Plk3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plk3
Entrez Gene ID	58936
Full Name	polo-like kinase 3
Synonyms	Cnk,Fnk
General protein information	Preferred Names polo-like kinase 3 Names serine/threonine-protein kinase PLK3 FGF-inducible kinase PLK-3 cytokine inducible kinase cytokine-inducible serine/threonine-protein kinase serine-threonine kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	cell cycle associated kinase; may be involved in long-term synaptic plasticity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022187.1	NP_071523.1	serine/threonine-protein kinase PLK3

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	PLK3	XP_001099497.1
Mus musculus (house mouse)	Plk3	NP_038835.2
Gallus gallus (chicken)	PLK3	XP_004936781.1
Homo sapiens (human)	PLK3	NP_004064.2
Canis lupus familiaris (dog)	PLK3	XP_532604.2
Bos taurus (cattle)	PLK3	NP_001068621.1
Xenopus tropicalis (tropical clawed frog)	plk3	NP_001006766.1
Rattus norvegicus (Norway rat)	Plk3	NP_071523.1
Danio rerio (zebrafish)	plk3	NP_958465.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Wang H, Tian C, Sun J, Chen LN, Lv Y, Yang XD, Xiao K, Wang J, Chen C, Shi Q, Shao QX, Dong XP
Molecular neurobiology54(6)4401-4413(2017 08)

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.
Wang J, Beauchemin M, Bertrand R
Cellular signalling23(12)2030-8(2011 Dec)

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.
Myer DL, Robbins SB, Yin M, Boivin GP, Liu Y, Greis KD, Bahassi el M, Stambrook PJ
Mutation research714(1-2)1-10(2011 Sep)

Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma.
Weichert W, Denkert C, Schmidt M, Gekeler V, Wolf G, Köbel M, Dietel M, Hauptmann S
British journal of cancer90(4)815-21(2004 Feb)

Targeted protein degradation and synapse remodeling by an inducible protein kinase.
Pak DT, Sheng M
Science (New York, N.Y.)302(5649)1368-73(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Plk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05386	NM_022187.1 Latest version!	Rattus norvegicus polo-like kinase 3 (Plk3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plk3 ( NM_022187.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071523.1 Rattus norvegicus polo-like kinase 3 (Plk3), mRNA.

