C4b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	C4b
Entrez Gene ID	406161
Full Name	complement C4B (Chido blood group)
Synonyms	C4-2,C4l
General protein information	Preferred Names complement C4B (Chido blood group) Names complement component 4, gene 2 complement C4-like protein complement component 4B (Chido blood group)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002805.2	NP_001002805.1	complement component 4, gene 2 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	C4a	NP_035543.2
Danio rerio (zebrafish)	si:dkey-8k3.2	XP_001334640.1
Mus musculus (house mouse)	C4b	NP_033910.2
Rattus norvegicus (Norway rat)	C4b	NP_001002805.1
Homo sapiens (human)	C4A	NP_009224.2
Pan troglodytes (chimpanzee)	C4A	XP_003311220.1
Canis lupus familiaris (dog)	C4A	XP_005627805.1
Bos taurus (cattle)	C4A	NP_001159957.1
Gallus gallus (chicken)	C4	NP_001070701.1
Homo sapiens (human)	C4B	NP_001002029.3
Xenopus tropicalis (tropical clawed frog)	c4a	NP_001107156.1
Rattus norvegicus (Norway rat)	C4a	NP_113692.2

Gene Ontology
Bibliography

Related articles in PubMed

Schizophrenia risk from complex variation of complement component 4.
Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE, , Daly MJ, Carroll MC, Stevens B, McCarroll SA
Nature530(7589)177-83(2016 Feb)

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM
Journal of proteomics75(12)3574-84(2012 Jun)

Increased frequency of complement C4B deficiency in rheumatoid arthritis.
Rigby WF, Wu YL, Zan M, Zhou B, Rosengren S, Carlson C, Hilton W, Yu CY
Arthritis and rheumatism64(5)1338-44(2012 May)

Complement regulator C4BP binds to Staphylococcus aureus and decreases opsonization.
Hair PS, Wagner SM, Friederich PT, Drake RR, Nyalwidhe JO, Cunnion KM
Molecular immunology50(4)253-61(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following C4b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C4b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05716	NM_001002805.2 Latest version!	Rattus norvegicus complement C4B (Chido blood group) (C4b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C4b ( NM_001002805.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001002805.1 Rattus norvegicus complement C4B (Chido blood group) (C4b), mRNA.

