Unc5c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Unc5c
Entrez Gene ID	362049
Full Name	unc-5 netrin receptor C
General protein information	Preferred Names unc-5 netrin receptor C Names netrin receptor UNC5C protein unc-5 homolog 3 protein unc-5 homolog C unc-5 homolog 3 unc-5 homolog C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q44
Summary	member of the UNC-5 family of netrin receptors; may be involved in cerebellar development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_199407.1	NP_955439.1	netrin receptor UNC5C precursor
XM_006233402.2	XP_006233464.1	netrin receptor UNC5C isoform X1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	unc5c	XP_004911160.1
Pan troglodytes (chimpanzee)	UNC5C	XP_526636.2
Macaca mulatta (Rhesus monkey)	UNC5C	XP_002804202.1
Gallus gallus (chicken)	UNC5C	NP_989782.1
Danio rerio (zebrafish)	unc5c	NP_001093454.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009061	XP_319812.4
Homo sapiens (human)	UNC5C	NP_003719.3
Canis lupus familiaris (dog)	UNC5C	XP_005639270.1
Bos taurus (cattle)	UNC5C	XP_005207793.1
Rattus norvegicus (Norway rat)	Unc5c	NP_955439.1
Drosophila melanogaster (fruit fly)	unc-5	NP_611033.2
Mus musculus (house mouse)	Unc5c	NP_033498.1

Gene Ontology
Bibliography

Related articles in PubMed

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
Shao Q, Yang T, Huang H, Alarmanazi F, Liu G
The Journal of neuroscience : the official journal of the Society for Neuroscience37(23)5620-5633(2017 06)

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling.
Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M
The Journal of biological chemistry291(23)12282-93(2016 Jun)

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, , Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR
Nature medicine20(12)1452-7(2014 Dec)

A network of genetic repression and derepression specifies projection fates in the developing neocortex.
Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK
Proceedings of the National Academy of Sciences of the United States of America109(47)19071-8(2012 Nov)

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G
The Journal of biological chemistry287(32)27126-38(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Unc5c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Unc5c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05352	NM_199407.1 Latest version!	Rattus norvegicus unc-5 netrin receptor C (Unc5c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
ORa25307	XM_006233402.2 Latest version!	Rattus norvegicus unc-5 netrin receptor C (Unc5c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Unc5c ( NM_199407.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_955439.1 Rattus norvegicus unc-5 netrin receptor C (Unc5c), mRNA.

