Gria1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gria1
Entrez Gene ID	50592
Full Name	glutamate ionotropic receptor AMPA type subunit 1
Synonyms	GluA1,gluR-A
General protein information	Preferred Names glutamate ionotropic receptor AMPA type subunit 1 Names glutamate receptor 1 AMPA-selective glutamate receptor 1 GluR1 gluR-1 gluR-K1 glutamate receptor A glutamate receptor subunit GluR1 glutamate receptor, ionotropic, AMPA 1 glutamate receptor, ionotropic, AMPA1 (alpha 1)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22
Summary	mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031608.1	NP_113796.1	glutamate receptor 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GRIA1	NP_001107655.1
Canis lupus familiaris (dog)	GRIA1	XP_546286.2
Bos taurus (cattle)	GRIA1	XP_002689365.1
Danio rerio (zebrafish)	gria1b	NP_991293.1
Rattus norvegicus (Norway rat)	Gria1	NP_113796.1
Macaca mulatta (Rhesus monkey)	GRIA1	XP_002804636.1
Mus musculus (house mouse)	Gria1	NP_001106796.1
Gallus gallus (chicken)	GRIA1	NP_001001774.1
Danio rerio (zebrafish)	gria1a	NP_991161.1
Pan troglodytes (chimpanzee)	GRIA1	XP_003310973.1
Xenopus tropicalis (tropical clawed frog)	gria1	XP_002941536.1

Gene Ontology
Bibliography

Related articles in PubMed

Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms.
Taoro-Gonzalez L, Arenas YM, Cabrera-Pastor A, Felipo V
Molecular neurobiology56(6)4428-4439(2019 Jun)

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8.
Herguedas B, Watson JF, Ho H, Cais O, García-Nafría J, Greger IH
Science (New York, N.Y.)364(6438)(2019 04)

Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment.
Wang XP, Ye P, Lv J, Zhou L, Qian ZY, Huang YJ, Mu ZH, Wang X, Liu XJ, Wan Q, Yang ZH, Wang F, Zou YY
Neurochemical research44(4)978-993(2019 Apr)

GluR1 protects hypoxic ischemic brain damage via activating Akt signaling pathway in neonatal rats.
Huang JZ, Ren Y, Jiang Y, Shen SY, Ding J, Hua F
European review for medical and pharmacological sciences22(24)8857-8865(2018 12)

Downregulation of neuroligin1 ameliorates postoperative pain through inhibiting neuroligin1/postsynaptic density 95-mediated synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluA1 subunits in rat dorsal horns.
Guo R, Li H, Li X, Xue Z, Sun Y, Ma D, Guan Y, Li J, Tian M, Wang Y
Molecular pain141744806918766745(2018 Jan-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gria1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gria1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08249	NM_031608.1 Latest version!	Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 1 (Gria1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gria1 ( NM_031608.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113796.1 Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 1 (Gria1), mRNA.

