TAACCCAGCA GCCTAGCAAA CACAGAGCAG ATGAGGAGCC CCAGCCGCCT 
CCCACTACTG TTGCCAGATC TGGAACGTCC GCAGTGGAAA ACAAACAGCA GATTGGGGAT 
GCAATCCGGA TGATAGTCAG GGGGACTCTC GGCAGCTGCA GCAGCAGCAG CGAATGCCTT 
GAAGACAGCA CCATGGGAAG TGTGGCAGAC ACAGTGGCAA GAGTCCTTCG AGGATGTCTA 
GAAAACATGC CGGAAGCTGA CTGTATCCCC AAAGAGCAGC TGAGCACGTC CTTTCAGTGG 
GTCACCAAGT GGGTCGACTA CTCCAACAAA TACGGCTTTG GGTACCAGCT CTCGGACCAC 
ACTGTTGGCG TCCTTTTCAA CAACGGGGCT CACATGAGCC TCCTTCCGGA CAAAAAGACA 
GTTCACTATT ATGCGGAACT TGGCCAATGC TCTGTTTTCC CAGCAACAGA TGCCCCTGAA 
CAATTTATTA GTCAAGTGAC GGTGCTGAAA TACTTTTCTC ATTACATGGA GGAGAACCTC 
ATGGATGGTG GTGATCTCCC GAGTGTTACT GACATTCGAA GACCTCGGCT CTACCTCCTG 
CAGTGGTTAA AGTCTGATAA AGCCTTAATG ATGCTCTTCA ATGACGGCAC ATTTCAGGTG 
AATTTCTACC ACGATCATAC AAAAATCATC ATCTGTAACC AGAGTGAAGA ATACCTTCTC 
ACCTACATCA ATGAGGACAG GATCTCTACA ACTTTCAGAC TGACGACTCT GCTGATGTCT 
GGCTGTTCGT TAGAATTGAA AAATCGAATG GAATATGCCC TGAACATGCT CTTACAGAGA 
TGTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690017.2
CDS	134..2182
Translation	MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQPQAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIYKLRHDLKKVSITQQPSKHRADEEPQPPPTTVARSGTSAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQSEEYLLTYINEDRISTTFRLTTLLMSGCSLELKNRMEYALNMLLQRCN

Target ORF information:

RefSeq Version	NM_152804.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus polo like kinase 2 (Plk2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152804.2

ORF Insert Sequence:

ATGGAGCTCC TGCGGACTAT CACCTACCAG CCGGCCGCCG GCACCAAGAT GTGCGAGCAG 
GCTCTGGGCA AAGCTTGCGG CGGGGACTCA AAGAAGAAGC GACCGCAGCA GCCTTCTGAA 
GATGGGCAGC CCCAAGCCCA GGTGACCCCG GCGGCCCCGC ACCACCATCA CCACCATTCC 
CACTCGGGAC CCGAGATCTC GCGGATTATA GTCGACCCCA CGACGGGGAA GCGCTACTGC 
CGGGGCAAAG TGCTGGGCAA GGGTGGATTT GCAAAGTGTT ACGAAATGAC AGATCTGACA 
AACAACAAAG TCTACGCTGC AAAAATTATT CCTCACAGCA GAGTAGCTAA ACCTCATCAG 
AGGGAAAAGA TCGACAAAGA AATCGAGCTT CACAGACTAC TGCACCATAA GCATGTCGTG 
CAGTTTTACC ACTACTTTGA AGACAAAGAA AACATTTACA TTCTCTTGGA ATACTGCAGT 
AGAAGGTCCA TGGCTCACAT CTTGAAAGCA AGAAAGGTGT TGACAGAGCC AGAAGTCCGA 
TACTACCTCA GGCAGATTGT GTCAGGACTC AAGTATCTTC ACGAACAAGA AATCTTGCAC 
AGGGATCTCA AGCTAGGGAA CTTTTTTATT AATGAAGCCA TGGAGCTGAA GGTGGGAGAC 
TTTGGTTTGG CAGCCAGACT GGAACCACTG GAACACAGAA GGAGAACAAT ATGTGGAACC 
CCAAATTATC TCTCCCCCGA AGTCCTCAAC AAACAAGGAC ACGGCTGTGA ATCAGACATC 
TGGGCCTTAG GCTGTGTAAT GTATACGATG CTGCTAGGAA GACCTCCATT CGAAACCACA 
AATCTGAAAG AAACGTACAG GTGCATAAGG GAAGCAAGGT ATACCATGCC ATCCTCATTG 
CTGGCCCCTG CTAAGCACTT GATAGCTAGC ATGCTGTCCA AAAACCCAGA GGACCGCCCC 
AGTTTGGATG ACATCATTCG GCATGACTTC TTCCTGCAGG GTTTCACTCC GGACAGACTC 
TCTTCCAGCT GTTGCCACAC AGTTCCAGAT TTCCACTTGT CAAGCCCAGC CAAGAATTTC 
TTTAAGAAAG CCGCAGCCGC TCTTTTTGGT GGCAAGAAGG ACAAAGCAAG ATATAACGAC 
ACACACAATA AGGTGTCTAA GGAAGATGAA GACATTTACA AGCTTCGGCA TGATTTGAAG 
AAAGTGTCGA TAACCCAGCA GCCTAGCAAA CACAGAGCAG ATGAGGAGCC CCAGCCGCCT 
CCCACTACTG TTGCCAGATC TGGAACGTCC GCAGTGGAAA ACAAACAGCA GATTGGGGAT 
GCAATCCGGA TGATAGTCAG GGGGACTCTC GGCAGCTGCA GCAGCAGCAG CGAATGCCTT 
GAAGACAGCA CCATGGGAAG TGTGGCAGAC ACAGTGGCAA GAGTCCTTCG AGGATGTCTA 
GAAAACATGC CGGAAGCTGA CTGTATCCCC AAAGAGCAGC TGAGCACGTC CTTTCAGTGG 
GTCACCAAGT GGGTCGACTA CTCCAACAAA TACGGCTTTG GGTACCAGCT CTCGGACCAC 
ACTGTTGGCG TCCTTTTCAA CAACGGGGCT CACATGAGCC TCCTTCCGGA CAAAAAGACA 
GTTCACTATT ATGCGGAACT TGGCCAATGC TCTGTTTTCC CAGCAACAGA TGCCCCTGAA 
CAATTTATTA GTCAAGTGAC GGTGCTGAAA TACTTTTCTC ATTACATGGA GGAGAACCTC 
ATGGATGGTG GTGATCTCCC GAGTGTTACT GACATTCGAA GACCTCGGCT CTACCTCCTG 
CAGTGGTTAA AGTCTGATAA AGCCTTAATG ATGCTCTTCA ATGACGGCAC ATTTCAGGTG 
AATTTCTACC ACGATCATAC AAAAATCATC ATCTGTAACC AGAGTGAAGA ATACCTTCTC 
ACCTACATCA ATGAGGACAG GATCTCTACA ACTTTCAGAC TGACGACTCT GCTGATGTCT 
GGCTGTTCGT TAGAATTGAA AAATCGAATG GAATATGCCC TGAACATGCT CTTACAGAGA 
TGTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice.
PloS one14(7)e0219691(2019)
Lee JS,Lee Y,André EA,Lee KJ,Nguyen T,Feng Y,Jia N,Harris BT,Burns MP,Pak DTS

Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production.
Neurobiology of disease10649-62(2017 Oct)
Kofoed RH,Zheng J,Ferreira N,Lykke-Andersen S,Salvi M,Betzer C,Reimer L,Jensen TH,Fog K,Jensen PH

Polo-Like Kinase 2 is Dynamically Regulated to Coordinate Proliferation and Early Lineage Specification Downstream of Yes-Associated Protein 1 in Cardiac Progenitor Cells.
Journal of the American Heart Association6(10)(2017 Oct)
Mochizuki M,Lorenz V,Ivanek R,Della Verde G,Gaudiello E,Marsano A,Pfister O,Kuster GM

Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development.
Proceedings of the National Academy of Sciences of the United States of America114(30)8029-8034(2017 07)
Stopp S,Gründl M,Fackler M,Malkmus J,Leone M,Naumann R,Frantz S,Wolf E,von Eyss B,Engel FB,Gaubatz S

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.
Arteriosclerosis, thrombosis, and vascular biology37(2)280-290(2017 Feb)
Deng S,Wang H,Jia C,Zhu S,Chu X,Ma Q,Wei J,Chen E,Zhu W,Macon CJ,Jayaweera DT,Dykxhoorn DM,Dong C

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Plk2 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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