Mmp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp2
Entrez Gene ID	81686
Full Name	matrix metallopeptidase 2
General protein information	Preferred Names matrix metallopeptidase 2 Names 72 kDa type IV collagenase 72 kDa gelatinase MMP-2 gelatinase A matrix metalloproteinase-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p11
Summary	plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031054.2	NP_112316.2	72 kDa type IV collagenase precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Mmp2	NP_112316.2
Danio rerio (zebrafish)	mmp2	NP_932333.1
Bos taurus (cattle)	MMP2	NP_777170.1
Pan troglodytes (chimpanzee)	MMP2	XP_001167520.2
Gallus gallus (chicken)	MMP2	NP_989751.1
Canis lupus familiaris (dog)	MMP2	XP_535300.4
Mus musculus (house mouse)	Mmp2	NP_032636.1
Homo sapiens (human)	MMP2	NP_004521.1
Macaca mulatta (Rhesus monkey)	MMP2	XP_001087939.1
Xenopus tropicalis (tropical clawed frog)	mmp2	NP_001015789.1

Gene Ontology
Bibliography

Related articles in PubMed

Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension.
Blascke de Mello MM, Parente JM, Schulz R, Castro MM
Vascular pharmacology11636-44(2019 05)

Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain.
Kwan MY, Choo A, Hanania T, Ghavami A, Beltran J, Shea J, Barboza A, Hu A, Fowler M, Neelagiri VR, Sucholeiki I
International journal of molecular sciences20(4)(2019 02)

Mitochondria-Associated Matrix Metalloproteinases 2 and 9 in Acute Renal Pathologies.
Pevzner IB, Zorova LD, Galkin FA, Plotnikov EY, Zorov DB
Bulletin of experimental biology and medicine166(3)334-338(2019 Jan)

Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects.
Rizzi E, Amaral JH, Guimarães DA, Conde-Tella SO, Pinheiro LC, Gerlach RF, Castro MM, Tanus-Santos JE
Free radical biology & medicine130234-243(2019 01)

Elevated IL-33 promotes expression of MMP2 and MMP9 via activating STAT3 in alveolar macrophages during LPS-induced acute lung injury.
Liang Y, Yang N, Pan G, Jin B, Wang S, Ji W
Cellular & molecular biology letters2352(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mmp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13253	NM_031054.2 Latest version!	Rattus norvegicus matrix metallopeptidase 2 (Mmp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp2 ( NM_031054.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112316.2 Rattus norvegicus matrix metallopeptidase 2 (Mmp2), mRNA.

