Eif6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eif6
Entrez Gene ID	305506
Full Name	eukaryotic translation initiation factor 6
Synonyms	Itgb4bp,eIF-6
General protein information	Preferred Names eukaryotic translation initiation factor 6 Names eukaryotic translation initiation factor 6 integrin beta 4 binding protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42

mRNA and Protein(s)

mRNA	Protein	Name
XM_017591667.1	XP_017447156.1	eukaryotic translation initiation factor 6 isoform X1
NM_001037352.1	NP_001032429.1	eukaryotic translation initiation factor 6
XM_006235316.3	XP_006235378.1	eukaryotic translation initiation factor 6 isoform X1

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0D02046g	XP_453159.1
Homo sapiens (human)	EIF6	NP_001254739.1
Mus musculus (house mouse)	Eif6	NP_034709.1
Saccharomyces cerevisiae (baker's yeast)	TIF6	NP_015341.1
Magnaporthe oryzae (rice blast fungus)	MGG_01671	XP_003714657.1
Pan troglodytes (chimpanzee)	EIF6	XP_003953760.1
Danio rerio (zebrafish)	eif6	NP_957238.1
Arabidopsis thaliana (thale cress)	emb1624	NP_191121.1
Eremothecium gossypii	AGOS_ADL030C	NP_984067.1
Oryza sativa (rice)	Os07g0639800	NP_001060417.1
Rattus norvegicus (Norway rat)	Eif6	NP_001032429.1
Xenopus tropicalis (tropical clawed frog)	eif6	NP_001006884.1
Canis lupus familiaris (dog)	EIF6	XP_534401.2
Bos taurus (cattle)	EIF6	NP_777255.1
Gallus gallus (chicken)	EIF6	NP_001026019.1
Drosophila melanogaster (fruit fly)	eIF6	NP_659573.1
Caenorhabditis elegans (roundworm)	eif-6	NP_493272.1
Neurospora crassa	NCU09004	XP_959032.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001380	XP_321758.5
Schizosaccharomyces pombe (fission yeast)	tif6	NP_588491.1

Gene Ontology
Bibliography

Related articles in PubMed

Upregulation of eIF6 inhibits cardiac hypertrophy induced by phenylephrine.
Romano N, Ricciardi S, Gallo P, Ceci M
Biochemical and biophysical research communications495(1)601-606(2018 01)

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.
Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti LG, Falciani F, Biffo S
Journal of thrombosis and haemostasis : JTH13(11)2108-18(2015 Nov)

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S
Nature communications68261(2015 Sep)

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Finch AJ, Hilcenko C, Basse N, Drynan LF, Goyenechea B, Menne TF, González Fernández A, Simpson P, D'Santos CS, Arends MJ, Donadieu J, Bellanné-Chantelot C, Costanzo M, Boone C, McKenzie AN, Freund SM, Warren AJ
Genes & development25(9)917-29(2011 May)

Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation.
Miluzio A, Beugnet A, Volta V, Biffo S
EMBO reports10(5)459-65(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Eif6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09285	NM_001037352.1 Latest version!	Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa09285	XM_006235316.3 Latest version!	Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa09285	XM_017591667.1 Latest version!	Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eif6 ( NM_001037352.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032429.1 Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), mRNA.

Price & Availability↑

CloneID	ORa09285
Clone ID Related Accession (Same CDS sequence)	XM_017591667.1 , NM_001037352.1 , XM_006235316.3
Accession Version	NM_001037352.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	eukaryotic translation initiation factor 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105764.1. On Nov 25, 2005 this sequence version replaced XM_223613.3. ##Evidence-Data-START## Transcript exon combination :: BC105764.1, FQ225904.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGTCA GAGCGTCGTT CGAGAACAAC TGTGAGGTCG GTTGTTTTGC CAAACTCACT 
AACACCTACT GCCTGGTGGC CATCGGAGGG TCAGAGAACT TCTACAGTGT GTTCGAGGGC 
GAGCTCTCCG ATACCATTCC TGTAGTGCAC GCATCCATCG CCGGCTGCCG AATCATCGGG 
CGCATGTGTG TGGGGAACAG GCATGGGCTG CTGGTACCCA ACAACACCAC CGACCAGGAG 
CTGCAGCATA TCCGCAACAG CCTTCCGGAT TCAGTGCAGA TACGGCGGGT AGAGGAGCGG 
CTCTCAGCCC TTGGCAATGT CACCACCTGC AATGACTATG TGGCCTTGGT CCACCCAGAC 
TTGGATAGGG AGACAGAAGA AATCCTGGCT GATGTGCTCA AGGTGGAAGT CTTCAGGCAG 
ACGGTTGCTG ACCAGGTGTT AGTTGGAAGC TACTGTGTCT TCAGTAATCA AGGAGGTCTG 
GTGCACCCTA AAACTTCGAT CGAGGATCAG GATGAGCTGT CCTCCCTTCT TCAGGTTCCC 
CTTGTGGCAG GCACTGTGAA CCGAGGGAGC GAGGTGATTG CTGCCGGGAT GGTAGTGAAT 
GATTGGTGTG CTTTCTGTGG CCTGGACACG ACCAGCACAG AGCTGTCAGT GGTGGAGAGT 
GTCTTCAAGC TGAATGAAGC CAAACCTAGC ACCATTGCCA CCAGCATGCG GGACTCCCTC 
ATTGACAGCC TCACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032429.1
CDS	226..963
Translation	MAVRASFENNCEVGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT

Target ORF information:

RefSeq Version	NM_001037352.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037352.1

ORF Insert Sequence:

ATGGCGGTCA GAGCGTCGTT CGAGAACAAC TGTGAGGTCG GTTGTTTTGC CAAACTCACT 
AACACCTACT GCCTGGTGGC CATCGGAGGG TCAGAGAACT TCTACAGTGT GTTCGAGGGC 
GAGCTCTCCG ATACCATTCC TGTAGTGCAC GCATCCATCG CCGGCTGCCG AATCATCGGG 
CGCATGTGTG TGGGGAACAG GCATGGGCTG CTGGTACCCA ACAACACCAC CGACCAGGAG 
CTGCAGCATA TCCGCAACAG CCTTCCGGAT TCAGTGCAGA TACGGCGGGT AGAGGAGCGG 
CTCTCAGCCC TTGGCAATGT CACCACCTGC AATGACTATG TGGCCTTGGT CCACCCAGAC 
TTGGATAGGG AGACAGAAGA AATCCTGGCT GATGTGCTCA AGGTGGAAGT CTTCAGGCAG 
ACGGTTGCTG ACCAGGTGTT AGTTGGAAGC TACTGTGTCT TCAGTAATCA AGGAGGTCTG 
GTGCACCCTA AAACTTCGAT CGAGGATCAG GATGAGCTGT CCTCCCTTCT TCAGGTTCCC 
CTTGTGGCAG GCACTGTGAA CCGAGGGAGC GAGGTGATTG CTGCCGGGAT GGTAGTGAAT 
GATTGGTGTG CTTTCTGTGG CCTGGACACG ACCAGCACAG AGCTGTCAGT GGTGGAGAGT 
GTCTTCAAGC TGAATGAAGC CAAACCTAGC ACCATTGCCA CCAGCATGCG GGACTCCCTC 
ATTGACAGCC TCACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Eif6 ( XM_017591667.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447156.1 Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09285
Clone ID Related Accession (Same CDS sequence)	XM_017591667.1 , NM_001037352.1 , XM_006235316.3
Accession Version	XM_017591667.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	eukaryotic translation initiation factor 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGTCA GAGCGTCGTT CGAGAACAAC TGTGAGGTCG GTTGTTTTGC CAAACTCACT 
AACACCTACT GCCTGGTGGC CATCGGAGGG TCAGAGAACT TCTACAGTGT GTTCGAGGGC 
GAGCTCTCCG ATACCATTCC TGTAGTGCAC GCATCCATCG CCGGCTGCCG AATCATCGGG 
CGCATGTGTG TGGGGAACAG GCATGGGCTG CTGGTACCCA ACAACACCAC CGACCAGGAG 
CTGCAGCATA TCCGCAACAG CCTTCCGGAT TCAGTGCAGA TACGGCGGGT AGAGGAGCGG 
CTCTCAGCCC TTGGCAATGT CACCACCTGC AATGACTATG TGGCCTTGGT CCACCCAGAC 
TTGGATAGGG AGACAGAAGA AATCCTGGCT GATGTGCTCA AGGTGGAAGT CTTCAGGCAG 
ACGGTTGCTG ACCAGGTGTT AGTTGGAAGC TACTGTGTCT TCAGTAATCA AGGAGGTCTG 
GTGCACCCTA AAACTTCGAT CGAGGATCAG GATGAGCTGT CCTCCCTTCT TCAGGTTCCC 
CTTGTGGCAG GCACTGTGAA CCGAGGGAGC GAGGTGATTG CTGCCGGGAT GGTAGTGAAT 
GATTGGTGTG CTTTCTGTGG CCTGGACACG ACCAGCACAG AGCTGTCAGT GGTGGAGAGT 
GTCTTCAAGC TGAATGAAGC CAAACCTAGC ACCATTGCCA CCAGCATGCG GGACTCCCTC 
ATTGACAGCC TCACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447156.1
CDS	159..896
Translation	MAVRASFENNCEVGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT

Target ORF information:

RefSeq Version	XM_017591667.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017591667.1

ORF Insert Sequence:

