Abl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abl1
Entrez Gene ID	311860
Full Name	ABL proto-oncogene 1, non-receptor tyrosine kinase
Synonyms	Abl
General protein information	Preferred Names ABL proto-oncogene 1, non-receptor tyrosine kinase Names tyrosine-protein kinase ABL1 Abelson murine leukemia viral (v-abl) oncogene homolog 1 c-abl oncogene 1, non-receptor tyrosine kinase c-abl oncogene 1, receptor tyrosine kinase v-abl Abelson murine leukemia viral oncogene 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001100850.1	NP_001094320.1	tyrosine-protein kinase ABL1
XM_006233918.3	XP_006233980.1	tyrosine-protein kinase ABL1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	ABL1	NP_009297.2
Danio rerio (zebrafish)	abl1	XP_001337829.1
Rattus norvegicus (Norway rat)	LOC100909750	XP_003749487.1
Gallus gallus (chicken)	ABL1	XP_001233812.1
Bos taurus (cattle)	ABL1	NP_001193789.1
Rattus norvegicus (Norway rat)	Abl1	NP_001094320.1
Pan troglodytes (chimpanzee)	ABL1	XP_001166213.2
Canis lupus familiaris (dog)	ABL1	XP_548413.3
Mus musculus (house mouse)	Abl1	NP_001106174.1
Xenopus tropicalis (tropical clawed frog)	abl1	XP_004916733.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.
Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J
Scientific reports7(1)887(2017 04)

Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.
Wang X, Charng WL, Chen CA, Rosenfeld JA, Al Shamsi A, Al-Gazali L, McGuire M, Mew NA, Arnold GL, Qu C, Ding Y, Muzny DM, Gibbs RA, Eng CM, Walkiewicz M, Xia F, Plon SE, Lupski JR, Schaaf CP, Yang Y
Nature genetics49(4)613-617(2017 Apr)

The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase.
Cao H, Schroeder B, Chen J, Schott MB, McNiven MA
The Journal of biological chemistry291(32)16424-37(2016 08)

NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.
Fantin A, Lampropoulou A, Gestri G, Raimondi C, Senatore V, Zachary I, Ruhrberg C
Cell reports11(10)1577-90(2015 Jun)

Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice.
Cai J, Wu G, Tan X, Han Y, Chen C, Li C, Wang N, Zou X, Chen X, Zhou F, He D, Zhou L, Jose PA, Zeng C
PloS one9(8)e105200(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Abl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11491	NM_001100850.1 Latest version!	Rattus norvegicus ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa25697	XM_006233918.3 Latest version!	Rattus norvegicus ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abl1 ( NM_001100850.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094320.1 Rattus norvegicus ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), mRNA.

