Ang cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ang
Entrez Gene ID	305843
Full Name	angiogenin
Synonyms	Ang1
General protein information	Preferred Names angiogenin Names angiogenin angiogenin ribonuclease 1 angiogenin, ribonuclease A family, member 1 angiogenin, ribonuclease, RNase A family, 5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p14

mRNA and Protein(s)

mRNA	Protein	Name
XM_006251874.3	XP_006251936.1	angiogenin isoform X1
NM_001006992.1	NP_001006993.1	angiogenin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANG	NP_001136.1
Pan troglodytes (chimpanzee)	ANG	NP_001009159.1
Rattus norvegicus (Norway rat)	Ang	NP_001006993.1
Rattus norvegicus (Norway rat)	Ang2	NP_001012359.1
Mus musculus (house mouse)	Ang	NP_001155203.1

Gene Ontology
Bibliography

Related articles in PubMed

Ribonuclease 5 coordinates signals for the regulation of intraocular pressure and inhibits neural apoptosis as a novel multi-functional anti-glaucomatous strategy.
Kim KW, Park SH, Oh DH, Lee SH, Lim KS, Joo K, Chun YS, Chang SI, Min KM, Kim JC
Biochimica et biophysica acta1862(2)145-54(2016 02)

The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex.
Yeo KJ, Hwang E, Min KM, Jee JG, Lee CK, Hwang KY, Jeon YH, Chang SI, Cheong HK
Chemical communications (Cambridge, England)50(85)12966-9(2014 Nov)

Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.
Padhi AK, Banerjee K, Gomes J, Banerjee M
PloS one9(11)e111963(2014)

Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.
Li Y, Xia Y, Wang Y, Mao L, Gao Y, He Q, Huang M, Chen S, Hu B
Molecular neurobiology47(3)967-75(2013 Jun)

Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues.
Iyer S, Holloway DE, Acharya KR
The FEBS journal280(1)302-18(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ang gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ang cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42809	NM_001006992.1 Latest version!	Rattus norvegicus angiogenin (Ang), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa36616	XM_006251874.3 Latest version!	Rattus norvegicus angiogenin (Ang), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ang ( NM_001006992.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001006993.1 Rattus norvegicus angiogenin (Ang), mRNA.

Price & Availability↑

CloneID	ORa42809
Clone ID Related Accession (Same CDS sequence)	NM_001006992.1
Accession Version	NM_001006992.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570550400000
Organism	Rattus norvegicus(Norway rat)
Product	angiogenin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY395869.1. On Nov 22, 2004 this sequence version replaced XM_223968.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY395869.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAGATGA GCCTGCGTCC TCTGTTGTCG GTTTTTGTGC TGGGTCTGGT TTCGACCCCT 
TCAACTCTGG CTCAGGACGA CCCCAGGTAC ACGAAGTTCC TGACTCAGCA CTATGATGCC 
AAGCCCAAGG GTCGGGATGC CAGATACTGC GAAAGTATGA TGAGGAGAAG AGGCCTAACC 
TCGCCCTGCA AAGAGGTCAA CACCTTTATC CATGGCAACA AGGGCAGCAT CAAGGCCATC 
TGTGGCGCGA ATGGAAGCCC TTACGGAGAA AACTTAAGAA TAAGCCAGTC TCCCTTCCAG 
ATCACCACCT GCAAGCATAC AGGAGGGTCT CCCCGGCCCC CTTGCCGGTA CCGAGCCTCT 
GCAGGGTTCA GACATGTTGT TATTGCCTGT GAAAATGGCT TGCCTGTCCA CTTTGATGAG 
TCTTTTATCA GTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001006993.1
CDS	1..438
Translation	MEMSLRPLLSVFVLGLVSTPSTLAQDDPRYTKFLTQHYDAKPKGRDARYCESMMRRRGLTSPCKEVNTFIHGNKGSIKAICGANGSPYGENLRISQSPFQITTCKHTGGSPRPPCRYRASAGFRHVVIACENGLPVHFDESFISL

Target ORF information:

RefSeq Version	NM_001006992.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus angiogenin (Ang), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001006992.1

ORF Insert Sequence:

ATGGAGATGA GCCTGCGTCC TCTGTTGTCG GTTTTTGTGC TGGGTCTGGT TTCGACCCCT 
TCAACTCTGG CTCAGGACGA CCCCAGGTAC ACGAAGTTCC TGACTCAGCA CTATGATGCC 
AAGCCCAAGG GTCGGGATGC CAGATACTGC GAAAGTATGA TGAGGAGAAG AGGCCTAACC 
TCGCCCTGCA AAGAGGTCAA CACCTTTATC CATGGCAACA AGGGCAGCAT CAAGGCCATC 
TGTGGCGCGA ATGGAAGCCC TTACGGAGAA AACTTAAGAA TAAGCCAGTC TCCCTTCCAG 
ATCACCACCT GCAAGCATAC AGGAGGGTCT CCCCGGCCCC CTTGCCGGTA CCGAGCCTCT 
GCAGGGTTCA GACATGTTGT TATTGCCTGT GAAAATGGCT TGCCTGTCCA CTTTGATGAG 
TCTTTTATCA GTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ang ( XM_006251874.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006251936.1 Rattus norvegicus angiogenin (Ang), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36616
Clone ID Related Accession (Same CDS sequence)	XM_006251874.3
Accession Version	XM_006251874.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	angiogenin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006251874.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCTCCC CACCCCTTCA CACGAGCCCT GTATATAACC AGACTGACAG GAGCCTCTGG 
CTTCACACCG CAGGACCCTG TCTCCAGGAG CCAACAGCTA GACTGGTCCC AGTCAGACGG 
AGGAAACCTG GCCAGCTTTT GCTGGAATCT CTGTTGGAAG AGATGGAGAT GAGCCTGCGT 
CCTCTGTTGT TGGTTTTTGT GCTGGGTCTG GTTTCGACCC CTTCAACTCT GGCTCAGGAC 
GACCCCAGGT ACACGAAGTT CCTGACTCAG CACTATGATG CCAAGCCCAA GGGTCGGGAT 
GCCAGATACT GCGAAAGTAT GATGAGGAGA AGAGGCCTAA CCTCGCCCTG CAAAGAGGTC 
AACACCTTTA TCCATGGCAA CAAGGGCAGC ATCAAGGCCA TCTGTGGCGC GAATGGAAGC 
CCTTACGGAG AAAACTTAAG AATAAGCCAG TCTCCCTTCC AGATCACCAC CTGCAAGCAT 
ACAGGAGGGT CTCCCCGGCC CCCTTGCCGG TACCGAGCCT CTGCAGGGTT CAGACATGTT 
GTTATTGCCT GTGAAAATGG CTTGCCTGTC CACTTTGATG AGTCTTTTAT CAGTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006251936.1
CDS	4..603
Translation	MFSPPLHTSPVYNQTDRSLWLHTAGPCLQEPTARLVPVRRRKPGQLLLESLLEEMEMSLRPLLLVFVLGLVSTPSTLAQDDPRYTKFLTQHYDAKPKGRDARYCESMMRRRGLTSPCKEVNTFIHGNKGSIKAICGANGSPYGENLRISQSPFQITTCKHTGGSPRPPCRYRASAGFRHVVIACENGLPVHFDESFISL

Target ORF information:

RefSeq Version	XM_006251874.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus angiogenin (Ang), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006251874.3

ORF Insert Sequence:

ATGTTCTCCC CACCCCTTCA CACGAGCCCT GTATATAACC AGACTGACAG GAGCCTCTGG 
CTTCACACCG CAGGACCCTG TCTCCAGGAG CCAACAGCTA GACTGGTCCC AGTCAGACGG 
AGGAAACCTG GCCAGCTTTT GCTGGAATCT CTGTTGGAAG AGATGGAGAT GAGCCTGCGT 
CCTCTGTTGT TGGTTTTTGT GCTGGGTCTG GTTTCGACCC CTTCAACTCT GGCTCAGGAC 
GACCCCAGGT ACACGAAGTT CCTGACTCAG CACTATGATG CCAAGCCCAA GGGTCGGGAT 
GCCAGATACT GCGAAAGTAT GATGAGGAGA AGAGGCCTAA CCTCGCCCTG CAAAGAGGTC 
AACACCTTTA TCCATGGCAA CAAGGGCAGC ATCAAGGCCA TCTGTGGCGC GAATGGAAGC 
CCTTACGGAG AAAACTTAAG AATAAGCCAG TCTCCCTTCC AGATCACCAC CTGCAAGCAT 
ACAGGAGGGT CTCCCCGGCC CCCTTGCCGG TACCGAGCCT CTGCAGGGTT CAGACATGTT 
GTTATTGCCT GTGAAAATGG CTTGCCTGTC CACTTTGATG AGTCTTTTAT CAGTCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribonuclease 5 coordinates signals for the regulation of intraocular pressure and inhibits neural apoptosis as a novel multi-functional anti-glaucomatous strategy.
Biochimica et biophysica acta1862(2)145-54(2016 02)
Kim KW,Park SH,Oh DH,Lee SH,Lim KS,Joo K,Chun YS,Chang SI,Min KM,Kim JC

The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex.
Chemical communications (Cambridge, England)50(85)12966-9(2014 Nov)
Yeo KJ,Hwang E,Min KM,Jee JG,Lee CK,Hwang KY,Jeon YH,Chang SI,Cheong HK

Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis.
PloS one9(11)e111963(2014)
Padhi AK,Banerjee K,Gomes J,Banerjee M

Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.
Molecular neurobiology47(3)967-75(2013 Jun)
Li Y,Xia Y,Wang Y,Mao L,Gao Y,He Q,Huang M,Chen S,Hu B

Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues.
The FEBS journal280(1)302-18(2013 Jan)
Iyer S,Holloway DE,Acharya KR