Price & Availability↑

CloneID	ORa08249
Clone ID Related Accession (Same CDS sequence)	NM_031608.1
Accession Version	NM_031608.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2724bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	glutamate receptor 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X17184.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X17184.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCGTACA TCTTTGCCTT TTTCTGCACC GGTTTTCTAG GTGCGGTTGT GGGTGCCAAT 
TTCCCCAACA ATATCCAGAT AGGGGGGTTA TTTCCAAACC AACAATCACA GGAACATGCG 
GCTTTTAGGT TTGCTTTGTC ACAACTCACG GAGCCCCCCA AGCTGCTTCC CCAGATCGAT 
ATTGTGAACA TCAGCGACAG CTTTGAGATG ACTTACCGTT TCTGTTCCCA GTTCTCCAAA 
GGAGTCTATG CCATCTTTGG ATTTTATGAA CGAAGGACTG TCAACATGCT GACCTCCTTC 
TGTGGGGCCC TCCATGTGTG CTTCATTACT CCAAGTTTTC CTGTTGACAC ATCCAATCAA 
TTTGTCCTTC AGCTACGCCC GGAACTACAG GAAGCTCTCA TTAGCATTAT CGACCATTAC 
AAGTGGCAAA CCTTTGTCTA CATTTATGAT GCTGACCGGG GCCTGTCAGT CCTGCAGAGA 
GTCTTGGATA CAGCCGCAGA GAAGAACTGG CAGGTAACGG CTGTCAACAT TCTGACAACC 
ACCGAGGAAG GATACCGGAT GCTCTTTCAG GACCTGGAGA AGAAAAAGGA GAGGCTGGTG 
GTGGTTGACT GTGAATCAGA ACGCCTCAAC GCCATCCTGG GCCAGATCGT GAAGCTAGAA 
AAGAATGGCA TCGGGTACCA CTACATCCTC GCCAATCTGG GCTTCATGGA CATTGACTTA 
AATAAGTTCA AGGAGAGCGG AGCCAATGTG ACAGGTTTCC AGCTGGTGAA CTACACAGAC 
ACGATCCCAG CCAGAATCAT GCAGCAATGG AGGACAAGTG ACTCCCGAGA CCATACCAGG 
GTGGACTGGA AGAGGCCAAA GTACACTTCT GCTCTCACCT ATGATGGTGT CAAGGTGATG 
GCTGAGGCCT TCCAAAGCCT GCGGAGGCAG AGGATTGACA TATCCCGCCG GGGGAATGCT 
GGGGACTGTC TGGCTAACCC AGCTGTGCCC TGGGGTCAAG GGATCGACAT CCAGAGAGCC 
CTGCAGCAGG TGCGCTTCGA AGGTTTGACA GGAAATGTGC AGTTCAACGA GAAAGGGCGC 
CGGACCAATT ACACCCTCCA CGTGATCGAA ATGAAACATG ATGGAATCCG AAAGATTGGT 
TACTGGAATG AAGACGATAA ATTTGTCCCC GCAGCCACCG ACGCTCAGGC TGGAGGGGAC 
AACTCAAGCG TCCAGAATAG GACCTACATC GTCACTACTA TCCTCGAAGA TCCTTACGTG 
ATGCTTAAAA AGAATGCCAA CCAGTTTGAG GGCAATGACC GCTATGAGGG CTACTGTGTG 
GAGCTGGCTG CAGAGATCGC CAAGCACGTG GGCTACTCCT ACCGACTTGA GATTGTCAGC 
GACGGCAAAT ATGGAGCCCG GGATCCCGAC ACAAAGGCTT GGAATGGCAT GGTGGGAGAA 
CTGGTCTATG GAAGAGCAGA CGTGGCTGTG GCTCCCTTGA CCATAACCTT GGTCCGGGAG 
GAAGTCATCG ACTTCTCCAA GCCATTCATG AGTTTGGGAA TCTCCATTAT GATTAAGAAG 
CCACAGAAGT CCAAGCCAGG TGTCTTCTCC TTTCTTGACC CTTTGGCCTA TGAGATCTGG 
ATGTGTATAG TGTTTGCCTA CATTGGAGTG AGCGTCGTCC TCTTCCTGGT CAGCCGTTTC 
AGCCCCTACG AATGGCACAG CGAAGAGTTT GAAGAGGGAC GAGACCAGAC AACCAGTGAC 
CAGTCAAATG AGTTTGGCAT ATTCAACAGC CTGTGGTTCT CCCTGGGGGC CTTCATGCAG 
CAAGGATGTG ACATTTCCCC CAGGTCCCTG TCCGGACGCA TCGTCGGCGG CGTCTGGTGG 
TTCTTCACTT TGATCATCAT CTCCTCGTAC ACAGCCAACC TGGCTGCCTT CCTGACTGTG 
GAGAGGATGG TGTCTCCCAT TGAGAGTGCA GAGGACCTGG CAAAGCAGAC GGAAATTGCT 
TATGGGACAT TGGAAGCAGG CTCCACTAAG GAGTTCTTCA GGAGATCTAA AATCGCTGTG 
TTTGAGAAGA TGTGGACATA CATGAAGTCT GCAGAACCAT CCGTGTTTGT TCGGACCACA 
GAGGAAGGCA TGATCAGAGT GAGAAAATCT AAAGGCAAAT ACGCCTACCT CCTGGAGTCC 
ACCATGAATG AGTATATTGA GCAACGAAAG CCCTGTGACA CCATGAAAGT GGGAGGTAAC 
TTGGATTCCA AAGGCTATGG CATTGCGACA CCCAAGGGGT CCGCCCTGAG AAATCCAGTA 
AACCTGGCAG TGTTAAAACT GAACGAGCAG GGGCTTTTGG ACAAATTGAA AAACAAATGG 
TGGTACGACA AGGGCGAGTG CGGCAGCGGG GGAGGTGACT CCAAGGACAA GACCAGCGCT 
TTGAGCCTCA GCAATGTGGC AGGCGTGTTC TACATCCTGA TTGGAGGGCT GGGACTGGCC 
ATGCTGGTTG CCTTAATCGA GTTCTGCTAC AAATCCCGTA GCGAGTCGAA GCGGATGAAG 
GGTTTCTGTT TGATCCCACA GCAATCCATC AATGAAGCCA TACGGACATC GACCCTCCCC 
CGGAACAGTG GGGCAGGAGC CAGCGGAGGA GGCGGCAGTG GAGAGAATGG CCGGGTGGTC 
AGCCAGGACT TCCCCAAGTC CATGCAATCC ATTCCCTGCA TGAGTCACAG TTCAGGGATG 
CCCTTGGGAG CCACAGGATT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113796.1
CDS	198..2921
Translation	MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL

Target ORF information:

RefSeq Version	NM_031608.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 1 (Gria1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031608.1

ORF Insert Sequence:

ATGCCGTACA TCTTTGCCTT TTTCTGCACC GGTTTTCTAG GTGCGGTTGT GGGTGCCAAT 
TTCCCCAACA ATATCCAGAT AGGGGGGTTA TTTCCAAACC AACAATCACA GGAACATGCG 
GCTTTTAGGT TTGCTTTGTC ACAACTCACG GAGCCCCCCA AGCTGCTTCC CCAGATCGAT 
ATTGTGAACA TCAGCGACAG CTTTGAGATG ACTTACCGTT TCTGTTCCCA GTTCTCCAAA 
GGAGTCTATG CCATCTTTGG ATTTTATGAA CGAAGGACTG TCAACATGCT GACCTCCTTC 
TGTGGGGCCC TCCATGTGTG CTTCATTACT CCAAGTTTTC CTGTTGACAC ATCCAATCAA 
TTTGTCCTTC AGCTACGCCC GGAACTACAG GAAGCTCTCA TTAGCATTAT CGACCATTAC 
AAGTGGCAAA CCTTTGTCTA CATTTATGAT GCTGACCGGG GCCTGTCAGT CCTGCAGAGA 
GTCTTGGATA CAGCCGCAGA GAAGAACTGG CAGGTAACGG CTGTCAACAT TCTGACAACC 
ACCGAGGAAG GATACCGGAT GCTCTTTCAG GACCTGGAGA AGAAAAAGGA GAGGCTGGTG 
GTGGTTGACT GTGAATCAGA ACGCCTCAAC GCCATCCTGG GCCAGATCGT GAAGCTAGAA 
AAGAATGGCA TCGGGTACCA CTACATCCTC GCCAATCTGG GCTTCATGGA CATTGACTTA 
AATAAGTTCA AGGAGAGCGG AGCCAATGTG ACAGGTTTCC AGCTGGTGAA CTACACAGAC 
ACGATCCCAG CCAGAATCAT GCAGCAATGG AGGACAAGTG ACTCCCGAGA CCATACCAGG 
GTGGACTGGA AGAGGCCAAA GTACACTTCT GCTCTCACCT ATGATGGTGT CAAGGTGATG 
GCTGAGGCCT TCCAAAGCCT GCGGAGGCAG AGGATTGACA TATCCCGCCG GGGGAATGCT 
GGGGACTGTC TGGCTAACCC AGCTGTGCCC TGGGGTCAAG GGATCGACAT CCAGAGAGCC 
CTGCAGCAGG TGCGCTTCGA AGGTTTGACA GGAAATGTGC AGTTCAACGA GAAAGGGCGC 
CGGACCAATT ACACCCTCCA CGTGATCGAA ATGAAACATG ATGGAATCCG AAAGATTGGT 
TACTGGAATG AAGACGATAA ATTTGTCCCC GCAGCCACCG ACGCTCAGGC TGGAGGGGAC 
AACTCAAGCG TCCAGAATAG GACCTACATC GTCACTACTA TCCTCGAAGA TCCTTACGTG 
ATGCTTAAAA AGAATGCCAA CCAGTTTGAG GGCAATGACC GCTATGAGGG CTACTGTGTG 
GAGCTGGCTG CAGAGATCGC CAAGCACGTG GGCTACTCCT ACCGACTTGA GATTGTCAGC 
GACGGCAAAT ATGGAGCCCG GGATCCCGAC ACAAAGGCTT GGAATGGCAT GGTGGGAGAA 
CTGGTCTATG GAAGAGCAGA CGTGGCTGTG GCTCCCTTGA CCATAACCTT GGTCCGGGAG 
GAAGTCATCG ACTTCTCCAA GCCATTCATG AGTTTGGGAA TCTCCATTAT GATTAAGAAG 
CCACAGAAGT CCAAGCCAGG TGTCTTCTCC TTTCTTGACC CTTTGGCCTA TGAGATCTGG 
ATGTGTATAG TGTTTGCCTA CATTGGAGTG AGCGTCGTCC TCTTCCTGGT CAGCCGTTTC 
AGCCCCTACG AATGGCACAG CGAAGAGTTT GAAGAGGGAC GAGACCAGAC AACCAGTGAC 
CAGTCAAATG AGTTTGGCAT ATTCAACAGC CTGTGGTTCT CCCTGGGGGC CTTCATGCAG 
CAAGGATGTG ACATTTCCCC CAGGTCCCTG TCCGGACGCA TCGTCGGCGG CGTCTGGTGG 