Price & Availability↑

CloneID	ORa11491
Clone ID Related Accession (Same CDS sequence)	NM_001100850.1
Accession Version	NM_001100850.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1552233600000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase ABL1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07072853.1. On or before May 13, 2010 this sequence version replaced XM_001079831.2, XM_001067860.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ294401.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGCAGC AGCCTGGAAA AGTACTTGGG GACCAAAGAA GGCCTAGTTT GCCCGCCCTA 
CATTTTATCA AAGGGGCAGG GAAGAGGGAC TCATCGAGAC ATGGGGGCCC ACACTGCAAT 
GTCTTTGTGG AACATGAAGC CCTGCAGAGG CCAGTGGCCT CTGACTTTGA GCCCCAGGGT 
CTCAGCGAAG CAGCTCGATG GAACTCCAAG GAAAACCTTC TTGCTGGGCC CAGCGAAAAT 
GACCCCAACC TTTTTGTGGC ACTCTATGAT TTTGTGGCCA GTGGAGACAA CACTCTCAGC 
ATCACTAAAG GCGAGAAGCT CCGGGTCTTA GGTTATAATC ACAATGGGGA GTGGTGTGAA 
GCCCAAACGA AAAATGGCCA AGGATGGGTC CCAAGCAACT ACATCACCCC TGTCAACAGC 
CTGGAGAAGC ACTCCTGGTA TCACGGGCCC GTGTCTCGAA ACGCTGCAGA GTACCTGCTG 
AGCAGTGGGA TCAACGGCAG CTTCTTAGTT CGGGAGAGCG AGAGCAGCCC GGGCCAGAGG 
TCCATCTCGC TGCGGTATGA AGGGAGGGTG TACCACTACA GGATCAACAC TGCCTCTGAT 
GGCAAGCTCT ACGTCTCCTC GGAGAGCCGC TTCAACACTC TGGCCGAGTT AGTTCACCAT 
CATTCCACTG TGGCTGACGG GCTCATCACC ACACTGCACT ACCCAGCTCC CAAGCGCAAC 
AAGCCCACCA TCTACGGCGT GTCCCCCAAC TATGACAAGT GGGAAATGGA GCGCACAGAC 
ATCACCATGA AGCACAAGCT GGGCGGAGGC CAGTACGGGG AGGTGTACGA GGGCGTCTGG 
AAGAAGTACA GCCTCACTGT GGCCGTGAAG ACCCTGAAGG AGGACACCAT GGAGGTGGAG 
GAGTTCCTGA AGGAAGCCGC AGTGATGAAG GAGATCAAGC ACCCTAACCT GGTGCAGCTG 
CTAGGGGTGT GTACCCGGGA ACCTCCGTTC TACATCATCA CCGAGTTCAT GACCTATGGG 
AACCTGCTGG ACTACCTGAG GGAATGTAAC CGGCAGGAGG TGAGCGCTGT GGTGCTGCTC 
TACATGGCCA CACAGATCTC ATCAGCCATG GAGTACCTGG AGAAGAAGAA CTTCATCCAC 
AGAGACCTTG CTGCCCGGAA CTGCCTGGTA GGGGAAAACC ACTTGGTGAA GGTGGCTGAT 
TTTGGCCTAA GCAGGTTGAT GACAGGGGAC ACCTACACAG CCCATGCTGG AGCCAAGTTC 
CCCATCAAGT GGACTGCACC CGAGAGCCTG GCCTATAACA AGTTCTCCAT CAAGTCGGAC 
GTCTGGGCAT TTGGAGTATT GCTCTGGGAA ATTGCTACCT ATGGCATGTC ACCTTACCCG 
GGAATTGACC TGTCTCAGGT TTATGAGCTG CTGGAAAAAG ACTACCGCAT GGAGCGCCCG 
GAAGGCTGCC CAGAGAAAGT CTACGAACTC ATGCGAGCAT GTTGGCAGTG GAACCCCTCT 
GATCGGCCCT CCTTTGCTGA AATCCATCAA GCCTTTGAAA CCATGTTCCA GGAGTCCAGC 
ATCTCAGACG AGGTGGAGAA GGAGCTGGGG AAACGAGGCA TGAGAGGAGC CGCCGGGAGC 
ACCCTGCAGG CCCCAGAGCT GCCCACCAAG ACCAGAACCT GCAGGAAAAC CGCTGAGCAG 
AAAGATGCAC CTGACGCCCT GGAACTGCTC CACACGAAGG GCCTGGGCGA AAGCGACGCA 
CTGGACAGTG AACCTGCTGT ATCACCACTG CTTCCTCGGA AAGAGCGTGG GCCCCCGGAC 
