Gucy1a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gucy1a2
Entrez Gene ID	66012
Full Name	guanylate cyclase 1 soluble subunit alpha 2
General protein information	Preferred Names guanylate cyclase 1 soluble subunit alpha 2 Names guanylate cyclase soluble subunit alpha-2 GCS-alpha-2 guanylate cyclase 1, soluble, alpha 2 soluble guanylyl cyclase alpha2 subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q11
Summary	guanylyl cyclase that is nitric oxide-sensitive [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_023956.1	NP_076446.1	guanylate cyclase soluble subunit alpha-2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	GUCY1A2	XP_536590.2
Rattus norvegicus (Norway rat)	Gucy1a2	NP_076446.1
Macaca mulatta (Rhesus monkey)	GUCY1A2	XP_002799832.1
Gallus gallus (chicken)	GUCY1A2	XP_004938891.1
Pan troglodytes (chimpanzee)	GUCY1A2	XP_001136693.1
Bos taurus (cattle)	GUCY1A2	NP_001178270.1
Mus musculus (house mouse)	Gucy1a2	NP_001028494.1
Drosophila melanogaster (fruit fly)	Gycalpha99B	NP_477088.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000280	XP_310840.5
Homo sapiens (human)	GUCY1A2	NP_001243353.1
Xenopus tropicalis (tropical clawed frog)	gucy1a2	NP_001120379.1

Gene Ontology
Bibliography

Related articles in PubMed

Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability?
Gabach LA, Carlini VP, Monti MC, Maglio LE, De Barioglio SR, Perez MF
Psychopharmacology229(1)41-50(2013 Sep)

Glucagon-like peptide-2 (GLP-2) modulates the cGMP signalling pathway by regulating the expression of the soluble guanylyl cyclase receptor subunits in cultured rat astrocytes.
Velázquez E, Blázquez E, Ruiz-Albusac JM
Molecular neurobiology46(2)242-50(2012 Oct)

Impact of biological gender and soluble guanylate cyclase stimulation on renal recovery after relief of unilateral ureteral obstruction.
Wang-Rosenke Y, Mika A, Khadzhynov D, Loof T, Neumayer HH, Peters H
The Journal of urology188(1)316-23(2012 Jul)

Nitric oxide sensitive-guanylyl cyclase subunit expression changes during estrous cycle in anterior pituitary glands.
Cabilla JP, Ronchetti SA, Nudler SI, Miler EA, Quinteros FA, Duvilanski BH
American journal of physiology. Endocrinology and metabolism296(4)E731-7(2009 Apr)

Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.
Dhaese I, Vanneste G, Sips P, Buys E, Brouckaert P, Lefebvre RA
European journal of pharmacology589(1-3)251-9(2008 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gucy1a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gucy1a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12523	NM_023956.1 Latest version!	Rattus norvegicus guanylate cyclase 1 soluble subunit alpha 2 (Gucy1a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gucy1a2 ( NM_023956.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_076446.1 Rattus norvegicus guanylate cyclase 1 soluble subunit alpha 2 (Gucy1a2), mRNA.