Price & Availability↑

CloneID	ORa13253
Clone ID Related Accession (Same CDS sequence)	NM_031054.2
Accession Version	NM_031054.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1989bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	72 kDa type IV collagenase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U65656.1. On May 4, 2007 this sequence version replaced NM_031054.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U65656.1, BC074013.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGGCAC GATTGGTCTG GGGAGTGCTC GTCGGCCCTC TGCGGGTTCT CTGCGTCCTG 
TGCTGCCTGC TGGGCCACGC CATCGCTGCA CCGTCGCCCA TCATCAAGTT CCCCGGCGAT 
GTCTCCCCCA AAACAGACAA AGAGTTGGCA GTGCAATACC TGAACACTTT CTATGGCTGC 
CCCAAGGAGA GTTGCAACCT CTTTGTGCTG AAGGACACCC TCAAGAAGAT GCAGAAGTTC 
TTTGGGCTGC CCCAGACAGG TGACCTTGAC CAGAACACCA TCGAGACCAT GCGGAAACCA 
AGATGTGGCA ACCCAGATGT GGCCAACTAC AACTTCTTTC CCCGCAAGCC CAAGTGGGAC 
AAGAATCAGA TCACATACAG GATCATTGGT TACACACCTG ACCTGGACCC TGAGACAGTG 
GATGATGCCT TTGCTCGGGC CTTAAAAGTA TGGAGCGACG TAACTCCACT ACGCTTTTCT 
CGAATCCATG ATGGGGAAGC TGACATCATG ATCAACTTTG GTCGATGGGA GCATGGAGAT 
GGATACCCAT TTGACGGCAA GGACGGACTC CTGGCACATG CCTTTGCCCC GGGCACTGGT 
GTTGGGGGAG ATTCTCACTT TGATGACGAT GAGCTGTGGA CTCTAGGAGA AGGACAAGTG 
GTCCGAGTAA AGTATGGGAA CGCTGATGGC GAGTACTGCA AGTTCCCCTT CTTGTTTAAT 
GGTCGGGAAT ACAGCAGCTG CACAGACACT GGCCGGAGTG ACGGCTTCCT CTGGTGTTCC 
ACCACGTACA ACTTTGAGAA GGACGGCAAA TATGGCTTCT GTCCCCACGA AGCCTTGTTT 
ACCATGGGTG GCAATGGAGA TGGACAGCCC TGCAAGTTCC CGTTCCGCTT CCAGGGCACC 
TCTTACAACA GCTGTACCAC CGAGGGCCGT ACAGACGGCT ACCGCTGGTG TGGCACCACC 
GAGGATTATG ACCGGGATAA GAAGTATGGA TTCTGCCCAG AGACTGCTAT GTCCACTGTG 
GGTGGAAATT CAGAAGGTGC CCCATGTGTC TTCCCCTTCA CTTTTCTGGG CAACAAGTAT 
GAGAGCTGCA CCAGCGCTGG CCGAAGCGAT GGCAAGGTGT GGTGTGCAAC CACAACCAAC 
TACGATGATG ACCGGAAGTG GGGCTTCTGT CCCGACCAAG GATATAGCCT ATTCCTTGTG 
GCAGCCCATG AGTTCGGCCA TGCCATGGGG CTGGAACACT CACAGGACCC TGGAGCTTTG 
ATGGCCCCTA TCTACACCTA CACCAAGAAC TTCCGACTAT CCAATGATGA CATCAAGGGG 
ATCCAGGAGC TCTATGGGCC CTCCCCTGAT GCTGATACTG ACACTGGTAC TGGACCCACG 
CCTACACTGG GACCTGTCAC TCCCGAGATC TGCAAGCAAG ACATTGTCTT TGATGGCATT 
GCTCAGATCC GTGGTGAGAT CTTCTTCTTC AAGGATCGGT TTATTTGGCG GACAGTGACA 
CCACGTGACA AGCCCACAGG TCCCTTGCTG GTGGCCACAT TCTGGCCTGA GCTCCCGGAA 
AAGATTGATG CCGTGTACGA GGCCCCACAG GAAGAGAAGG CTGTGTTCTT CGCAGGGAAT 
GAGTACTGGG TCTATTCTGC CAGCACTTTG GAAAGAGGAT ACCCCAAGCC ACTGACCAGC 
CTGGGTTTAC CCCCTGATGT CCAGCAAGTA GACGCTGCCT TTAACTGGAG TAAGAACAAG 
AAGACATACA TCTTTTCTGG GGACAAGTTC TGGAGATACA ATGAAGTAAA GAAGAAAATG 
GACCCCGGTT TCCCGAAGCT CATCGCAGAC TCCTGGAATG CCATCCCTGA TAACCTGGAT 
GCAGTCGTGG ACCTGCAGGG TGGTGGTCAC AGCTATTTCT TCAAGGGTGC TTATTACCTG 
AAGTTGGAGA ACCAAAGTCT GAAGAGTGTG AAGTTTGGAA GCATCAAATC GGACTGGCTG 
GGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112316.2
CDS	292..2280
Translation	MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC

Target ORF information:

RefSeq Version	NM_031054.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus matrix metallopeptidase 2 (Mmp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031054.2

ORF Insert Sequence:

