Erbb4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Erbb4
Entrez Gene ID	59323
Full Name	erb-b2 receptor tyrosine kinase 4
General protein information	Preferred Names erb-b2 receptor tyrosine kinase 4 Names receptor tyrosine-protein kinase erbB-4 c-erbB-4 proto-oncogene-like protein c-ErbB-4 receptor tyrosine kinase v-erb-a erythroblastic leukemia viral oncogene homolog 4 v-erb-b2 avian erythroblastic leukemia viral oncogene 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q32-q33
Summary	binds neuregulins; involved in epithelial-mesenchymal interactions during development; may play a role in tooth morphogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021687.1	NP_067719.1	receptor tyrosine-protein kinase erbB-4 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Erbb4	NP_067719.1
Mus musculus (house mouse)	Erbb4	NP_034284.1
Homo sapiens (human)	ERBB4	NP_005226.1
Danio rerio (zebrafish)	erbb4a	NP_001137223.1
Pan troglodytes (chimpanzee)	ERBB4	XP_516067.2
Bos taurus (cattle)	ERBB4	XP_002685604.3
Xenopus tropicalis (tropical clawed frog)	erbb4	XP_004917906.1
Canis lupus familiaris (dog)	ERBB4	XP_003640239.1
Gallus gallus (chicken)	ERBB4	NP_001025536.1

Gene Ontology
Bibliography

Related articles in PubMed

High glucose forces a positive feedback loop connecting ErbB4 expression and mTOR/S6K pathway to aggravate the formation of tau hyperphosphorylation in differentiated SH-SY5Y cells.
Nie SD, Li X, Tang CE, Min FY, Shi XJ, Wu LY, Zhou SL, Chen Z, Wu J, Song T, Dai ZJ, Zheng J, Liu JJ, Wang S
Neurobiology of aging67171-180(2018 07)

The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.
Pankratova S, Klingelhofer J, Dmytriyeva O, Owczarek S, Renziehausen A, Syed N, Porter AE, Dexter DT, Kiryushko D
Theranostics8(14)3977-3990(2018)

ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage.
Yan F, Tan X, Wan W, Dixon BJ, Fan R, Enkhjargal B, Li Q, Zhang J, Chen G, Zhang JH
Experimental neurology29792-100(2017 11)

The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response.
Siltanen A, Nuutila K, Imanishi Y, Uenaka H, Mäkelä J, Pätilä T, Vento A, Miyagawa S, Sawa Y, Harjula A, Kankuri E
Cell transplantation25(1)55-69(2016)

A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Vullhorst D, Mitchell RM, Keating C, Roychowdhury S, Karavanova I, Tao-Cheng JH, Buonanno A
Nature communications67222(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Erbb4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Erbb4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05058	NM_021687.1 Latest version!	Rattus norvegicus erb-b2 receptor tyrosine kinase 4 (Erbb4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Erbb4 ( NM_021687.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067719.1 Rattus norvegicus erb-b2 receptor tyrosine kinase 4 (Erbb4), mRNA.

