Kcnd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnd2
Entrez Gene ID	65180
Full Name	potassium voltage-gated channel subfamily D member 2
Synonyms	Kv4.2,RK5,Shal1
General protein information	Preferred Names potassium voltage-gated channel subfamily D member 2 Names potassium voltage-gated channel subfamily D member 2 potassium channel, voltage-gated Shal-related subfamily D, member 2 potassium voltage gated channel, Shal-related family, member 2 potassium voltage-gated channel, Shal-related subfamily, member 2 voltage-gated potassium channel subunit Kv4.2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q22
Summary	a potassium channel responsible for transient outward K+ currents in cardiomyocytes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031730.2	NP_113918.2	potassium voltage-gated channel subfamily D member 2 precursor

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Shal	NP_001097646.1
Caenorhabditis elegans (roundworm)	shl-1	NP_500975.2
Pan troglodytes (chimpanzee)	KCND2	XP_001141749.1
Macaca mulatta (Rhesus monkey)	KCND2	XP_001082011.2
Mus musculus (house mouse)	Kcnd2	NP_062671.1
Rattus norvegicus (Norway rat)	Kcnd2	NP_113918.2
Gallus gallus (chicken)	KCND2	NP_989610.1
Xenopus tropicalis (tropical clawed frog)	kcnd2	XP_002935005.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007046	XP_308716.2
Bos taurus (cattle)	KCND2	NP_001178113.1
Homo sapiens (human)	KCND2	NP_036413.1
Canis lupus familiaris (dog)	KCND2	XP_852736.1
Danio rerio (zebrafish)	kcnd2	NP_001076336.1

Gene Ontology
Bibliography

Related articles in PubMed

ERK5 Phosphorylates K
Kashino Y, Obara Y, Okamoto Y, Saneyoshi T, Hayashi Y, Ishii K
International journal of molecular sciences19(7)(2018 Jul)

The activation of
Liu X, Shi S, Yang H, Qu C, Chen Y, Liang J, Yang B
American journal of physiology. Cell physiology313(2)C187-C196(2017 Aug)

Reduced expression of IA channels is associated with post-ischemic seizures.
Lei Z, Zhang H, Liang Y, Xu ZC
Epilepsy research12440-8(2016 08)

MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction.
Liu X, Zhang Y, Du W, Liang H, He H, Zhang L, Pan Z, Li X, Xu C, Zhou Y, Wang L, Qian M, Liu T, Yin H, Lu Y, Yang B, Shan H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(1)102-14(2016)

Estrogen suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons.
Zhang Y, Huang Y, Liu X, Wang G, Wang X, Wang Y
International journal of molecular medicine36(3)865-72(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kcnd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08613	NM_031730.2 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily D member 2 (Kcnd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnd2 ( NM_031730.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113918.2 Rattus norvegicus potassium voltage-gated channel subfamily D member 2 (Kcnd2), mRNA.