Price & Availability↑

CloneID	ORa05716
Clone ID Related Accession (Same CDS sequence)	NM_001002805.2
Accession Version	NM_001002805.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5214bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Rattus norvegicus(Norway rat)
Product	complement component 4, gene 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX883044.1. On Sep 22, 2009 this sequence version replaced NM_001002805.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCGGCTCC TCTGGGGCCT GGCCTGGGCA TTCAGCTTCT TCGCCTCCTC TCTGCAGAAG 
CCCAGGTTGC TCCTGTTCTC CCCTTCTGTG GTTAATTTGG GGACCCCCCT GTCAGTAGGG 
GTGCAGCTCC TGGATGCCCC TGCAGGACAG GAGGTGAAAG GCTCAGTGTA CCTCAGAAAC 
CCAACAAGCG GTCCCTGCTC CCCAAAGAAG GACTTTAAGC TCAGCTCGGG AAATGACTTT 
GTGCTTCTCA GACTTGAGGT CCCACTGGAA GATGTGAGGA ATTGTGGCCT CTTTGACCTA 
CGCAGAGCCC CCCACATCCA GCTGGTGGCT TACTCTCCGT GGCTAAAGAA CACAGCACCC 
AAAGCCACCG AGACTCAGGG GGTCAACCTG CTTTTCTCTT CCCGACGAGG CCACATCTTT 
GTGCAGACCG ATCAGCCTAT CTATAACCCT GGGCAGCGGG TACGTTATCG GGTCTTTGCA 
CTGGATCAAA AGATGCGTCC ATCTACGGAC ACCCTCACGG TCACAGTAGA GAACTCCCAT 
GGCCTCCGTG TACGCAAGAA GGTGGTATTT GCCCCCACAT CCATCTTCAC AGATGACTTC 
GTAATTCCAG ACATCTCAGA GCCGGGGACC TGGAAGATCT CAGCTAGGTT CTCAGATGGC 
CTCGAGTCCA ACAGAAGCAC CCACTTTGAA GTGAAGAAAT ATGTCCTTCC CAACTTTGAG 
GTGAAGCTTA CTCCTTGGAA GCCATATATC CTGACAGTGC CTAGCTACCG TGAAGAAATC 
CAGTTAGACA TCCAGGCCAG ATACGTCTAC GGGAAGCCCG TGCAGGGCGT GGCATATACC 
CGCTTCGCAC TCATGGATGA GCAGGGGAAG AAGACTTTCC TTCGGGGCCT AGAGACCCAG 
ACCAAGTTGG TGGAAGGCCA GACTCACATC TCCATCTCAA GGGACCAGTT CCAGGCTGCC 
CTGGGTAAAG TGAATACTGA GATCGGAGAC CTGGAGGGGC TGCGGCTCTA CGCTGCTGTA 
GCTGTCATTG AGTCTCCAGG AGGAGAGATG GAGGAAGCAG AGCTCACATC CTGGCCCTTC 
GTGTCATCTG CCTTCTCCTT GGATCTCAGC CACACCAAGC AGCATCTTGT GCCCGGGGCC 
CCCTTCCTGC TGCAGGCCCT GGTTCGAGAA ATGTCAGGCT CTGAAGCCTC TGATGTTCCT 
GTCAAAGTCT CTGCCACATT GTTATCTGGG TCCGACTCGA AAGTCCTTGA CTTTCAACAG 
AACACCAACG GGATTGGCCA AGTCAGCTTT TCTATCCATG TCCCGCCAAC CATCACAGAA 
CTTCGACTCT TGGTATCTGC CGGTTCCCTC TACCCAGCTG TAGCCAAGCT CACTGTGCAA 
GCCCCACCTT CAAGAGGCCC TGGCTTTCTG TCCATTGAGC CACTAGACCT TCGGTCCCCT 