ATGGAGGCAC GATTGGTCTG GGGAGTGCTC GTCGGCCCTC TGCGGGTTCT CTGCGTCCTG 
TGCTGCCTGC TGGGCCACGC CATCGCTGCA CCGTCGCCCA TCATCAAGTT CCCCGGCGAT 
GTCTCCCCCA AAACAGACAA AGAGTTGGCA GTGCAATACC TGAACACTTT CTATGGCTGC 
CCCAAGGAGA GTTGCAACCT CTTTGTGCTG AAGGACACCC TCAAGAAGAT GCAGAAGTTC 
TTTGGGCTGC CCCAGACAGG TGACCTTGAC CAGAACACCA TCGAGACCAT GCGGAAACCA 
AGATGTGGCA ACCCAGATGT GGCCAACTAC AACTTCTTTC CCCGCAAGCC CAAGTGGGAC 
AAGAATCAGA TCACATACAG GATCATTGGT TACACACCTG ACCTGGACCC TGAGACAGTG 
GATGATGCCT TTGCTCGGGC CTTAAAAGTA TGGAGCGACG TAACTCCACT ACGCTTTTCT 
CGAATCCATG ATGGGGAAGC TGACATCATG ATCAACTTTG GTCGATGGGA GCATGGAGAT 
GGATACCCAT TTGACGGCAA GGACGGACTC CTGGCACATG CCTTTGCCCC GGGCACTGGT 
GTTGGGGGAG ATTCTCACTT TGATGACGAT GAGCTGTGGA CTCTAGGAGA AGGACAAGTG 
GTCCGAGTAA AGTATGGGAA CGCTGATGGC GAGTACTGCA AGTTCCCCTT CTTGTTTAAT 
GGTCGGGAAT ACAGCAGCTG CACAGACACT GGCCGGAGTG ACGGCTTCCT CTGGTGTTCC 
ACCACGTACA ACTTTGAGAA GGACGGCAAA TATGGCTTCT GTCCCCACGA AGCCTTGTTT 
ACCATGGGTG GCAATGGAGA TGGACAGCCC TGCAAGTTCC CGTTCCGCTT CCAGGGCACC 
TCTTACAACA GCTGTACCAC CGAGGGCCGT ACAGACGGCT ACCGCTGGTG TGGCACCACC 
GAGGATTATG ACCGGGATAA GAAGTATGGA TTCTGCCCAG AGACTGCTAT GTCCACTGTG 
GGTGGAAATT CAGAAGGTGC CCCATGTGTC TTCCCCTTCA CTTTTCTGGG CAACAAGTAT 
GAGAGCTGCA CCAGCGCTGG CCGAAGCGAT GGCAAGGTGT GGTGTGCAAC CACAACCAAC 
TACGATGATG ACCGGAAGTG GGGCTTCTGT CCCGACCAAG GATATAGCCT ATTCCTTGTG 
GCAGCCCATG AGTTCGGCCA TGCCATGGGG CTGGAACACT CACAGGACCC TGGAGCTTTG 
ATGGCCCCTA TCTACACCTA CACCAAGAAC TTCCGACTAT CCAATGATGA CATCAAGGGG 
ATCCAGGAGC TCTATGGGCC CTCCCCTGAT GCTGATACTG ACACTGGTAC TGGACCCACG 
CCTACACTGG GACCTGTCAC TCCCGAGATC TGCAAGCAAG ACATTGTCTT TGATGGCATT 
GCTCAGATCC GTGGTGAGAT CTTCTTCTTC AAGGATCGGT TTATTTGGCG GACAGTGACA 
CCACGTGACA AGCCCACAGG TCCCTTGCTG GTGGCCACAT TCTGGCCTGA GCTCCCGGAA 
AAGATTGATG CCGTGTACGA GGCCCCACAG GAAGAGAAGG CTGTGTTCTT CGCAGGGAAT 
GAGTACTGGG TCTATTCTGC CAGCACTTTG GAAAGAGGAT ACCCCAAGCC ACTGACCAGC 
CTGGGTTTAC CCCCTGATGT CCAGCAAGTA GACGCTGCCT TTAACTGGAG TAAGAACAAG 
AAGACATACA TCTTTTCTGG GGACAAGTTC TGGAGATACA ATGAAGTAAA GAAGAAAATG 
GACCCCGGTT TCCCGAAGCT CATCGCAGAC TCCTGGAATG CCATCCCTGA TAACCTGGAT 
GCAGTCGTGG ACCTGCAGGG TGGTGGTCAC AGCTATTTCT TCAAGGGTGC TTATTACCTG 
AAGTTGGAGA ACCAAAGTCT GAAGAGTGTG AAGTTTGGAA GCATCAAATC GGACTGGCTG 
GGCTGCTGA