Pmepa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pmepa1
Entrez Gene ID	311676
Full Name	prostate transmembrane protein, androgen induced 1
Synonyms	Tmepai
General protein information	Preferred Names prostate transmembrane protein, androgen induced 1 Names protein TMEPAI transmembrane prostate androgen-induced protein transmembrane, prostate androgen induced RNA
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107807.2	NP_001101277.1	protein TMEPAI precursor
XM_006235689.1	XP_006235751.1	protein TMEPAI isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PMEPA1	XP_005635269.1
Homo sapiens (human)	PMEPA1	NP_064567.2
Bos taurus (cattle)	PMEPA1	NP_001071546.1
Mus musculus (house mouse)	Pmepa1	NP_075371.2
Xenopus tropicalis (tropical clawed frog)	pmepa1	XP_002941498.1
Pan troglodytes (chimpanzee)	PMEPA1	XP_003953839.1
Rattus norvegicus (Norway rat)	Pmepa1	NP_001101277.1
Gallus gallus (chicken)	PMEPA1	NP_001026663.1
Macaca mulatta (Rhesus monkey)	LOC695968	XP_001086224.1

Gene Ontology
Bibliography

Related articles in PubMed

Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis.
Funakubo N, Xu X, Kukita T, Nakamura S, Miyamoto H, Kukita A
Journal of cellular physiology233(4)3105-3118(2018 04)

C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.
Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S
The Journal of biological chemistry289(18)12680-92(2014 May)

TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.
Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang W, Shi L, Tanaka A, Nakano N, Mommaas AM, Shibuya H, Ten Dijke P, Kato M
Molecular cell37(1)123-34(2010 Jan)

EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer.
Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A
Molecular carcinogenesis38(4)188-200(2003 Dec)

PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression.
Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S
Cancer research63(15)4299-304(2003 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pmepa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pmepa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00197	NM_001107807.2 Latest version!	Rattus norvegicus prostate transmembrane protein, androgen induced 1 (Pmepa1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa26748	XM_006235689.1 Latest version!	Rattus norvegicus prostate transmembrane protein, androgen induced 1 (Pmepa1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pmepa1 ( NM_001107807.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101277.1 Rattus norvegicus prostate transmembrane protein, androgen induced 1 (Pmepa1), mRNA.

Price & Availability↑

CloneID	ORa00197
Clone ID Related Accession (Same CDS sequence)	NM_001107807.2
Accession Version	NM_001107807.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1545408000000
Organism	Rattus norvegicus(Norway rat)
Product	protein TMEPAI precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474062.2. On Mar 3, 2011 this sequence version replaced NM_001107807.1. ##Evidence-Data-START## Transcript exon combination :: BF547056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGATGGTGA TGGTGGTGAT GATCACGTGC CTGCTGAGCC ACTACAAGCT GTCAGCCCGC 
TCCTTCATCA GCCGACACAG CCAGGCCCGG AGGAGAGACG ACGGAGGACT GTCCTCGGAA 
GGATGCCTCT GGCCGTCGGA GAGCACGGTG TCAGGCGGAA TGCCGGAGCC ACAGGTCTAT 
GCCCCACCTC GGCCCACTGA CCGCCTCGCT GTGCCCCCCT TCGTCCAGCG GAGCCGTTTC 
CAGCCCACCT ACCCCTACCT GCAGCACGAA ATTGCCCTGC CACCCACCAT CTCGCTGTCT 
GATGGGGAGG AGCCCCCACC CTACCAGGGC CCCTGCACCC TCCAGTTACG GGACCCGGAG 
CAACAGCTGG AGCTGAACCG AGAGTCTGTG CGCGCGCCCC CCAACCGGAC CATCTTCGAC 
AGTGACCTCA TAGACAGCAG CATGCTGGGG GGCCCCTGTC CCCCCAGCAG TAACTCCGGC 
ATCAGCGCTA CCTGCTATAG CAGCGGCGGG CGCATGGAGG GGCCTCCTCC CACCTACAGT 
GAGGTCATTG GTCACTACCC GGGCTCCTCC TTCCAGCAGC ACCAGCAAAG TAACGGGCAG 
TCCTCCCTGC TAGAAGGGAC CCGGCTCCAT CACCCTCACA TTGCCCCACT GGAGAACAAG 
GAGAAGGAGA AACAGAAAGG TCACCCTCTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101277.1
CDS	1..693
Translation	MMVMVVMITCLLSHYKLSARSFISRHSQARRRDDGGLSSEGCLWPSESTVSGGMPEPQVYAPPRPTDRLAVPPFVQRSRFQPTYPYLQHEIALPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLIDSSMLGGPCPPSSNSGISATCYSSGGRMEGPPPTYSEVIGHYPGSSFQQHQQSNGQSSLLEGTRLHHPHIAPLENKEKEKQKGHPL