CGTGTGGGGG ACACCTTCAT CCTGAACCTT CGAACCGTGG GCATCCCTGT GCCTACCTTC 
TCTCATTACT ACTACATGAT CATCTCCAGA GGCCAGATCA TGGCCATGAG TCGGGAGCCC 
AGGACGACCC TGACCTCCAT CTCTGTCTTG GTGGACCATC ACCTGGCTCC CTCTTTCTAC 
TTTGTGGCCT ACTTCTATCA CCAAGGACTC CCAGTGGCCA ACTCCCTGCT CATCAATGTC 
CAGCCTGGGG ACTGTGAGGG CAAGCTGGAA TTGAAGGTGG ACGGTGCCAA GGAGTATCGA 
AATGGGGAGA GCATGAAGCT CCAACTTCAA ACTGACTCCG AAGCCCTGGT GGCACTGGGA 
GCTGTGGACA CAGCTCTGTA TGCTGTGGGT GGCCGGTCTC ACAAACCCCT CGACATGAGC 
AAGGTCTTTG AAGTAATGAA CAGTTATAAC CTTGGCTGTG GTCCTGGAGG TGGGGACGAT 
GCCCTTCAGG TGTTCCAGAC TGCTGGTTTG GCCTTTTCTG ACGGTGATCG ACTAACTCAG 
ACCAAAGAGG ACTTGAGCTG TCCCAAGGAG AAGATAAGTC GGCAAAAGAG AAATGTTAAC 
TTCCAGAAGG CTATTAGCGA GAAGTTGGGC CAGTATTCCT CTCCAGACAC CAAGCGCTGC 
TGCCAGGATG GGATGACCAA GCTGCCCATG GCACGCACCT GCGAGCAGCG GGCAGCCCGA 
GTGCCTCAGC CGGCCTGCCG GGAGCCCTTC TTGTCCTGTT GCAAGTTTGC TGAGGACCTC 
CGCAGGAACC AGACCAGGAG CCAGGCGGGC CTCGCCCGAG CCCAGAACGT GATGCAGGAG 
GAGGATCTGA TAGATGAAGA TGACATTCTT GTGCGCAGCT TCTTCCCAGA GAACTGGCTC 
TGGAAAGTGG AACCTGTGGA CCGCTCCAAA CTGTTGACTG TGTGGCTCCC TGACTCTCTG 
ACCACATGGG AGATTCATGG TGTGAGCCTG TCCAAAAGCA AAGGCCTGTG TGTAGCCAAG 
CCAACTCGCG TGCGAGTGTT CCGAGAATTC CACCTGCACC TGCGCCTGCC CATCTCTGTC 
CGGCGCTTCG AGCAGCTTGA ATTACGGCCC GTTCTCTACA ACTATCTGAG TGAGGACGTG 
ACTGTGAGTG TCCATGTGTC CCCAGTGGAG GGGCTGTGCC TGGCTGGTGG TGGATTGCTG 
GCCCAGCAGG TATCAGTGCC TGCAGGCTCC GCCCGGCCTG TGGCCTTCTC TGTGGTACCC 
ACAGCTGCTG CCAGCATGCC CCTGAAAGTG GTGGCTCGGG GGTCTTTTGA TATAGGGGAT 
GCTGTGTCTA AGATTCTCCA AATTGAGAAG GAAGGGGCCA TCCACAGAGA AGAGATAGTC 
TACAACCTCG ACCCCCTAAA TAACCTTGGT CGGAGTTTGG AAATCCCTGG CAGCTCAGAC 
CCCAACGTCA TTCCTGATGG AGATTTCAGC AGCTTCGTCA GGGTTACAGC CTCCGAACCC 
TTGGAGACTT TGGGCTCTGA AGGCGCCTTG TCCCCAGGGG GAGTGGCCTC CCTCCTGAAG 
CTCCCCACGG GCTGCGCAGA ACAAACCATG GTCCTTTTGG CCCCTACCCT GACTGCTTCC 
CGCTACCTGG ACAGGACCGA GCAGTGGAGC AAACTGCCCC CTGAGACAAA GGACCATGCT 
GTGGATCTGA TCCAGAAAGG CCACATGCGG ATCCAGCAGT TTAGGAAGAA AGATGGCTCC 
TTTGGGGCGT GGTTAGACCG GGACAGCAGC ACCTGGCTCA CGGCCTTTGT GCTGAAGATT 
CTGAGTCTGG CCCAGGAACA GATTGGTGAC TCCCCCGAGA AGCTGCAAGA GACCGCCGGG 
