Gabre cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabre
Entrez Gene ID	65191
Full Name	gamma-aminobutyric acid type A receptor epsilon subunit
General protein information	Preferred Names gamma-aminobutyric acid type A receptor epsilon subunit Names gamma-aminobutyric acid receptor subunit epsilon GABA(A) receptor subunit epsilon gamma-aminobutyric acid A receptor, epsilon gamma-aminobutyric acid (GABA) A receptor, epsilon gamma-aminobutyric acid (GABA-A) receptor, subunit epsilon
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq37
Summary	subunit that may modify GABA-A receptor activity to confer benzodiazepine insensitivity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_023091.1	NP_075579.1	gamma-aminobutyric acid receptor subunit epsilon precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	GABRE	XP_001093865.1
Rattus norvegicus (Norway rat)	Gabre	NP_075579.1
Homo sapiens (human)	GABRE	NP_004952.2
Bos taurus (cattle)	GABRE	XP_002699718.1
Canis lupus familiaris (dog)	GABRE	XP_549340.3

Gene Ontology
Bibliography

Related articles in PubMed

Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of ε-subunit containing GABA ARs.
Hengen KB, Nelson NR, Stang KM, Johnson SM, Smith SM, Watters JJ, Mitchell GS, Behan M
PloS one10(3)e0119351(2015)

Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy.
Hengen KB, Nelson NR, Stang KM, Johnson SM, Crader SM, Watters JJ, Mitchell GS, Behan M
PloS one7(1)e30608(2012)

Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties.
Belujon P, Baufreton J, Grandoso L, Boué-Grabot E, Batten TF, Ugedo L, Garret M, Taupignon AI
Journal of neurophysiology102(4)2312-25(2009 Oct)

Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord.
Pape JR, Bertrand SS, Lafon P, Odessa MF, Chaigniau M, Stiles JK, Garret M
Neuroscience160(1)85-96(2009 Apr)

Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
Sergeeva OA, Andreeva N, Garret M, Scherer A, Haas HL
The Journal of neuroscience : the official journal of the Society for Neuroscience25(1)88-95(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gabre gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabre cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06578	NM_023091.1 Latest version!	Rattus norvegicus gamma-aminobutyric acid type A receptor subunit epsilon (Gabre), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabre ( NM_023091.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_075579.1 Rattus norvegicus gamma-aminobutyric acid type A receptor subunit epsilon (Gabre), mRNA.

Price & Availability↑

CloneID	ORa06578
Clone ID Related Accession (Same CDS sequence)	NM_023091.1
Accession Version	NM_023091.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2970bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575907200000
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid receptor subunit epsilon precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF189262.1. ##Evidence-Data-START## Transcript exon combination :: AF189262.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END##

