Rrm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rrm1
Entrez Gene ID	685579
Full Name	ribonucleotide reductase catalytic subunit M1
General protein information	Preferred Names ribonucleotide reductase catalytic subunit M1 Names ribonucleoside-diphosphate reductase large subunit ribonucleotide reductase M1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32
Summary	putative ribonucleotide reductase enzyme; human homolog encodes an enzyme required for production of deoxyribonucleotides prior to DNA synthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013236.1	NP_001013254.1	ribonucleoside-diphosphate reductase large subunit

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RRM1	XP_534027.2
Mus musculus (house mouse)	Rrm1	NP_033129.2
Gallus gallus (chicken)	RRM1	NP_001026008.1
Saccharomyces cerevisiae (baker's yeast)	RNR3	NP_012198.3
Eremothecium gossypii	AGOS_ADL057W	NP_984039.2
Schizosaccharomyces pombe (fission yeast)	cdc22	NP_594491.1
Pan troglodytes (chimpanzee)	RRM1	XP_001160029.1
Bos taurus (cattle)	RRM1	NP_001106767.1
Rattus norvegicus (Norway rat)	Rrm1	NP_001013254.1
Caenorhabditis elegans (roundworm)	rnr-1	NP_499039.1
Saccharomyces cerevisiae (baker's yeast)	RNR1	NP_010993.1
Oryza sativa (rice)	Os06g0168600	NP_001056926.1
Magnaporthe oryzae (rice blast fungus)	MGG_07000	XP_003709756.1
Danio rerio (zebrafish)	rrm1	NP_571530.1
Neurospora crassa	NCU03539	XP_956818.1
Xenopus tropicalis (tropical clawed frog)	rrm1	NP_001120566.1
Kluyveromyces lactis	KLLA0C07887g	XP_452551.1
Homo sapiens (human)	RRM1	NP_001024.1
Macaca mulatta (Rhesus monkey)	RRM1	XP_001113010.1
Drosophila melanogaster (fruit fly)	RnrL	NP_477027.1
Arabidopsis thaliana (thale cress)	RNR1	NP_179770.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010198	XP_554103.3

Gene Ontology
Bibliography

Related articles in PubMed

Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.
Korte FS, Dai J, Buckley K, Feest ER, Adamek N, Geeves MA, Murry CE, Regnier M
Journal of molecular and cellular cardiology51(6)894-901(2011 Dec)

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG
Nature structural & molecular biology18(3)316-22(2011 Mar)

Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.
Daino K, Ugolin N, Altmeyer-Morel S, Guilly MN, Chevillard S
International journal of cancer125(3)612-20(2009 Aug)

Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase.
Zahedi Avval F, Holmgren A
The Journal of biological chemistry284(13)8233-40(2009 Mar)

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.
Wang J, Lohman GJ, Stubbe J
Proceedings of the National Academy of Sciences of the United States of America104(36)14324-9(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rrm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rrm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13916	NM_001013236.1 Latest version!	Rattus norvegicus ribonucleotide reductase catalytic subunit M1 (Rrm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rrm1 ( NM_001013236.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013254.1 Rattus norvegicus ribonucleotide reductase catalytic subunit M1 (Rrm1), mRNA.