TGGCTGCTGG GCCAGCAGCT GGACGATGGC TCATTCCACG ACCCGTGTCC GGTCATTCAA 
AGAGGCATGC AGGGGGGCTT GGTGGGGACC GACGAGACAG TGGCACTGAC CGCCTTTGTG 
GTCATCGCCC TTCACCACGG GCTGGCCGTC TTCCAAGACG AGAACTCGCA GCAGCTGAAG 
AAGAGGGTGG AAGCCTCCAT CATGAAGGCA AACTCGTTCT TGGGGCAGAA GGCAAGTGCT 
GGGCTCCTGG GTGCACACGC ATCCGCCATC ACAGCCTATG CCCTGACACT GACCAAGGCC 
TCGGAGGACC TGCGGAATGT TGCCCACAAC AGCCTGATGG CCATGGCTGA GGAAACAGGG 
GAAAACCTCT ACTGGGGCTT AGCCATTGGC TCTCAGGACA ACGTTGTGTC ATCCACCGCA 
GCCCCTCGTA ATCCCTCAGA ACCTGTGCCC CAGGCCCCAG CCCTGTGGAT CGAAACCACA 
GCCTACGGCC TGCTACATCT GCTGCTGCGG GAGGGGAAGG GAGAAATGGC TGACAAGGCG 
GCAACCTGGC TCACACACCA GGGAAGCTTC CAAGGGGGAT TCCGCAGTAC CCAGGACACT 
GTGGTCGCCC TGGATGCCCT GTCTGCATAC TGGATCGCTT CACACACCAC CGAGGAGAAG 
GCACTCAATG TGACTCTCAG CTCCATGGGC CGCAATGGGT ACAAGTCCCA CCTGCTACAG 
CTGAACAACC ACCAAGTCAA GGGCCTGGAG GAGGAGCTGA AGTTCTCCCT GGGCAGCACC 
ATCAATGTGA AAGTGGGAGG AAATAGCAAA GGCACCTTAA AGATCCTTCG TACCTACAAT 
GTCCTGGACA TGAAGAACAC AACATGCCAA GACCTTCGGA TAGAAGTGAC AATCACAGGC 
TATGTGGAAT ATACAAGGGA GGCCAACGAA GACTATGAAT ACGACTATGA TATGCCAGCC 
GCAGATGACC CCAGTGTCCA CTCGCAGCCT GTGACACCCC TGCAGCTGTT TGAGGGTCGT 
CGGAGCCGCC GCAGGAGGGA GGCCCCCAAG GCTGCGGATG AGCAGGAGTC CAGAGTGCAG 
TACACCGTGT GCATCTGGCG GAACGGTAAC CTGGGGCTGT CTGGGATGGC CATTGCTGAC 
ATCACCCTCC TGAGTGGATT CCAAGCCCTG AGGGCTGACC TGGAGAAGCT GACCTCCCTC 
TCTGACCGTT ACGTGAGTCA CTTTGAGACC GACGGGCCCC ACGTCCTACT GTACTTTGAC 
TCGGTCCCGA CCACCCGGGA GTGTGTGGGC TTTGGAGCTT TGCAGGAGGT GGCCGTGGGG 
CTGGTGCAGC CAGCCAGTGC TGTCCTGTAT GACTACTACA GCCCTGATCA CAAGTGCTCT 
GTGTTCTATG CTGGACCCAC CAAGAGCAAG CTCCTCTCCA CCTTGTGCTC TGCAGACGTC 
TGCCAGTGCG CTGAAGGGAA GTGTCCTCGA CAGCGAAGGT CACTGGAGCG AGGGGTGGAG 
GACAAGGATG GTTACCGGAT GAAGTTCGCC TGCTATTATC CCCGAGTGGA GTATGGCTTC 
CAGGTTAAGG TTCTCCGAGA AGACAGCAGA TCTGCCTTCC GCCTCTTTGA GACCAAGATC 
ACCCAAGTCC TGCATTTCAC AAAGGATGCC AAGGCCTCCA TAGGTCAGAC CCGCAACTTT 
CTGGTCCGGG CTTCTTGCCG CCTTCGTTTG GAGCCTAGCA AAGAGTACTT AATCATGGGG 
ATGGACGGAG TCACCAGTGA CCTCAAGGGA GACCCCCAGT ACTTGCTGGA CTCAAACAGT 
TGGATCGAGG AGATGCCATC TGAGCGCCTG TGCAGGAGCA CCCGTCAGCG GGCAGCCTGT 