Price & Availability↑

CloneID	ORa05386
Clone ID Related Accession (Same CDS sequence)	NM_022187.1
Accession Version	NM_022187.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase PLK3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC119459.6. On or before Oct 25, 2008 this sequence version replaced XM_342888.3, XM_001071757.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF136584.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCG CCGCCGGCTT CTTGTCCCCG CGCCCCTTCC CGCGCGCGGC TGCTCCGTCC 
TCGCCCCCCG CCGGTCCGGG GCCGCCCGCC AGTGCCTCCC CACGGTCGGA ACCTGGGGTG 
CTGGCCGGGC CACAGACGCC GGATGCCAGT CGCCTCATCA CCGACCCTCG CAGCGGCCGT 
ACCTACATCA AGGGTCGCTT GTTGGGCAAG GGGGGCTTCG CTCGCTGCTA TGAAGCCACT 
GACACTGAGA CTAGTATAGC CTACGCGGTC AAAGTCATCC CGCAGAGTCG CGTCGCCAAG 
CCGCATCAGC GCGAGAAGAT CATAAACGAG ATAGAGTTGC ACCGAGACCT ACAGCACCGC 
CATATCGTTC GATTTTCGCA TCATTTCGAG GATGCTGACA ACATATATAT TTTCCTGGAG 
CTCTGTAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GTCACACCCT ACTGGAACCA 
GAGGTTCGCT ACTACCTGCG CCAGATTCTT TCTGGTCTCA AGTACTTGCA CCAGAGGGGT 
ATCTTGCACA GAGATCTCAA GCTGGGAAAT TTTTTCATCA CTGATAACAT GGAACTGAAG 
GTGGGAGATT TTGGGCTGGC AGCTCGGCTA GAGCCTCCAG AGCAGAGGAA AAAGACCATC 
TGTGGTACTC CCAACTATGT GGCCCCAGAA GTGCTGCTGA GGCAGGGCCA TGGCCCCGAG 
GCAGATGTGT GGTCCCTTGG TTGTGTCATG TACACACTCC TGTGTGGGAG CCCCCCGTTT 
GAGACAGCTG ACCTAAAGGA GACCTATCGC TGCATCAAGC AGGTTCATTA CACACTGCCT 
GCCAGCCTCT CACTGCCTGC CCGCCAGCTC CTGGCTGCCA TCCTTCGAGC TTCACCCCGA 
GACCGCCCTT CCATTGAGCA GATCCTGCGC CATGACTTCT TTACAAAGGG CTACACCCCT 
GATCGGCTCC CTGTCAGCAG CTGTGTGACA GTCCCAGATC TGACACCCCC CAACCCTGCG 
AGGAGTCTGT TTGCTAAAGT TACCAAGAGC CTGTTTGGCA GGAGAAAGAG CAAGAATAAG 
AACCATTCTG AGGAACAGGA TAATGTCTCC TGCTTGGTGA GCGGCCTCAT GCGCACATCC 
ATCGGTCATC CAGATGTCAG GCCGGAGGCT CCAGCAGCCT CAGCTCTGGC CCCTGTCAGC 
TTGGTAGAGA CAGCTGCTGA GGACAGCTCA CCCCGTGGGA CACTGGCAAG CAGTGGAGAT 
GGATTTGAAG AAGGTTTGAC TGTGACCACG GTGGTGGAGT CTGCCCTCTG TGCACTGAGA 
AACTGTGTGG CCTTCATGCC CCCAGCTGAA CAGAACCCAG CCCCGTTGGC ACAGCCAGAG 
CCTCTGGTGT GGGTCAGCAA GTGGGTTGAC TACTCCAACA AGTTTGGCTT TGGCTATCAG 
CTGTCCAGCC GCCGTGTAGC CGTGCTCTTC AATGACGGCA CACACATGGC CCTGTCAGCC 
AATAGGAAGA CTGTGCACTA CAACCCCACC AGCACGAAGC ACTTCTCTTT CTCTGTGGGT 
TCTGTGCCCC GTGCTCTGCA GCCTCAGCTG GGCATCCTCC GGTATTTCGC CTCCTACATG 
GAGCAGCACC TCATGAAGGG TGGAGATCTG CCCAGTGTGG AGGAGGTAGA GGTCCCTGCC 
CCACCCTTGC TGCTGCAGTG GGTCAAGACG GACCAGGCCC TTCTCATGCT GTTCAGTGAC 
GGCACTGTCC AGGTGAACTT CTACGGGGAC CATACGAAGC TGATCCTCAG TGGCTGGGAG 
CCTCTCCTCG TGACCTTCGT GGCCCGAAAT CGCAGTGCTT GTACTTACCT CGCCTCCCAC 
CTCCGGCAGC TGGGCTGCTC CCCAGACTTG CGGCAGCGAC TGCGCTATGC TCTGCGCCTG 
CTCAGGGACC GAAGCCCTGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071523.1
CDS	114..2057
Translation	MEPAAGFLSPRPFPRAAAPSSPPAGPGPPASASPRSEPGVLAGPQTPDASRLITDPRSGRTYIKGRLLGKGGFARCYEATDTETSIAYAVKVIPQSRVAKPHQREKIINEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKSLFGRRKSKNKNHSEEQDNVSCLVSGLMRTSIGHPDVRPEAPAASALAPVSLVETAAEDSSPRGTLASSGDGFEEGLTVTTVVESALCALRNCVAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGSVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA

Target ORF information:

RefSeq Version	NM_022187.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus polo-like kinase 3 (Plk3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022187.1

ORF Insert Sequence:

ATGGAGCCCG CCGCCGGCTT CTTGTCCCCG CGCCCCTTCC CGCGCGCGGC TGCTCCGTCC 
TCGCCCCCCG CCGGTCCGGG GCCGCCCGCC AGTGCCTCCC CACGGTCGGA ACCTGGGGTG 
CTGGCCGGGC CACAGACGCC GGATGCCAGT CGCCTCATCA CCGACCCTCG CAGCGGCCGT 
ACCTACATCA AGGGTCGCTT GTTGGGCAAG GGGGGCTTCG CTCGCTGCTA TGAAGCCACT 
GACACTGAGA CTAGTATAGC CTACGCGGTC AAAGTCATCC CGCAGAGTCG CGTCGCCAAG 
CCGCATCAGC GCGAGAAGAT CATAAACGAG ATAGAGTTGC ACCGAGACCT ACAGCACCGC 
CATATCGTTC GATTTTCGCA TCATTTCGAG GATGCTGACA ACATATATAT TTTCCTGGAG 
CTCTGTAGCC GAAAGTCCCT GGCCCACATC TGGAAGGCCC GTCACACCCT ACTGGAACCA 
GAGGTTCGCT ACTACCTGCG CCAGATTCTT TCTGGTCTCA AGTACTTGCA CCAGAGGGGT 
ATCTTGCACA GAGATCTCAA GCTGGGAAAT TTTTTCATCA CTGATAACAT GGAACTGAAG 
GTGGGAGATT TTGGGCTGGC AGCTCGGCTA GAGCCTCCAG AGCAGAGGAA AAAGACCATC 
TGTGGTACTC CCAACTATGT GGCCCCAGAA GTGCTGCTGA GGCAGGGCCA TGGCCCCGAG 
GCAGATGTGT GGTCCCTTGG TTGTGTCATG TACACACTCC TGTGTGGGAG CCCCCCGTTT 
GAGACAGCTG ACCTAAAGGA GACCTATCGC TGCATCAAGC AGGTTCATTA CACACTGCCT 
GCCAGCCTCT CACTGCCTGC CCGCCAGCTC CTGGCTGCCA TCCTTCGAGC TTCACCCCGA 
GACCGCCCTT CCATTGAGCA GATCCTGCGC CATGACTTCT TTACAAAGGG CTACACCCCT 
GATCGGCTCC CTGTCAGCAG CTGTGTGACA GTCCCAGATC TGACACCCCC CAACCCTGCG 
AGGAGTCTGT TTGCTAAAGT TACCAAGAGC CTGTTTGGCA GGAGAAAGAG CAAGAATAAG 
AACCATTCTG AGGAACAGGA TAATGTCTCC TGCTTGGTGA GCGGCCTCAT GCGCACATCC 
ATCGGTCATC CAGATGTCAG GCCGGAGGCT CCAGCAGCCT CAGCTCTGGC CCCTGTCAGC 
TTGGTAGAGA CAGCTGCTGA GGACAGCTCA CCCCGTGGGA CACTGGCAAG CAGTGGAGAT 
GGATTTGAAG AAGGTTTGAC TGTGACCACG GTGGTGGAGT CTGCCCTCTG TGCACTGAGA 
AACTGTGTGG CCTTCATGCC CCCAGCTGAA CAGAACCCAG CCCCGTTGGC ACAGCCAGAG 
CCTCTGGTGT GGGTCAGCAA GTGGGTTGAC TACTCCAACA AGTTTGGCTT TGGCTATCAG 
CTGTCCAGCC GCCGTGTAGC CGTGCTCTTC AATGACGGCA CACACATGGC CCTGTCAGCC 
AATAGGAAGA CTGTGCACTA CAACCCCACC AGCACGAAGC ACTTCTCTTT CTCTGTGGGT 
TCTGTGCCCC GTGCTCTGCA GCCTCAGCTG GGCATCCTCC GGTATTTCGC CTCCTACATG 
GAGCAGCACC TCATGAAGGG TGGAGATCTG CCCAGTGTGG AGGAGGTAGA GGTCCCTGCC 
CCACCCTTGC TGCTGCAGTG GGTCAAGACG GACCAGGCCC TTCTCATGCT GTTCAGTGAC 
GGCACTGTCC AGGTGAACTT CTACGGGGAC CATACGAAGC TGATCCTCAG TGGCTGGGAG 
CCTCTCCTCG TGACCTTCGT GGCCCGAAAT CGCAGTGCTT GTACTTACCT CGCCTCCCAC 
CTCCGGCAGC TGGGCTGCTC CCCAGACTTG CGGCAGCGAC TGCGCTATGC TCTGCGCCTG 
CTCAGGGACC GAAGCCCTGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Molecular neurobiology54(6)4401-4413(2017 08)
Wang H,Tian C,Sun J,Chen LN,Lv Y,Yang XD,Xiao K,Wang J,Chen C,Shi Q,Shao QX,Dong XP

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.
Cellular signalling23(12)2030-8(2011 Dec)
Wang J,Beauchemin M,Bertrand R

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.
Mutation research714(1-2)1-10(2011 Sep)
Myer DL,Robbins SB,Yin M,Boivin GP,Liu Y,Greis KD,Bahassi el M,Stambrook PJ

Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma.
British journal of cancer90(4)815-21(2004 Feb)
Weichert W,Denkert C,Schmidt M,Gekeler V,Wolf G,Köbel M,Dietel M,Hauptmann S

Targeted protein degradation and synapse remodeling by an inducible protein kinase.
Science (New York, N.Y.)302(5649)1368-73(2003 Nov)
Pak DT,Sheng M

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Plk3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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