Price & Availability↑

CloneID	ORa05058
Clone ID Related Accession (Same CDS sequence)	NM_021687.1
Accession Version	NM_021687.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573660800000
Organism	Rattus norvegicus(Norway rat)
Product	receptor tyrosine-protein kinase erbB-4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF041838.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF041838.1, AY375306.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAAGCTGG CGACGGGACT GTGGGTCTGG GGGAGCCTTC TGGTGGCAGC CAGGACCGTC 
CAGCCCAGCG CTTCTCAGTC AGTGTGTGCC GGAACAGAGA ACAAACTGAG CTCTCTCTCT 
GATCTGGAGC AGCAGTACCG AGCCTTGCGC AAATACTATG AAAACTGCGA GGTAGTCATG 
GGCAACCTGG AGATCACCAG CATAGAGCAC AACCGGGACC TCTCCTTCCT GCGGTCTATC 
CGAGAAGTCA CAGGCTATGT ACTTGTGGCC CTCAACCAGT TTCGTTACCT GCCTCTGGAG 
AATTTACGCA TTATTCGTGG GACAAAACTG TATGAAGATC GCTATGCCTT AGCAATATTC 
TTAAACTACA GGAAAGATGG CAACTTTGGA CTTCAAGAAC TGGGATTAAA GAACCTGACC 
GAAATACTAA ATGGTGGAGT CTATGTAGAC CAGAACAAAT TCCTATGTTA TGCTGATACT 
ATACACTGGC AAGATATTGT TCGGAATCCA TGGCCTTCCA ACATGACTCT GGTGTCAACA 
ATTGGAAGTT CTGGATGCGG AAGATGCCAT AAGTCTTGCA CTGGTCGATG CTGGGGACCC 
ACAGAAAATC ACTGCCAGAC CTTGACAAGG ACTGTGTGTG CAGAACAATG TGATGGCAGG 
TGCTATGGAC CCTACGTCAG TGACTGCTGC CATCGAGAAT GTGCCGGAGG CTGCTCAGGA 
CCAAAAGACA CTGACTGCTT TGCCTGCATG AACTTCAATG ACAGTGGAGC ATGTGTTACT 
CAGTGTCCCC AAACGTTCGT CTACAATCCA ACCACCTTTC AACTGGAACA CAACTTCAAT 
GCAAAGTACA CATATGGAGC ATTCTGTGTT AAGAAATGTC CACATAACTT CGTGGTAGAT 
TCCAGTTCTT GTGTACGAGC CTGCCCTAGT TCCAAGATGG AAGTCGAAGA AAATGGAATT 
AAAATGTGTA AGCCTTGCAC TGATATTTGC CCCAAAGCAT GTGATGGAAT CGGCACCGGA 
TCCTTGATGT CTGCTCAGAC TGTGGATTCC AGTAACATTG ACAAATTCAT AAACTGCACC 
AAGATCAACG GGAATCTCAT CTTTCTTGTC ACTGGCATTC ATGGGGACCC TTACAATGCT 
ATTGACGCCA TAGACCCAGA GAAACTGAAT GTCTTTCGGA CAGTCAGAGA AATAACAGGT 
TTCCTGAACA TACAGACTTG GCCCCCAAAT ATGACAGATT TCAGTGTTTT CTCCAACCTT 
GTAACCATTG GAGGAAGAGT CCTCTACAGT GGTCTGTCAT TGCTTATCCT CAAACAACAA 
GGTATCACTT CACTACAGTT CCAGTCTCTG AAGGAAATCA GTGCGGGCAA TATCTACATC 
ACGGACAACA GCAACCTGTG TTATTACCAC ACCATCAACT GGACAACACT GTTCAGCACC 
GTTAACCAGA GGATAGTGAT CCGAGACAAC AGGAGGGCTG AGAACTGTAC TGCTGAAGGG 
ATGGTGTGTA ACCACCTGTG TTCAAATGAT GGTTGTTGGG GACCTGGGCC AGACCAGTGT 
CTGTCATGTC GGCGCTTCAG CAGGGGAAAG ATCTGTATAG AGTCCTGCAA CCTTTATGAT 
GGGGAGTTTC GAGAGTTTGA AAATGGCTCC ATCTGTGTTG AGTGTGACTC CCAGTGTGAG 
AAAATGGAAG ACGGACTCCT CACATGCCAT GGACCGGGAC CTGACAACTG TACAAAGTGT 
TCTCATTTTA AAGATGGTCC AAACTGTGTA GAGAAATGTC CAGATGTCCT ACAGGGAGCA 
AACAGTTTCA TATTTAAGTA CGCAGATCAG GATCGGGAGT GCCACCCTTG CCATCCAAAC 
TGCACCCAGG GGTGTAACGG TCCCACTAGT CATGACTGCA TTTACTACCC ATGGACGGGC 
CATTCCACTT TACCACAACA TGCTAGAACT CCACTGATTG CAGCCGGAGT CATTGGTGGG 
CTCTTCATCC TGGTCATCAT GGCTCTGACA TTTGCCGTTT ATGTCAGAAG GAAGAGCATC 
AAAAAGAAAC GCGCTTTGAG AAGATTCCTG GAGACCGAGT TAGTCGAGCC CTTAACCCCT 
