Ago2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ago2
Entrez Gene ID	59117
Full Name	argonaute 2, RISC catalytic component
Synonyms	Eif2c2
General protein information	Preferred Names argonaute 2, RISC catalytic component Names protein argonaute-2 GERp95 argonaute RISC catalytic component 2 argonaute2 eIF-2C 2 eIF2C 2 eukaryotic translation initiation factor 2C 2 golgi ER protein 95 kDa
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	may have important roles in development and exert the effects on cell differentiation from the level of intracellular membranes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_021597.1	NP_067608.1	protein argonaute-2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	ago2	NP_001004877.1
Pan troglodytes (chimpanzee)	EIF2C2	XP_001142838.1
Rattus norvegicus (Norway rat)	Ago2	NP_067608.1
Drosophila melanogaster (fruit fly)	AGO1	NP_001246314.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011717	XP_320795.4
Homo sapiens (human)	AGO2	NP_036286.2
Canis lupus familiaris (dog)	AGO2	XP_005628049.1
Bos taurus (cattle)	EIF2C2	NP_991363.1
Danio rerio (zebrafish)	LOC570630	XP_699226.2
Mus musculus (house mouse)	Ago2	NP_694818.3
Caenorhabditis elegans (roundworm)	alg-1	NP_001257238.1
Arabidopsis thaliana (thale cress)	AGO5	NP_850110.1
Macaca mulatta (Rhesus monkey)	LOC711873	XP_001100725.2
Caenorhabditis elegans (roundworm)	alg-2	NP_871992.1
Gallus gallus (chicken)	LOC100858102	XP_004940122.1

Gene Ontology
Bibliography

Related articles in PubMed

Posttranscriptional regulation of cyclin D1 by ARE-binding proteins AUF1 and HuR in cycling myoblasts.
Ghosh U, Adhya S
Journal of biosciences43(4)685-691(2018 Sep)

NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.
Paradis-Isler N, Boehm J
The Journal of biological chemistry293(24)9311-9325(2018 06)

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.
Beltrami C, Besnier M, Shantikumar S, Shearn AI, Rajakaruna C, Laftah A, Sessa F, Spinetti G, Petretto E, Angelini GD, Emanueli C
Molecular therapy : the journal of the American Society of Gene Therapy25(3)679-693(2017 03)

miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and in a model of angiogenesis defects related to inflammation.
Yang M, Chen Y, Chen L, Wang K, Pan T, Liu X, Xu W
Placenta4162-73(2016 05)

Argonaute2 Protein in Rat Spermatogenic Cells Is Localized to Nuage Structures and LAMP2-Positive Vesicles Surrounding Chromatoid Bodies.
Fujii Y, Onohara Y, Fujita H, Yokota S
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society64(4)268-79(2016 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ago2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ago2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04942	NM_021597.1 Latest version!	Rattus norvegicus argonaute RISC catalytic component 2 (Ago2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ago2 ( NM_021597.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_067608.1 Rattus norvegicus argonaute RISC catalytic component 2 (Ago2), mRNA.

Price & Availability↑

CloneID	ORa04942
Clone ID Related Accession (Same CDS sequence)	NM_021597.1
Accession Version	NM_021597.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2592bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564761600000
Organism	Rattus norvegicus(Norway rat)
Product	protein argonaute-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF195534.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF195534.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906353 [ECO:0000348] ##Evidence-Data-END##