Price & Availability↑

CloneID	ORa13916
Clone ID Related Accession (Same CDS sequence)	NM_001013236.1
Accession Version	NM_001013236.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2379bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527264000000
Organism	Rattus norvegicus(Norway rat)
Product	ribonucleoside-diphosphate reductase large subunit
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085906.1. On Apr 20, 2005 this sequence version replaced XM_344927.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAGCGAGTTA TGTTTGACAA AATTACATCC 
CGAATCCAGA AACTCTGTTA TGGACTCAAT ATGGACTTTG TGGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCCT ATACAGTGGG GTCACCACAG TGGAACTGGA CACCCTGGCT 
GCTGAGACAG CTGCCACCTT GACTACGAAG CACCCTGACT ATGCCATCCT GGCAGCAAGG 
ATCGCTGTCT CTAACTTGCA CAAGGAAACA AAGAAAGTGT TCAGTGACGT GATGGAGGAT 
CTCTACAACT ACATAAATCC ACACAACGGC AGACATTCTC CCATGGTGGC CAGCTCAACA 
CTCGAGATTG TTATGGCCCA TAAGGATCGC CTGAATTCTG CCATTATCTA TGACCGGGAT 
TTCTCTTACA ACTACTTTGG TTTTAAGACA CTGGAACGGT CATATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAGCACATG TTGATGAGGG TATCTGTGGG GATTCACAAA 
GAAGATATTG ATGCTGCAAT TGAAACATAC AATCTACTTT CTGAGAAGTG GTTTACTCAC 
GCCTCTCCGA CTCTCTTCAA TGCTGGGACC AACCGCCCAC AGTTGTCCAG CTGTTTCCTC 
TTGAGTATGA AAGATGACAG CATTGAGGGG ATTTATGATA CTCTGAAGCA GTGTGCCTTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCCGTGAGTT GTATTCGGGC CACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCTAAT GGCCTTGTGC CAATGCTGAG AGTCTATAAC 
AACACAGCTC GTTATGTGGA TCAAGGTGGA AACAAGCGCC CAGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCACCTGGA CATCTTTGAG TTTCTTGACT TGAAGAAGAA CACAGGCAAG 
GAAGAACAGC GCGCGCGGGA TCTCTTCTTT GCACTGTGGA TCCCAGATCT CTTCATGAAG 
CGAGTGGAGA CCAACCAGGA CTGGTCACTG ATGTGTCCCA ATGAGTGTCC TGGTCTGGAC 
GAGGTCTGGG GAGAGGAGTT TGAGAAGTTA TATGAAAGTT ACGAGAAGCA GGGCCGTGTC 
CGAAAAGTTG TGAAGGCTCA GCAGCTTTGG TACGCCATCA TTGAGTCTCA GACGGAGACG 
GGCACCCCAT ACATGCTCTA CAAAGACTCC TGTAACCGGA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AGTGCAGCAA CCTGTGCACA GAGATAGTAG AGTACACCAG TAAAGATGAG 
GTTGCGGTTT GTAACTTGGC TTCTCTGGCT CTGAACATGT ATGTCACACC AGAACACACG 
TATGACTTTG AGAAACTGGC AGAAGTCACT AAAGTCATTG TCCGAAATCT GAATAAAATA 
ATTGATATAA ACTACTATCC TATTCCAGAG GCACACTTAT CAAATAAACG CCATCGGCCC 
ATTGGAATTG GGGTACAAGG TCTAGCAGAT GCTTTCATCC TGATGAGGTA TCCCTTTGAG 
AGCCCAGAAG CCCAGCTACT AAATAAGCAA ATCTTTGAAA CCATCTATTA TGGAGCCCTG 
GAAGCCAGCT GTGACCTAGC CAAGGAGTAT GGCCCCTACG AAACGTATGA GGGATCTCCA 
GTCAGCAAGG GTATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTGTGGGAC 
TGGAAGCTTC TCAAGGAGAA GATTGCAAAG TACGGTATAA GAAACAGTTT ACTTATTGCC 
CCAATGCCTA CTGCTTCAAC TGCTCAGATT CTGGGGAATA ATGAGTCCAT TGAGCCTTAC 
ACCAGTAACA TCTACACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT GAATCCTCAC 
TTACTGAAAG ATCTTACTGA GCGGGGCTTG TGGAATGAAG AGATGAAAAA TCAGATTATT 
GCCTGCAATG GCTCCATTCA GAGCATACCA GAAATTCCTG AGGACCTGAA GCAGCTCTAT 
AAGACCGTGT GGGAAATCTC TCAGAAGACT GTTCTCAAGA TGGCAGCCGA GAGAGGTGCT 
TTCATCGATC AAAGCCAGTC TTTAAACATC CATATCGCTG AGCCCAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG TTGGAAGCAG GGTTTAAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCTG CCGCTAATCC AATCCAGTTC ACTCTGAACA AGGAAAAGCT GAAAGATAAG 
GAAAAGGCAC TGAAGGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAACA GAGAGGAGTG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013254.1
CDS	206..2584
Translation	MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLEIVMAHKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEEEKERNTAAMVCSLENREECLMCGS

Target ORF information:

RefSeq Version	NM_001013236.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ribonucleotide reductase catalytic subunit M1 (Rrm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013236.1

ORF Insert Sequence:

ATGCATGTGA TCAAGCGAGA TGGCCGCCAA GAGCGAGTTA TGTTTGACAA AATTACATCC 
CGAATCCAGA AACTCTGTTA TGGACTCAAT ATGGACTTTG TGGATCCTGC TCAGATCACC 
ATGAAAGTAA TCCAAGGCCT ATACAGTGGG GTCACCACAG TGGAACTGGA CACCCTGGCT 
GCTGAGACAG CTGCCACCTT GACTACGAAG CACCCTGACT ATGCCATCCT GGCAGCAAGG 
ATCGCTGTCT CTAACTTGCA CAAGGAAACA AAGAAAGTGT TCAGTGACGT GATGGAGGAT 
CTCTACAACT ACATAAATCC ACACAACGGC AGACATTCTC CCATGGTGGC CAGCTCAACA 
CTCGAGATTG TTATGGCCCA TAAGGATCGC CTGAATTCTG CCATTATCTA TGACCGGGAT 
TTCTCTTACA ACTACTTTGG TTTTAAGACA CTGGAACGGT CATATTTGTT GAAGATCAAT 
GGAAAAGTGG CTGAAAGACC ACAGCACATG TTGATGAGGG TATCTGTGGG GATTCACAAA 
GAAGATATTG ATGCTGCAAT TGAAACATAC AATCTACTTT CTGAGAAGTG GTTTACTCAC 
GCCTCTCCGA CTCTCTTCAA TGCTGGGACC AACCGCCCAC AGTTGTCCAG CTGTTTCCTC 
TTGAGTATGA AAGATGACAG CATTGAGGGG ATTTATGATA CTCTGAAGCA GTGTGCCTTG 
ATTTCTAAGT CTGCTGGAGG AATTGGTGTT GCCGTGAGTT GTATTCGGGC CACTGGCAGC 
TACATTGCTG GGACTAATGG CAATTCTAAT GGCCTTGTGC CAATGCTGAG AGTCTATAAC 
AACACAGCTC GTTATGTGGA TCAAGGTGGA AACAAGCGCC CAGGGGCATT TGCTATTTAC 
CTGGAGCCTT GGCACCTGGA CATCTTTGAG TTTCTTGACT TGAAGAAGAA CACAGGCAAG 
GAAGAACAGC GCGCGCGGGA TCTCTTCTTT GCACTGTGGA TCCCAGATCT CTTCATGAAG 
CGAGTGGAGA CCAACCAGGA CTGGTCACTG ATGTGTCCCA ATGAGTGTCC TGGTCTGGAC 
GAGGTCTGGG GAGAGGAGTT TGAGAAGTTA TATGAAAGTT ACGAGAAGCA GGGCCGTGTC 
CGAAAAGTTG TGAAGGCTCA GCAGCTTTGG TACGCCATCA TTGAGTCTCA GACGGAGACG 
GGCACCCCAT ACATGCTCTA CAAAGACTCC TGTAACCGGA AGAGCAACCA GCAGAACCTG 
GGAACCATCA AGTGCAGCAA CCTGTGCACA GAGATAGTAG AGTACACCAG TAAAGATGAG 
GTTGCGGTTT GTAACTTGGC TTCTCTGGCT CTGAACATGT ATGTCACACC AGAACACACG 
TATGACTTTG AGAAACTGGC AGAAGTCACT AAAGTCATTG TCCGAAATCT GAATAAAATA 
ATTGATATAA ACTACTATCC TATTCCAGAG GCACACTTAT CAAATAAACG CCATCGGCCC 
ATTGGAATTG GGGTACAAGG TCTAGCAGAT GCTTTCATCC TGATGAGGTA TCCCTTTGAG 
AGCCCAGAAG CCCAGCTACT AAATAAGCAA ATCTTTGAAA CCATCTATTA TGGAGCCCTG 
GAAGCCAGCT GTGACCTAGC CAAGGAGTAT GGCCCCTACG AAACGTATGA GGGATCTCCA 
GTCAGCAAGG GTATTCTTCA GTATGATATG TGGAATGTTA CTCCTACAGA CCTGTGGGAC 
TGGAAGCTTC TCAAGGAGAA GATTGCAAAG TACGGTATAA GAAACAGTTT ACTTATTGCC 
CCAATGCCTA CTGCTTCAAC TGCTCAGATT CTGGGGAATA ATGAGTCCAT TGAGCCTTAC 
ACCAGTAACA TCTACACTCG CAGAGTCTTG TCAGGAGAAT TTCAGATTGT GAATCCTCAC 
TTACTGAAAG ATCTTACTGA GCGGGGCTTG TGGAATGAAG AGATGAAAAA TCAGATTATT 
GCCTGCAATG GCTCCATTCA GAGCATACCA GAAATTCCTG AGGACCTGAA GCAGCTCTAT 
AAGACCGTGT GGGAAATCTC TCAGAAGACT GTTCTCAAGA TGGCAGCCGA GAGAGGTGCT 
TTCATCGATC AAAGCCAGTC TTTAAACATC CATATCGCTG AGCCCAACTA TGGCAAACTC 
ACTAGTATGC ACTTCTACGG TTGGAAGCAG GGTTTAAAGA CTGGGATGTA TTATTTAAGG 
ACAAGACCTG CCGCTAATCC AATCCAGTTC ACTCTGAACA AGGAAAAGCT GAAAGATAAG 
GAAAAGGCAC TGAAGGAGGA AGAAGAGAAG GAGAGGAACA CAGCAGCCAT GGTGTGCTCT 
TTGGAGAACA GAGAGGAGTG TCTGATGTGT GGATCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Upregulation of cardiomyocyte ribonucleotide reductase increases intracellular 2 deoxy-ATP, contractility, and relaxation.
Journal of molecular and cellular cardiology51(6)894-901(2011 Dec)
Korte FS,Dai J,Buckley K,Feest ER,Adamek N,Geeves MA,Murry CE,Regnier M

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
Nature structural & molecular biology18(3)316-22(2011 Mar)
Fairman JW,Wijerathna SR,Ahmad MF,Xu H,Nakano R,Jha S,Prendergast J,Welin RM,Flodin S,Roos A,Nordlund P,Li Z,Walz T,Dealwis CG

Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone.
International journal of cancer125(3)612-20(2009 Aug)
Daino K,Ugolin N,Altmeyer-Morel S,Guilly MN,Chevillard S

Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase.
The Journal of biological chemistry284(13)8233-40(2009 Mar)
Zahedi Avval F,Holmgren A

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.
Proceedings of the National Academy of Sciences of the United States of America104(36)14324-9(2007 Sep)
Wang J,Lohman GJ,Stubbe J

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Rrm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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