Chchd10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chchd10
Entrez Gene ID	361824
Full Name	coiled-coil-helix-coiled-coil-helix domain containing 10
Synonyms	Ndg2
General protein information	Preferred Names coiled-coil-helix-coiled-coil-helix domain containing 10 Names coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial Nur77 downstream gene 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001007008.1	NP_001007009.1	coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CHCHD10	XP_001162555.1
Canis lupus familiaris (dog)	CHCHD10	XP_534755.3
Gallus gallus (chicken)	LOC416933	XP_003642270.1
Danio rerio (zebrafish)	chchd10	NP_957078.1
Xenopus tropicalis (tropical clawed frog)	chchd10	XP_002940705.1
Homo sapiens (human)	CHCHD10	NP_998885.1
Rattus norvegicus (Norway rat)	Chchd10	NP_001007009.1
Bos taurus (cattle)	CHCHD10	NP_001077243.1
Mus musculus (house mouse)	Chchd10	NP_780538.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases.
Genin EC, Bannwarth S, Lespinasse F, Ortega-Vila B, Fragaki K, Itoh K, Villa E, Lacas-Gervais S, Jokela M, Auranen M, Ylikallio E, Mauri-Crouzet A, Tyynismaa H, Vihola A, Augé G, Cochaud C, Sesaki H, Ricci JE, Udd B, Vives-Bauza C, Paquis-Flucklinger V
Neurobiology of disease119159-171(2018 11)

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.
Woo JA, Liu T, Trotter C, Fang CC, De Narvaez E, LePochat P, Maslar D, Bukhari A, Zhao X, Deonarine A, Westerheide SD, Kang DE
Nature communications815558(2017 06)

CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.
Genin EC, Plutino M, Bannwarth S, Villa E, Cisneros-Barroso E, Roy M, Ortega-Vila B, Fragaki K, Lespinasse F, Pinero-Martos E, Augé G, Moore D, Burté F, Lacas-Gervais S, Kageyama Y, Itoh K, Yu-Wai-Man P, Sesaki H, Ricci JE, Vives-Bauza C, Paquis-Flucklinger V
EMBO molecular medicine8(1)58-72(2016 Jan)

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.
Bannwarth S, Ait-El-Mkadem S, Chaussenot A, Genin EC, Lacas-Gervais S, Fragaki K, Berg-Alonso L, Kageyama Y, Serre V, Moore DG, Verschueren A, Rouzier C, Le Ber I, Augé G, Cochaud C, Lespinasse F, N'Guyen K, de Septenville A, Brice A, Yu-Wai-Man P, Sesaki H, Pouget J, Paquis-Flucklinger V
Brain : a journal of neurology137(Pt 8)2329-45(2014 Aug)

Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association.
Martherus RS, Sluiter W, Timmer ED, VanHerle SJ, Smeets HJ, Ayoubi TA
Biochemical and biophysical research communications402(2)203-8(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Chchd10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chchd10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10821	NM_001007008.1 Latest version!	Rattus norvegicus coiled-coil-helix-coiled-coil-helix domain containing 10 (Chchd10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chchd10 ( NM_001007008.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007009.1 Rattus norvegicus coiled-coil-helix-coiled-coil-helix domain containing 10 (Chchd10), mRNA.