Price & Availability↑

CloneID	ORa12523
Clone ID Related Accession (Same CDS sequence)	NM_023956.1
Accession Version	NM_023956.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2193bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568995200000
Organism	Rattus norvegicus(Norway rat)
Product	guanylate cyclase soluble subunit alpha-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF109963.2. On Dec 17, 2003 this sequence version replaced XM_346814.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF109963.2, AB097860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCGCA GGAAGATTTC ATCCGAGTCC TTCAGCTCTC TGGGCTCCGA TTACCTGGAG 
ACCAGCCCGG AAGAGGAAGG GGAATGCCCC TTGTCTAAGC TCTGCTGGAA TGGCAGCCGG 
AGCCCGCCAG GGCCACCTGG CTCCAGAGCA GCCGCTATGG CTGCCACCCC AGTCCCCGCT 
GCCTCTGTCG CTGCGGCAGC TGCTGCAGTC GCCGCCGGGT CCAAGAGAGC CCAACGCCGC 
CGGAGGGTCA ACCTGGACTC ACTGGGCGAG AGTATCAGTC TCCTGACGGC GCCCTCGCCT 
CAGACGATAC ACATGACTCT CAAGAGGACA TTGCAGTATT ATGAACATCA AGTTATTGGT 
TATAGGGATG CAGAAAAGAA TTTCCACAAT ATCTCTAATA GATGCTCCTC TGCAGACCAT 
TCCAACAAAG AGGAAATTGA AGATGTCTCA GGAATTCTTC GGTGTACTGC AAATGTACTC 
GGACTGAAGT TCCAAGAAAT TCAAGAGAGG TTTGGTGAGG AATTCTTTAA GATATGCTTT 
GATGAGAATG AGCGAGTCCT TCGAGCTGTA GGCAGCACAT TGCAGGATTT CTTCAATGGC 
TTCGATGCAT TGTTGGAACA CATTAGGACT TCATTTGGGA AACAGGCCAC TCTAGAGTCA 
CCATCTTTCC TATGCAAAGA GCTTCCTGAA GGTACTCTCA AACTCCACTA CTTCCACCCC 
CACCATACAG TGGGCTTCGC AATGCTGGGA ATGATCAAGG CTGCAGGAAA GAGAATCTAT 
CACTTAAATG TGGAAGTTGA ACAAATTGAA AATGAGAAAT TTTGCTCTGA TGGTTCAACC 
CCAAGCAATT ATAGCTGTCT TACCTTCCTT ATCAAAGAAT GTGAGACTAC TCAGATCACA 
AAGAACATTC CACAAGGTAC TTCCCAAATT CCTACAGACC TCAGAATCAG TATCAACACC 
TTCTGCAGAA CCTTCCCATT CCATTTGATG TTCGACCCTA ACATGGTGGT CCTTCAACTT 
GGAGAGGGCC TACGAAAGCA ACTTCGATGT GACAATCACA AAGTACTGAA GTTTGAGGAC 
TGTTTTGAGA TCGTCTCTCC AAAGGTTAAT GCCACTTTTG ATAGAGTCTT GCTACGATTG 
TCCACCCCAT TTGTGATAAG GACAAAGCCT GAAGCTTCTG GTACTGACAA TGAAGATAAG 
GTGATGGAAA TCAAAGGACA AATGATCCAT GTCCCAGAAT CAAATGCCAT TTTGTTTTTG 
GGCTCTCCAT GTGTGGACAA GTTGGATGAA CTCATAGGCC GAGGACTGCA TCTCTCAGAC 
ATCCCCATTC ATGATGCCAC TCGAGATGTC ATTTTAGTTG GAGAGCAAGC AAAGGCCCAG 
GATGGCTTGA AAAAGAGGAT GGATAAATTA AAAGCCACCT TAGAAAAAAC TCACCAGGCC 
CTGGAAGAAG AGAAAAAGAA GACAGTGGAT CTGCTGTATT CCATTTTCCC TGGTGATGTA 
GCCCAGCAGT TGTGGCAACG ACAGCAAGTA CAGGCCAGAA AGTTTGATGA TGTCACTATG 
CTCTTCTCTG ACATTGTGGG CTTCACAGCT ATATGTGCCC AGTGTACTCC CATGCAGGTG 
ATCAGCATGC TCAATGAACT TTACACGAGA TTTGATCACC AGTGTGGCTT TTTGGATATT 
TACAAGGTAG AAACAATAGG GGACGCATAC TGTGTTGCAT CAGGGCTTCA CAGGAAAAGC 
CTATGCCATG CGAAGCCCAT TGCTCTGATG GCCTTAAAGA TGATGGAGCT TTCAGAAGAG 
GTTCTGACTC CTGATGGAAG ACCCATTCAG ATGCGGATAG GCATTCATTC AGGCTCTGTG 
CTAGCTGGTG TGGTCGGAGT GAGAATGCCG CGATATTGTC TTTTTGGAAA TAATGTCACT 
CTGGCAAGCA AATTTGAATC TGGAAGTCAT CCTCGGCGCA TCAACATCAG CCCAACTACT 
TACCAATTAC TAAAACGAGA AGACAGTTTC ACATTTATTC CTCGTTCTCG TGAAGAACTT 
CCAGACAACT TTCCAAAGGA AATCCCTGGG GTCTGCTATT TCCTGGAGTT AAGGACTGGC 
CCAAAGCCAC CAAAGCCATC CCTGTCTTCA TCGAGAATAA AAAAGGTTTC CTACAATATT 
GGCACGATGT TCCTCCGAGA AACTAGCCTC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076446.1
CDS	421..2613
Translation	MSRRKISSESFSSLGSDYLETSPEEEGECPLSKLCWNGSRSPPGPPGSRAAAMAATPVPAASVAAAAAAVAAGSKRAQRRRRVNLDSLGESISLLTAPSPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSSADHSNKEEIEDVSGILRCTANVLGLKFQEIQERFGEEFFKICFDENERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKFCSDGSTPSNYSCLTFLIKECETTQITKNIPQGTSQIPTDLRISINTFCRTFPFHLMFDPNMVVLQLGEGLRKQLRCDNHKVLKFEDCFEIVSPKVNATFDRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL

Target ORF information:

RefSeq Version	NM_023956.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus guanylate cyclase 1 soluble subunit alpha 2 (Gucy1a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023956.1

ORF Insert Sequence:

ATGTCTCGCA GGAAGATTTC ATCCGAGTCC TTCAGCTCTC TGGGCTCCGA TTACCTGGAG 
ACCAGCCCGG AAGAGGAAGG GGAATGCCCC TTGTCTAAGC TCTGCTGGAA TGGCAGCCGG 
AGCCCGCCAG GGCCACCTGG CTCCAGAGCA GCCGCTATGG CTGCCACCCC AGTCCCCGCT 
GCCTCTGTCG CTGCGGCAGC TGCTGCAGTC GCCGCCGGGT CCAAGAGAGC CCAACGCCGC 
CGGAGGGTCA ACCTGGACTC ACTGGGCGAG AGTATCAGTC TCCTGACGGC GCCCTCGCCT 
CAGACGATAC ACATGACTCT CAAGAGGACA TTGCAGTATT ATGAACATCA AGTTATTGGT 
TATAGGGATG CAGAAAAGAA TTTCCACAAT ATCTCTAATA GATGCTCCTC TGCAGACCAT 
TCCAACAAAG AGGAAATTGA AGATGTCTCA GGAATTCTTC GGTGTACTGC AAATGTACTC 
GGACTGAAGT TCCAAGAAAT TCAAGAGAGG TTTGGTGAGG AATTCTTTAA GATATGCTTT 
GATGAGAATG AGCGAGTCCT TCGAGCTGTA GGCAGCACAT TGCAGGATTT CTTCAATGGC 
TTCGATGCAT TGTTGGAACA CATTAGGACT TCATTTGGGA AACAGGCCAC TCTAGAGTCA 
CCATCTTTCC TATGCAAAGA GCTTCCTGAA GGTACTCTCA AACTCCACTA CTTCCACCCC 
CACCATACAG TGGGCTTCGC AATGCTGGGA ATGATCAAGG CTGCAGGAAA GAGAATCTAT 
CACTTAAATG TGGAAGTTGA ACAAATTGAA AATGAGAAAT TTTGCTCTGA TGGTTCAACC 
CCAAGCAATT ATAGCTGTCT TACCTTCCTT ATCAAAGAAT GTGAGACTAC TCAGATCACA 
AAGAACATTC CACAAGGTAC TTCCCAAATT CCTACAGACC TCAGAATCAG TATCAACACC 
TTCTGCAGAA CCTTCCCATT CCATTTGATG TTCGACCCTA ACATGGTGGT CCTTCAACTT 
GGAGAGGGCC TACGAAAGCA ACTTCGATGT GACAATCACA AAGTACTGAA GTTTGAGGAC 
TGTTTTGAGA TCGTCTCTCC AAAGGTTAAT GCCACTTTTG ATAGAGTCTT GCTACGATTG 
TCCACCCCAT TTGTGATAAG GACAAAGCCT GAAGCTTCTG GTACTGACAA TGAAGATAAG 
GTGATGGAAA TCAAAGGACA AATGATCCAT GTCCCAGAAT CAAATGCCAT TTTGTTTTTG 
GGCTCTCCAT GTGTGGACAA GTTGGATGAA CTCATAGGCC GAGGACTGCA TCTCTCAGAC 
ATCCCCATTC ATGATGCCAC TCGAGATGTC ATTTTAGTTG GAGAGCAAGC AAAGGCCCAG 
GATGGCTTGA AAAAGAGGAT GGATAAATTA AAAGCCACCT TAGAAAAAAC TCACCAGGCC 
CTGGAAGAAG AGAAAAAGAA GACAGTGGAT CTGCTGTATT CCATTTTCCC TGGTGATGTA 
GCCCAGCAGT TGTGGCAACG ACAGCAAGTA CAGGCCAGAA AGTTTGATGA TGTCACTATG 
CTCTTCTCTG ACATTGTGGG CTTCACAGCT ATATGTGCCC AGTGTACTCC CATGCAGGTG 
ATCAGCATGC TCAATGAACT TTACACGAGA TTTGATCACC AGTGTGGCTT TTTGGATATT 
TACAAGGTAG AAACAATAGG GGACGCATAC TGTGTTGCAT CAGGGCTTCA CAGGAAAAGC 
CTATGCCATG CGAAGCCCAT TGCTCTGATG GCCTTAAAGA TGATGGAGCT TTCAGAAGAG 
GTTCTGACTC CTGATGGAAG ACCCATTCAG ATGCGGATAG GCATTCATTC AGGCTCTGTG 
CTAGCTGGTG TGGTCGGAGT GAGAATGCCG CGATATTGTC TTTTTGGAAA TAATGTCACT 
CTGGCAAGCA AATTTGAATC TGGAAGTCAT CCTCGGCGCA TCAACATCAG CCCAACTACT 
TACCAATTAC TAAAACGAGA AGACAGTTTC ACATTTATTC CTCGTTCTCG TGAAGAACTT 
CCAGACAACT TTCCAAAGGA AATCCCTGGG GTCTGCTATT TCCTGGAGTT AAGGACTGGC 
CCAAAGCCAC CAAAGCCATC CCTGTCTTCA TCGAGAATAA AAAAGGTTTC CTACAATATT 
GGCACGATGT TCCTCCGAGA AACTAGCCTC TGA