GGCAGCCTAA ATGAAGATGA GCGTCTCCTC CCCAAAGACA AAAAGACCAA CCTGTTCAGC 
GCCTTGATCA AGAAGAAGAA GAAAATGGCG CCGACGCCCC CTAAGCGCAG CAGTTCCTTC 
CGAGAGATGG ATGGCCAGTC AGAACGCAGA GGGGCTAGTG AGGATGACGG CCGGGAAATC 
AGCAATGGGC CACCAGCTCT CACCTCAGAT GCAGTAGAGC CTACCAAGTC CCCAAAGGCC 
AGCAATGGGG CTGGCGTCCC CAATGGAGCC TTCCGGGAGC CAGGCAACTC GGGCTTCCGC 
TCTCCCCATG TGTGGAAGAA GAGCAGCACA CTGACCAGCA GCCGCCTCGC TGCTGCTGAA 
GAGGAGAGTG GCCTCAGTTC CAGTAAGCGC TTCCTGCGCT CCTGCTCGGC CTCCTGCATG 
CCCCATGGGG TTAGGGACAC TGAGTGGCGG TCAGTCACGC TGCCTCGGGA CCTGCCGTCT 
GCTGGTAAGC AGTTTGACTC TTCCACCTTT GGAGGGCACA AAAGTGAAAA GCCAGCTCTG 
CCTCGGAAAC GCACCAGTGA GAGCAGGTCT GAGCAGGTGG CCAAAAGCAC AGCGACACCC 
CCTCCTCGGC TGGTGAAGAA GACTGAGGAG GCCGCCGAAG ATGTCTTCAA AGACACGGAA 
TCCAGCCCTG GCTCCAGCCC TCCCAGCTTG ACCCCCAAAC TCCTCCGTAG GCAGGTCCCT 
GCCTCCCCCT CCTCTGGCCC CTCTCACAAG GACGAGGCCA CCAAGGGCAA TGCCTCGGGC 
ATGGGGACTC CTGCCACTGC AGAGCCAGCA GCCCCCAGCA ACAAAGCGGG CCTCAGCAAG 
GCCTCCTCCG AGGAGCCCCG TGCAAGGAGA CACAAGCACA GCTCGGAGTC CCCAGGGAGA 
GACAAGGGGC GGCTGTCCAA GCTCAAGCCG GCCCCGCCAC CTCCGCCCTC CTCCACAGGG 
AAAGCAGGGA AGCCTGCACA GAGCCCCAGC CAAGATGTGG CTGGGGAGGC AGGTGGGGCC 
ACCAAGACAA AATGCACAAG TCTGTCTGTG GATGCTGTGA ACAGTGACCC CACCAAGGCT 
GGCCAGCCTG GAGAAGGACT GAGAAAATCT GTGCCCCCAT CTGTGCCAAA GCCTCAGTCA 
GCTACTAAGC CACCGGGGAC CCCCACCAGC CCGGTCTCCA CCCCCTCCAC AGCGCCAGCA 
CCTTCACCCC TGGCTGGGGA CCAGCAGCCA TCTTCTGCTG CCTTCATCCC CCTCATATCA 
ACCCGTGTGT CTCTTCGAAA GACCCGACAG CCGCCAGAGC GCATCGCCAG TGGCACCATC 
ACCAAGGGTG TGGTTCTGGA CAGTACTGAG GCCCTGTGCC TTGCCATCTC CCGGAACTCG 
GAGCAGATGG CCAGCCACAG TGCTGTGCTG GAGGCGGGCA AGAACCTGTA CACATTCTGT 
GTGAGCTACG TGGACTCTAT CCAGCAGATG AGGAACAAGT TTGCCTTCCG CGAGGCTATC 
AACAAGCTGG AGAGCAACCT CCGAGAGCTG CAGATCTGCC CTGCGACAGC CTCCAGTGGG 
CCAGCGGCCA CACAAGACTT CAGCAAGCTG CTTAGCTCTG TGAAGGAGAT CAGCGACATT 
GTCCGGAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094320.1
CDS	1259..4690
Translation	MGQQPGKVLGDQRRPSLPALHFIKGAGKRDSSRHGGPHCNVFVEHEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGMRGAAGSTLQAPELPTKTRTCRKTAEQKDAPDALELLHTKGLGESDALDSEPAVSPLLPRKERGPPDGSLNEDERLLPKDKKTNLFSALIKKKKKMAPTPPKRSSSFREMDGQSERRGASEDDGREISNGPPALTSDAVEPTKSPKASNGAGVPNGAFREPGNSGFRSPHVWKKSSTLTSSRLAAAEEESGLSSSKRFLRSCSASCMPHGVRDTEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRSEQVAKSTATPPPRLVKKTEEAAEDVFKDTESSPGSSPPSLTPKLLRRQVPASPSSGPSHKDEATKGNASGMGTPATAEPAAPSNKAGLSKASSEEPRARRHKHSSESPGRDKGRLSKLKPAPPPPPSSTGKAGKPAQSPSQDVAGEAGGATKTKCTSLSVDAVNSDPTKAGQPGEGLRKSVPPSVPKPQSATKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR

Target ORF information:

RefSeq Version	NM_001100850.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100850.1

ORF Insert Sequence:

ATGGGGCAGC AGCCTGGAAA AGTACTTGGG GACCAAAGAA GGCCTAGTTT GCCCGCCCTA 
CATTTTATCA AAGGGGCAGG GAAGAGGGAC TCATCGAGAC ATGGGGGCCC ACACTGCAAT 
GTCTTTGTGG AACATGAAGC CCTGCAGAGG CCAGTGGCCT CTGACTTTGA GCCCCAGGGT 
CTCAGCGAAG CAGCTCGATG GAACTCCAAG GAAAACCTTC TTGCTGGGCC CAGCGAAAAT 
GACCCCAACC TTTTTGTGGC ACTCTATGAT TTTGTGGCCA GTGGAGACAA CACTCTCAGC 
ATCACTAAAG GCGAGAAGCT CCGGGTCTTA GGTTATAATC ACAATGGGGA GTGGTGTGAA 
GCCCAAACGA AAAATGGCCA AGGATGGGTC CCAAGCAACT ACATCACCCC TGTCAACAGC 
CTGGAGAAGC ACTCCTGGTA TCACGGGCCC GTGTCTCGAA ACGCTGCAGA GTACCTGCTG 
AGCAGTGGGA TCAACGGCAG CTTCTTAGTT CGGGAGAGCG AGAGCAGCCC GGGCCAGAGG 
TCCATCTCGC TGCGGTATGA AGGGAGGGTG TACCACTACA GGATCAACAC TGCCTCTGAT 
GGCAAGCTCT ACGTCTCCTC GGAGAGCCGC TTCAACACTC TGGCCGAGTT AGTTCACCAT 
CATTCCACTG TGGCTGACGG GCTCATCACC ACACTGCACT ACCCAGCTCC CAAGCGCAAC 
AAGCCCACCA TCTACGGCGT GTCCCCCAAC TATGACAAGT GGGAAATGGA GCGCACAGAC 
ATCACCATGA AGCACAAGCT GGGCGGAGGC CAGTACGGGG AGGTGTACGA GGGCGTCTGG 
AAGAAGTACA GCCTCACTGT GGCCGTGAAG ACCCTGAAGG AGGACACCAT GGAGGTGGAG 
GAGTTCCTGA AGGAAGCCGC AGTGATGAAG GAGATCAAGC ACCCTAACCT GGTGCAGCTG 
CTAGGGGTGT GTACCCGGGA ACCTCCGTTC TACATCATCA CCGAGTTCAT GACCTATGGG 
AACCTGCTGG ACTACCTGAG GGAATGTAAC CGGCAGGAGG TGAGCGCTGT GGTGCTGCTC 
TACATGGCCA CACAGATCTC ATCAGCCATG GAGTACCTGG AGAAGAAGAA CTTCATCCAC 
AGAGACCTTG CTGCCCGGAA CTGCCTGGTA GGGGAAAACC ACTTGGTGAA GGTGGCTGAT 
TTTGGCCTAA GCAGGTTGAT GACAGGGGAC ACCTACACAG CCCATGCTGG AGCCAAGTTC 
CCCATCAAGT GGACTGCACC CGAGAGCCTG GCCTATAACA AGTTCTCCAT CAAGTCGGAC 
GTCTGGGCAT TTGGAGTATT GCTCTGGGAA ATTGCTACCT ATGGCATGTC ACCTTACCCG 
GGAATTGACC TGTCTCAGGT TTATGAGCTG CTGGAAAAAG ACTACCGCAT GGAGCGCCCG 
GAAGGCTGCC CAGAGAAAGT CTACGAACTC ATGCGAGCAT GTTGGCAGTG GAACCCCTCT 
GATCGGCCCT CCTTTGCTGA AATCCATCAA GCCTTTGAAA CCATGTTCCA GGAGTCCAGC 
ATCTCAGACG AGGTGGAGAA GGAGCTGGGG AAACGAGGCA TGAGAGGAGC CGCCGGGAGC 
ACCCTGCAGG CCCCAGAGCT GCCCACCAAG ACCAGAACCT GCAGGAAAAC CGCTGAGCAG 
AAAGATGCAC CTGACGCCCT GGAACTGCTC CACACGAAGG GCCTGGGCGA AAGCGACGCA 
CTGGACAGTG AACCTGCTGT ATCACCACTG CTTCCTCGGA AAGAGCGTGG GCCCCCGGAC 
GGCAGCCTAA ATGAAGATGA GCGTCTCCTC CCCAAAGACA AAAAGACCAA CCTGTTCAGC 
GCCTTGATCA AGAAGAAGAA GAAAATGGCG CCGACGCCCC CTAAGCGCAG CAGTTCCTTC 
CGAGAGATGG ATGGCCAGTC AGAACGCAGA GGGGCTAGTG AGGATGACGG CCGGGAAATC 
AGCAATGGGC CACCAGCTCT CACCTCAGAT GCAGTAGAGC CTACCAAGTC CCCAAAGGCC 
AGCAATGGGG CTGGCGTCCC CAATGGAGCC TTCCGGGAGC CAGGCAACTC GGGCTTCCGC 
TCTCCCCATG TGTGGAAGAA GAGCAGCACA CTGACCAGCA GCCGCCTCGC TGCTGCTGAA 
GAGGAGAGTG GCCTCAGTTC CAGTAAGCGC TTCCTGCGCT CCTGCTCGGC CTCCTGCATG 
CCCCATGGGG TTAGGGACAC TGAGTGGCGG TCAGTCACGC TGCCTCGGGA CCTGCCGTCT 
GCTGGTAAGC AGTTTGACTC TTCCACCTTT GGAGGGCACA AAAGTGAAAA GCCAGCTCTG 
CCTCGGAAAC GCACCAGTGA GAGCAGGTCT GAGCAGGTGG CCAAAAGCAC AGCGACACCC 
CCTCCTCGGC TGGTGAAGAA GACTGAGGAG GCCGCCGAAG ATGTCTTCAA AGACACGGAA 
TCCAGCCCTG GCTCCAGCCC TCCCAGCTTG ACCCCCAAAC TCCTCCGTAG GCAGGTCCCT 