Target ORF information:

RefSeq Version	NM_001107807.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prostate transmembrane protein, androgen induced 1 (Pmepa1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107807.2

ORF Insert Sequence:

ATGATGGTGA TGGTGGTGAT GATCACGTGC CTGCTGAGCC ACTACAAGCT GTCAGCCCGC 
TCCTTCATCA GCCGACACAG CCAGGCCCGG AGGAGAGACG ACGGAGGACT GTCCTCGGAA 
GGATGCCTCT GGCCGTCGGA GAGCACGGTG TCAGGCGGAA TGCCGGAGCC ACAGGTCTAT 
GCCCCACCTC GGCCCACTGA CCGCCTCGCT GTGCCCCCCT TCGTCCAGCG GAGCCGTTTC 
CAGCCCACCT ACCCCTACCT GCAGCACGAA ATTGCCCTGC CACCCACCAT CTCGCTGTCT 
GATGGGGAGG AGCCCCCACC CTACCAGGGC CCCTGCACCC TCCAGTTACG GGACCCGGAG 
CAACAGCTGG AGCTGAACCG AGAGTCTGTG CGCGCGCCCC CCAACCGGAC CATCTTCGAC 
AGTGACCTCA TAGACAGCAG CATGCTGGGG GGCCCCTGTC CCCCCAGCAG TAACTCCGGC 
ATCAGCGCTA CCTGCTATAG CAGCGGCGGG CGCATGGAGG GGCCTCCTCC CACCTACAGT 
GAGGTCATTG GTCACTACCC GGGCTCCTCC TTCCAGCAGC ACCAGCAAAG TAACGGGCAG 
TCCTCCCTGC TAGAAGGGAC CCGGCTCCAT CACCCTCACA TTGCCCCACT GGAGAACAAG 
GAGAAGGAGA AACAGAAAGG TCACCCTCTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pmepa1 ( XM_006235689.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235751.1 Rattus norvegicus prostate transmembrane protein, androgen induced 1 (Pmepa1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26748
Clone ID Related Accession (Same CDS sequence)	XM_006235689.1
Accession Version	XM_006235689.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	protein TMEPAI isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGGTCA ACGGCACCGC CGCCGCAGCC GCCGCCGGGC AGCCCAATGT CTCCTGCGCG 
TGCAACTGCC AGCGCTCTTT GTTCCCCAGC ATGGAGATCA CGGAGCTGGA GTTCGTGCAG 
ATCGTGGTCA TCGTGGTCGT GATGATGGTG ATGGTGGTGA TGATCACGTG CCTGCTGAGC 
CACTACAAGC TGTCAGCCCG CTCCTTCATC AGCCGACACA GCCAGGCCCG GAGGAGAGAC 
GACGGAGGAC TGTCCTCGGA AGGATGCCTC TGGCCGTCGG AGAGCACGGT GTCAGGCGGA 
ATGCCGGAGC CACAGGTCTA TGCCCCACCT CGGCCCACTG ACCGCCTCGC TGTGCCCCCC 
TTCGTCCAGC GGAGCCGTTT CCAGCCCACC TACCCCTACC TGCAGCACGA AATTGCCCTG 
CCACCCACCA TCTCGCTGTC TGATGGGGAG GAGCCCCCAC CCTACCAGGG CCCCTGCACC 
CTCCAGTTAC GGGACCCGGA GCAACAGCTG GAGCTGAACC GAGAGTCTGT GCGCGCGCCC 
CCCAACCGGA CCATCTTCGA CAGTGACCTC ATAGACAGCA GCATGCTGGG GGGCCCCTGT 
CCCCCCAGCA GTAACTCCGG CATCAGCGCT ACCTGCTATA GCAGCGGCGG GCGCATGGAG 
GGGCCTCCTC CCACCTACAG TGAGGTCATT GGTCACTACC CGGGCTCCTC CTTCCAGCAG 
CACCAGCAAA GTAACGGGCA GTCCTCCCTG CTAGAAGGGA CCCGGCTCCA TCACCCTCAC 
ATTGCCCCAC TGGAGAACAA GGAGAAGGAG AAACAGAAAG GTCACCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235751.1
CDS	25..858
Translation	MGVNGTAAAAAAGQPNVSCACNCQRSLFPSMEITELEFVQIVVIVVVMMVMVVMITCLLSHYKLSARSFISRHSQARRRDDGGLSSEGCLWPSESTVSGGMPEPQVYAPPRPTDRLAVPPFVQRSRFQPTYPYLQHEIALPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLIDSSMLGGPCPPSSNSGISATCYSSGGRMEGPPPTYSEVIGHYPGSSFQQHQQSNGQSSLLEGTRLHHPHIAPLENKEKEKQKGHPL

