Vrk2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vrk2
Entrez Gene ID	360991
Full Name	vaccinia related kinase 2
General protein information	Preferred Names vaccinia related kinase 2 Names serine/threonine-protein kinase VRK2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14q22

mRNA and Protein(s)

mRNA	Protein	Name
XM_008770432.2	XP_008768654.1	serine/threonine-protein kinase VRK2 isoform X1
NM_001108366.1	NP_001101836.1	serine/threonine-protein kinase VRK2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Vrk2	NP_081536.2
Rattus norvegicus (Norway rat)	Vrk2	NP_001101836.1
Danio rerio (zebrafish)	vrk2	NP_957464.1
Xenopus tropicalis (tropical clawed frog)	vrk2	XP_002936873.2
Homo sapiens (human)	VRK2	NP_001123952.1
Macaca mulatta (Rhesus monkey)	VRK2	XP_001112841.2
Bos taurus (cattle)	VRK2	NP_001069319.1
Pan troglodytes (chimpanzee)	VRK2	XP_001157703.2
Gallus gallus (chicken)	VRK2	XP_004940169.1
Canis lupus familiaris (dog)	VRK2	XP_005626178.1

Gene Ontology
Bibliography

Related articles in PubMed

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.
Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, Schweder T
Biosensors & bioelectronics36(1)207-11(2012 Jun-Jul)

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.
Fernández IF, Blanco S, Lozano J, Lazo PA
Molecular and cellular biology30(19)4687-97(2010 Oct)

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.
Blanco S, Sanz-García M, Santos CR, Lazo PA
PloS one3(2)e1660(2008 Feb)

Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1.
Blanco S, Santos C, Lazo PA
Molecular and cellular biology27(20)7273-83(2007 Oct)

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.
Blanco S, Klimcakova L, Vega FM, Lazo PA
The FEBS journal273(11)2487-504(2006 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Vrk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vrk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41638	NM_001108366.1 Latest version!	Rattus norvegicus VRK serine/threonine kinase 2 (Vrk2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa47812	XM_008770432.2 Latest version!	Rattus norvegicus vaccinia related kinase 2 (Vrk2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vrk2 ( NM_001108366.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101836.1 Rattus norvegicus VRK serine/threonine kinase 2 (Vrk2), mRNA.

Price & Availability↑

CloneID	ORa41638
Clone ID Related Accession (Same CDS sequence)	NM_001108366.1
Accession Version	NM_001108366.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1535385600000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase VRK2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473996.1. On or before Oct 4, 2007 this sequence version replaced XM_001064313.1, XM_341265.3. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCACCGA GAAGAAAAGA GAAATACAAG CTTCCGGTTC CACTTCCAGA AGGCAAAATT 
CTGGATGATA TGGAAGGAAA CCAGTGGGCA CTGGGCAAGA TGATTGGCTC CGGAGGGTTT 
GGGCTGATAT ACTTAGCTTT CCCCACAAAT AAACCAGAGA AAGATGCAAG ACATGTCATA 
AAAGTGGAAT ATCAGGAAAA TGGCCCATTA TTTTCAGAGC TTAAATTTTA TCAGAGAGCT 
GCAAAAAGAG AATGTATCCA AAAGTGGGTA AAACAGAGGA AACTTGATTA TTTAGGAGTT 
CCTGTATTTT ATGGATTTGG TCTGACTGAT TTCAAAGGAA GAAGCTACAG ATTCATGGTA 
ATGGAAAGAC TGGGGATCGA TTTACAGAAG CTCTTGAACC AGAACGGTGC TTTTAAAAAA 
TTAACTGTCC TGCAACTTGG AATCAGGATG CTCGATGTAC TGGAATATAT ACATGAAAAT 
GAATATGTTC ATGGCGATAT AAAAGCAGCA AATCTACTGC TGGGTTACGC AAATCCAGAC 
CGGCTTTCTT ATCCTCCCCT TTCTGCAGCC CCTTCCAGGA GGAGCGATGT TGAGATCCTT 
GGTTACTGCA TGCTGCGCTG GCTCTGCGGA AAGCTGCCTT GGGAAACAAA CCTAGAGAAC 
CCCGTGGCTG TCCAGACCAC TGCTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101836.1
CDS	76..765
Translation	MAPRRKEKYKLPVPLPEGKILDDMEGNQWALGKMIGSGGFGLIYLAFPTNKPEKDARHVIKVEYQENGPLFSELKFYQRAAKRECIQKWVKQRKLDYLGVPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLNQNGAFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYANPDRLSYPPLSAAPSRRSDVEILGYCMLRWLCGKLPWETNLENPVAVQTTAG

Target ORF information:

RefSeq Version	NM_001108366.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus VRK serine/threonine kinase 2 (Vrk2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108366.1

ORF Insert Sequence:

ATGGCACCGA GAAGAAAAGA GAAATACAAG CTTCCGGTTC CACTTCCAGA AGGCAAAATT 
CTGGATGATA TGGAAGGAAA CCAGTGGGCA CTGGGCAAGA TGATTGGCTC CGGAGGGTTT 
GGGCTGATAT ACTTAGCTTT CCCCACAAAT AAACCAGAGA AAGATGCAAG ACATGTCATA 
AAAGTGGAAT ATCAGGAAAA TGGCCCATTA TTTTCAGAGC TTAAATTTTA TCAGAGAGCT 
GCAAAAAGAG AATGTATCCA AAAGTGGGTA AAACAGAGGA AACTTGATTA TTTAGGAGTT 
CCTGTATTTT ATGGATTTGG TCTGACTGAT TTCAAAGGAA GAAGCTACAG ATTCATGGTA 
ATGGAAAGAC TGGGGATCGA TTTACAGAAG CTCTTGAACC AGAACGGTGC TTTTAAAAAA 
TTAACTGTCC TGCAACTTGG AATCAGGATG CTCGATGTAC TGGAATATAT ACATGAAAAT 
GAATATGTTC ATGGCGATAT AAAAGCAGCA AATCTACTGC TGGGTTACGC AAATCCAGAC 
CGGCTTTCTT ATCCTCCCCT TTCTGCAGCC CCTTCCAGGA GGAGCGATGT TGAGATCCTT 
GGTTACTGCA TGCTGCGCTG GCTCTGCGGA AAGCTGCCTT GGGAAACAAA CCTAGAGAAC 
CCCGTGGCTG TCCAGACCAC TGCTGGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Vrk2 ( XM_008770432.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768654.1 Rattus norvegicus vaccinia related kinase 2 (Vrk2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa47812
Clone ID Related Accession (Same CDS sequence)	XM_008770432.2
Accession Version	XM_008770432.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase VRK2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770432.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCACCGA GAAGAAAAGA GAAATACAAG CTTCCGGTTC CACTTCCAGA AGGCAAAATT 
CTGGATGATA TGGAAGGAAA CCAGTGGGCA CTGGGCAAGA TGATTGGCTC CGGAGGGTTT 
GGGCTGATAT ACTTAGCTTT CCCCACAAAT AAACCAGAGA AAGATGCAAG ACATGTCATA 
AAAGTGGAAT ATCAGGAAAA TGGCCCATTA TTTTCAGAGC TTAAATTTTA TCAGAGAGCT 
GCAAAAAGAG AATGTATCCA AAAGTGGGTA AAACAGAGGA AACTTGATTA TTTAGGAGTT 
CCTGTATTTT ATGGATTTGG TCTGACTGAT TTCAAAGGAA GAAGCTACAG ATTCATGGTA 
ATGGAAAGAC TGGGGATCGA TTTACAGAAG CTCTTGAACC AGAACGGTGC TTTTAAAAAA 
TTAACTGTCC TGCAACTTGG AATCAGGATG CTCGATGTAC TGGAATATAT ACATGAAAAT 
GAATATGTTC ATGGCGATAT AAAAGCAGCA AATCTACTGC TGGGTTACGC AAATCCAGAC 
CGGGTTTATC TTGCAGACTA CGGACTTTCC TACAGATATT GTCCCAACGG GAACCACAAA 
CAGTATCACG AAGATCCCCG AAAGGGCCAT AACGGGACAC TAGAATTTAC AAGTTTGGAT 
GCACACAAAG GAGTCGCCCC TTCCAGGAGG AGCGATGTTG AGATCCTTGG TTACTGCATG 
CTGCGCTGGC TCTGCGGAAA GCTGCCTTGG GAAACAAACC TAGAGAACCC CGTGGCTGTC 
CAGACCGCTA AAACCAAACT GCTGGATGAA CTCCCGGAGT CTGTGCTTAA GTGGACTACG 
TCTGGAAGCA GTTGCCGTGA ACTTGCCGAG TTCTTCATGT ATGTTCATAA TTTAGCTTAC 
GATGCCAAGC CAGACTATCA GAAGCTCAAG AAAATTCTGA ATCCAGATGG AGTACCTTTA 
GGGCCACTGG ACTTTTCCAC CAAAGCACAG GGCGTCAATA TGCAGACTCC AATCCACCGA 
AAAGTTGATT CACCAAAGGC TATAAAGAAA CCAGCCAATG AATTCCCAAC TAAGTACACA 
AGGAAAGTCT GTGGAGAGAC AAGAGCAACA TGGAGAGAGG AGCAGGAAGA GCGCCGGCCT 
GCAGTGCTGC TGAGCGACTT GGCAACACCA GAAAACTCCA GAACAAGGAA AGTACGTGAG 
TATTCTGATA CTTTCAGTGA AATGCTGAGT TTCCGACAGA CACAGAGCTA TCCACGTTTC 
CAAGGCTCAC ACTGTAAGCC CTATCTGGAC TGCACCAGGA GAGATCCCAT CAGGAAGCCG 
AGACCCCTGC CCCAGTATGG ATCCAAGCCC ACGGGCAATC TGGGTGTCAC CGACTTGGAA 
AGCTCTCCAA GATTCTGGCC TGCAGTTCTT CAGCTGACTC TGAGTGAAGA GGCAAAGGCA 
GATGTGTACT ACTATGGACT CACTATATTC TGCCTGCTCA CATTAGTATG TCTTGCTTTG 
TGTTTTCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768654.1
CDS	109..1620
Translation	MAPRRKEKYKLPVPLPEGKILDDMEGNQWALGKMIGSGGFGLIYLAFPTNKPEKDARHVIKVEYQENGPLFSELKFYQRAAKRECIQKWVKQRKLDYLGVPVFYGFGLTDFKGRSYRFMVMERLGIDLQKLLNQNGAFKKLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYANPDRVYLADYGLSYRYCPNGNHKQYHEDPRKGHNGTLEFTSLDAHKGVAPSRRSDVEILGYCMLRWLCGKLPWETNLENPVAVQTAKTKLLDELPESVLKWTTSGSSCRELAEFFMYVHNLAYDAKPDYQKLKKILNPDGVPLGPLDFSTKAQGVNMQTPIHRKVDSPKAIKKPANEFPTKYTRKVCGETRATWREEQEERRPAVLLSDLATPENSRTRKVREYSDTFSEMLSFRQTQSYPRFQGSHCKPYLDCTRRDPIRKPRPLPQYGSKPTGNLGVTDLESSPRFWPAVLQLTLSEEAKADVYYYGLTIFCLLTLVCLALCFL

