Igfbp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp4
Entrez Gene ID	360622
Full Name	insulin-like growth factor binding protein 4
Synonyms	IBP4,IGF-BP4
General protein information	Preferred Names insulin-like growth factor binding protein 4 Names insulin-like growth factor-binding protein 4 IBP-4 IGF-binding protein 4 IGFBP-4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	may be involved in prolonging the half-life of the insulin growth factor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004274.2	NP_001004274.1	insulin-like growth factor-binding protein 4 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IGFBP4	NP_776982.1
Mus musculus (house mouse)	Igfbp4	NP_034647.1
Rattus norvegicus (Norway rat)	Igfbp4	NP_001004274.1
Xenopus tropicalis (tropical clawed frog)	igfbp4	XP_002942630.2
Canis lupus familiaris (dog)	IGFBP4	XP_850184.2
Gallus gallus (chicken)	IGFBP4	NP_989684.1
Macaca mulatta (Rhesus monkey)	IGFBP4	XP_001097914.1
Homo sapiens (human)	IGFBP4	NP_001543.2
Pan troglodytes (chimpanzee)	IGFBP4	XP_003953075.1

Gene Ontology
Bibliography

Related articles in PubMed

Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells.
Wu J, Wang C, Miao X, Wu Y, Yuan J, Ding M, Li J, Shi Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(2)640-650(2017)

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)

Temporal expression patterns of insulin-like growth factor binding protein-4 in the embryonic and postnatal rat brain.
Jiang X, Zhao J, Ju L, Liu Y, Wang B, Zou X, Xu C
BMC neuroscience14132(2013 Oct)

TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: a cautionary tale of the use of this cell line in studies on dioxin toxicity.
Brandner S, Eberhagen C, Lichtmannegger J, Hieber L, Andrae U
Toxicology309107-16(2013 Jul)

GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4.
Li H, Zuo S, Pasha Z, Yu B, He Z, Wang Y, Yang X, Ashraf M, Xu M
Cytotherapy13(9)1057-65(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Igfbp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12734	NM_001004274.2 Latest version!	Rattus norvegicus insulin-like growth factor binding protein 4 (Igfbp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp4 ( NM_001004274.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004274.1 Rattus norvegicus insulin-like growth factor binding protein 4 (Igfbp4), mRNA.

Price & Availability↑

CloneID	ORa12734
Clone ID Related Accession (Same CDS sequence)	NM_001004274.2
Accession Version	NM_001004274.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	insulin-like growth factor-binding protein 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098750.1. On Jul 13, 2005 this sequence version replaced NM_001004274.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098750.1, EX490420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCCCT TCGGCCTCGT GGCCGCCCTG CTGCTGGCCG CAGGGCCTCG GCCGAGCCTG 
GGCGACGAAG CCATCCACTG CCCTCCTTGC TCCGAGGAGA AGCTGGCGCG CTGCCGCCCC 
CCCGTGGGTT GTGAGGAGCT GGTGCGGGAG CCTGGCTGCG GTTGTTGTGC CACTTGCGCC 
CTGGGCTTGG GGATGCCTTG CGGGGTGTAC ACCCCACGCT GTGGCTCAGG CATGCGCTGC 
TACCCGCCCC GGGGGGTGGA GAAGCCCCTG CGCACATTGA TGCACGGGCA AGGTGTATGC 
ACGGAGCTGT CGGAAATCGA AGCCATCCAG GAAAGCCTGC AGACCTCTGA CAAGGATGAG 
AGTGAGCATC CCAACAACAG CTTCAACCCC TGCAGCGCCC ACGATCACAG GTGCCTGCAG 
AAGCATATGG CCAAAGTGAG AGATCGGAGC AAGATGAAGG TTGTGGGGAC ACCTCGGGAG 
GAACCCCGTC CTGTGCCCCA GGGTTCTTGC CAGAGCGAGC TGCACCGGGC CCTGGAACGA 
CTGGCCGCCT CGCAGAGCCG TACCCACGAA GACCTCTTCA TCATCCCCAT CCCCAACTGT 
GACCGCAACG GCAACTTCCA CCCCAAACAG TGTCATCCTG CTCTGGATGG ACAGCGTGGC 
AAATGCTGGT GTGTGGATCG GAAGACAGGG GTGAAGCTTC CAGGGGGCTT GGAACCCAAG 
GGGGAGCTGG ACTGCCACCA ACTGGCTGAC AGCCTCCAAG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004274.1
CDS	242..1006
Translation	MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTELSEIEAIQESLQTSDKDESEHPNNSFNPCSAHDHRCLQKHMAKVRDRSKMKVVGTPREEPRPVPQGSCQSELHRALERLAASQSRTHEDLFIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSLQE

Target ORF information:

RefSeq Version	NM_001004274.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin-like growth factor binding protein 4 (Igfbp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004274.2

ORF Insert Sequence:

ATGCTGCCCT TCGGCCTCGT GGCCGCCCTG CTGCTGGCCG CAGGGCCTCG GCCGAGCCTG 
GGCGACGAAG CCATCCACTG CCCTCCTTGC TCCGAGGAGA AGCTGGCGCG CTGCCGCCCC 
CCCGTGGGTT GTGAGGAGCT GGTGCGGGAG CCTGGCTGCG GTTGTTGTGC CACTTGCGCC 
CTGGGCTTGG GGATGCCTTG CGGGGTGTAC ACCCCACGCT GTGGCTCAGG CATGCGCTGC 
TACCCGCCCC GGGGGGTGGA GAAGCCCCTG CGCACATTGA TGCACGGGCA AGGTGTATGC 
ACGGAGCTGT CGGAAATCGA AGCCATCCAG GAAAGCCTGC AGACCTCTGA CAAGGATGAG 
AGTGAGCATC CCAACAACAG CTTCAACCCC TGCAGCGCCC ACGATCACAG GTGCCTGCAG 
AAGCATATGG CCAAAGTGAG AGATCGGAGC AAGATGAAGG TTGTGGGGAC ACCTCGGGAG 
GAACCCCGTC CTGTGCCCCA GGGTTCTTGC CAGAGCGAGC TGCACCGGGC CCTGGAACGA 
CTGGCCGCCT CGCAGAGCCG TACCCACGAA GACCTCTTCA TCATCCCCAT CCCCAACTGT 
GACCGCAACG GCAACTTCCA CCCCAAACAG TGTCATCCTG CTCTGGATGG ACAGCGTGGC 
AAATGCTGGT GTGTGGATCG GAAGACAGGG GTGAAGCTTC CAGGGGGCTT GGAACCCAAG 
GGGGAGCTGG ACTGCCACCA ACTGGCTGAC AGCCTCCAAG AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Age-Related Insulin-Like Growth Factor Binding Protein-4 Overexpression Inhibits Osteogenic Differentiation of Rat Mesenchymal Stem Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(2)640-650(2017)
Wu J,Wang C,Miao X,Wu Y,Yuan J,Ding M,Li J,Shi Z

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Circulation research113(10)1138-47(2013 Oct)
Abonnenc M,Nabeebaccus AA,Mayr U,Barallobre-Barreiro J,Dong X,Cuello F,Sur S,Drozdov I,Langley SR,Lu R,Stathopoulou K,Didangelos A,Yin X,Zimmermann WH,Shah AM,Zampetaki A,Mayr M

Temporal expression patterns of insulin-like growth factor binding protein-4 in the embryonic and postnatal rat brain.
BMC neuroscience14132(2013 Oct)
Jiang X,Zhao J,Ju L,Liu Y,Wang B,Zou X,Xu C

TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: a cautionary tale of the use of this cell line in studies on dioxin toxicity.
Toxicology309107-16(2013 Jul)
Brandner S,Eberhagen C,Lichtmannegger J,Hieber L,Andrae U

GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4.
Cytotherapy13(9)1057-65(2011 Oct)
Li H,Zuo S,Pasha Z,Yu B,He Z,Wang Y,Yang X,Ashraf M,Xu M