| Gene Symbol | Chchd10 |
| Entrez Gene ID | 103172 |
| Full Name | coiled-coil-helix-coiled-coil-helix domain containing 10 |
| Synonyms | 1620401E04Rik,AI267078,Ndg2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Chchd10 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Chchd10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chchd10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu05179 Clone ID Related Accession (Same CDS sequence) NM_175329.4 , XM_006512993.1 Accession Version NM_175329.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 417bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1567958400000 Organism Mus musculus(house mouse) Product coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM934773.1, BC083357.1 and W16247.1. On Feb 8, 2017 this sequence version replaced NM_175329.3. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361ATGCCTCGGG GAAGCCGCAG TGCGGCTGCC AGGCCGGTCA GCCGCCCAGC CCCGCCTCCT
GCGCACCCAC CACCCTCAGC GGCCGCCCCG GCACCTGCCG CTCCCGGCCA GCCGGGTCTT
ATGGCTCAGA TGGCATCCAC CGCCGCAGGC GTAGCCGTGG GCTCAGCTGT AGGGCATGTC
ATGGGTAGCG CCCTGACCAG TGCCTTCAGT GGGGGAAATT CAGAGCCTGC CCAGCCTGCC
GTCCAGCAGG CCCCTGCCCG GCCTGCCTCT CACCCCCTGC AGATGGGGCC CTGCTCCTAT
GAGATCAAGC AGTTCCTGGA CTGCTCCACC ACTCAGAGCG ACCTAACCCT GTGTGAGGGC
TTCAGCGAGG CCCTCAAACA GTGCAAATAC AATCACGGTC TGAGCTCCCT GCCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_780538.2 CDS 919..1335 Translation 
Target ORF information:
RefSeq Version NM_175329.4 Organism Mus musculus(house mouse) Definition Mus musculus coiled-coil-helix-coiled-coil-helix domain containing 10 (Chchd10), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_175329.4
ORF Insert Sequence:
1
61
121
181
241
301
361ATGCCTCGGG GAAGCCGCAG TGCGGCTGCC AGGCCGGTCA GCCGCCCAGC CCCGCCTCCT
GCGCACCCAC CACCCTCAGC GGCCGCCCCG GCACCTGCCG CTCCCGGCCA GCCGGGTCTT
ATGGCTCAGA TGGCATCCAC CGCCGCAGGC GTAGCCGTGG GCTCAGCTGT AGGGCATGTC
ATGGGTAGCG CCCTGACCAG TGCCTTCAGT GGGGGAAATT CAGAGCCTGC CCAGCCTGCC
GTCCAGCAGG CCCCTGCCCG GCCTGCCTCT CACCCCCTGC AGATGGGGCC CTGCTCCTAT
GAGATCAAGC AGTTCCTGGA CTGCTCCACC ACTCAGAGCG ACCTAACCCT GTGTGAGGGC
TTCAGCGAGG CCCTCAAACA GTGCAAATAC AATCACGGTC TGAGCTCCCT GCCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu05179 Clone ID Related Accession (Same CDS sequence) NM_175329.4 , XM_006512993.1 Accession Version XM_006512993.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 417bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1466438400000 Organism Mus musculus(house mouse) Product coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361ATGCCTCGGG GAAGCCGCAG TGCGGCTGCC AGGCCGGTCA GCCGCCCAGC CCCGCCTCCT
GCGCACCCAC CACCCTCAGC GGCCGCCCCG GCACCTGCCG CTCCCGGCCA GCCGGGTCTT
ATGGCTCAGA TGGCATCCAC CGCCGCAGGC GTAGCCGTGG GCTCAGCTGT AGGGCATGTC
ATGGGTAGCG CCCTGACCAG TGCCTTCAGT GGGGGAAATT CAGAGCCTGC CCAGCCTGCC
GTCCAGCAGG CCCCTGCCCG GCCTGCCTCT CACCCCCTGC AGATGGGGCC CTGCTCCTAT
GAGATCAAGC AGTTCCTGGA CTGCTCCACC ACTCAGAGCG ACCTAACCCT GTGTGAGGGC
TTCAGCGAGG CCCTCAAACA GTGCAAATAC AATCACGGTC TGAGCTCCCT GCCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_006513056.1 CDS 1079..1495 Translation
Target ORF information:
RefSeq Version XM_006512993.1 Organism Mus musculus(house mouse) Definition Mus musculus coiled-coil-helix-coiled-coil-helix domain containing 10 (Chchd10), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_006512993.1
ORF Insert Sequence:
1
61
121
181
241
301
361ATGCCTCGGG GAAGCCGCAG TGCGGCTGCC AGGCCGGTCA GCCGCCCAGC CCCGCCTCCT
GCGCACCCAC CACCCTCAGC GGCCGCCCCG GCACCTGCCG CTCCCGGCCA GCCGGGTCTT
ATGGCTCAGA TGGCATCCAC CGCCGCAGGC GTAGCCGTGG GCTCAGCTGT AGGGCATGTC
ATGGGTAGCG CCCTGACCAG TGCCTTCAGT GGGGGAAATT CAGAGCCTGC CCAGCCTGCC
GTCCAGCAGG CCCCTGCCCG GCCTGCCTCT CACCCCCTGC AGATGGGGCC CTGCTCCTAT
GAGATCAAGC AGTTCCTGGA CTGCTCCACC ACTCAGAGCG ACCTAACCCT GTGTGAGGGC
TTCAGCGAGG CCCTCAAACA GTGCAAATAC AATCACGGTC TGAGCTCCCT GCCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response.
Acta neuropathologica138(1)103-121(2019 07)
Anderson CJ,Bredvik K,Burstein SR,Davis C,Meadows SM,Dash J,Case L,Milner TA,Kawamata H,Zuberi A,Piersigilli A,Lutz C,Manfredi G
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10.
Human molecular genetics27(22)3881-3900(2018 11)
Huang X,Wu BP,Nguyen D,Liu YT,Marani M,Hench J,Bénit P,Kozjak-Pavlovic V,Rustin P,Frank S,Narendra DP
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.
Human molecular genetics27(1)160-177(2018 01)
Burstein SR,Valsecchi F,Kawamata H,Bourens M,Zeng R,Zuberi A,Milner TA,Cloonan SM,Lutz C,Barrientos A,Manfredi G
Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.
Nature communications815558(2017 06)
Woo JA,Liu T,Trotter C,Fang CC,De Narvaez E,LePochat P,Maslar D,Bukhari A,Zhao X,Deonarine A,Westerheide SD,Kang DE
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
PloS one6(6)e21208(2011)
Tang F,Barbacioru C,Nordman E,Bao S,Lee C,Wang X,Tuch BB,Heard E,Lao K,Surani MA
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