Dok1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dok1
Entrez Gene ID	312477
Full Name	docking protein 1
Synonyms	Dok-1
General protein information	Preferred Names docking protein 1 Names docking protein 1 downstream of tyrosine kinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q34

mRNA and Protein(s)

mRNA	Protein	Name
XM_008763022.2	XP_008761244.1	docking protein 1 isoform X1
NM_001025416.1	NP_001020587.1	docking protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DOK1	NP_001372.1
Rattus norvegicus (Norway rat)	Dok1	NP_001020587.1
Macaca mulatta (Rhesus monkey)	DOK1	XP_001111248.2
Danio rerio (zebrafish)	dok1b	NP_998253.1
Xenopus tropicalis (tropical clawed frog)	LOC101730410	XP_004920263.1
Canis lupus familiaris (dog)	DOK1	XP_540216.4
Bos taurus (cattle)	DOK1	NP_001019714.2
Pan troglodytes (chimpanzee)	DOK1	XP_001161802.1
Mus musculus (house mouse)	Dok1	NP_034200.4

Gene Ontology
Bibliography

Related articles in PubMed

The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1.
Goel RK, Miah S, Black K, Kalra N, Dai C, Lukong KE
The FEBS journal280(18)4539-59(2013 Sep)

Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells.
Hiragun T, Peng Z, Beaven MA
Molecular pharmacology67(3)598-603(2005 Mar)

Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor.
Abramson J, Rozenblum G, Pecht I
European journal of immunology33(1)85-91(2003 Jan)

SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages.
Berg KL, Siminovitch KA, Stanley ER
The Journal of biological chemistry274(50)35855-65(1999 Dec)

Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok.
Yamanashi Y, Baltimore D
Cell88(2)205-11(1997 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dok1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dok1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07565	NM_001025416.1 Latest version!	Rattus norvegicus docking protein 1 (Dok1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa47138	XM_008763022.2 Latest version!	Rattus norvegicus docking protein 1 (Dok1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dok1 ( NM_001025416.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020587.1 Rattus norvegicus docking protein 1 (Dok1), mRNA.

Price & Availability↑

CloneID	ORa07565
Clone ID Related Accession (Same CDS sequence)	NM_001025416.1
Accession Version	NM_001025416.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	docking protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097972.1. On Jul 15, 2005 this sequence version replaced XM_232106.3. ##Evidence-Data-START## Transcript exon combination :: BC097972.1, CV115728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGGGG CTTTGATGGA GGGTCCGCTT TTTCTGCAGA GTCAGCGCTT CGGGACCAAG 
AGGTGGAAGA AAACTTGGGC TGTGCTTTAC CCAGCCAGCC CTCACGGCGT GGCGCGGCTG 
GAATTCTTTG ATCACAAGGG GTCGAGCTCT GGAGGGGGTC GAGGCGGCTC TCGCCGTCTA 
GACTGCAAGA TGATACGCCT GGCTGAATGT GTGAGCGTGG TGCCTGTGAC TGTGGAGAGT 
CCCCCTGAGC CCGGCGCCTC TGCCTTCCGC CTGGACACCG CACAACGCTC GCACCTGCTT 
GCAGCGGACG CCGCATCCAG CACTGCCTGG GTGCAGATTT TATGCAGAAC CGCTTTTCCG 
AAAGGCGGCT GGGCTTTGGC TCAGACGGAG AACCCACCTA AGTTTTCTGC CCTGGAGATG 
CTGGAGAATT CGCTGTACAG CCCCACCTGG GAAGGATCCC AATTCTGGGT AACCTCGCAG 
AAGACCGAGG CTTCTGAACG CTGCGGCTTG CAAGGCTCCT ACGTACTGAG GGTAGAAGCT 
GAGAAGCTGA CCCTTCTGAC TTTGGGTGCA CAGAGTCAAA TCCTGGAGCC GCTCCTTTTC 
TGGCCCTACA CTCTGTTGCG ACGCTATGGC CGAGACAAGG TAATGTTCTC CTTTGAAGCG 
GGTCGCCGCT GCCCCTCTGG CCCTGGGACC TTCACCTTCC AGACTGCCCA GGGAAATGAC 
ATCTTTCAGG CAGTTGAGGC TGCTATCCAG CAGCAGAAAG CCCAAGGAAA GGTGGGACAG 
GGACAAGATA TCACCAGAAC TGACTCCCAT GATGGGGAGA CAGAGGGGAA GATGGCTCCC 
ACTCCTGTTC CCCAGGAACC CCTGGGCAGC CCTCCAGCCC TATATGCAGA GCCTTTAGAC 
TCCCTGCGAA TTCCTCCAGG CCCTTCTCAG GACTCTTTGT ATTCAGACCC CCTGGGCAGC 
ACCCCTGCTG GGGCAGGGGA AGGGGTGCAG CGGAAGAAAC CTCTCTATTG GGATTTGTAT 
GGGCACGTGC AGCAGCAGTT GCTGAAAACC AAGCTGATAG ACTCCAAAGA GGACCCCATC 
TATGATGAGC CTGAGGGCCT GGCCCCTGCC CCTCTCCGGG GCCTTTATGA TCTGCCTCAG 
GAGCCTAAGG ATGCATGGTG GTGCCAGGCT CGGCTGAAGG AAGAGGGCTA TGAGCTCCCT 
TACAACCCCG CCACCGACGA CTACGCTGTG CCACCCCCTC GGAGCTCAAA GCCTACCCCT 
GCCCCCAAGC CACAGGGCTT GATCCTTCCT GAATCTGGTA CCACAGCTGG CAGTGGCAGC 
AAAGGCTCAG ATACAGCTCT GTACAGCCAG GTCCAGAAAA GTGGGACCCC AGGGAGATGG 
GACTGTGGAC TCTCTAGAGT AGGGAATGAC AGGGTGGGGG TCAAGTCAGA GGGTTCCACC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020587.1
CDS	9..1451
Translation	MDGALMEGPLFLQSQRFGTKRWKKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGASAFRLDTAQRSHLLAADAASSTAWVQILCRTAFPKGGWALAQTENPPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYVLRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVEAAIQQQKAQGKVGQGQDITRTDSHDGETEGKMAPTPVPQEPLGSPPALYAEPLDSLRIPPGPSQDSLYSDPLGSTPAGAGEGVQRKKPLYWDLYGHVQQQLLKTKLIDSKEDPIYDEPEGLAPAPLRGLYDLPQEPKDAWWCQARLKEEGYELPYNPATDDYAVPPPRSSKPTPAPKPQGLILPESGTTAGSGSKGSDTALYSQVQKSGTPGRWDCGLSRVGNDRVGVKSEGST