ATGTTGCCTA AAGTTCTCCT GATGCTCCTC AACATGTTCC TGGCCCTCCA GTGGAGGGTT 
GGACCTCACA TTAAACTGGA GAATAAACCC CCTGCCCAAG ATAAGGTAGT CTTTGGCCCT 
CAGCCTCAGC CTGTGCCACA ACCTCTGATT CCGCCTGAAT CTCCTGCTGG AGATGATGTA 
GTCTTCGACT CTCAGCCCCA GCCCCAGTCG GAATCCCCTG GCCATGATGA TGTCTTTAGC 
TCCCAGCCCC AGCCTCTGCC CCAGCCCCAG CCTCTGCCGG AGCCCCAGCC TCTGCCGGAG 
CCTGAGCCAC AGCCGCAGCC ACAGCCACAG CCGCAGCCGC AGCCACAGCC CCTGGCTGGG 
CGCCAGCCTC TGCCCCAGCC CCTGCCTTGG CCCCTGCCTC AGCCTCAGCC CGAACCGGAG 
CCCCAGCCGG AGCCCCAGCC GGAGCCCCAG CCTGAGCCCC AGCCGGAGCC CCAGCCTGAG 
CCCCAACCAG AACCCCAGCC AGAACCCCAG CCTCAACCTC AGCCTCTGGC TGGGCGCCAG 
CCTTTGCCTT GGCCCCTGCC ACTGCCCCTG CCCGAGCCCC AACCTGATCC CCAGCCTGAT 
CCCCAACCGG AGCCTCAGCC AGAACCCCAA CCTGAGCCCC AGCCTCAGCC CCAGACCCCA 
GGCCAGGTCC AGGCTGGGCG CCAACCCCGC CCCAAACCTC AGCCTGATCC CCATCCCCAT 
CCGCAGCCTG AACCTCAGCC TGAGCCACGT CTCCATCCCT TTCACCGTCT CCGTCTCCGT 
CCCCATCCCT ATCCTGAGCC CCATCCAGGA CCCCAGCCGG AGCCTGAGCC TGAGCCTGAG 
CCGGAGCCCC AGCCGGAGCC CCAGCCGGAG CCCCAGCCGG AGCCCCAACC GGAGCCTGAG 
CCCCAGCCGG AGCCGGAGCC GGAGCCTGAG CCTGAGCCTG AGCCTGAGCC TGAGCCCGAG 
CCCGAGCCCG AGCCCGAGCC TGAGCCTGAG CCTGAGCCTG AGCCTGAGCC TGAGCCTGAG 
CCTGAGCCCC AGCCGGAGCC GGAGCCGGAG CCGGAGCCGG AGCCCGAACC TGAGCCCGAG 
CCCGAGCCCG AGCCCGAGCC TCAGCCAGAG CCCCAGCCAG AACCTGAGCC TGAGCCCGAG 
CCCCAGCCCG AGCCCCAGCC CGAGCCCGAG CCCGAGCCCG AGCCCGAGCC CGAGCCCGAG 
CCCGAACCTG AACCTGAGCC TCAGCCGGAG CCCCAGCCTG AGCCTGAGCC CCAGCCTGAG 
CCCCAGCCAG ATCCTGAGCC TCAGCCTGAG CCCGGACCTG AACCTGGACC TGAACCTGAA 
CCTGAGCCTC AGCTGGAGCC CCAGCCAGAG CCTGAGCCTG AGCCACAGCC GGAGCCTGAG 
TCGGAGCTGG ACCTGGAGCC GGAACCAGAG CCCCAGCCCC TGCCGGAGCC CCAGCCTGAG 
CCTGAGCCTG AGCCTGAGCC GGAGCCGGAG CCGGAGCCGG AGCCGGAGCC GGAGCCGGAG 
CCGGAGCCGG AGCCGGAGCC TGAGCCAGAA CCGGAGCCAG AGCTGGAACT GGAGCCCCAG 
TCCCAGCTGG AGCCTCAGCC TAGTGGAAAG AAGCTTCCAG CAAGAGAAAC AGAACTCACT 
GCTGATCATA CAACTGAACG CCCACGTGGA AAACTGACAA GAGCTTCTCA AATCCTTAAC 
ACCATCCTGA GCAACTACGA CCATAAACTG CGCCCTAGCA TTGGAGAGAA GCCTACCGTG 
GTCACTGTTA AAGTCTTTGT CAACAGCCTC GGACCTATTT CCATCCTAGA CATGGAATAT 
TCCATTGACA TCATCTTCTA CCAGACCTGG TATGATGAGC GTCTTCGTTA CAATGACACC 
TTTGAGACAC TTATTCTACA TGGCAACGTG GTGAGCCAGT TGTGGATCCC GGATACTTTT 
TTTAGGAATT CTAAGAGGAC CCAAGAGTAT GATATCACCA TACCCAACCA GATGGCTCTC 