GCCTCCCCCT CCTCTGGCCC CTCTCACAAG GACGAGGCCA CCAAGGGCAA TGCCTCGGGC 
ATGGGGACTC CTGCCACTGC AGAGCCAGCA GCCCCCAGCA ACAAAGCGGG CCTCAGCAAG 
GCCTCCTCCG AGGAGCCCCG TGCAAGGAGA CACAAGCACA GCTCGGAGTC CCCAGGGAGA 
GACAAGGGGC GGCTGTCCAA GCTCAAGCCG GCCCCGCCAC CTCCGCCCTC CTCCACAGGG 
AAAGCAGGGA AGCCTGCACA GAGCCCCAGC CAAGATGTGG CTGGGGAGGC AGGTGGGGCC 
ACCAAGACAA AATGCACAAG TCTGTCTGTG GATGCTGTGA ACAGTGACCC CACCAAGGCT 
GGCCAGCCTG GAGAAGGACT GAGAAAATCT GTGCCCCCAT CTGTGCCAAA GCCTCAGTCA 
GCTACTAAGC CACCGGGGAC CCCCACCAGC CCGGTCTCCA CCCCCTCCAC AGCGCCAGCA 
CCTTCACCCC TGGCTGGGGA CCAGCAGCCA TCTTCTGCTG CCTTCATCCC CCTCATATCA 
ACCCGTGTGT CTCTTCGAAA GACCCGACAG CCGCCAGAGC GCATCGCCAG TGGCACCATC 
ACCAAGGGTG TGGTTCTGGA CAGTACTGAG GCCCTGTGCC TTGCCATCTC CCGGAACTCG 
GAGCAGATGG CCAGCCACAG TGCTGTGCTG GAGGCGGGCA AGAACCTGTA CACATTCTGT 
GTGAGCTACG TGGACTCTAT CCAGCAGATG AGGAACAAGT TTGCCTTCCG CGAGGCTATC 
AACAAGCTGG AGAGCAACCT CCGAGAGCTG CAGATCTGCC CTGCGACAGC CTCCAGTGGG 
CCAGCGGCCA CACAAGACTT CAGCAAGCTG CTTAGCTCTG TGAAGGAGAT CAGCGACATT 
GTCCGGAGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abl1 ( XM_006233918.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233980.1 Rattus norvegicus ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25697
Clone ID Related Accession (Same CDS sequence)	XM_006233918.3
Accession Version	XM_006233918.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase ABL1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233918.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGGAGA TCTGCTTGAA GTTGGTGGGC TGCAAATCCA AGAAGGGGCT CTCTTCGTCC 
TCCAGCTGCT ACCTAGAAGA AGCCCTGCAG AGGCCAGTGG CCTCTGACTT TGAGCCCCAG 
GGTCTCAGCG AAGCAGCTCG ATGGAACTCC AAGGAAAACC TTCTTGCTGG GCCCAGCGAA 
AATGACCCCA ACCTTTTTGT GGCACTCTAT GATTTTGTGG CCAGTGGAGA CAACACTCTC 
AGCATCACTA AAGGCGAGAA GCTCCGGGTC TTAGGTTATA ATCACAATGG GGAGTGGTGT 
GAAGCCCAAA CGAAAAATGG CCAAGGATGG GTCCCAAGCA ACTACATCAC CCCTGTCAAC 
AGCCTGGAGA AGCACTCCTG GTATCACGGG CCCGTGTCTC GAAACGCTGC AGAGTACCTG 
CTGAGCAGTG GGATCAACGG CAGCTTCTTA GTTCGGGAGA GCGAGAGCAG CCCGGGCCAG 
AGGTCCATCT CGCTGCGGTA TGAAGGGAGG GTGTACCACT ACAGGATCAA CACTGCCTCT 
GATGGCAAGC TCTACGTCTC CTCGGAGAGC CGCTTCAACA CTCTGGCCGA GTTAGTTCAC 
CATCATTCCA CTGTGGCTGA CGGGCTCATC ACCACACTGC ACTACCCAGC TCCCAAGCGC 
AACAAGCCCA CCATCTACGG CGTGTCCCCC AACTATGACA AGTGGGAAAT GGAGCGCACA 
GACATCACCA TGAAGCACAA GCTGGGCGGA GGCCAGTACG GGGAGGTGTA CGAGGGCGTC 
TGGAAGAAGT ACAGCCTCAC TGTGGCCGTG AAGACCCTGA AGGAGGACAC CATGGAGGTG 
GAGGAGTTCC TGAAGGAAGC CGCAGTGATG AAGGAGATCA AGCACCCTAA CCTGGTGCAG 
CTGCTAGGGG TGTGTACCCG GGAACCTCCG TTCTACATCA TCACCGAGTT CATGACCTAT 
GGGAACCTGC TGGACTACCT GAGGGAATGT AACCGGCAGG AGGTGAGCGC TGTGGTGCTG 
CTCTACATGG CCACACAGAT CTCATCAGCC ATGGAGTACC TGGAGAAGAA GAACTTCATC 
CACAGAGACC TTGCTGCCCG GAACTGCCTG GTAGGGGAAA ACCACTTGGT GAAGGTGGCT 
GATTTTGGCC TAAGCAGGTT GATGACAGGG GACACCTACA CAGCCCATGC TGGAGCCAAG 
TTCCCCATCA AGTGGACTGC ACCCGAGAGC CTGGCCTATA ACAAGTTCTC CATCAAGTCG 
GACGTCTGGG CATTTGGAGT ATTGCTCTGG GAAATTGCTA CCTATGGCAT GTCACCTTAC 