GGCCAGCTCA ATGACTTCCT GCAGGAGTAC AGAAGCCAGG GGTGCCAGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002805.1
CDS	38..5251
Translation	MRLLWGLAWAFSFFASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPAGQEVKGSVYLRNPTSGPCSPKKDFKLSSGNDFVLLRLEVPLEDVRNCGLFDLRRAPHIQLVAYSPWLKNTAPKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDTLTVTVENSHGLRVRKKVVFAPTSIFTDDFVIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDIQARYVYGKPVQGVAYTRFALMDEQGKKTFLRGLETQTKLVEGQTHISISRDQFQAALGKVNTEIGDLEGLRLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVREMSGSEASDVPVKVSATLLSGSDSKVLDFQQNTNGIGQVSFSIHVPPTITELRLLVSAGSLYPAVAKLTVQAPPSRGPGFLSIEPLDLRSPRVGDTFILNLRTVGIPVPTFSHYYYMIISRGQIMAMSREPRTTLTSISVLVDHHLAPSFYFVAYFYHQGLPVANSLLINVQPGDCEGKLELKVDGAKEYRNGESMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEVMNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKEDLSCPKEKISRQKRNVNFQKAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAGLARAQNVMQEEDLIDEDDILVRSFFPENWLWKVEPVDRSKLLTVWLPDSLTTWEIHGVSLSKSKGLCVAKPTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSEDVTVSVHVSPVEGLCLAGGGLLAQQVSVPAGSARPVAFSVVPTAAASMPLKVVARGSFDIGDAVSKILQIEKEGAIHREEIVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSFVRVTASEPLETLGSEGALSPGGVASLLKLPTGCAEQTMVLLAPTLTASRYLDRTEQWSKLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGAWLDRDSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDGSFHDPCPVIQRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKKRVEASIMKANSFLGQKASAGLLGAHASAITAYALTLTKASEDLRNVAHNSLMAMAEETGENLYWGLAIGSQDNVVSSTAAPRNPSEPVPQAPALWIETTAYGLLHLLLREGKGEMADKAATWLTHQGSFQGGFRSTQDTVVALDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGSTINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTITGYVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQLFEGRRSRRRREAPKAADEQESRVQYTVCIWRNGNLGLSGMAIADITLLSGFQALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGALQEVAVGLVQPASAVLYDYYSPDHKCSVFYAGPTKSKLLSTLCSADVCQCAEGKCPRQRRSLERGVEDKDGYRMKFACYYPRVEYGFQVKVLREDSRSAFRLFETKITQVLHFTKDAKASIGQTRNFLVRASCRLRLEPSKEYLIMGMDGVTSDLKGDPQYLLDSNSWIEEMPSERLCRSTRQRAACGQLNDFLQEYRSQGCQV