Price & Availability↑

CloneID	ORa05352
Clone ID Related Accession (Same CDS sequence)	NM_199407.1
Accession Version	NM_199407.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2796bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573660800000
Organism	Rattus norvegicus(Norway rat)
Product	netrin receptor UNC5C precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB118026.1. On Jan 12, 2004 this sequence version replaced XM_342351.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB118026.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTCAGCGCCA GTGGCACCGG CTCGGCCGCT 
CAAGATGATG ACTTTTTCCA TGAACTCCCA GAAACCTTTC CATCAGACCC ACCTGAGCCA 
TTACCACACT TTCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAATGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGG GTAGATGAAA CCTCCGGTCT CATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTCGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCG GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTTGAG CAGGAACCCT TGGGAAAAGA AGTGTCCTTG 
GAGCAGGAAG TGTTACTCCA GTGCCGGCCA CCTGAAGGGA TCCCAATGGC TGAGGTGGAG 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GTCGAAGATC GGAATTTTTA TATCACTATC 
GATCACAACC TGATCATCAA GCAGGCACGA CTCTCAGATA CAGCGAATTA TACCTGTGTT 
GCCAAAAACA TTGTTGCCAA GAGGAAAAGC ACCACAGCCA CCGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGGC AGAATGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCCCTCA ATGGTGGGGC CTTCTGCGAG 
GGGCAGAGTG TACAGAAAAT AGCATGCACC ACGTTATGCC CAGTGGATGG CAGGTGGACT 
TCGTGGAGCA AATGGTCAAC TTGTGGGACT GAGTGCACCC ACTGGCGGAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACCG ATGGGCTGTG CATGCAGGCT GCTCCTGACT CAGATGACGT TGCTCTCTAC 
GTTGGGATTG TGATCGCTGT AACCGTTTGT CTGGCAATCA CTGTTGTGGT GGCCCTGTTC 
GTGTATCGCA AGAACCACCG TGACTTTGAG TCTAATATCA TTGACTCCTC AGCACTCAAT 
GGCGGCTTTC AGCCTGTGAA CATCAAGGCT GCCAGACAAG ATCTCCTGGC AGTACCCCCG 
GATCTCACCT CAGCTGCAGC CATGTACAGG GGACCCGTCT ATGCTCTCCA TGATGTCTCA 
GACAAAATCC CAATGACCAA TTCTCCAATT CTAGACCCAC TGCCCAATTT GAAAATCAAA 
GTGTACAACA GCTCAGGTGC TGTCACTCCT CAGGACGACC TTGCTGAGTT CTCATCCAAG 
CTGTCACCCC AGATGACCCA ATCCTTGCTA GAGAATGAGG CCCTGAACCT GAAGAACCAG 
AGTCTCGCAA GACAGACTGA CCCATCCTGC ACAGCGTTTG GCACCTTCAA CTCCCTGGGC 
GGTCACCTCA TCATCCCTAA TTCAGGAGTA AGCTTGCTGA TTCCCGCTGG GGCCATTCCT 
CAGGGGAGAG TCTATGAAAT GTATGTGACT GTACACAGGA AAGAAAATAT GAGGCCCCCC 
ATGGAAGACT CTCAGACCCT GCTGACCCCT GTGGTGAGCT GTGGGCCTCC TGGAGCTCTG 
TTGACCCGTC CTGTCATCCT CACTCTGCAT CACTGTGCAG ACCCTAACAC CGAGGACTGG 
AAGATCCAGC TCAAAAACCA GGCAGTGCAG GGACAGTGGG AGGATGTTGT GGTTGTTGGA 
GAGGAAAACT TCACAACCCC CTGTTACATT CAGCTGGATG CAGAGGCTTG CCATATTCTC 
ACGGAGAACC TCAGTACCTA TGCCCTGGTT GGGCAGTCCA CCACCAAAGC AGCTGCCAAG 
CGTCTGAAGC TGGCCATCTT TGGGCCCCTC TGCTGCTCTT CCCTGGAGTA TAGCATCAGA 
GTCTACTGCC TGGATGACAC ACAGGATGCC CTGAAGGAAG TTCTACAACT GGAAAGGCAA 
ATGGGAGGAC AGCTCCTAGA AGAACCCAAG GCTCTTCATT TTAAAGGCAG CATCCACAAC 
CTGCGCCTCT CAATTCATGA CATCACCCAT TCCCTCTGGA AGAGCAAATT GCTGGCTAAG 
TATCAGGAAA TTCCATTTTA CCACATCTGG AGTGGCTCTC AAAGAAACCT CCACTGTACC 
TTCACTCTGG AAAGACTCAG CCTAAACACA GTAGAGCTGG TTTGCAAACT CTGTGTGCGG 
CAGGTTGAAG GAGAAGGGCA GATCTTCCAG CTCAACTGTA CTGTGTCAGA GGAACCTACT 
GGTATCGATT TGCCTCTCCT GGACCCTGCT AGCACCATTA CCACTGTCAC TGGACCAAGT 
GCTTTCAGCA TCCCTCTTCC TATCCGGCAG AAGCTATGTA GCAGCCTGGA TGCCCCCCAA 
ACAAGAGGCC ATGACTGGAG GATGCTGGCC CACAAACTTA ACCTGGACAG GTACTTGAAT 
TACTTTGCCA CCAAATCGAG CCCGACTGGC GTAATCCTGG ATCTCTGGGA AGCACAGAAC 
TTCCCCGATG GAAACCTGAG CATGCTGGCA GCCGTCCTGG AAGAAATGGG AAGACACGAA 
ACCGTAGTGT CCTTGGCAGC AGAAGGTCAG TATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_955439.1
CDS	151..2946
Translation	MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPMAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWAEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESNIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPNTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDITHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

Target ORF information:

RefSeq Version	NM_199407.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus unc-5 netrin receptor C (Unc5c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199407.1

ORF Insert Sequence:

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTCAGCGCCA GTGGCACCGG CTCGGCCGCT 
CAAGATGATG ACTTTTTCCA TGAACTCCCA GAAACCTTTC CATCAGACCC ACCTGAGCCA 
TTACCACACT TTCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAATGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGG GTAGATGAAA CCTCCGGTCT CATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTCGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCG GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTTGAG CAGGAACCCT TGGGAAAAGA AGTGTCCTTG 
GAGCAGGAAG TGTTACTCCA GTGCCGGCCA CCTGAAGGGA TCCCAATGGC TGAGGTGGAG 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GTCGAAGATC GGAATTTTTA TATCACTATC 
GATCACAACC TGATCATCAA GCAGGCACGA CTCTCAGATA CAGCGAATTA TACCTGTGTT 
GCCAAAAACA TTGTTGCCAA GAGGAAAAGC ACCACAGCCA CCGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGGC AGAATGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCCCTCA ATGGTGGGGC CTTCTGCGAG 
GGGCAGAGTG TACAGAAAAT AGCATGCACC ACGTTATGCC CAGTGGATGG CAGGTGGACT 
TCGTGGAGCA AATGGTCAAC TTGTGGGACT GAGTGCACCC ACTGGCGGAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACCG ATGGGCTGTG CATGCAGGCT GCTCCTGACT CAGATGACGT TGCTCTCTAC 
GTTGGGATTG TGATCGCTGT AACCGTTTGT CTGGCAATCA CTGTTGTGGT GGCCCTGTTC 
GTGTATCGCA AGAACCACCG TGACTTTGAG TCTAATATCA TTGACTCCTC AGCACTCAAT 
GGCGGCTTTC AGCCTGTGAA CATCAAGGCT GCCAGACAAG ATCTCCTGGC AGTACCCCCG 
GATCTCACCT CAGCTGCAGC CATGTACAGG GGACCCGTCT ATGCTCTCCA TGATGTCTCA 
GACAAAATCC CAATGACCAA TTCTCCAATT CTAGACCCAC TGCCCAATTT GAAAATCAAA 
GTGTACAACA GCTCAGGTGC TGTCACTCCT CAGGACGACC TTGCTGAGTT CTCATCCAAG 
CTGTCACCCC AGATGACCCA ATCCTTGCTA GAGAATGAGG CCCTGAACCT GAAGAACCAG 
AGTCTCGCAA GACAGACTGA CCCATCCTGC ACAGCGTTTG GCACCTTCAA CTCCCTGGGC 
GGTCACCTCA TCATCCCTAA TTCAGGAGTA AGCTTGCTGA TTCCCGCTGG GGCCATTCCT 
CAGGGGAGAG TCTATGAAAT GTATGTGACT GTACACAGGA AAGAAAATAT GAGGCCCCCC 
ATGGAAGACT CTCAGACCCT GCTGACCCCT GTGGTGAGCT GTGGGCCTCC TGGAGCTCTG 
TTGACCCGTC CTGTCATCCT CACTCTGCAT CACTGTGCAG ACCCTAACAC CGAGGACTGG 
AAGATCCAGC TCAAAAACCA GGCAGTGCAG GGACAGTGGG AGGATGTTGT GGTTGTTGGA 
GAGGAAAACT TCACAACCCC CTGTTACATT CAGCTGGATG CAGAGGCTTG CCATATTCTC 
ACGGAGAACC TCAGTACCTA TGCCCTGGTT GGGCAGTCCA CCACCAAAGC AGCTGCCAAG 
CGTCTGAAGC TGGCCATCTT TGGGCCCCTC TGCTGCTCTT CCCTGGAGTA TAGCATCAGA 
GTCTACTGCC TGGATGACAC ACAGGATGCC CTGAAGGAAG TTCTACAACT GGAAAGGCAA 
ATGGGAGGAC AGCTCCTAGA AGAACCCAAG GCTCTTCATT TTAAAGGCAG CATCCACAAC 
CTGCGCCTCT CAATTCATGA CATCACCCAT TCCCTCTGGA AGAGCAAATT GCTGGCTAAG 
TATCAGGAAA TTCCATTTTA CCACATCTGG AGTGGCTCTC AAAGAAACCT CCACTGTACC 
TTCACTCTGG AAAGACTCAG CCTAAACACA GTAGAGCTGG TTTGCAAACT CTGTGTGCGG 
CAGGTTGAAG GAGAAGGGCA GATCTTCCAG CTCAACTGTA CTGTGTCAGA GGAACCTACT 
GGTATCGATT TGCCTCTCCT GGACCCTGCT AGCACCATTA CCACTGTCAC TGGACCAAGT 
GCTTTCAGCA TCCCTCTTCC TATCCGGCAG AAGCTATGTA GCAGCCTGGA TGCCCCCCAA 
ACAAGAGGCC ATGACTGGAG GATGCTGGCC CACAAACTTA ACCTGGACAG GTACTTGAAT 
TACTTTGCCA CCAAATCGAG CCCGACTGGC GTAATCCTGG ATCTCTGGGA AGCACAGAAC 
TTCCCCGATG GAAACCTGAG CATGCTGGCA GCCGTCCTGG AAGAAATGGG AAGACACGAA 
ACCGTAGTGT CCTTGGCAGC AGAAGGTCAG TATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Unc5c ( XM_006233402.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233464.1 Rattus norvegicus unc-5 netrin receptor C (Unc5c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25307
Clone ID Related Accession (Same CDS sequence)	XM_006233402.2
Accession Version	XM_006233402.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2853bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	netrin receptor UNC5C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006233402.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTCAGCGCCA GTGGCACCGG CTCGGCCGCT 
