Ywhag cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ywhag
Entrez Gene ID	56010
Full Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
Synonyms	14-3-3G
General protein information	Preferred Names tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma Names 14-3-3 protein gamma 14-3-3 protein gamma-subtype 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	belongs to the 14-3-3 family of proteins; mediates signal transduction via activation of protein kinase C and calcium/calmodulin-dependent protein kinase II [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019376.2	NP_062249.1	14-3-3 protein gamma
XM_006249184.3	XP_006249246.2	14-3-3 protein gamma isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	YWHAG	XP_519163.3
Macaca mulatta (Rhesus monkey)	YWHAG	XP_001109164.1
Bos taurus (cattle)	YWHAG	NP_777218.2
Gallus gallus (chicken)	YWHAG	NP_001026648.1
Homo sapiens (human)	YWHAG	NP_036611.2
Canis lupus familiaris (dog)	YWHAG	XP_005621043.1
Mus musculus (house mouse)	Ywhag	NP_061359.2
Rattus norvegicus (Norway rat)	Ywhag	NP_062249.1
Xenopus tropicalis (tropical clawed frog)	ywhag	NP_001072309.1

Gene Ontology
Bibliography

Related articles in PubMed

Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Otsuka S, Sakakima H, Terashi T, Takada S, Nakanishi K, Kikuchi K
Brain structure & function224(2)727-738(2019 Mar)

14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα
Gerber KJ, Squires KE, Hepler JR
The Journal of biological chemistry293(38)14616-14631(2018 09)

Selective 14-3-3γ induction quenches p-β-catenin Ser37/Bax-enhanced cell death in cerebral cortical neurons during ischemia.
Lai XJ, Ye SQ, Zheng L, Li L, Liu QR, Yu SB, Pang Y, Jin S, Li Q, Yu AC, Chen XQ
Cell death & disease5e1184(2014 Apr)

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Muda K, Bertinetti D, Gesellchen F, Hermann JS, von Zweydorf F, Geerlof A, Jacob A, Ueffing M, Gloeckner CJ, Herberg FW
Proceedings of the National Academy of Sciences of the United States of America111(1)E34-43(2014 Jan)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ywhag gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ywhag cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04601	NM_019376.2 Latest version!	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma (Ywhag), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa04601	XM_006249184.3 Latest version!	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma (Ywhag), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ywhag ( NM_019376.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062249.1 Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma (Ywhag), mRNA.

Price & Availability↑

CloneID	ORa04601
Clone ID Related Accession (Same CDS sequence)	NM_019376.2 , XM_006249184.3
Accession Version	NM_019376.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	14-3-3 protein gamma
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC127496.1. On Jun 10, 2007 this sequence version replaced NM_019376.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC127496.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGGACC GCGAGCAACT AGTGCAGAAA GCCCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGATATGG CCGCGGCCAT GAAGAACGTG ACAGAGCTGA ATGAACCACT GTCCAACGAG 
GAACGGAACC TCCTGTCGGT GGCCTACAAG AACGTGGTTG GGGCTCGCCG CTCCTCCTGG 
AGGGTCATCA GCAGCATCGA GCAGAAGACG TCTGCGGATG GCAACGAGAA GAAGATAGAG 
ATGGTCCGAG CCTACCGGGA AAAGATTGAG AAGGAGCTGG AGGCCGTGTG CCAGGACGTG 
CTGAGCCTGC TGGACAACTA CCTGATCAAG AACTGCAGCG AGACCCAGTA CGAGAGCAAG 
GTGTTCTACC TGAAGATGAA AGGGGACTAT TACCGCTACC TGGCCGAAGT GGCCACTGGG 
GAGAAAAGGG CGACCGTGGT GGAGTCGTCC GAGAAGGCCT ACAGCGAAGC CCACGAGATC 
AGCAAGGAGC ACATGCAGCC CACCCACCCC ATCCGGCTGG GCCTGGCGCT CAACTACTCC 
GTTTTCTACT ACGAGATCCA GAACGCCCCA GAGCAAGCCT GCCACCTGGC CAAGACCGCC 
TTCGATGACG CCATCGCCGA GCTCGACACT CTGAACGAGG ACTCCTACAA GGACTCCACT 
CTGATCATGC AGCTGCTCCG AGACAACCTA ACGCTCTGGA CGAGCGACCA GCAAGACGAC 
GACGGCGGCG AAGGCAACAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062249.1
CDS	146..889
Translation	MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN

Target ORF information:

RefSeq Version	NM_019376.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma (Ywhag), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019376.2

ORF Insert Sequence:

ATGGTGGACC GCGAGCAACT AGTGCAGAAA GCCCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGATATGG CCGCGGCCAT GAAGAACGTG ACAGAGCTGA ATGAACCACT GTCCAACGAG 
GAACGGAACC TCCTGTCGGT GGCCTACAAG AACGTGGTTG GGGCTCGCCG CTCCTCCTGG 
AGGGTCATCA GCAGCATCGA GCAGAAGACG TCTGCGGATG GCAACGAGAA GAAGATAGAG 
ATGGTCCGAG CCTACCGGGA AAAGATTGAG AAGGAGCTGG AGGCCGTGTG CCAGGACGTG 
CTGAGCCTGC TGGACAACTA CCTGATCAAG AACTGCAGCG AGACCCAGTA CGAGAGCAAG 
GTGTTCTACC TGAAGATGAA AGGGGACTAT TACCGCTACC TGGCCGAAGT GGCCACTGGG 
GAGAAAAGGG CGACCGTGGT GGAGTCGTCC GAGAAGGCCT ACAGCGAAGC CCACGAGATC 
AGCAAGGAGC ACATGCAGCC CACCCACCCC ATCCGGCTGG GCCTGGCGCT CAACTACTCC 
GTTTTCTACT ACGAGATCCA GAACGCCCCA GAGCAAGCCT GCCACCTGGC CAAGACCGCC 
TTCGATGACG CCATCGCCGA GCTCGACACT CTGAACGAGG ACTCCTACAA GGACTCCACT 
CTGATCATGC AGCTGCTCCG AGACAACCTA ACGCTCTGGA CGAGCGACCA GCAAGACGAC 
GACGGCGGCG AAGGCAACAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ywhag ( XM_006249184.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249246.2 Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma (Ywhag), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa04601
Clone ID Related Accession (Same CDS sequence)	NM_019376.2 , XM_006249184.3
Accession Version	XM_006249184.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	14-3-3 protein gamma isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249184.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGACC GCGAGCAACT AGTGCAGAAA GCCCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGATATGG CCGCGGCCAT GAAGAACGTG ACAGAGCTGA ATGAACCACT GTCCAACGAG 
GAACGGAACC TCCTGTCGGT GGCCTACAAG AACGTGGTTG GGGCTCGCCG CTCCTCCTGG 
AGGGTCATCA GCAGCATCGA GCAGAAGACG TCTGCGGATG GCAACGAGAA GAAGATAGAG 
ATGGTCCGAG CCTACCGGGA AAAGATTGAG AAGGAGCTGG AGGCCGTGTG CCAGGACGTG 
CTGAGCCTGC TGGACAACTA CCTGATCAAG AACTGCAGCG AGACCCAGTA CGAGAGCAAG 
GTGTTCTACC TGAAGATGAA AGGGGACTAT TACCGCTACC TGGCCGAAGT GGCCACTGGG 
GAGAAAAGGG CGACCGTGGT GGAGTCGTCC GAGAAGGCCT ACAGCGAAGC CCACGAGATC 
AGCAAGGAGC ACATGCAGCC CACCCACCCC ATCCGGCTGG GCCTGGCGCT CAACTACTCC 
GTTTTCTACT ACGAGATCCA GAACGCCCCA GAGCAAGCCT GCCACCTGGC CAAGACCGCC 
TTCGATGACG CCATCGCCGA GCTCGACACT CTGAACGAGG ACTCCTACAA GGACTCCACT 
CTGATCATGC AGCTGCTCCG AGACAACCTA ACGCTCTGGA CGAGCGACCA GCAAGACGAC 
GACGGCGGCG AAGGCAACAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249246.2
CDS	237..980
Translation	MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDDDGGEGNN

Target ORF information:

RefSeq Version	XM_006249184.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma (Ywhag), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249184.3

ORF Insert Sequence:

ATGGTGGACC GCGAGCAACT AGTGCAGAAA GCCCGGCTGG CCGAGCAGGC GGAGCGCTAC 
GACGATATGG CCGCGGCCAT GAAGAACGTG ACAGAGCTGA ATGAACCACT GTCCAACGAG 
GAACGGAACC TCCTGTCGGT GGCCTACAAG AACGTGGTTG GGGCTCGCCG CTCCTCCTGG 
AGGGTCATCA GCAGCATCGA GCAGAAGACG TCTGCGGATG GCAACGAGAA GAAGATAGAG 
ATGGTCCGAG CCTACCGGGA AAAGATTGAG AAGGAGCTGG AGGCCGTGTG CCAGGACGTG 
CTGAGCCTGC TGGACAACTA CCTGATCAAG AACTGCAGCG AGACCCAGTA CGAGAGCAAG 
GTGTTCTACC TGAAGATGAA AGGGGACTAT TACCGCTACC TGGCCGAAGT GGCCACTGGG 
GAGAAAAGGG CGACCGTGGT GGAGTCGTCC GAGAAGGCCT ACAGCGAAGC CCACGAGATC 
AGCAAGGAGC ACATGCAGCC CACCCACCCC ATCCGGCTGG GCCTGGCGCT CAACTACTCC 
GTTTTCTACT ACGAGATCCA GAACGCCCCA GAGCAAGCCT GCCACCTGGC CAAGACCGCC 
TTCGATGACG CCATCGCCGA GCTCGACACT CTGAACGAGG ACTCCTACAA GGACTCCACT 
CTGATCATGC AGCTGCTCCG AGACAACCTA ACGCTCTGGA CGAGCGACCA GCAAGACGAC 
GACGGCGGCG AAGGCAACAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats.
Brain structure & function224(2)727-738(2019 Mar)
Otsuka S,Sakakima H,Terashi T,Takada S,Nakanishi K,Kikuchi K

14-3-3γ binds regulator of G protein signaling 14 (RGS14) at distinct sites to inhibit the RGS14:Gα
The Journal of biological chemistry293(38)14616-14631(2018 09)
Gerber KJ,Squires KE,Hepler JR

Selective 14-3-3γ induction quenches p-β-catenin Ser37/Bax-enhanced cell death in cerebral cortical neurons during ischemia.
Cell death & disease5e1184(2014 Apr)
Lai XJ,Ye SQ,Zheng L,Li L,Liu QR,Yu SB,Pang Y,Jin S,Li Q,Yu AC,Chen XQ

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Proceedings of the National Academy of Sciences of the United States of America111(1)E34-43(2014 Jan)
Muda K,Bertinetti D,Gesellchen F,Hermann JS,von Zweydorf F,Geerlof A,Jacob A,Ueffing M,Gloeckner CJ,Herberg FW

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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Ywhag cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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