Target ORF information:

RefSeq Version	XM_008770432.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vaccinia related kinase 2 (Vrk2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770432.2

ORF Insert Sequence:

ATGGCACCGA GAAGAAAAGA GAAATACAAG CTTCCGGTTC CACTTCCAGA AGGCAAAATT 
CTGGATGATA TGGAAGGAAA CCAGTGGGCA CTGGGCAAGA TGATTGGCTC CGGAGGGTTT 
GGGCTGATAT ACTTAGCTTT CCCCACAAAT AAACCAGAGA AAGATGCAAG ACATGTCATA 
AAAGTGGAAT ATCAGGAAAA TGGCCCATTA TTTTCAGAGC TTAAATTTTA TCAGAGAGCT 
GCAAAAAGAG AATGTATCCA AAAGTGGGTA AAACAGAGGA AACTTGATTA TTTAGGAGTT 
CCTGTATTTT ATGGATTTGG TCTGACTGAT TTCAAAGGAA GAAGCTACAG ATTCATGGTA 
ATGGAAAGAC TGGGGATCGA TTTACAGAAG CTCTTGAACC AGAACGGTGC TTTTAAAAAA 
TTAACTGTCC TGCAACTTGG AATCAGGATG CTCGATGTAC TGGAATATAT ACATGAAAAT 
GAATATGTTC ATGGCGATAT AAAAGCAGCA AATCTACTGC TGGGTTACGC AAATCCAGAC 
CGGGTTTATC TTGCAGACTA CGGACTTTCC TACAGATATT GTCCCAACGG GAACCACAAA 
CAGTATCACG AAGATCCCCG AAAGGGCCAT AACGGGACAC TAGAATTTAC AAGTTTGGAT 
GCACACAAAG GAGTCGCCCC TTCCAGGAGG AGCGATGTTG AGATCCTTGG TTACTGCATG 
CTGCGCTGGC TCTGCGGAAA GCTGCCTTGG GAAACAAACC TAGAGAACCC CGTGGCTGTC 
CAGACCGCTA AAACCAAACT GCTGGATGAA CTCCCGGAGT CTGTGCTTAA GTGGACTACG 
TCTGGAAGCA GTTGCCGTGA ACTTGCCGAG TTCTTCATGT ATGTTCATAA TTTAGCTTAC 
GATGCCAAGC CAGACTATCA GAAGCTCAAG AAAATTCTGA ATCCAGATGG AGTACCTTTA 
GGGCCACTGG ACTTTTCCAC CAAAGCACAG GGCGTCAATA TGCAGACTCC AATCCACCGA 
AAAGTTGATT CACCAAAGGC TATAAAGAAA CCAGCCAATG AATTCCCAAC TAAGTACACA 
AGGAAAGTCT GTGGAGAGAC AAGAGCAACA TGGAGAGAGG AGCAGGAAGA GCGCCGGCCT 
GCAGTGCTGC TGAGCGACTT GGCAACACCA GAAAACTCCA GAACAAGGAA AGTACGTGAG 
TATTCTGATA CTTTCAGTGA AATGCTGAGT TTCCGACAGA CACAGAGCTA TCCACGTTTC 
CAAGGCTCAC ACTGTAAGCC CTATCTGGAC TGCACCAGGA GAGATCCCAT CAGGAAGCCG 
AGACCCCTGC CCCAGTATGG ATCCAAGCCC ACGGGCAATC TGGGTGTCAC CGACTTGGAA 
AGCTCTCCAA GATTCTGGCC TGCAGTTCTT CAGCTGACTC TGAGTGAAGA GGCAAAGGCA 
GATGTGTACT ACTATGGACT CACTATATTC TGCCTGCTCA CATTAGTATG TCTTGCTTTG 
TGTTTTCTCT GA