CAAGATGATG ACTTTTTCCA TGAACTCCCA GAAACCTTTC CATCAGACCC ACCTGAGCCA 
TTACCACACT TTCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAATGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGG GTAGATGAAA CCTCCGGTCT CATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTCGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCG GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTTGAG CAGGAACCCT TGGGAAAAGA AGTGTCCTTG 
GAGCAGGAAG TGTTACTCCA GTGCCGGCCA CCTGAAGGGA TCCCAATGGC TGAGGTGGAG 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GTCGAAGATC GGAATTTTTA TATCACTATC 
GATCACAACC TGATCATCAA GCAGGCACGA CTCTCAGATA CAGCGAATTA TACCTGTGTT 
GCCAAAAACA TTGTTGCCAA GAGGAAAAGC ACCACAGCCA CCGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGGC AGAATGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCCCTCA ATGGTGGGGC CTTCTGCGAG 
GGGCAGAGTG TACAGAAAAT AGCATGCACC ACGTTATGCC CAGTGGATGG CAGGTGGACT 
TCGTGGAGCA AATGGTCAAC TTGTGGGACT GAGTGCACCC ACTGGCGGAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACCG ATGGGCTGTG CATGCAGGGA TTCATTTACC CCATTTCAAC TGAGCACAGA 
ACCCAGAGTG AATATGGATT TTCTTCTGCT CCTGACTCAG ATGACGTTGC TCTCTACGTT 
GGGATTGTGA TCGCTGTAAC CGTTTGTCTG GCAATCACTG TTGTGGTGGC CCTGTTCGTG 
TATCGCAAGA ACCACCGTGA CTTTGAGTCT GATATCATTG ACTCCTCAGC ACTCAATGGC 
GGCTTTCAGC CTGTGAACAT CAAGGCTGCC AGACAAGATC TCCTGGCAGT ACCCCCGGAT 
CTCACCTCAG CTGCAGCCAT GTACAGGGGA CCCGTCTATG CTCTGCATGA TGTCTCAGAC 
AAAATCCCAA TGACCAATTC TCCAATTCTA GACCCACTGC CCAATTTGAA AATCAAAGTG 
TACAACAGCT CAGGTGCTGT CACTCCTCAG GACGACCTTG CTGAGTTCTC ATCCAAGCTG 
TCACCCCAGA TGACCCAATC CTTGCTAGAG AATGAGGCCC TGAACCTGAA GAACCAGAGT 
CTCGCAAGAC AGACTGACCC ATCCTGCACA GCGTTTGGCA CCTTCAACTC CCTGGGCGGT 
CACCTCATCA TCCCTAATTC AGGAGTAAGC TTGCTGATTC CCGCTGGGGC CATTCCTCAG 
GGGAGAGTCT ATGAAATGTA TGTGACTGTA CACAGGAAAG AAAATATGAG GCCCCCCATG 
GAAGACTCTC AGACCCTGCT GACCCCTGTG GTGAGCTGTG GGCCTCCTGG AGCTCTGTTG 
ACCCGTCCTG TCATCCTCAC TCTGCATCAC TGTGCAGACC CTAACACCGA GGACTGGAAG 
ATCCAGCTCA AAAACCAGGC AGTGCAGGGA CAGTGGGAGG ATGTTGTGGT TGTTGGAGAG 
GAAAACTTCA CAACCCCCTG TTACATTCAG CTGGATGCAG AGGCTTGCCA TATTCTCACG 
GAGAACCTCA GTACCTATGC CCTGGTTGGG CAGTCCACCA CCAAAGCAGC TGCCAAGCGT 
CTGAAGCTGG CCATCTTTGG GCCCCTCTGC TGCTCTTCCC TGGAGTATAG CATCAGAGTC 
TACTGCCTGG ATGACACACA GGATGCCCTG AAGGAAGTTC TACAACTGGA AAGGCAAATG 
GGAGGACAGC TCCTAGAAGA ACCCAAGGCT CTTCATTTTA AAGGCAGCAT CCACAACCTG 
CGCCTCTCAA TTCATGACAT CACCCATTCC CTCTGGAAGA GCAAATTGCT GGCTAAGTAT 
CAGGAAATTC CATTTTACCA CATCTGGAGT GGCTCTCAAA GAAACCTCCA CTGTACCTTC 
ACTCTGGAAA GACTCAGCCT AAACACAGTA GAGCTGGTTT GCAAACTCTG TGTGCGGCAG 
GTTGAAGGAG AAGGGCAGAT CTTCCAGCTC AACTGTACTG TGTCAGAGGA ACCTACTGGT 
ATCGATTTGC CTCTCCTGGA CCCTGCTAGC ACCATTACCA CTGTCACTGG ACCAAGTGCT 
TTCAGCATCC CTCTTCCTAT CCGGCAGAAG CTATGTAGCA GCCTGGATGC CCCCCAAACA 
AGAGGCCATG ACTGGAGGAT GCTGGCCCAC AAACTTAACC TGGACAGGTA CTTGAATTAC 
TTTGCCACCA AATCGAGCCC GACTGGCGTA ATCCTGGATC TCTGGGAAGC ACAGAACTTC 
CCCGATGGAA ACCTGAGCAT GCTGGCAGCC GTCCTGGAAG AAATGGGAAG ACACGAAACC 
GTAGTGTCCT TGGCAGCAGA AGGTCAGTAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233464.1
CDS	99..2951
Translation	MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPMAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWAEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQGFIYPISTEHRTQSEYGFSSAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPNTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDITHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