ATCCATAAGG ATGGAAAAGT GTTGTACACA GTTAGGATGA CCATTGATGC AAGATGCTCA 
CTCCACATGC TCAATTTTCC AATGGATTCT CACTCTTGCC CTCTGTCTTT CTCTAGCTTT 
TCCTATGATG AGCATGAGAT GATATACAAG TGGGAGAATT TCAAACTCAA AATCGATGCG 
AAGAACACTT GGAAGCTATT GGAGTTTGAT TTTACAGGAG TGAACAACAA AACTGAAATC 
ATCTCCACCC CAGTTGGTGA CTTCATGGTC ATGACATTCT TCTTCAATGT AAGCAGGAGG 
TTTGGCTTCA TTGTCTTTCA AAACTATATC CCTTCATCTG TTACCACAAT GCTTTCCTGG 
GTGTCCTTCT GGATCAAGAT AGAAGCTGCT GCTGCCAGGG CCTCTGTAGG GGTCAGTTCT 
GTGCTCACCA TGGCCACACT GGGTACCTTT TCTCGTAAGA ATTTCCCTCG TGTCTCCTAT 
CTCACAGCTT TGGACTTCTA TATTGCAATT TGTTTCGTCT TGTGCTTCTG TACTCTACTA 
GAGTTCACTG TGCTCAACTT CCTGACCTAC AATAATATTG AACGACAGGC TTCTCCAAAG 
TTCTACCAAT TTCCAACCAA TAGCCGTGCT AATGCACGTA CTCGTGCTCG TGCCCGCACT 
CGTGCTCGTG CTCGTGCCCG TGCTCGTCAG CAGCAGGAAG TGTTTGTGTG TGAGATTGTT 
ACCTATGAGG AAAATGCTGA AGAGGGTTAC CAGTGGTCTC CAAGATCAAG AAGACCTCAG 
TGTCCCTGGA GGCGATGTGG CCGAAGCTAT GTGTGCTTCA GGGTTCTCAG GAAGTATTTC 
TGCATGGTTC CTGGTTGTGA GGGCAACAGC TGGCAGCGGG GCCGCATCTG CATCCACGTT 
TATCGCCTGG ATAACTACTC GCGGGTGCTT TTCCCCATTA CATTCTTCTT CTTTAATGTG 
GTCTACTGGG TGATTTGCCT TAACCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075579.1
CDS	21..2990
Translation	MLPKVLLMLLNMFLALQWRVGPHIKLENKPPAQDKVVFGPQPQPVPQPLIPPESPAGDDVVFDSQPQPQSESPGHDDVFSSQPQPLPQPQPLPEPQPLPEPEPQPQPQPQPQPQPQPLAGRQPLPQPLPWPLPQPQPEPEPQPEPQPEPQPEPQPEPQPEPQPEPQPEPQPQPQPLAGRQPLPWPLPLPLPEPQPDPQPDPQPEPQPEPQPEPQPQPQTPGQVQAGRQPRPKPQPDPHPHPQPEPQPEPRLHPFHRLRLRPHPYPEPHPGPQPEPEPEPEPEPQPEPQPEPQPEPQPEPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPQPEPEPEPEPEPEPEPEPEPEPEPQPEPQPEPEPEPEPQPEPQPEPEPEPEPEPEPEPEPEPEPQPEPQPEPEPQPEPQPDPEPQPEPGPEPGPEPEPEPQLEPQPEPEPEPQPEPESELDLEPEPEPQPLPEPQPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPELELEPQSQLEPQPSGKKLPARETELTADHTTERPRGKLTRASQILNTILSNYDHKLRPSIGEKPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDERLRYNDTFETLILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYTVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDEHEMIYKWENFKLKIDAKNTWKLLEFDFTGVNNKTEIISTPVGDFMVMTFFFNVSRRFGFIVFQNYIPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFVLCFCTLLEFTVLNFLTYNNIERQASPKFYQFPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSPRSRRPQCPWRRCGRSYVCFRVLRKYFCMVPGCEGNSWQRGRICIHVYRLDNYSRVLFPITFFFFNVVYWVICLNL