AGTGGCACAG CACCCAATCA AGCTCAACTT CGAATTTTGA AGGAAACAGA GCTAAAGAGG 
GTAAAAGTCC TTGGCTCGGG AGCATTTGGA ACCGTTTATA AAGGAATCTG GGTACCTGAA 
GGAGAAACTG TGAAAATCCC TGTGGCTATT AAGATCCTCA ATGAGACAAC TGGCCCCAAA 
GCCAATGTGG AGTTCATGGA TGAGGCACTG ATTATGGCAA GTGTGGATCA CCCACACCTA 
GTGCGTTTAC TGGGTGTGTG TTTGAGCCCC ACTATCCAGT TGGTTACTCA GTTGATGCCA 
CATGGCTGCC TACTGGAATA TGTCCACGAA CACAAGGATA ACATCGGATC ACAACTGCTG 
TTGAACTGGT GTGTCCAGAT TGCTAAGGGA ATGATGTATC TGGAGGAAAG GCGGCTTGTT 
CATCGGGATC TGGCAGCCCG CAATGTGTTG GTGAAATCTC CAAATCATGT TAAAATCACA 
GACTTTGGAC TGGCCCGGCT CTTGGAAGGA GATGAAAAAG AATACAATGC TGACGGTGGC 
AAGATGCCAA TTAAATGGAT GGCTCTGGAA TGTATACATT ATAGGAAATT CACACATCAA 
AGCGATGTTT GGAGCTACGG TGTCACTATA TGGGAACTGA TGACCTTTGG AGGAAAGCCC 
TATGATGGAA TTCCAACGCG AGAAATCCCT GATTTATTAG AGAAGGGAGA GCGTTTGCCT 
CAACCTCCCA TCTGCACTAT TGACGTTTAC ATCGTCATGG TCAAATGTTG GATGATCGAT 
GCTGACAGCA GACCTAAATT CAAAGAACTG GCTGCTGAGT TTTCAAGGAT GGCTAGAGAC 
CCTCAAAGAT ACCTAGTAAT TCAGGGGGAT GATCGCATGA AGCTTCCCAG TCCAAACGAC 
AGCAAATTCT TCCAGAATCT CTTGGATGAA GAGGATTTGG AAGATATGAT GGACGCTGAG 
GAATATTTGG TCCCCCAGGC TTTCAATATC CCACCTCCTA TCTACACATC CAGAACAAGA 
ATTGACTCCA ATAGGAGTGA AATTGGACAC AGCCCTCCTC CTGCCTACAC CCCCATGTCG 
GGAAGTCAGT TTGTGTACCA GGATGGGGGT TTCGCTACAC AACAAGGAAT GCCCATGCCC 
TACACAGCCA CAACCAGCAC CATACCAGAG GCTCCAGTCG CCCAGGGTGC AACGGCTGAG 
ATGTTTGATG ACTCCTGCTG TAATGGTACC CTGCGAAAGC CAGTGGTACC CCACGTCCAA 
GAGGACAGTA GCACTCAGAG GTATAGTGCC GACCCCACAG TGTTCGCCCC AGAACGGAAC 
CCACGAGCAG AACTGGATGA AGAAGGCTAC ATGACTCCCA TGCATGACAA GCCAAAACAA 
GAATATCTGA ATCCTGTGGA AGAGAACCCT TTTGTGTCCC GGAGGAAGAA TGGAGACCTT 
CAAGCTTTAG ATAATCCAGA GTATCACAGC GCTTCCAGCG GTCCCCCCAA GGCAGAGGAT 
GAGTACGTGA ATGAGCCCCT TTATCTCAAC ACCTTCACCA ACGCCTTGGG AAATGCAGAG 
TACATGAAAA ACAGCTTACT GTCTGTGCCA GAGAAAGCCA AGAAAGCATT TGACAACCCC 
GACTACTGGA ACCACAGCCT GCCACCCCGG AGCACTCTTC AGCACCCAGA CTACCTGCAG 
GAATACAGCA CAAAATATTT TTATAAACAG AATGGACGGA TCCGCCCTAT TGTGGCAGAG 
AATCCTGAGT ACCTCTCAGA GTTCTCGCTG AAGCCAGGCA CTATGCTGCC CCCTCCGCCC 
TACAGACACC GGAATACTGT GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067719.1
CDS	34..3960
Translation	MKLATGLWVWGSLLVAARTVQPSASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNMTLVSTIGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIDAIDPEKLNVFRTVREITGFLNIQTWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTVNQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDVLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYIVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIGHSPPPAYTPMSGSQFVYQDGGFATQQGMPMPYTATTSTIPEAPVAQGATAEMFDDSCCNGTLRKPVVPHVQEDSSTQRYSADPTVFAPERNPRAELDEEGYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHSASSGPPKAEDEYVNEPLYLNTFTNALGNAEYMKNSLLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTMLPPPPYRHRNTVV

Target ORF information:

RefSeq Version	NM_021687.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus erb-b2 receptor tyrosine kinase 4 (Erbb4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021687.1

ORF Insert Sequence:

ATGAAGCTGG CGACGGGACT GTGGGTCTGG GGGAGCCTTC TGGTGGCAGC CAGGACCGTC 
CAGCCCAGCG CTTCTCAGTC AGTGTGTGCC GGAACAGAGA ACAAACTGAG CTCTCTCTCT 
GATCTGGAGC AGCAGTACCG AGCCTTGCGC AAATACTATG AAAACTGCGA GGTAGTCATG 
GGCAACCTGG AGATCACCAG CATAGAGCAC AACCGGGACC TCTCCTTCCT GCGGTCTATC 
CGAGAAGTCA CAGGCTATGT ACTTGTGGCC CTCAACCAGT TTCGTTACCT GCCTCTGGAG 
AATTTACGCA TTATTCGTGG GACAAAACTG TATGAAGATC GCTATGCCTT AGCAATATTC 
TTAAACTACA GGAAAGATGG CAACTTTGGA CTTCAAGAAC TGGGATTAAA GAACCTGACC 
GAAATACTAA ATGGTGGAGT CTATGTAGAC CAGAACAAAT TCCTATGTTA TGCTGATACT 
ATACACTGGC AAGATATTGT TCGGAATCCA TGGCCTTCCA ACATGACTCT GGTGTCAACA 
ATTGGAAGTT CTGGATGCGG AAGATGCCAT AAGTCTTGCA CTGGTCGATG CTGGGGACCC 
ACAGAAAATC ACTGCCAGAC CTTGACAAGG ACTGTGTGTG CAGAACAATG TGATGGCAGG 
TGCTATGGAC CCTACGTCAG TGACTGCTGC CATCGAGAAT GTGCCGGAGG CTGCTCAGGA 
CCAAAAGACA CTGACTGCTT TGCCTGCATG AACTTCAATG ACAGTGGAGC ATGTGTTACT 
CAGTGTCCCC AAACGTTCGT CTACAATCCA ACCACCTTTC AACTGGAACA CAACTTCAAT 
GCAAAGTACA CATATGGAGC ATTCTGTGTT AAGAAATGTC CACATAACTT CGTGGTAGAT 
TCCAGTTCTT GTGTACGAGC CTGCCCTAGT TCCAAGATGG AAGTCGAAGA AAATGGAATT 
AAAATGTGTA AGCCTTGCAC TGATATTTGC CCCAAAGCAT GTGATGGAAT CGGCACCGGA 
TCCTTGATGT CTGCTCAGAC TGTGGATTCC AGTAACATTG ACAAATTCAT AAACTGCACC 
AAGATCAACG GGAATCTCAT CTTTCTTGTC ACTGGCATTC ATGGGGACCC TTACAATGCT 
ATTGACGCCA TAGACCCAGA GAAACTGAAT GTCTTTCGGA CAGTCAGAGA AATAACAGGT 
TTCCTGAACA TACAGACTTG GCCCCCAAAT ATGACAGATT TCAGTGTTTT CTCCAACCTT 
GTAACCATTG GAGGAAGAGT CCTCTACAGT GGTCTGTCAT TGCTTATCCT CAAACAACAA 
GGTATCACTT CACTACAGTT CCAGTCTCTG AAGGAAATCA GTGCGGGCAA TATCTACATC 
ACGGACAACA GCAACCTGTG TTATTACCAC ACCATCAACT GGACAACACT GTTCAGCACC 
GTTAACCAGA GGATAGTGAT CCGAGACAAC AGGAGGGCTG AGAACTGTAC TGCTGAAGGG 
ATGGTGTGTA ACCACCTGTG TTCAAATGAT GGTTGTTGGG GACCTGGGCC AGACCAGTGT 