Target ORF information:

RefSeq Version	NM_001002805.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement C4B (Chido blood group) (C4b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002805.2

ORF Insert Sequence:

ATGCGGCTCC TCTGGGGCCT GGCCTGGGCA TTCAGCTTCT TCGCCTCCTC TCTGCAGAAG 
CCCAGGTTGC TCCTGTTCTC CCCTTCTGTG GTTAATTTGG GGACCCCCCT GTCAGTAGGG 
GTGCAGCTCC TGGATGCCCC TGCAGGACAG GAGGTGAAAG GCTCAGTGTA CCTCAGAAAC 
CCAACAAGCG GTCCCTGCTC CCCAAAGAAG GACTTTAAGC TCAGCTCGGG AAATGACTTT 
GTGCTTCTCA GACTTGAGGT CCCACTGGAA GATGTGAGGA ATTGTGGCCT CTTTGACCTA 
CGCAGAGCCC CCCACATCCA GCTGGTGGCT TACTCTCCGT GGCTAAAGAA CACAGCACCC 
AAAGCCACCG AGACTCAGGG GGTCAACCTG CTTTTCTCTT CCCGACGAGG CCACATCTTT 
GTGCAGACCG ATCAGCCTAT CTATAACCCT GGGCAGCGGG TACGTTATCG GGTCTTTGCA 
CTGGATCAAA AGATGCGTCC ATCTACGGAC ACCCTCACGG TCACAGTAGA GAACTCCCAT 
GGCCTCCGTG TACGCAAGAA GGTGGTATTT GCCCCCACAT CCATCTTCAC AGATGACTTC 
GTAATTCCAG ACATCTCAGA GCCGGGGACC TGGAAGATCT CAGCTAGGTT CTCAGATGGC 
CTCGAGTCCA ACAGAAGCAC CCACTTTGAA GTGAAGAAAT ATGTCCTTCC CAACTTTGAG 
GTGAAGCTTA CTCCTTGGAA GCCATATATC CTGACAGTGC CTAGCTACCG TGAAGAAATC 
CAGTTAGACA TCCAGGCCAG ATACGTCTAC GGGAAGCCCG TGCAGGGCGT GGCATATACC 
CGCTTCGCAC TCATGGATGA GCAGGGGAAG AAGACTTTCC TTCGGGGCCT AGAGACCCAG 
ACCAAGTTGG TGGAAGGCCA GACTCACATC TCCATCTCAA GGGACCAGTT CCAGGCTGCC 
CTGGGTAAAG TGAATACTGA GATCGGAGAC CTGGAGGGGC TGCGGCTCTA CGCTGCTGTA 
GCTGTCATTG AGTCTCCAGG AGGAGAGATG GAGGAAGCAG AGCTCACATC CTGGCCCTTC 
GTGTCATCTG CCTTCTCCTT GGATCTCAGC CACACCAAGC AGCATCTTGT GCCCGGGGCC 
CCCTTCCTGC TGCAGGCCCT GGTTCGAGAA ATGTCAGGCT CTGAAGCCTC TGATGTTCCT 
GTCAAAGTCT CTGCCACATT GTTATCTGGG TCCGACTCGA AAGTCCTTGA CTTTCAACAG 
AACACCAACG GGATTGGCCA AGTCAGCTTT TCTATCCATG TCCCGCCAAC CATCACAGAA 
CTTCGACTCT TGGTATCTGC CGGTTCCCTC TACCCAGCTG TAGCCAAGCT CACTGTGCAA 
GCCCCACCTT CAAGAGGCCC TGGCTTTCTG TCCATTGAGC CACTAGACCT TCGGTCCCCT 
CGTGTGGGGG ACACCTTCAT CCTGAACCTT CGAACCGTGG GCATCCCTGT GCCTACCTTC 
TCTCATTACT ACTACATGAT CATCTCCAGA GGCCAGATCA TGGCCATGAG TCGGGAGCCC 
AGGACGACCC TGACCTCCAT CTCTGTCTTG GTGGACCATC ACCTGGCTCC CTCTTTCTAC 
TTTGTGGCCT ACTTCTATCA CCAAGGACTC CCAGTGGCCA ACTCCCTGCT CATCAATGTC 
CAGCCTGGGG ACTGTGAGGG CAAGCTGGAA TTGAAGGTGG ACGGTGCCAA GGAGTATCGA 
AATGGGGAGA GCATGAAGCT CCAACTTCAA ACTGACTCCG AAGCCCTGGT GGCACTGGGA 
GCTGTGGACA CAGCTCTGTA TGCTGTGGGT GGCCGGTCTC ACAAACCCCT CGACATGAGC 
AAGGTCTTTG AAGTAATGAA CAGTTATAAC CTTGGCTGTG GTCCTGGAGG TGGGGACGAT 