TTCTTCACTT TGATCATCAT CTCCTCGTAC ACAGCCAACC TGGCTGCCTT CCTGACTGTG 
GAGAGGATGG TGTCTCCCAT TGAGAGTGCA GAGGACCTGG CAAAGCAGAC GGAAATTGCT 
TATGGGACAT TGGAAGCAGG CTCCACTAAG GAGTTCTTCA GGAGATCTAA AATCGCTGTG 
TTTGAGAAGA TGTGGACATA CATGAAGTCT GCAGAACCAT CCGTGTTTGT TCGGACCACA 
GAGGAAGGCA TGATCAGAGT GAGAAAATCT AAAGGCAAAT ACGCCTACCT CCTGGAGTCC 
ACCATGAATG AGTATATTGA GCAACGAAAG CCCTGTGACA CCATGAAAGT GGGAGGTAAC 
TTGGATTCCA AAGGCTATGG CATTGCGACA CCCAAGGGGT CCGCCCTGAG AAATCCAGTA 
AACCTGGCAG TGTTAAAACT GAACGAGCAG GGGCTTTTGG ACAAATTGAA AAACAAATGG 
TGGTACGACA AGGGCGAGTG CGGCAGCGGG GGAGGTGACT CCAAGGACAA GACCAGCGCT 
TTGAGCCTCA GCAATGTGGC AGGCGTGTTC TACATCCTGA TTGGAGGGCT GGGACTGGCC 
ATGCTGGTTG CCTTAATCGA GTTCTGCTAC AAATCCCGTA GCGAGTCGAA GCGGATGAAG 
GGTTTCTGTT TGATCCCACA GCAATCCATC AATGAAGCCA TACGGACATC GACCCTCCCC 
CGGAACAGTG GGGCAGGAGC CAGCGGAGGA GGCGGCAGTG GAGAGAATGG CCGGGTGGTC 
AGCCAGGACT TCCCCAAGTC CATGCAATCC ATTCCCTGCA TGAGTCACAG TTCAGGGATG 
CCCTTGGGAG CCACAGGATT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Extracellular cGMP Reverses Altered Membrane Expression of AMPA Receptors in Hippocampus of Hyperammonemic Rats: Underlying Mechanisms.
Molecular neurobiology56(6)4428-4439(2019 Jun)
Taoro-Gonzalez L,Arenas YM,Cabrera-Pastor A,Felipo V

Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8.
Science (New York, N.Y.)364(6438)(2019 04)
Herguedas B,Watson JF,Ho H,Cais O,García-Nafría J,Greger IH

Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment.
Neurochemical research44(4)978-993(2019 Apr)
Wang XP,Ye P,Lv J,Zhou L,Qian ZY,Huang YJ,Mu ZH,Wang X,Liu XJ,Wan Q,Yang ZH,Wang F,Zou YY

GluR1 protects hypoxic ischemic brain damage via activating Akt signaling pathway in neonatal rats.
European review for medical and pharmacological sciences22(24)8857-8865(2018 12)
Huang JZ,Ren Y,Jiang Y,Shen SY,Ding J,Hua F

Downregulation of neuroligin1 ameliorates postoperative pain through inhibiting neuroligin1/postsynaptic density 95-mediated synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluA1 subunits in rat dorsal horns.
Molecular pain141744806918766745(2018 Jan-Dec)
Guo R,Li H,Li X,Xue Z,Sun Y,Ma D,Guan Y,Li J,Tian M,Wang Y

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Gria1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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