CCGGGAATTG ACCTGTCTCA GGTTTATGAG CTGCTGGAAA AAGACTACCG CATGGAGCGC 
CCGGAAGGCT GCCCAGAGAA AGTCTACGAA CTCATGCGAG CATGTTGGCA GTGGAACCCC 
TCTGATCGGC CCTCCTTTGC TGAAATCCAT CAAGCCTTTG AAACCATGTT CCAGGAGTCC 
AGCATCTCAG ACGAGGTGGA GAAGGAGCTG GGGAAACGAG GCATGAGAGG AGCCGCCGGG 
AGCACCCTGC AGGCCCCAGA GCTGCCCACC AAGACCAGAA CCTGCAGGAA AACCGCTGAG 
CAGAAAGATG CACCTGACGC CCTGGAACTG CTCCACACGA AGGGCCTGGG CGAAAGCGAC 
GCACTGGACA GTGAACCTGC TGTATCACCA CTGCTTCCTC GGAAAGAGCG TGGGCCCCCG 
GACGGCAGCC TAAATGAAGA TGAGCGTCTC CTCCCCAAAG ACAAAAAGAC CAACCTGTTC 
AGCGCCTTGA TCAAGAAGAA GAAGAAAATG GCGCCGACGC CCCCTAAGCG CAGCAGTTCC 
TTCCGAGAGA TGGATGGCCA GTCAGAACGC AGAGGGGCTA GTGAGGATGA CGGCCGGGAA 
ATCAGCAATG GGCCACCAGC TCTCACCTCA GATGCAGTAG AGCCTACCAA GTCCCCAAAG 
GCCAGCAATG GGGCTGGCGT CCCCAATGGA GCCTTCCGGG AGCCAGGCAA CTCGGGCTTC 
CGCTCTCCCC ATGTGTGGAA GAAGAGCAGC ACACTGACCA GCAGCCGCCT CGCTGCTGCT 
GAAGAGGAGA GTGGCCTCAG TTCCAGTAAG CGCTTCCTGC GCTCCTGCTC GGCCTCCTGC 
ATGCCCCATG GGGTTAGGGA CACTGAGTGG CGGTCAGTCA CGCTGCCTCG GGACCTGCCG 
TCTGCTGGTA AGCAGTTTGA CTCTTCCACC TTTGGAGGGC ACAAAAGTGA AAAGCCAGCT 
CTGCCTCGGA AACGCACCAG TGAGAGCAGG TCTGAGCAGG TGGCCAAAAG CACAGCGACA 
CCCCCTCCTC GGCTGGTGAA GAAGACTGAG GAGGCCGCCG AAGATGTCTT CAAAGACACG 
GAATCCAGCC CTGGCTCCAG CCCTCCCAGC TTGACCCCCA AACTCCTCCG TAGGCAGGTC 
CCTGCCTCCC CCTCCTCTGG CCCCTCTCAC AAGGACGAGG CCACCAAGGG CAATGCCTCG 
GGCATGGGGA CTCCTGCCAC TGCAGAGCCA GCAGCCCCCA GCAACAAAGC GGGCCTCAGC 
AAGGCCTCCT CCGAGGAGCC CCGTGCAAGG AGACACAAGC ACAGCTCGGA GTCCCCAGGG 
AGAGACAAGG GGCGGCTGTC CAAGCTCAAG CCGGCCCCGC CACCTCCGCC CTCCTCCACA 
GGGAAAGCAG GGAAGCCTGC ACAGAGCCCC AGCCAAGATG TGGCTGGGGA GGCAGGTGGG 
GCCACCAAGA CAAAATGCAC AAGTCTGTCT GTGGATGCTG TGAACAGTGA CCCCACCAAG 
GCTGGCCAGC CTGGAGAAGG ACTGAGAAAA TCTGTGCCCC CATCTGTGCC AAAGCCTCAG 
TCAGCTACTA AGCCACCGGG GACCCCCACC AGCCCGGTCT CCACCCCCTC CACAGCGCCA 
GCACCTTCAC CCCTGGCTGG GGACCAGCAG CCATCTTCTG CTGCCTTCAT CCCCCTCATA 
TCAACCCGTG TGTCTCTTCG AAAGACCCGA CAGCCGCCAG AGCGCATCGC CAGTGGCACC 
ATCACCAAGG GTGTGGTTCT GGACAGTACT GAGGCCCTGT GCCTTGCCAT CTCCCGGAAC 
TCGGAGCAGA TGGCCAGCCA CAGTGCTGTG CTGGAGGCGG GCAAGAACCT GTACACATTC 
TGTGTGAGCT ACGTGGACTC TATCCAGCAG ATGAGGAACA AGTTTGCCTT CCGCGAGGCT 
ATCAACAAGC TGGAGAGCAA CCTCCGAGAG CTGCAGATCT GCCCTGCGAC AGCCTCCAGT 
GGGCCAGCGG CCACACAAGA CTTCAGCAAG CTGCTTAGCT CTGTGAAGGA GATCAGCGAC 
ATTGTCCGGA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233980.1
CDS	88..3462
Translation	MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGMRGAAGSTLQAPELPTKTRTCRKTAEQKDAPDALELLHTKGLGESDALDSEPAVSPLLPRKERGPPDGSLNEDERLLPKDKKTNLFSALIKKKKKMAPTPPKRSSSFREMDGQSERRGASEDDGREISNGPPALTSDAVEPTKSPKASNGAGVPNGAFREPGNSGFRSPHVWKKSSTLTSSRLAAAEEESGLSSSKRFLRSCSASCMPHGVRDTEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRSEQVAKSTATPPPRLVKKTEEAAEDVFKDTESSPGSSPPSLTPKLLRRQVPASPSSGPSHKDEATKGNASGMGTPATAEPAAPSNKAGLSKASSEEPRARRHKHSSESPGRDKGRLSKLKPAPPPPPSSTGKAGKPAQSPSQDVAGEAGGATKTKCTSLSVDAVNSDPTKAGQPGEGLRKSVPPSVPKPQSATKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGPAATQDFSKLLSSVKEISDIVRR