Target ORF information:

RefSeq Version	XM_006233402.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus unc-5 netrin receptor C (Unc5c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233402.2

ORF Insert Sequence:

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTCAGCGCCA GTGGCACCGG CTCGGCCGCT 
CAAGATGATG ACTTTTTCCA TGAACTCCCA GAAACCTTTC CATCAGACCC ACCTGAGCCA 
TTACCACACT TTCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAATGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGG GTAGATGAAA CCTCCGGTCT CATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTCGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCG GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTTGAG CAGGAACCCT TGGGAAAAGA AGTGTCCTTG 
GAGCAGGAAG TGTTACTCCA GTGCCGGCCA CCTGAAGGGA TCCCAATGGC TGAGGTGGAG 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GTCGAAGATC GGAATTTTTA TATCACTATC 
GATCACAACC TGATCATCAA GCAGGCACGA CTCTCAGATA CAGCGAATTA TACCTGTGTT 
GCCAAAAACA TTGTTGCCAA GAGGAAAAGC ACCACAGCCA CCGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGGC AGAATGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCCCTCA ATGGTGGGGC CTTCTGCGAG 
GGGCAGAGTG TACAGAAAAT AGCATGCACC ACGTTATGCC CAGTGGATGG CAGGTGGACT 
TCGTGGAGCA AATGGTCAAC TTGTGGGACT GAGTGCACCC ACTGGCGGAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACCG ATGGGCTGTG CATGCAGGGA TTCATTTACC CCATTTCAAC TGAGCACAGA 
ACCCAGAGTG AATATGGATT TTCTTCTGCT CCTGACTCAG ATGACGTTGC TCTCTACGTT 
GGGATTGTGA TCGCTGTAAC CGTTTGTCTG GCAATCACTG TTGTGGTGGC CCTGTTCGTG 
TATCGCAAGA ACCACCGTGA CTTTGAGTCT GATATCATTG ACTCCTCAGC ACTCAATGGC 
GGCTTTCAGC CTGTGAACAT CAAGGCTGCC AGACAAGATC TCCTGGCAGT ACCCCCGGAT 
CTCACCTCAG CTGCAGCCAT GTACAGGGGA CCCGTCTATG CTCTGCATGA TGTCTCAGAC 
AAAATCCCAA TGACCAATTC TCCAATTCTA GACCCACTGC CCAATTTGAA AATCAAAGTG 
TACAACAGCT CAGGTGCTGT CACTCCTCAG GACGACCTTG CTGAGTTCTC ATCCAAGCTG 
TCACCCCAGA TGACCCAATC CTTGCTAGAG AATGAGGCCC TGAACCTGAA GAACCAGAGT 
CTCGCAAGAC AGACTGACCC ATCCTGCACA GCGTTTGGCA CCTTCAACTC CCTGGGCGGT 
CACCTCATCA TCCCTAATTC AGGAGTAAGC TTGCTGATTC CCGCTGGGGC CATTCCTCAG 
GGGAGAGTCT ATGAAATGTA TGTGACTGTA CACAGGAAAG AAAATATGAG GCCCCCCATG 
GAAGACTCTC AGACCCTGCT GACCCCTGTG GTGAGCTGTG GGCCTCCTGG AGCTCTGTTG 
ACCCGTCCTG TCATCCTCAC TCTGCATCAC TGTGCAGACC CTAACACCGA GGACTGGAAG 