Target ORF information:

RefSeq Version	NM_023091.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type A receptor subunit epsilon (Gabre), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023091.1

ORF Insert Sequence:

ATGTTGCCTA AAGTTCTCCT GATGCTCCTC AACATGTTCC TGGCCCTCCA GTGGAGGGTT 
GGACCTCACA TTAAACTGGA GAATAAACCC CCTGCCCAAG ATAAGGTAGT CTTTGGCCCT 
CAGCCTCAGC CTGTGCCACA ACCTCTGATT CCGCCTGAAT CTCCTGCTGG AGATGATGTA 
GTCTTCGACT CTCAGCCCCA GCCCCAGTCG GAATCCCCTG GCCATGATGA TGTCTTTAGC 
TCCCAGCCCC AGCCTCTGCC CCAGCCCCAG CCTCTGCCGG AGCCCCAGCC TCTGCCGGAG 
CCTGAGCCAC AGCCGCAGCC ACAGCCACAG CCGCAGCCGC AGCCACAGCC CCTGGCTGGG 
CGCCAGCCTC TGCCCCAGCC CCTGCCTTGG CCCCTGCCTC AGCCTCAGCC CGAACCGGAG 
CCCCAGCCGG AGCCCCAGCC GGAGCCCCAG CCTGAGCCCC AGCCGGAGCC CCAGCCTGAG 
CCCCAACCAG AACCCCAGCC AGAACCCCAG CCTCAACCTC AGCCTCTGGC TGGGCGCCAG 
CCTTTGCCTT GGCCCCTGCC ACTGCCCCTG CCCGAGCCCC AACCTGATCC CCAGCCTGAT 
CCCCAACCGG AGCCTCAGCC AGAACCCCAA CCTGAGCCCC AGCCTCAGCC CCAGACCCCA 
GGCCAGGTCC AGGCTGGGCG CCAACCCCGC CCCAAACCTC AGCCTGATCC CCATCCCCAT 
CCGCAGCCTG AACCTCAGCC TGAGCCACGT CTCCATCCCT TTCACCGTCT CCGTCTCCGT 
CCCCATCCCT ATCCTGAGCC CCATCCAGGA CCCCAGCCGG AGCCTGAGCC TGAGCCTGAG 
CCGGAGCCCC AGCCGGAGCC CCAGCCGGAG CCCCAGCCGG AGCCCCAACC GGAGCCTGAG 
CCCCAGCCGG AGCCGGAGCC GGAGCCTGAG CCTGAGCCTG AGCCTGAGCC TGAGCCCGAG 
CCCGAGCCCG AGCCCGAGCC TGAGCCTGAG CCTGAGCCTG AGCCTGAGCC TGAGCCTGAG 
CCTGAGCCCC AGCCGGAGCC GGAGCCGGAG CCGGAGCCGG AGCCCGAACC TGAGCCCGAG 
CCCGAGCCCG AGCCCGAGCC TCAGCCAGAG CCCCAGCCAG AACCTGAGCC TGAGCCCGAG 
CCCCAGCCCG AGCCCCAGCC CGAGCCCGAG CCCGAGCCCG AGCCCGAGCC CGAGCCCGAG 
CCCGAACCTG AACCTGAGCC TCAGCCGGAG CCCCAGCCTG AGCCTGAGCC CCAGCCTGAG 
CCCCAGCCAG ATCCTGAGCC TCAGCCTGAG CCCGGACCTG AACCTGGACC TGAACCTGAA 
CCTGAGCCTC AGCTGGAGCC CCAGCCAGAG CCTGAGCCTG AGCCACAGCC GGAGCCTGAG 
TCGGAGCTGG ACCTGGAGCC GGAACCAGAG CCCCAGCCCC TGCCGGAGCC CCAGCCTGAG 
CCTGAGCCTG AGCCTGAGCC GGAGCCGGAG CCGGAGCCGG AGCCGGAGCC GGAGCCGGAG 
CCGGAGCCGG AGCCGGAGCC TGAGCCAGAA CCGGAGCCAG AGCTGGAACT GGAGCCCCAG 
TCCCAGCTGG AGCCTCAGCC TAGTGGAAAG AAGCTTCCAG CAAGAGAAAC AGAACTCACT 
GCTGATCATA CAACTGAACG CCCACGTGGA AAACTGACAA GAGCTTCTCA AATCCTTAAC 
ACCATCCTGA GCAACTACGA CCATAAACTG CGCCCTAGCA TTGGAGAGAA GCCTACCGTG 
GTCACTGTTA AAGTCTTTGT CAACAGCCTC GGACCTATTT CCATCCTAGA CATGGAATAT 
TCCATTGACA TCATCTTCTA CCAGACCTGG TATGATGAGC GTCTTCGTTA CAATGACACC 