CTGTCATGTC GGCGCTTCAG CAGGGGAAAG ATCTGTATAG AGTCCTGCAA CCTTTATGAT 
GGGGAGTTTC GAGAGTTTGA AAATGGCTCC ATCTGTGTTG AGTGTGACTC CCAGTGTGAG 
AAAATGGAAG ACGGACTCCT CACATGCCAT GGACCGGGAC CTGACAACTG TACAAAGTGT 
TCTCATTTTA AAGATGGTCC AAACTGTGTA GAGAAATGTC CAGATGTCCT ACAGGGAGCA 
AACAGTTTCA TATTTAAGTA CGCAGATCAG GATCGGGAGT GCCACCCTTG CCATCCAAAC 
TGCACCCAGG GGTGTAACGG TCCCACTAGT CATGACTGCA TTTACTACCC ATGGACGGGC 
CATTCCACTT TACCACAACA TGCTAGAACT CCACTGATTG CAGCCGGAGT CATTGGTGGG 
CTCTTCATCC TGGTCATCAT GGCTCTGACA TTTGCCGTTT ATGTCAGAAG GAAGAGCATC 
AAAAAGAAAC GCGCTTTGAG AAGATTCCTG GAGACCGAGT TAGTCGAGCC CTTAACCCCT 
AGTGGCACAG CACCCAATCA AGCTCAACTT CGAATTTTGA AGGAAACAGA GCTAAAGAGG 
GTAAAAGTCC TTGGCTCGGG AGCATTTGGA ACCGTTTATA AAGGAATCTG GGTACCTGAA 
GGAGAAACTG TGAAAATCCC TGTGGCTATT AAGATCCTCA ATGAGACAAC TGGCCCCAAA 
GCCAATGTGG AGTTCATGGA TGAGGCACTG ATTATGGCAA GTGTGGATCA CCCACACCTA 
GTGCGTTTAC TGGGTGTGTG TTTGAGCCCC ACTATCCAGT TGGTTACTCA GTTGATGCCA 
CATGGCTGCC TACTGGAATA TGTCCACGAA CACAAGGATA ACATCGGATC ACAACTGCTG 
TTGAACTGGT GTGTCCAGAT TGCTAAGGGA ATGATGTATC TGGAGGAAAG GCGGCTTGTT 
CATCGGGATC TGGCAGCCCG CAATGTGTTG GTGAAATCTC CAAATCATGT TAAAATCACA 
GACTTTGGAC TGGCCCGGCT CTTGGAAGGA GATGAAAAAG AATACAATGC TGACGGTGGC 
AAGATGCCAA TTAAATGGAT GGCTCTGGAA TGTATACATT ATAGGAAATT CACACATCAA 
AGCGATGTTT GGAGCTACGG TGTCACTATA TGGGAACTGA TGACCTTTGG AGGAAAGCCC 
TATGATGGAA TTCCAACGCG AGAAATCCCT GATTTATTAG AGAAGGGAGA GCGTTTGCCT 
CAACCTCCCA TCTGCACTAT TGACGTTTAC ATCGTCATGG TCAAATGTTG GATGATCGAT 
GCTGACAGCA GACCTAAATT CAAAGAACTG GCTGCTGAGT TTTCAAGGAT GGCTAGAGAC 
CCTCAAAGAT ACCTAGTAAT TCAGGGGGAT GATCGCATGA AGCTTCCCAG TCCAAACGAC 
AGCAAATTCT TCCAGAATCT CTTGGATGAA GAGGATTTGG AAGATATGAT GGACGCTGAG 
GAATATTTGG TCCCCCAGGC TTTCAATATC CCACCTCCTA TCTACACATC CAGAACAAGA 
ATTGACTCCA ATAGGAGTGA AATTGGACAC AGCCCTCCTC CTGCCTACAC CCCCATGTCG 
GGAAGTCAGT TTGTGTACCA GGATGGGGGT TTCGCTACAC AACAAGGAAT GCCCATGCCC 
TACACAGCCA CAACCAGCAC CATACCAGAG GCTCCAGTCG CCCAGGGTGC AACGGCTGAG 