Target ORF information:

RefSeq Version	XM_006235689.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prostate transmembrane protein, androgen induced 1 (Pmepa1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235689.1

ORF Insert Sequence:

ATGGGGGTCA ACGGCACCGC CGCCGCAGCC GCCGCCGGGC AGCCCAATGT CTCCTGCGCG 
TGCAACTGCC AGCGCTCTTT GTTCCCCAGC ATGGAGATCA CGGAGCTGGA GTTCGTGCAG 
ATCGTGGTCA TCGTGGTCGT GATGATGGTG ATGGTGGTGA TGATCACGTG CCTGCTGAGC 
CACTACAAGC TGTCAGCCCG CTCCTTCATC AGCCGACACA GCCAGGCCCG GAGGAGAGAC 
GACGGAGGAC TGTCCTCGGA AGGATGCCTC TGGCCGTCGG AGAGCACGGT GTCAGGCGGA 
ATGCCGGAGC CACAGGTCTA TGCCCCACCT CGGCCCACTG ACCGCCTCGC TGTGCCCCCC 
TTCGTCCAGC GGAGCCGTTT CCAGCCCACC TACCCCTACC TGCAGCACGA AATTGCCCTG 
CCACCCACCA TCTCGCTGTC TGATGGGGAG GAGCCCCCAC CCTACCAGGG CCCCTGCACC 
CTCCAGTTAC GGGACCCGGA GCAACAGCTG GAGCTGAACC GAGAGTCTGT GCGCGCGCCC 
CCCAACCGGA CCATCTTCGA CAGTGACCTC ATAGACAGCA GCATGCTGGG GGGCCCCTGT 
CCCCCCAGCA GTAACTCCGG CATCAGCGCT ACCTGCTATA GCAGCGGCGG GCGCATGGAG 
GGGCCTCCTC CCACCTACAG TGAGGTCATT GGTCACTACC CGGGCTCCTC CTTCCAGCAG 
CACCAGCAAA GTAACGGGCA GTCCTCCCTG CTAGAAGGGA CCCGGCTCCA TCACCCTCAC 
ATTGCCCCAC TGGAGAACAA GGAGAAGGAG AAACAGAAAG GTCACCCTCT CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis.
Journal of cellular physiology233(4)3105-3118(2018 04)
Funakubo N,Xu X,Kukita T,Nakamura S,Miyamoto H,Kukita A

C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.
The Journal of biological chemistry289(18)12680-92(2014 May)
Nakano N,Maeyama K,Sakata N,Itoh F,Akatsu R,Nakata M,Katsu Y,Ikeno S,Togawa Y,Vo Nguyen TT,Watanabe Y,Kato M,Itoh S

TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.
Molecular cell37(1)123-34(2010 Jan)
Watanabe Y,Itoh S,Goto T,Ohnishi E,Inamitsu M,Itoh F,Satoh K,Wiercinska E,Yang W,Shi L,Tanaka A,Nakano N,Mommaas AM,Shibuya H,Ten Dijke P,Kato M

EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer.
Molecular carcinogenesis38(4)188-200(2003 Dec)
Giannini G,Ambrosini MI,Di Marcotullio L,Cerignoli F,Zani M,MacKay AR,Screpanti I,Frati L,Gulino A

PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression.
Cancer research63(15)4299-304(2003 Aug)
Xu LL,Shi Y,Petrovics G,Sun C,Makarem M,Zhang W,Sesterhenn IA,McLeod DG,Sun L,Moul JW,Srivastava S

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Pmepa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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