Price & Availability↑

CloneID	ORa10821
Clone ID Related Accession (Same CDS sequence)	NM_001007008.1
Accession Version	NM_001007008.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 417bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555516800000
Organism	Rattus norvegicus(Norway rat)
Product	coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC082751.1. On Nov 22, 2004 this sequence version replaced XM_342118.1. ##Evidence-Data-START## Transcript exon combination :: BC082751.1, FQ216195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906353, SAMN01906354 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCCACGAG GAAGCCGCAG TGCGGCTGCC AGGCCGGCCA GCCGCCCAGC CCATCCTCCT 
GCGCACCCAC CACCCTCAGC CCCCGCCCCC GCACCTGCCA CCTCGGGACA GCCGGGTCTT 
ATGGCTCAGA TGGCATCCAC CGCCGCGGGC GTAGCTGTGG GCTCAGCTGT AGGGCATGTC 
ATGGGTAGCG CCCTGACCAG TGCCTTCAGT GGGGGAAGCT CAGAGCCTGC CCAGCCTGCG 
GTCCAGCAGG CCCCTGCCCG TCCTGCCTCT CACCCCCTGC AGATGGGGCC CTGCGCCTAT 
GAGATCAAGC AGTTCCTGGA CTGCTCCACC ACTCAGAGCG ACCTAACCCT GTGTGAGGGC 
TTCAGTGAGG CCCTCAAACA GTGCAAATAC AATCACGGTC TGAGCTCCCT ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007009.1
CDS	59..475
Translation	MPRGSRSAAARPASRPAHPPAHPPPSAPAPAPATSGQPGLMAQMASTAAGVAVGSAVGHVMGSALTSAFSGGSSEPAQPAVQQAPARPASHPLQMGPCAYEIKQFLDCSTTQSDLTLCEGFSEALKQCKYNHGLSSLP

Target ORF information:

RefSeq Version	NM_001007008.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus coiled-coil-helix-coiled-coil-helix domain containing 10 (Chchd10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007008.1

ORF Insert Sequence:

ATGCCACGAG GAAGCCGCAG TGCGGCTGCC AGGCCGGCCA GCCGCCCAGC CCATCCTCCT 
GCGCACCCAC CACCCTCAGC CCCCGCCCCC GCACCTGCCA CCTCGGGACA GCCGGGTCTT 
ATGGCTCAGA TGGCATCCAC CGCCGCGGGC GTAGCTGTGG GCTCAGCTGT AGGGCATGTC 
ATGGGTAGCG CCCTGACCAG TGCCTTCAGT GGGGGAAGCT CAGAGCCTGC CCAGCCTGCG 
GTCCAGCAGG CCCCTGCCCG TCCTGCCTCT CACCCCCTGC AGATGGGGCC CTGCGCCTAT 
GAGATCAAGC AGTTCCTGGA CTGCTCCACC ACTCAGAGCG ACCTAACCCT GTGTGAGGGC 
TTCAGTGAGG CCCTCAAACA GTGCAAATAC AATCACGGTC TGAGCTCCCT ACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases.
Neurobiology of disease119159-171(2018 11)
Genin EC,Bannwarth S,Lespinasse F,Ortega-Vila B,Fragaki K,Itoh K,Villa E,Lacas-Gervais S,Jokela M,Auranen M,Ylikallio E,Mauri-Crouzet A,Tyynismaa H,Vihola A,Augé G,Cochaud C,Sesaki H,Ricci JE,Udd B,Vives-Bauza C,Paquis-Flucklinger V

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.
Nature communications815558(2017 06)
Woo JA,Liu T,Trotter C,Fang CC,De Narvaez E,LePochat P,Maslar D,Bukhari A,Zhao X,Deonarine A,Westerheide SD,Kang DE

CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.
EMBO molecular medicine8(1)58-72(2016 Jan)
Genin EC,Plutino M,Bannwarth S,Villa E,Cisneros-Barroso E,Roy M,Ortega-Vila B,Fragaki K,Lespinasse F,Pinero-Martos E,Augé G,Moore D,Burté F,Lacas-Gervais S,Kageyama Y,Itoh K,Yu-Wai-Man P,Sesaki H,Ricci JE,Vives-Bauza C,Paquis-Flucklinger V

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.
Brain : a journal of neurology137(Pt 8)2329-45(2014 Aug)
Bannwarth S,Ait-El-Mkadem S,Chaussenot A,Genin EC,Lacas-Gervais S,Fragaki K,Berg-Alonso L,Kageyama Y,Serre V,Moore DG,Verschueren A,Rouzier C,Le Ber I,Augé G,Cochaud C,Lespinasse F,N'Guyen K,de Septenville A,Brice A,Yu-Wai-Man P,Sesaki H,Pouget J,Paquis-Flucklinger V

Functional annotation of heart enriched mitochondrial genes GBAS and CHCHD10 through guilt by association.
Biochemical and biophysical research communications402(2)203-8(2010 Nov)
Martherus RS,Sluiter W,Timmer ED,VanHerle SJ,Smeets HJ,Ayoubi TA

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Chchd10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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