Target ORF information:

RefSeq Version	NM_001025416.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus docking protein 1 (Dok1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025416.1

ORF Insert Sequence:

ATGGACGGGG CTTTGATGGA GGGTCCGCTT TTTCTGCAGA GTCAGCGCTT CGGGACCAAG 
AGGTGGAAGA AAACTTGGGC TGTGCTTTAC CCAGCCAGCC CTCACGGCGT GGCGCGGCTG 
GAATTCTTTG ATCACAAGGG GTCGAGCTCT GGAGGGGGTC GAGGCGGCTC TCGCCGTCTA 
GACTGCAAGA TGATACGCCT GGCTGAATGT GTGAGCGTGG TGCCTGTGAC TGTGGAGAGT 
CCCCCTGAGC CCGGCGCCTC TGCCTTCCGC CTGGACACCG CACAACGCTC GCACCTGCTT 
GCAGCGGACG CCGCATCCAG CACTGCCTGG GTGCAGATTT TATGCAGAAC CGCTTTTCCG 
AAAGGCGGCT GGGCTTTGGC TCAGACGGAG AACCCACCTA AGTTTTCTGC CCTGGAGATG 
CTGGAGAATT CGCTGTACAG CCCCACCTGG GAAGGATCCC AATTCTGGGT AACCTCGCAG 
AAGACCGAGG CTTCTGAACG CTGCGGCTTG CAAGGCTCCT ACGTACTGAG GGTAGAAGCT 
GAGAAGCTGA CCCTTCTGAC TTTGGGTGCA CAGAGTCAAA TCCTGGAGCC GCTCCTTTTC 
TGGCCCTACA CTCTGTTGCG ACGCTATGGC CGAGACAAGG TAATGTTCTC CTTTGAAGCG 
GGTCGCCGCT GCCCCTCTGG CCCTGGGACC TTCACCTTCC AGACTGCCCA GGGAAATGAC 
ATCTTTCAGG CAGTTGAGGC TGCTATCCAG CAGCAGAAAG CCCAAGGAAA GGTGGGACAG 
GGACAAGATA TCACCAGAAC TGACTCCCAT GATGGGGAGA CAGAGGGGAA GATGGCTCCC 
ACTCCTGTTC CCCAGGAACC CCTGGGCAGC CCTCCAGCCC TATATGCAGA GCCTTTAGAC 
TCCCTGCGAA TTCCTCCAGG CCCTTCTCAG GACTCTTTGT ATTCAGACCC CCTGGGCAGC 
ACCCCTGCTG GGGCAGGGGA AGGGGTGCAG CGGAAGAAAC CTCTCTATTG GGATTTGTAT 
GGGCACGTGC AGCAGCAGTT GCTGAAAACC AAGCTGATAG ACTCCAAAGA GGACCCCATC 
TATGATGAGC CTGAGGGCCT GGCCCCTGCC CCTCTCCGGG GCCTTTATGA TCTGCCTCAG 
GAGCCTAAGG ATGCATGGTG GTGCCAGGCT CGGCTGAAGG AAGAGGGCTA TGAGCTCCCT 
TACAACCCCG CCACCGACGA CTACGCTGTG CCACCCCCTC GGAGCTCAAA GCCTACCCCT 
GCCCCCAAGC CACAGGGCTT GATCCTTCCT GAATCTGGTA CCACAGCTGG CAGTGGCAGC 
AAAGGCTCAG ATACAGCTCT GTACAGCCAG GTCCAGAAAA GTGGGACCCC AGGGAGATGG 
GACTGTGGAC TCTCTAGAGT AGGGAATGAC AGGGTGGGGG TCAAGTCAGA GGGTTCCACC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dok1 ( XM_008763022.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008761244.1 Rattus norvegicus docking protein 1 (Dok1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa47138
Clone ID Related Accession (Same CDS sequence)	XM_008763022.2