ATGTTACCCA TGTACTCGGG AGCCGGCCCC GTTCTTGCGT CTCCTGCTCC GACAACATCA 
CCCATCCCAG GATATGCCTT CAAGCCTCCA CCTCGGCCGG ATTTCGGCAC CACCGGGAGA 
ACAATCAAAC TACAGGCCAA TTTCTTTGAA ATGGACATCC CCAAAATTGA CATCTATCAC 
TATGAATTGG ACATCAAACC TGAGAAATGC CCTCGGAGAG TGAACAGGGA AATAGTGGAG 
CATATGGTCC AGCACTTTAA AACCCAGATC TTCGGGGACC GGAAGCCAGT GTTTGATGGA 
CGGAAGAATC TGTACACAGC TATGCCCCTT CCAATTGGCA GGGACAAGGT GGAACTGGAG 
GTCACGCTGC CAGGAGAAGG CAAAGATCGC ATCTTCAAGG TATCCATCAA GTGGGTATCC 
TGCGTGAGCT TGCAGGCGTT ACACGATGCA CTTTCGGGGC GGCTGCCCAG CGTCCCCTTC 
GAGACGATCC AGGCCCTGGA CGTTGTCATG AGGCACTTGC CATCCATGAG GTACACCCCT 
GTTGGCCGTT CCTTCTTCAC TGCATCGGAA GGCTGTTCCA ACCCTCTGGG AGGGGGCAGA 
GAAGTGTGGT TTGGCTTCCA TCAGTCCGTC CGACCTTCTC TTTGGAAAAT GATGCTGAAC 
ATCGATGTAT CAGCAACAGC ATTTTACAAG GCACAGCCAG TGATCGAGTT TGTTTGTGAA 
GTGTTGGATT TTAAAAGTAT TGAAGAACAA CAAAAACCTC TGACAGATTC CCAAAGGGTA 
AAGTTTACCA AAGAAATTAA AGGTCTAAAG GTGGAGATAA CGCACTGTGG TCAGATGAAG 
AGGAAATACC GTGTCTGCAA TGTGACCCGG CGGCCTGCCA GTCACCAAAC GTTCCCACTG 
CAGCAGGAGA GTGGGCAGAC AGTGGAGTGT ACAGTGGCTC AGTACTTCAA GGACAGGCAC 
AAGCTGGTTT TGCGCTACCC CCACCTCCCA TGTTTACAAG TTGGACAAGA GCAGAAACAC 
ACCTACCTTC CTTTGGAGGT CTGTAACATA GTTGCTGGAC AGAGATGTAT AAAAAAATTA 
ACAGACAATC AGACCTCAAC CATGATCAGA GCAACTGCCA GGTCAGCACC CGATCGGCAA 
GAGGAGATCA GCAAATTGAT GCGAAGTGCA AGTTTCAATA CAGACCCGTA TGTTCGTGAA 
TTTGGGATCA TGGTGAAAGA TGAGATGACA GATGTGACAG GACGGGTTCT GCAGCCGCCC 
TCCATCCTCT ACGGGGGCAG GAACAAAGCG ATTGCCACCC CTGTCCAGGG TGTGTGGGAC 
ATGAGAAACA AGCAGTTCCA CACGGGCATC GAGATCAAGG TGTGGGCCAT CGCCTGCTTT 
GCACCCCAGC GCCAGTGTAC AGAAGTCCAT CTCAAGTCCT TCACAGAGCA ACTGAGGAAG 
ATCTCAAGAG ATGCTGGGAT GCCTATCCAG GGTCAGCCCT GCTTCTGTAA ATACGCACAG 
GGGGCAGACA GTGTGGAACC CATGTTCCGA CACCTGAAGA ACACATACGC TGGTCTCCAG 
CTGGTGGTGG TTATCCTGCC TGGCAAGACT CCTGTGTACG CGGAAGTCAA GCGTGTGGGA 
GACACGGTGC TGGGCATGGC CACGCAGTGT GTCCAGATGA AGAACGTGCA GAGGACCACG 
CCACAGACCC TATCCAATCT CTGCTTAAAG ATCAATGTCA AACTGGGAGG AGTCAACAAC 
ATCCTGCTGC CACAGGGCAG GCCTCCAGTG TTCCAGCAGC CTGTCATCTT CCTGGGAGCC 
GATGTCACCC ACCCACCAGC TGGGGATGGG AAGAAACCTT CAATTGCTGC CGTCGTGGGC 
AGCATGGACG CACACCCCAA CCGCTACTGT GCCACCGTGC GCGTACAGCA GCACCGACAG 
GAGATCATCC AGGACCTGGC TGCTATGGTG CGAGAGCTGC TCATTCAGTT CTACAAATCT 
ACACGCTTCA AGCCCACCCG CATCATCTTC TACCGAGACG GCGTCTCTGA GGGCCAGTTC 
CAGCAGGTTC TTCACCATGA GCTCCTGGCC ATCAGAGAGG CCTGCATAAA GCTGGAGAAG 
GAATATCAGC CAGGGATCAC ATTCATCGTG GTGCAGAAGC GGCACCACAC ACGTCTCTTC 
TGCACAGACA AGAATGAGCG GGTTGGAAAG AGTGGGAACA TCCCAGCAGG CACAACCGTC 
GACACAAAGA TCACCCACCC AACTGAGTTT GACTTCTACC TGTGCAGTCA TGCTGGCATC 
CAGGGGACAA GCCGTCCTTC CCACTACCAC GTGCTCTGGG ATGACAATCG TTTCTCTTCT 
GATGAGCTTC AGATTCTGAC CTACCAGCTG TGTCACACCT ACGTGCGCTG CACACGCTCT 
GTGTCAATTC CTGCGCCAGC TTACTATGCC CACCTGGTGG CCTTCCGAGC CAGGTACCAC 
CTGGTGGATA AAGAACATGA CAGCGCTGAA GGAAGCCATA CCTCTGGGCA GAGCAACGGG 
CGAGATCACC AGGCGCTGGC CAAGGCGGTC CAGGTCCACC AGGACACACT GCGCACCATG 
TACTTTGCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067608.1
CDS	1..2592
Translation	MLPMYSGAGPVLASPAPTTSPIPGYAFKPPPRPDFGTTGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKEYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA

Target ORF information:

RefSeq Version	NM_021597.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus argonaute RISC catalytic component 2 (Ago2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021597.1

ORF Insert Sequence:

ATGTTACCCA TGTACTCGGG AGCCGGCCCC GTTCTTGCGT CTCCTGCTCC GACAACATCA 
CCCATCCCAG GATATGCCTT CAAGCCTCCA CCTCGGCCGG ATTTCGGCAC CACCGGGAGA 
ACAATCAAAC TACAGGCCAA TTTCTTTGAA ATGGACATCC CCAAAATTGA CATCTATCAC 
TATGAATTGG ACATCAAACC TGAGAAATGC CCTCGGAGAG TGAACAGGGA AATAGTGGAG 
CATATGGTCC AGCACTTTAA AACCCAGATC TTCGGGGACC GGAAGCCAGT GTTTGATGGA 
CGGAAGAATC TGTACACAGC TATGCCCCTT CCAATTGGCA GGGACAAGGT GGAACTGGAG 
GTCACGCTGC CAGGAGAAGG CAAAGATCGC ATCTTCAAGG TATCCATCAA GTGGGTATCC 
TGCGTGAGCT TGCAGGCGTT ACACGATGCA CTTTCGGGGC GGCTGCCCAG CGTCCCCTTC 
GAGACGATCC AGGCCCTGGA CGTTGTCATG AGGCACTTGC CATCCATGAG GTACACCCCT 
GTTGGCCGTT CCTTCTTCAC TGCATCGGAA GGCTGTTCCA ACCCTCTGGG AGGGGGCAGA 
GAAGTGTGGT TTGGCTTCCA TCAGTCCGTC CGACCTTCTC TTTGGAAAAT GATGCTGAAC 
ATCGATGTAT CAGCAACAGC ATTTTACAAG GCACAGCCAG TGATCGAGTT TGTTTGTGAA 
GTGTTGGATT TTAAAAGTAT TGAAGAACAA CAAAAACCTC TGACAGATTC CCAAAGGGTA 
AAGTTTACCA AAGAAATTAA AGGTCTAAAG GTGGAGATAA CGCACTGTGG TCAGATGAAG 
AGGAAATACC GTGTCTGCAA TGTGACCCGG CGGCCTGCCA GTCACCAAAC GTTCCCACTG 
CAGCAGGAGA GTGGGCAGAC AGTGGAGTGT ACAGTGGCTC AGTACTTCAA GGACAGGCAC 
AAGCTGGTTT TGCGCTACCC CCACCTCCCA TGTTTACAAG TTGGACAAGA GCAGAAACAC 
ACCTACCTTC CTTTGGAGGT CTGTAACATA GTTGCTGGAC AGAGATGTAT AAAAAAATTA 
ACAGACAATC AGACCTCAAC CATGATCAGA GCAACTGCCA GGTCAGCACC CGATCGGCAA 
GAGGAGATCA GCAAATTGAT GCGAAGTGCA AGTTTCAATA CAGACCCGTA TGTTCGTGAA 
TTTGGGATCA TGGTGAAAGA TGAGATGACA GATGTGACAG GACGGGTTCT GCAGCCGCCC 
TCCATCCTCT ACGGGGGCAG GAACAAAGCG ATTGCCACCC CTGTCCAGGG TGTGTGGGAC 
ATGAGAAACA AGCAGTTCCA CACGGGCATC GAGATCAAGG TGTGGGCCAT CGCCTGCTTT 
GCACCCCAGC GCCAGTGTAC AGAAGTCCAT CTCAAGTCCT TCACAGAGCA ACTGAGGAAG 
ATCTCAAGAG ATGCTGGGAT GCCTATCCAG GGTCAGCCCT GCTTCTGTAA ATACGCACAG 
GGGGCAGACA GTGTGGAACC CATGTTCCGA CACCTGAAGA ACACATACGC TGGTCTCCAG 
CTGGTGGTGG TTATCCTGCC TGGCAAGACT CCTGTGTACG CGGAAGTCAA GCGTGTGGGA 
GACACGGTGC TGGGCATGGC CACGCAGTGT GTCCAGATGA AGAACGTGCA GAGGACCACG 
CCACAGACCC TATCCAATCT CTGCTTAAAG ATCAATGTCA AACTGGGAGG AGTCAACAAC 