ATCCAGCTCA AAAACCAGGC AGTGCAGGGA CAGTGGGAGG ATGTTGTGGT TGTTGGAGAG 
GAAAACTTCA CAACCCCCTG TTACATTCAG CTGGATGCAG AGGCTTGCCA TATTCTCACG 
GAGAACCTCA GTACCTATGC CCTGGTTGGG CAGTCCACCA CCAAAGCAGC TGCCAAGCGT 
CTGAAGCTGG CCATCTTTGG GCCCCTCTGC TGCTCTTCCC TGGAGTATAG CATCAGAGTC 
TACTGCCTGG ATGACACACA GGATGCCCTG AAGGAAGTTC TACAACTGGA AAGGCAAATG 
GGAGGACAGC TCCTAGAAGA ACCCAAGGCT CTTCATTTTA AAGGCAGCAT CCACAACCTG 
CGCCTCTCAA TTCATGACAT CACCCATTCC CTCTGGAAGA GCAAATTGCT GGCTAAGTAT 
CAGGAAATTC CATTTTACCA CATCTGGAGT GGCTCTCAAA GAAACCTCCA CTGTACCTTC 
ACTCTGGAAA GACTCAGCCT AAACACAGTA GAGCTGGTTT GCAAACTCTG TGTGCGGCAG 
GTTGAAGGAG AAGGGCAGAT CTTCCAGCTC AACTGTACTG TGTCAGAGGA ACCTACTGGT 
ATCGATTTGC CTCTCCTGGA CCCTGCTAGC ACCATTACCA CTGTCACTGG ACCAAGTGCT 
TTCAGCATCC CTCTTCCTAT CCGGCAGAAG CTATGTAGCA GCCTGGATGC CCCCCAAACA 
AGAGGCCATG ACTGGAGGAT GCTGGCCCAC AAACTTAACC TGGACAGGTA CTTGAATTAC 
TTTGCCACCA AATCGAGCCC GACTGGCGTA ATCCTGGATC TCTGGGAAGC ACAGAACTTC 
CCCGATGGAA ACCTGAGCAT GCTGGCAGCC GTCCTGGAAG AAATGGGAAG ACACGAAACC 
GTAGTGTCCT TGGCAGCAGA AGGTCAGTAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(23)5620-5633(2017 06)
Shao Q,Yang T,Huang H,Alarmanazi F,Liu G

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling.
The Journal of biological chemistry291(23)12282-93(2016 Jun)
Hashimoto Y,Toyama Y,Kusakari S,Nawa M,Matsuoka M

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Nature medicine20(12)1452-7(2014 Dec)
Wetzel-Smith MK,Hunkapiller J,Bhangale TR,Srinivasan K,Maloney JA,Atwal JK,Sa SM,Yaylaoglu MB,Foreman O,Ortmann W,Rathore N,Hansen DV,Tessier-Lavigne M,,Mayeux R,Pericak-Vance M,Haines J,Farrer LA,Schellenberg GD,Goate A,Behrens TW,Cruchaga C,Watts RJ,Graham RR

A network of genetic repression and derepression specifies projection fates in the developing neocortex.
Proceedings of the National Academy of Sciences of the United States of America109(47)19071-8(2012 Nov)
Srinivasan K,Leone DP,Bateson RK,Dobreva G,Kohwi Y,Kohwi-Shigematsu T,Grosschedl R,McConnell SK

Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
The Journal of biological chemistry287(32)27126-38(2012 Aug)
Purohit AA,Li W,Qu C,Dwyer T,Shao Q,Guan KL,Liu G

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Unc5c cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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