Accession Version	XM_008763022.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	docking protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008763022.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCCGC TCACTCTCGA GTCTTTCGTT CTTTCCCAGA GGTGGAAGAA AACTTGGGCT 
GTGCTTTACC CAGCCAGCCC TCACGGCGTG GCGCGGCTGG AATTCTTTGA TCACAAGGGG 
TCGAGCTCTG GAGGGGGTCG AGGCGGCTCT CGCCGTCTAG ACTGCAAGAT GATACGCCTG 
GCTGAATGTG TGAGCGTGGT GCCTGTGACT GTGGAGAGTC CCCCTGAGCC CGGCGCCTCT 
GCCTTCCGCC TGGACACCGC ACAACGCTCG CACCTGCTTG CAGCGGACGC CGCATCCAGC 
ACTGCCTGGG TGCAGATTTT ATGCAGAACC GCTTTTCCGA AAGGCGGCTG GGCTTTGGCT 
CAGACGGAGA ACCCACCTAA GTTTTCTGCC CTGGAGATGC TGGAGAATTC GCTGTACAGC 
CCCACCTGGG AAGGATCCCA ATTCTGGGTA ACCTCGCAGA AGACCGAGGC TTCTGAACGC 
TGCGGCTTGC AAGGCTCCTA CGTACTGAGG GTAGAAGCTG AGAAGCTGAC CCTTCTGACT 
TTGGGTGCAC AGAGTCAAAT CCTGGAGCCG CTCCTTTTCT GGCCCTACAC TCTGTTGCGA 
CGCTATGGCC GAGACAAGGT AATGTTCTCC TTTGAAGCGG GTCGCCGCTG CCCCTCTGGC 
CCTGGGACCT TCACCTTCCA GACTGCCCAG GGAAATGACA TCTTTCAGGC AGTTGAGGCT 
GCTATCCAGC AGCAGAAAGC CCAAGGAAAG GTGGGACAGG GACAAGATAT CACCAGAACT 
GACTCCCATG ATGGGGAGAC AGAGGGGAAG ATGGCTCCCA CTCCTGTTCC CCAGGAACCC 
CTGGGCAGCC CTCCAGCCCT ATATGCAGAG CCTTTAGACT CCCTGCGAAT TCCTCCAGGC 
CCTTCTCAGG ACTCTTTGTA TTCAGACCCC CTGGGCAGCA CCCCTGCTGG GGCAGGGGAA 
GGGGTGCAGC GGAAGAAACC TCTCTATTGG GATTTGTATG GGCACGTGCA GCAGCAGTTG 
CTGAAAACCA AGCTGATAGA CTCCAAAGAG GACCCCATCT ATGATGAGCC TGAGGGCCTG 
GCCCCTGCCC CTCTCCGGGG CCTTTATGAT CTGCCTCAGG AGCCTAAGGA TGCATGGTGG 
TGCCAGGCTC GGCTGAAGGA AGAGGGCTAT GAGCTCCCTT ACAACCCCGC CACCGACGAC 
TACGCTGTGC CACCCCCTCG GAGCTCAAAG CCTACCCCTG CCCCCAAGCC ACAGGGCTTG 
ATCCTTCCTG AATCTGGTAC CACAGCTGGC AGTGGCAGCA AAGGCTCAGA TACAGCTCTG 
TACAGCCAGG TCCAGAAAAG TGGGACCCCA GGGAGATGGG ACTGTGGACT CTCTAGAGTA 
GGGAATGACA GGGTGGGGGT CAAGTCAGAG GGTTCCACCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008761244.1
CDS	95..1516
Translation	MLPLTLESFVLSQRWKKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGGSRRLDCKMIRLAECVSVVPVTVESPPEPGASAFRLDTAQRSHLLAADAASSTAWVQILCRTAFPKGGWALAQTENPPKFSALEMLENSLYSPTWEGSQFWVTSQKTEASERCGLQGSYVLRVEAEKLTLLTLGAQSQILEPLLFWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVEAAIQQQKAQGKVGQGQDITRTDSHDGETEGKMAPTPVPQEPLGSPPALYAEPLDSLRIPPGPSQDSLYSDPLGSTPAGAGEGVQRKKPLYWDLYGHVQQQLLKTKLIDSKEDPIYDEPEGLAPAPLRGLYDLPQEPKDAWWCQARLKEEGYELPYNPATDDYAVPPPRSSKPTPAPKPQGLILPESGTTAGSGSKGSDTALYSQVQKSGTPGRWDCGLSRVGNDRVGVKSEGST