ATCCTGCTGC CACAGGGCAG GCCTCCAGTG TTCCAGCAGC CTGTCATCTT CCTGGGAGCC 
GATGTCACCC ACCCACCAGC TGGGGATGGG AAGAAACCTT CAATTGCTGC CGTCGTGGGC 
AGCATGGACG CACACCCCAA CCGCTACTGT GCCACCGTGC GCGTACAGCA GCACCGACAG 
GAGATCATCC AGGACCTGGC TGCTATGGTG CGAGAGCTGC TCATTCAGTT CTACAAATCT 
ACACGCTTCA AGCCCACCCG CATCATCTTC TACCGAGACG GCGTCTCTGA GGGCCAGTTC 
CAGCAGGTTC TTCACCATGA GCTCCTGGCC ATCAGAGAGG CCTGCATAAA GCTGGAGAAG 
GAATATCAGC CAGGGATCAC ATTCATCGTG GTGCAGAAGC GGCACCACAC ACGTCTCTTC 
TGCACAGACA AGAATGAGCG GGTTGGAAAG AGTGGGAACA TCCCAGCAGG CACAACCGTC 
GACACAAAGA TCACCCACCC AACTGAGTTT GACTTCTACC TGTGCAGTCA TGCTGGCATC 
CAGGGGACAA GCCGTCCTTC CCACTACCAC GTGCTCTGGG ATGACAATCG TTTCTCTTCT 
GATGAGCTTC AGATTCTGAC CTACCAGCTG TGTCACACCT ACGTGCGCTG CACACGCTCT 
GTGTCAATTC CTGCGCCAGC TTACTATGCC CACCTGGTGG CCTTCCGAGC CAGGTACCAC 
CTGGTGGATA AAGAACATGA CAGCGCTGAA GGAAGCCATA CCTCTGGGCA GAGCAACGGG 
CGAGATCACC AGGCGCTGGC CAAGGCGGTC CAGGTCCACC AGGACACACT GCGCACCATG 
TACTTTGCTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Posttranscriptional regulation of cyclin D1 by ARE-binding proteins AUF1 and HuR in cycling myoblasts.
Journal of biosciences43(4)685-691(2018 Sep)
Ghosh U,Adhya S

NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.
The Journal of biological chemistry293(24)9311-9325(2018 06)
Paradis-Isler N,Boehm J

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.
Molecular therapy : the journal of the American Society of Gene Therapy25(3)679-693(2017 03)
Beltrami C,Besnier M,Shantikumar S,Shearn AI,Rajakaruna C,Laftah A,Sessa F,Spinetti G,Petretto E,Angelini GD,Emanueli C

miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and in a model of angiogenesis defects related to inflammation.
Placenta4162-73(2016 05)
Yang M,Chen Y,Chen L,Wang K,Pan T,Liu X,Xu W

Argonaute2 Protein in Rat Spermatogenic Cells Is Localized to Nuage Structures and LAMP2-Positive Vesicles Surrounding Chromatoid Bodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society64(4)268-79(2016 04)
Fujii Y,Onohara Y,Fujita H,Yokota S

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Ago2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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