GCCCTTCAGG TGTTCCAGAC TGCTGGTTTG GCCTTTTCTG ACGGTGATCG ACTAACTCAG 
ACCAAAGAGG ACTTGAGCTG TCCCAAGGAG AAGATAAGTC GGCAAAAGAG AAATGTTAAC 
TTCCAGAAGG CTATTAGCGA GAAGTTGGGC CAGTATTCCT CTCCAGACAC CAAGCGCTGC 
TGCCAGGATG GGATGACCAA GCTGCCCATG GCACGCACCT GCGAGCAGCG GGCAGCCCGA 
GTGCCTCAGC CGGCCTGCCG GGAGCCCTTC TTGTCCTGTT GCAAGTTTGC TGAGGACCTC 
CGCAGGAACC AGACCAGGAG CCAGGCGGGC CTCGCCCGAG CCCAGAACGT GATGCAGGAG 
GAGGATCTGA TAGATGAAGA TGACATTCTT GTGCGCAGCT TCTTCCCAGA GAACTGGCTC 
TGGAAAGTGG AACCTGTGGA CCGCTCCAAA CTGTTGACTG TGTGGCTCCC TGACTCTCTG 
ACCACATGGG AGATTCATGG TGTGAGCCTG TCCAAAAGCA AAGGCCTGTG TGTAGCCAAG 
CCAACTCGCG TGCGAGTGTT CCGAGAATTC CACCTGCACC TGCGCCTGCC CATCTCTGTC 
CGGCGCTTCG AGCAGCTTGA ATTACGGCCC GTTCTCTACA ACTATCTGAG TGAGGACGTG 
ACTGTGAGTG TCCATGTGTC CCCAGTGGAG GGGCTGTGCC TGGCTGGTGG TGGATTGCTG 
GCCCAGCAGG TATCAGTGCC TGCAGGCTCC GCCCGGCCTG TGGCCTTCTC TGTGGTACCC 
ACAGCTGCTG CCAGCATGCC CCTGAAAGTG GTGGCTCGGG GGTCTTTTGA TATAGGGGAT 
GCTGTGTCTA AGATTCTCCA AATTGAGAAG GAAGGGGCCA TCCACAGAGA AGAGATAGTC 
TACAACCTCG ACCCCCTAAA TAACCTTGGT CGGAGTTTGG AAATCCCTGG CAGCTCAGAC 
CCCAACGTCA TTCCTGATGG AGATTTCAGC AGCTTCGTCA GGGTTACAGC CTCCGAACCC 
TTGGAGACTT TGGGCTCTGA AGGCGCCTTG TCCCCAGGGG GAGTGGCCTC CCTCCTGAAG 
CTCCCCACGG GCTGCGCAGA ACAAACCATG GTCCTTTTGG CCCCTACCCT GACTGCTTCC 
CGCTACCTGG ACAGGACCGA GCAGTGGAGC AAACTGCCCC CTGAGACAAA GGACCATGCT 
GTGGATCTGA TCCAGAAAGG CCACATGCGG ATCCAGCAGT TTAGGAAGAA AGATGGCTCC 
TTTGGGGCGT GGTTAGACCG GGACAGCAGC ACCTGGCTCA CGGCCTTTGT GCTGAAGATT 
CTGAGTCTGG CCCAGGAACA GATTGGTGAC TCCCCCGAGA AGCTGCAAGA GACCGCCGGG 
TGGCTGCTGG GCCAGCAGCT GGACGATGGC TCATTCCACG ACCCGTGTCC GGTCATTCAA 
AGAGGCATGC AGGGGGGCTT GGTGGGGACC GACGAGACAG TGGCACTGAC CGCCTTTGTG 
GTCATCGCCC TTCACCACGG GCTGGCCGTC TTCCAAGACG AGAACTCGCA GCAGCTGAAG 
AAGAGGGTGG AAGCCTCCAT CATGAAGGCA AACTCGTTCT TGGGGCAGAA GGCAAGTGCT 
GGGCTCCTGG GTGCACACGC ATCCGCCATC ACAGCCTATG CCCTGACACT GACCAAGGCC 
TCGGAGGACC TGCGGAATGT TGCCCACAAC AGCCTGATGG CCATGGCTGA GGAAACAGGG 
GAAAACCTCT ACTGGGGCTT AGCCATTGGC TCTCAGGACA ACGTTGTGTC ATCCACCGCA 
GCCCCTCGTA ATCCCTCAGA ACCTGTGCCC CAGGCCCCAG CCCTGTGGAT CGAAACCACA 
GCCTACGGCC TGCTACATCT GCTGCTGCGG GAGGGGAAGG GAGAAATGGC TGACAAGGCG 
GCAACCTGGC TCACACACCA GGGAAGCTTC CAAGGGGGAT TCCGCAGTAC CCAGGACACT 
GTGGTCGCCC TGGATGCCCT GTCTGCATAC TGGATCGCTT CACACACCAC CGAGGAGAAG 
GCACTCAATG TGACTCTCAG CTCCATGGGC CGCAATGGGT ACAAGTCCCA CCTGCTACAG 