Price & Availability↑

CloneID	ORa08613
Clone ID Related Accession (Same CDS sequence)	NM_031730.2
Accession Version	NM_031730.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily D member 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07060003.1, M59980.1, CO393575.1, CB790894.1 and AC117109.5. On Oct 4, 2005 this sequence version replaced NM_031730.1. Sequence Note: This RefSeq record was created using sequences from two different strains, BN/SsNHsdMCW and Sprague-Dawley, because no single transcript from the same strain was available for the full length of the gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M59980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCCG GTGTTGCAGC ATGGCTACCC TTTGCCAGGG CAGCCGCCAT TGGGTGGATG 
CCTGTTGCCT CCGGGCCTAT GCCAGCTCCC CCAAGGCAGG AGAGAAAAAG GACTCAGGAC 
GCTCTAATTG TGCTGAACGT GAGTGGCACC CGTTTCCAGA CATGGCAAGA CACCCTGGAA 
CGATACCCAG ACACTCTGCT GGGCAGTTCC GAGAGAGACT TTTTCTACCA CCCAGAGACC 
CAACAATATT TCTTTGACCG TGACCCAGAC ATCTTCCGCC ACATCCTCAA CTTCTACCGC 
ACGGGGAAGC TTCACTATCC CCGCCATGAG TGCATCTCGG CTTATGATGA AGAATTGGCC 
TTCTTTGGCC TCATCCCAGA AATTATTGGC GACTGCTGTT ATGAGGAGTA CAAGGACCGC 
AGGCGGGAGA ATGCAGAGCG CCTCCAGGAT GATGCAGACA CTGACAATAC AGGAGAGAGT 
GCTCTGCCCA CCATGACTGC TAGGCAGAGG GTCTGGAGGG CCTTTGAGAA CCCCCACACC 
AGCACCATGG CCCTGGTGTT CTACTATGTG ACCGGGTTCT TCATTGCCGT CTCAGTCATC 
GCGAATGTGG TGGAAACAGT TCCATGTGGG TCTAGCCCAG GCCACATAAA AGAACTGCCT 
TGTGGGGAAA GGTATGCAGT GGCCTTCTTC TGCTTGGATA CCGCCTGTGT CATGATCTTT 
ACGGTTGAGT ACTTGCTACG CCTGGCCGCA GCGCCTAGTC GTTACCGTTT TGTGCGCAGT 
GTCATGAGTA TCATCGATGT GGTGGCCATC CTACCCTATT ACATTGGGCT GGTGATGACA 
GACAATGAGG ATGTCAGTGG CGCCTTTGTC ACACTCCGAG TCTTTCGAGT CTTCAGGATC 
TTTAAGTTTT CCCGCCACTC TCAAGGCCTG CGTATACTGG GGTACACACT GAAGAGCTGT 
GCGTCAGAAC TGGGCTTCTT GCTCTTTTCC CTCACAATGG CTATCATCAT TTTCGCTACG 
GTTATGTTCT ACGCAGAGAA GGGCTCTTCA GCAAGCAAGT TCACCAGCAT CCCTGCAGCC 
TTCTGGTACA CCATCGTCAC CATGACAACA CTGGGGTATG GCGACATGGT ACCAAAAACC 
ATAGCAGGGA AGATTTTCGG GTCTATCTGC TCTCTGAGCG GAGTCTTGGT CATCGCGCTA 
CCCGTGCCTG TGATCGTGTC TAACTTCAGT CGGATCTACC ACCAAAACCA ACGAGCGGAC 
AAACGAAGGG CACAGAAGAA AGCGAGGCTG GCCAGGATCC GGGCAGCCAA AAGTGGAAGT 
GCAAATGCCT ACATGCAGAG CAAGCGGAAT GGGTTACTGA GCAACCAACT GCAGTCCTCG 
GAGGATGAAC CGGCCTTCGT TAGCAAATCT GGATCCAGCT TCGAGACACA ACACCACCAC 
CTGCTTCACT GCCTGGAGAA AACCACGAAC CATGAGTTTG TGGATGAACA AGTCTTTGAA 
GAAAGCTGCA TGGAAGTGGC CACTGTTAAT CGCCCTTCAA GTCACAGCCC CTCCCTCTCT 
TCCCAACAAG GAGTCACCAG CACTTGCTGC TCACGGAGAC ACAAAAAAAC TTTCCGAATC 
CCAAATGCCA ATGTGTCAGG AAGTCATAGA GGCAGCGTGC AAGAACTCAG TACAATTCAG 
ATCAGATGTG TGGAGAGAAC TCCACTATCC AACAGCCGAT CCAGCTTAAA TGCCAAAATG 
GAAGAGTGTG TCAAACTAAA CTGTGAACAA CCTTACGTGA CCACAGCAAT AATTAGCATT 
CCAACACCTC CAGTAACCAC CCCAGAAGGC GACGACAGGC CCGAGTCTCC TGAGTATTCG 
GGAGGAAACA TCGTCAGGGT GTCTGCTTTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113918.2
CDS	554..2446
Translation	MAAGVAAWLPFARAAAIGWMPVASGPMPAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSSERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENAERLQDDADTDNTGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGNIVRVSAL

Target ORF information:

RefSeq Version	NM_031730.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily D member 2 (Kcnd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031730.2

ORF Insert Sequence:

ATGGCAGCCG GTGTTGCAGC ATGGCTACCC TTTGCCAGGG CAGCCGCCAT TGGGTGGATG 
CCTGTTGCCT CCGGGCCTAT GCCAGCTCCC CCAAGGCAGG AGAGAAAAAG GACTCAGGAC 
GCTCTAATTG TGCTGAACGT GAGTGGCACC CGTTTCCAGA CATGGCAAGA CACCCTGGAA 
CGATACCCAG ACACTCTGCT GGGCAGTTCC GAGAGAGACT TTTTCTACCA CCCAGAGACC 
CAACAATATT TCTTTGACCG TGACCCAGAC ATCTTCCGCC ACATCCTCAA CTTCTACCGC 
ACGGGGAAGC TTCACTATCC CCGCCATGAG TGCATCTCGG CTTATGATGA AGAATTGGCC 
TTCTTTGGCC TCATCCCAGA AATTATTGGC GACTGCTGTT ATGAGGAGTA CAAGGACCGC 
AGGCGGGAGA ATGCAGAGCG CCTCCAGGAT GATGCAGACA CTGACAATAC AGGAGAGAGT 
GCTCTGCCCA CCATGACTGC TAGGCAGAGG GTCTGGAGGG CCTTTGAGAA CCCCCACACC 
AGCACCATGG CCCTGGTGTT CTACTATGTG ACCGGGTTCT TCATTGCCGT CTCAGTCATC 
GCGAATGTGG TGGAAACAGT TCCATGTGGG TCTAGCCCAG GCCACATAAA AGAACTGCCT 
TGTGGGGAAA GGTATGCAGT GGCCTTCTTC TGCTTGGATA CCGCCTGTGT CATGATCTTT 
ACGGTTGAGT ACTTGCTACG CCTGGCCGCA GCGCCTAGTC GTTACCGTTT TGTGCGCAGT 
GTCATGAGTA TCATCGATGT GGTGGCCATC CTACCCTATT ACATTGGGCT GGTGATGACA 
GACAATGAGG ATGTCAGTGG CGCCTTTGTC ACACTCCGAG TCTTTCGAGT CTTCAGGATC 
TTTAAGTTTT CCCGCCACTC TCAAGGCCTG CGTATACTGG GGTACACACT GAAGAGCTGT 
GCGTCAGAAC TGGGCTTCTT GCTCTTTTCC CTCACAATGG CTATCATCAT TTTCGCTACG 
GTTATGTTCT ACGCAGAGAA GGGCTCTTCA GCAAGCAAGT TCACCAGCAT CCCTGCAGCC 
TTCTGGTACA CCATCGTCAC CATGACAACA CTGGGGTATG GCGACATGGT ACCAAAAACC 
ATAGCAGGGA AGATTTTCGG GTCTATCTGC TCTCTGAGCG GAGTCTTGGT CATCGCGCTA 
CCCGTGCCTG TGATCGTGTC TAACTTCAGT CGGATCTACC ACCAAAACCA ACGAGCGGAC 
AAACGAAGGG CACAGAAGAA AGCGAGGCTG GCCAGGATCC GGGCAGCCAA AAGTGGAAGT 
GCAAATGCCT ACATGCAGAG CAAGCGGAAT GGGTTACTGA GCAACCAACT GCAGTCCTCG 
GAGGATGAAC CGGCCTTCGT TAGCAAATCT GGATCCAGCT TCGAGACACA ACACCACCAC 
CTGCTTCACT GCCTGGAGAA AACCACGAAC CATGAGTTTG TGGATGAACA AGTCTTTGAA 
GAAAGCTGCA TGGAAGTGGC CACTGTTAAT CGCCCTTCAA GTCACAGCCC CTCCCTCTCT 
TCCCAACAAG GAGTCACCAG CACTTGCTGC TCACGGAGAC ACAAAAAAAC TTTCCGAATC 
CCAAATGCCA ATGTGTCAGG AAGTCATAGA GGCAGCGTGC AAGAACTCAG TACAATTCAG 
ATCAGATGTG TGGAGAGAAC TCCACTATCC AACAGCCGAT CCAGCTTAAA TGCCAAAATG 
GAAGAGTGTG TCAAACTAAA CTGTGAACAA CCTTACGTGA CCACAGCAAT AATTAGCATT 
CCAACACCTC CAGTAACCAC CCCAGAAGGC GACGACAGGC CCGAGTCTCC TGAGTATTCG 
GGAGGAAACA TCGTCAGGGT GTCTGCTTTG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ERK5 Phosphorylates K
International journal of molecular sciences19(7)(2018 Jul)
Kashino Y,Obara Y,Okamoto Y,Saneyoshi T,Hayashi Y,Ishii K

The activation of
American journal of physiology. Cell physiology313(2)C187-C196(2017 Aug)
Liu X,Shi S,Yang H,Qu C,Chen Y,Liang J,Yang B

Reduced expression of IA channels is associated with post-ischemic seizures.
Epilepsy research12440-8(2016 08)
Lei Z,Zhang H,Liang Y,Xu ZC

MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(1)102-14(2016)
Liu X,Zhang Y,Du W,Liang H,He H,Zhang L,Pan Z,Li X,Xu C,Zhou Y,Wang L,Qian M,Liu T,Yin H,Lu Y,Yang B,Shan H

Estrogen suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons.
International journal of molecular medicine36(3)865-72(2015 Sep)
Zhang Y,Huang Y,Liu X,Wang G,Wang X,Wang Y

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Kcnd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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