Target ORF information:

RefSeq Version	XM_008763022.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus docking protein 1 (Dok1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008763022.2

ORF Insert Sequence:

ATGCTGCCGC TCACTCTCGA GTCTTTCGTT CTTTCCCAGA GGTGGAAGAA AACTTGGGCT 
GTGCTTTACC CAGCCAGCCC TCACGGCGTG GCGCGGCTGG AATTCTTTGA TCACAAGGGG 
TCGAGCTCTG GAGGGGGTCG AGGCGGCTCT CGCCGTCTAG ACTGCAAGAT GATACGCCTG 
GCTGAATGTG TGAGCGTGGT GCCTGTGACT GTGGAGAGTC CCCCTGAGCC CGGCGCCTCT 
GCCTTCCGCC TGGACACCGC ACAACGCTCG CACCTGCTTG CAGCGGACGC CGCATCCAGC 
ACTGCCTGGG TGCAGATTTT ATGCAGAACC GCTTTTCCGA AAGGCGGCTG GGCTTTGGCT 
CAGACGGAGA ACCCACCTAA GTTTTCTGCC CTGGAGATGC TGGAGAATTC GCTGTACAGC 
CCCACCTGGG AAGGATCCCA ATTCTGGGTA ACCTCGCAGA AGACCGAGGC TTCTGAACGC 
TGCGGCTTGC AAGGCTCCTA CGTACTGAGG GTAGAAGCTG AGAAGCTGAC CCTTCTGACT 
TTGGGTGCAC AGAGTCAAAT CCTGGAGCCG CTCCTTTTCT GGCCCTACAC TCTGTTGCGA 
CGCTATGGCC GAGACAAGGT AATGTTCTCC TTTGAAGCGG GTCGCCGCTG CCCCTCTGGC 
CCTGGGACCT TCACCTTCCA GACTGCCCAG GGAAATGACA TCTTTCAGGC AGTTGAGGCT 
GCTATCCAGC AGCAGAAAGC CCAAGGAAAG GTGGGACAGG GACAAGATAT CACCAGAACT 
GACTCCCATG ATGGGGAGAC AGAGGGGAAG ATGGCTCCCA CTCCTGTTCC CCAGGAACCC 
CTGGGCAGCC CTCCAGCCCT ATATGCAGAG CCTTTAGACT CCCTGCGAAT TCCTCCAGGC 
CCTTCTCAGG ACTCTTTGTA TTCAGACCCC CTGGGCAGCA CCCCTGCTGG GGCAGGGGAA 
GGGGTGCAGC GGAAGAAACC TCTCTATTGG GATTTGTATG GGCACGTGCA GCAGCAGTTG 
CTGAAAACCA AGCTGATAGA CTCCAAAGAG GACCCCATCT ATGATGAGCC TGAGGGCCTG 
GCCCCTGCCC CTCTCCGGGG CCTTTATGAT CTGCCTCAGG AGCCTAAGGA TGCATGGTGG 
TGCCAGGCTC GGCTGAAGGA AGAGGGCTAT GAGCTCCCTT ACAACCCCGC CACCGACGAC 
TACGCTGTGC CACCCCCTCG GAGCTCAAAG CCTACCCCTG CCCCCAAGCC ACAGGGCTTG 
ATCCTTCCTG AATCTGGTAC CACAGCTGGC AGTGGCAGCA AAGGCTCAGA TACAGCTCTG 
TACAGCCAGG TCCAGAAAAG TGGGACCCCA GGGAGATGGG ACTGTGGACT CTCTAGAGTA 
GGGAATGACA GGGTGGGGGT CAAGTCAGAG GGTTCCACCT GA