Target ORF information:

RefSeq Version	XM_006233918.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233918.3

ORF Insert Sequence:

ATGTTGGAGA TCTGCTTGAA GTTGGTGGGC TGCAAATCCA AGAAGGGGCT CTCTTCGTCC 
TCCAGCTGCT ACCTAGAAGA AGCCCTGCAG AGGCCAGTGG CCTCTGACTT TGAGCCCCAG 
GGTCTCAGCG AAGCAGCTCG ATGGAACTCC AAGGAAAACC TTCTTGCTGG GCCCAGCGAA 
AATGACCCCA ACCTTTTTGT GGCACTCTAT GATTTTGTGG CCAGTGGAGA CAACACTCTC 
AGCATCACTA AAGGCGAGAA GCTCCGGGTC TTAGGTTATA ATCACAATGG GGAGTGGTGT 
GAAGCCCAAA CGAAAAATGG CCAAGGATGG GTCCCAAGCA ACTACATCAC CCCTGTCAAC 
AGCCTGGAGA AGCACTCCTG GTATCACGGG CCCGTGTCTC GAAACGCTGC AGAGTACCTG 
CTGAGCAGTG GGATCAACGG CAGCTTCTTA GTTCGGGAGA GCGAGAGCAG CCCGGGCCAG 
AGGTCCATCT CGCTGCGGTA TGAAGGGAGG GTGTACCACT ACAGGATCAA CACTGCCTCT 
GATGGCAAGC TCTACGTCTC CTCGGAGAGC CGCTTCAACA CTCTGGCCGA GTTAGTTCAC 
CATCATTCCA CTGTGGCTGA CGGGCTCATC ACCACACTGC ACTACCCAGC TCCCAAGCGC 
AACAAGCCCA CCATCTACGG CGTGTCCCCC AACTATGACA AGTGGGAAAT GGAGCGCACA 
GACATCACCA TGAAGCACAA GCTGGGCGGA GGCCAGTACG GGGAGGTGTA CGAGGGCGTC 
TGGAAGAAGT ACAGCCTCAC TGTGGCCGTG AAGACCCTGA AGGAGGACAC CATGGAGGTG 
GAGGAGTTCC TGAAGGAAGC CGCAGTGATG AAGGAGATCA AGCACCCTAA CCTGGTGCAG 
CTGCTAGGGG TGTGTACCCG GGAACCTCCG TTCTACATCA TCACCGAGTT CATGACCTAT 
GGGAACCTGC TGGACTACCT GAGGGAATGT AACCGGCAGG AGGTGAGCGC TGTGGTGCTG 
CTCTACATGG CCACACAGAT CTCATCAGCC ATGGAGTACC TGGAGAAGAA GAACTTCATC 
CACAGAGACC TTGCTGCCCG GAACTGCCTG GTAGGGGAAA ACCACTTGGT GAAGGTGGCT 
GATTTTGGCC TAAGCAGGTT GATGACAGGG GACACCTACA CAGCCCATGC TGGAGCCAAG 
TTCCCCATCA AGTGGACTGC ACCCGAGAGC CTGGCCTATA ACAAGTTCTC CATCAAGTCG 
GACGTCTGGG CATTTGGAGT ATTGCTCTGG GAAATTGCTA CCTATGGCAT GTCACCTTAC 
CCGGGAATTG ACCTGTCTCA GGTTTATGAG CTGCTGGAAA AAGACTACCG CATGGAGCGC 
CCGGAAGGCT GCCCAGAGAA AGTCTACGAA CTCATGCGAG CATGTTGGCA GTGGAACCCC 
TCTGATCGGC CCTCCTTTGC TGAAATCCAT CAAGCCTTTG AAACCATGTT CCAGGAGTCC 
AGCATCTCAG ACGAGGTGGA GAAGGAGCTG GGGAAACGAG GCATGAGAGG AGCCGCCGGG 
AGCACCCTGC AGGCCCCAGA GCTGCCCACC AAGACCAGAA CCTGCAGGAA AACCGCTGAG 
CAGAAAGATG CACCTGACGC CCTGGAACTG CTCCACACGA AGGGCCTGGG CGAAAGCGAC 
GCACTGGACA GTGAACCTGC TGTATCACCA CTGCTTCCTC GGAAAGAGCG TGGGCCCCCG 
GACGGCAGCC TAAATGAAGA TGAGCGTCTC CTCCCCAAAG ACAAAAAGAC CAACCTGTTC 
AGCGCCTTGA TCAAGAAGAA GAAGAAAATG GCGCCGACGC CCCCTAAGCG CAGCAGTTCC 
TTCCGAGAGA TGGATGGCCA GTCAGAACGC AGAGGGGCTA GTGAGGATGA CGGCCGGGAA 
ATCAGCAATG GGCCACCAGC TCTCACCTCA GATGCAGTAG AGCCTACCAA GTCCCCAAAG 
GCCAGCAATG GGGCTGGCGT CCCCAATGGA GCCTTCCGGG AGCCAGGCAA CTCGGGCTTC 
CGCTCTCCCC ATGTGTGGAA GAAGAGCAGC ACACTGACCA GCAGCCGCCT CGCTGCTGCT 
GAAGAGGAGA GTGGCCTCAG TTCCAGTAAG CGCTTCCTGC GCTCCTGCTC GGCCTCCTGC 