TTTGAGACAC TTATTCTACA TGGCAACGTG GTGAGCCAGT TGTGGATCCC GGATACTTTT 
TTTAGGAATT CTAAGAGGAC CCAAGAGTAT GATATCACCA TACCCAACCA GATGGCTCTC 
ATCCATAAGG ATGGAAAAGT GTTGTACACA GTTAGGATGA CCATTGATGC AAGATGCTCA 
CTCCACATGC TCAATTTTCC AATGGATTCT CACTCTTGCC CTCTGTCTTT CTCTAGCTTT 
TCCTATGATG AGCATGAGAT GATATACAAG TGGGAGAATT TCAAACTCAA AATCGATGCG 
AAGAACACTT GGAAGCTATT GGAGTTTGAT TTTACAGGAG TGAACAACAA AACTGAAATC 
ATCTCCACCC CAGTTGGTGA CTTCATGGTC ATGACATTCT TCTTCAATGT AAGCAGGAGG 
TTTGGCTTCA TTGTCTTTCA AAACTATATC CCTTCATCTG TTACCACAAT GCTTTCCTGG 
GTGTCCTTCT GGATCAAGAT AGAAGCTGCT GCTGCCAGGG CCTCTGTAGG GGTCAGTTCT 
GTGCTCACCA TGGCCACACT GGGTACCTTT TCTCGTAAGA ATTTCCCTCG TGTCTCCTAT 
CTCACAGCTT TGGACTTCTA TATTGCAATT TGTTTCGTCT TGTGCTTCTG TACTCTACTA 
GAGTTCACTG TGCTCAACTT CCTGACCTAC AATAATATTG AACGACAGGC TTCTCCAAAG 
TTCTACCAAT TTCCAACCAA TAGCCGTGCT AATGCACGTA CTCGTGCTCG TGCCCGCACT 
CGTGCTCGTG CTCGTGCCCG TGCTCGTCAG CAGCAGGAAG TGTTTGTGTG TGAGATTGTT 
ACCTATGAGG AAAATGCTGA AGAGGGTTAC CAGTGGTCTC CAAGATCAAG AAGACCTCAG 
TGTCCCTGGA GGCGATGTGG CCGAAGCTAT GTGTGCTTCA GGGTTCTCAG GAAGTATTTC 
TGCATGGTTC CTGGTTGTGA GGGCAACAGC TGGCAGCGGG GCCGCATCTG CATCCACGTT 
TATCGCCTGG ATAACTACTC GCGGGTGCTT TTCCCCATTA CATTCTTCTT CTTTAATGTG 
GTCTACTGGG TGATTTGCCT TAACCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of ε-subunit containing GABA ARs.
PloS one10(3)e0119351(2015)
Hengen KB,Nelson NR,Stang KM,Johnson SM,Smith SM,Watters JJ,Mitchell GS,Behan M

Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy.
PloS one7(1)e30608(2012)
Hengen KB,Nelson NR,Stang KM,Johnson SM,Crader SM,Watters JJ,Mitchell GS,Behan M

Inhibitory transmission in locus coeruleus neurons expressing GABAA receptor epsilon subunit has a number of unique properties.
Journal of neurophysiology102(4)2312-25(2009 Oct)
Belujon P,Baufreton J,Grandoso L,Boué-Grabot E,Batten TF,Ugedo L,Garret M,Taupignon AI

Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord.
Neuroscience160(1)85-96(2009 Apr)
Pape JR,Bertrand SS,Lafon P,Odessa MF,Chaigniau M,Stiles JK,Garret M

Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience25(1)88-95(2005 Jan)
Sergeeva OA,Andreeva N,Garret M,Scherer A,Haas HL

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Gabre cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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