CTGAACAACC ACCAAGTCAA GGGCCTGGAG GAGGAGCTGA AGTTCTCCCT GGGCAGCACC 
ATCAATGTGA AAGTGGGAGG AAATAGCAAA GGCACCTTAA AGATCCTTCG TACCTACAAT 
GTCCTGGACA TGAAGAACAC AACATGCCAA GACCTTCGGA TAGAAGTGAC AATCACAGGC 
TATGTGGAAT ATACAAGGGA GGCCAACGAA GACTATGAAT ACGACTATGA TATGCCAGCC 
GCAGATGACC CCAGTGTCCA CTCGCAGCCT GTGACACCCC TGCAGCTGTT TGAGGGTCGT 
CGGAGCCGCC GCAGGAGGGA GGCCCCCAAG GCTGCGGATG AGCAGGAGTC CAGAGTGCAG 
TACACCGTGT GCATCTGGCG GAACGGTAAC CTGGGGCTGT CTGGGATGGC CATTGCTGAC 
ATCACCCTCC TGAGTGGATT CCAAGCCCTG AGGGCTGACC TGGAGAAGCT GACCTCCCTC 
TCTGACCGTT ACGTGAGTCA CTTTGAGACC GACGGGCCCC ACGTCCTACT GTACTTTGAC 
TCGGTCCCGA CCACCCGGGA GTGTGTGGGC TTTGGAGCTT TGCAGGAGGT GGCCGTGGGG 
CTGGTGCAGC CAGCCAGTGC TGTCCTGTAT GACTACTACA GCCCTGATCA CAAGTGCTCT 
GTGTTCTATG CTGGACCCAC CAAGAGCAAG CTCCTCTCCA CCTTGTGCTC TGCAGACGTC 
TGCCAGTGCG CTGAAGGGAA GTGTCCTCGA CAGCGAAGGT CACTGGAGCG AGGGGTGGAG 
GACAAGGATG GTTACCGGAT GAAGTTCGCC TGCTATTATC CCCGAGTGGA GTATGGCTTC 
CAGGTTAAGG TTCTCCGAGA AGACAGCAGA TCTGCCTTCC GCCTCTTTGA GACCAAGATC 
ACCCAAGTCC TGCATTTCAC AAAGGATGCC AAGGCCTCCA TAGGTCAGAC CCGCAACTTT 
CTGGTCCGGG CTTCTTGCCG CCTTCGTTTG GAGCCTAGCA AAGAGTACTT AATCATGGGG 
ATGGACGGAG TCACCAGTGA CCTCAAGGGA GACCCCCAGT ACTTGCTGGA CTCAAACAGT 
TGGATCGAGG AGATGCCATC TGAGCGCCTG TGCAGGAGCA CCCGTCAGCG GGCAGCCTGT 
GGCCAGCTCA ATGACTTCCT GCAGGAGTAC AGAAGCCAGG GGTGCCAGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Schizophrenia risk from complex variation of complement component 4.
Nature530(7589)177-83(2016 Feb)
Sekar A,Bialas AR,de Rivera H,Davis A,Hammond TR,Kamitaki N,Tooley K,Presumey J,Baum M,Van Doren V,Genovese G,Rose SA,Handsaker RE,,Daly MJ,Carroll MC,Stevens B,McCarroll SA

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Journal of proteomics75(12)3574-84(2012 Jun)
Bastos-Amador P,Royo F,Gonzalez E,Conde-Vancells J,Palomo-Diez L,Borras FE,Falcon-Perez JM

Increased frequency of complement C4B deficiency in rheumatoid arthritis.
Arthritis and rheumatism64(5)1338-44(2012 May)
Rigby WF,Wu YL,Zan M,Zhou B,Rosengren S,Carlson C,Hilton W,Yu CY

Complement regulator C4BP binds to Staphylococcus aureus and decreases opsonization.
Molecular immunology50(4)253-61(2012 Apr)
Hair PS,Wagner SM,Friederich PT,Drake RR,Nyalwidhe JO,Cunnion KM

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C4b cDNA ORF clone, Rattus norvegicus(Norway rat)

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