ATGCCCCATG GGGTTAGGGA CACTGAGTGG CGGTCAGTCA CGCTGCCTCG GGACCTGCCG 
TCTGCTGGTA AGCAGTTTGA CTCTTCCACC TTTGGAGGGC ACAAAAGTGA AAAGCCAGCT 
CTGCCTCGGA AACGCACCAG TGAGAGCAGG TCTGAGCAGG TGGCCAAAAG CACAGCGACA 
CCCCCTCCTC GGCTGGTGAA GAAGACTGAG GAGGCCGCCG AAGATGTCTT CAAAGACACG 
GAATCCAGCC CTGGCTCCAG CCCTCCCAGC TTGACCCCCA AACTCCTCCG TAGGCAGGTC 
CCTGCCTCCC CCTCCTCTGG CCCCTCTCAC AAGGACGAGG CCACCAAGGG CAATGCCTCG 
GGCATGGGGA CTCCTGCCAC TGCAGAGCCA GCAGCCCCCA GCAACAAAGC GGGCCTCAGC 
AAGGCCTCCT CCGAGGAGCC CCGTGCAAGG AGACACAAGC ACAGCTCGGA GTCCCCAGGG 
AGAGACAAGG GGCGGCTGTC CAAGCTCAAG CCGGCCCCGC CACCTCCGCC CTCCTCCACA 
GGGAAAGCAG GGAAGCCTGC ACAGAGCCCC AGCCAAGATG TGGCTGGGGA GGCAGGTGGG 
GCCACCAAGA CAAAATGCAC AAGTCTGTCT GTGGATGCTG TGAACAGTGA CCCCACCAAG 
GCTGGCCAGC CTGGAGAAGG ACTGAGAAAA TCTGTGCCCC CATCTGTGCC AAAGCCTCAG 
TCAGCTACTA AGCCACCGGG GACCCCCACC AGCCCGGTCT CCACCCCCTC CACAGCGCCA 
GCACCTTCAC CCCTGGCTGG GGACCAGCAG CCATCTTCTG CTGCCTTCAT CCCCCTCATA 
TCAACCCGTG TGTCTCTTCG AAAGACCCGA CAGCCGCCAG AGCGCATCGC CAGTGGCACC 
ATCACCAAGG GTGTGGTTCT GGACAGTACT GAGGCCCTGT GCCTTGCCAT CTCCCGGAAC 
TCGGAGCAGA TGGCCAGCCA CAGTGCTGTG CTGGAGGCGG GCAAGAACCT GTACACATTC 
TGTGTGAGCT ACGTGGACTC TATCCAGCAG ATGAGGAACA AGTTTGCCTT CCGCGAGGCT 
ATCAACAAGC TGGAGAGCAA CCTCCGAGAG CTGCAGATCT GCCCTGCGAC AGCCTCCAGT 
GGGCCAGCGG CCACACAAGA CTTCAGCAAG CTGCTTAGCT CTGTGAAGGA GATCAGCGAC 
ATTGTCCGGA GGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.
Scientific reports7(1)887(2017 04)
Cobbaut M,Derua R,Döppler H,Lou HJ,Vandoninck S,Storz P,Turk BE,Seufferlein T,Waelkens E,Janssens V,Van Lint J

Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.
Nature genetics49(4)613-617(2017 Apr)
Wang X,Charng WL,Chen CA,Rosenfeld JA,Al Shamsi A,Al-Gazali L,McGuire M,Mew NA,Arnold GL,Qu C,Ding Y,Muzny DM,Gibbs RA,Eng CM,Walkiewicz M,Xia F,Plon SE,Lupski JR,Schaaf CP,Yang Y

The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase.
The Journal of biological chemistry291(32)16424-37(2016 08)
Cao H,Schroeder B,Chen J,Schott MB,McNiven MA

NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.
Cell reports11(10)1577-90(2015 Jun)
Fantin A,Lampropoulou A,Gestri G,Raimondi C,Senatore V,Zachary I,Ruhrberg C

Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice.
PloS one9(8)e105200(2014)
Cai J,Wu G,Tan X,Han Y,Chen C,Li C,Wang N,Zou X,Chen X,Zhou F,He D,Zhou L,Jose PA,Zeng C

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Abl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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