ATGTTTGATG ACTCCTGCTG TAATGGTACC CTGCGAAAGC CAGTGGTACC CCACGTCCAA 
GAGGACAGTA GCACTCAGAG GTATAGTGCC GACCCCACAG TGTTCGCCCC AGAACGGAAC 
CCACGAGCAG AACTGGATGA AGAAGGCTAC ATGACTCCCA TGCATGACAA GCCAAAACAA 
GAATATCTGA ATCCTGTGGA AGAGAACCCT TTTGTGTCCC GGAGGAAGAA TGGAGACCTT 
CAAGCTTTAG ATAATCCAGA GTATCACAGC GCTTCCAGCG GTCCCCCCAA GGCAGAGGAT 
GAGTACGTGA ATGAGCCCCT TTATCTCAAC ACCTTCACCA ACGCCTTGGG AAATGCAGAG 
TACATGAAAA ACAGCTTACT GTCTGTGCCA GAGAAAGCCA AGAAAGCATT TGACAACCCC 
GACTACTGGA ACCACAGCCT GCCACCCCGG AGCACTCTTC AGCACCCAGA CTACCTGCAG 
GAATACAGCA CAAAATATTT TTATAAACAG AATGGACGGA TCCGCCCTAT TGTGGCAGAG 
AATCCTGAGT ACCTCTCAGA GTTCTCGCTG AAGCCAGGCA CTATGCTGCC CCCTCCGCCC 
TACAGACACC GGAATACTGT GGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High glucose forces a positive feedback loop connecting ErbB4 expression and mTOR/S6K pathway to aggravate the formation of tau hyperphosphorylation in differentiated SH-SY5Y cells.
Neurobiology of aging67171-180(2018 07)
Nie SD,Li X,Tang CE,Min FY,Shi XJ,Wu LY,Zhou SL,Chen Z,Wu J,Song T,Dai ZJ,Zheng J,Liu JJ,Wang S

The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.
Theranostics8(14)3977-3990(2018)
Pankratova S,Klingelhofer J,Dmytriyeva O,Owczarek S,Renziehausen A,Syed N,Porter AE,Dexter DT,Kiryushko D

ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage.
Experimental neurology29792-100(2017 11)
Yan F,Tan X,Wan W,Dixon BJ,Fan R,Enkhjargal B,Li Q,Zhang J,Chen G,Zhang JH

The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response.
Cell transplantation25(1)55-69(2016)
Siltanen A,Nuutila K,Imanishi Y,Uenaka H,Mäkelä J,Pätilä T,Vento A,Miyagawa S,Sawa Y,Harjula A,Kankuri E

A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Nature communications67222(2015 Jun)
Vullhorst D,Mitchell RM,Keating C,Roychowdhury S,Karavanova I,Tao-Cheng JH,Buonanno A

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Erbb4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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