ATGGCGGTCA GAGCGTCGTT CGAGAACAAC TGTGAGGTCG GTTGTTTTGC CAAACTCACT 
AACACCTACT GCCTGGTGGC CATCGGAGGG TCAGAGAACT TCTACAGTGT GTTCGAGGGC 
GAGCTCTCCG ATACCATTCC TGTAGTGCAC GCATCCATCG CCGGCTGCCG AATCATCGGG 
CGCATGTGTG TGGGGAACAG GCATGGGCTG CTGGTACCCA ACAACACCAC CGACCAGGAG 
CTGCAGCATA TCCGCAACAG CCTTCCGGAT TCAGTGCAGA TACGGCGGGT AGAGGAGCGG 
CTCTCAGCCC TTGGCAATGT CACCACCTGC AATGACTATG TGGCCTTGGT CCACCCAGAC 
TTGGATAGGG AGACAGAAGA AATCCTGGCT GATGTGCTCA AGGTGGAAGT CTTCAGGCAG 
ACGGTTGCTG ACCAGGTGTT AGTTGGAAGC TACTGTGTCT TCAGTAATCA AGGAGGTCTG 
GTGCACCCTA AAACTTCGAT CGAGGATCAG GATGAGCTGT CCTCCCTTCT TCAGGTTCCC 
CTTGTGGCAG GCACTGTGAA CCGAGGGAGC GAGGTGATTG CTGCCGGGAT GGTAGTGAAT 
GATTGGTGTG CTTTCTGTGG CCTGGACACG ACCAGCACAG AGCTGTCAGT GGTGGAGAGT 
GTCTTCAAGC TGAATGAAGC CAAACCTAGC ACCATTGCCA CCAGCATGCG GGACTCCCTC 
ATTGACAGCC TCACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Eif6 ( XM_006235316.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235378.1 Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa09285
Clone ID Related Accession (Same CDS sequence)	XM_017591667.1 , NM_001037352.1 , XM_006235316.3
Accession Version	XM_006235316.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 738bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	eukaryotic translation initiation factor 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235316.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGTCA GAGCGTCGTT CGAGAACAAC TGTGAGGTCG GTTGTTTTGC CAAACTCACT 
AACACCTACT GCCTGGTGGC CATCGGAGGG TCAGAGAACT TCTACAGTGT GTTCGAGGGC 
GAGCTCTCCG ATACCATTCC TGTAGTGCAC GCATCCATCG CCGGCTGCCG AATCATCGGG 
CGCATGTGTG TGGGGAACAG GCATGGGCTG CTGGTACCCA ACAACACCAC CGACCAGGAG 
CTGCAGCATA TCCGCAACAG CCTTCCGGAT TCAGTGCAGA TACGGCGGGT AGAGGAGCGG 
CTCTCAGCCC TTGGCAATGT CACCACCTGC AATGACTATG TGGCCTTGGT CCACCCAGAC 
TTGGATAGGG AGACAGAAGA AATCCTGGCT GATGTGCTCA AGGTGGAAGT CTTCAGGCAG 
ACGGTTGCTG ACCAGGTGTT AGTTGGAAGC TACTGTGTCT TCAGTAATCA AGGAGGTCTG 
GTGCACCCTA AAACTTCGAT CGAGGATCAG GATGAGCTGT CCTCCCTTCT TCAGGTTCCC 
CTTGTGGCAG GCACTGTGAA CCGAGGGAGC GAGGTGATTG CTGCCGGGAT GGTAGTGAAT 
GATTGGTGTG CTTTCTGTGG CCTGGACACG ACCAGCACAG AGCTGTCAGT GGTGGAGAGT 
GTCTTCAAGC TGAATGAAGC CAAACCTAGC ACCATTGCCA CCAGCATGCG GGACTCCCTC 
ATTGACAGCC TCACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235378.1
CDS	132..869
Translation	MAVRASFENNCEVGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDSVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAKPSTIATSMRDSLIDSLT

Target ORF information:

RefSeq Version	XM_006235316.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus eukaryotic translation initiation factor 6 (Eif6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235316.3

ORF Insert Sequence:

ATGGCGGTCA GAGCGTCGTT CGAGAACAAC TGTGAGGTCG GTTGTTTTGC CAAACTCACT 
AACACCTACT GCCTGGTGGC CATCGGAGGG TCAGAGAACT TCTACAGTGT GTTCGAGGGC 
GAGCTCTCCG ATACCATTCC TGTAGTGCAC GCATCCATCG CCGGCTGCCG AATCATCGGG 
CGCATGTGTG TGGGGAACAG GCATGGGCTG CTGGTACCCA ACAACACCAC CGACCAGGAG 
CTGCAGCATA TCCGCAACAG CCTTCCGGAT TCAGTGCAGA TACGGCGGGT AGAGGAGCGG 
CTCTCAGCCC TTGGCAATGT CACCACCTGC AATGACTATG TGGCCTTGGT CCACCCAGAC 
TTGGATAGGG AGACAGAAGA AATCCTGGCT GATGTGCTCA AGGTGGAAGT CTTCAGGCAG 
ACGGTTGCTG ACCAGGTGTT AGTTGGAAGC TACTGTGTCT TCAGTAATCA AGGAGGTCTG 
GTGCACCCTA AAACTTCGAT CGAGGATCAG GATGAGCTGT CCTCCCTTCT TCAGGTTCCC 
CTTGTGGCAG GCACTGTGAA CCGAGGGAGC GAGGTGATTG CTGCCGGGAT GGTAGTGAAT 
GATTGGTGTG CTTTCTGTGG CCTGGACACG ACCAGCACAG AGCTGTCAGT GGTGGAGAGT 
GTCTTCAAGC TGAATGAAGC CAAACCTAGC ACCATTGCCA CCAGCATGCG GGACTCCCTC 
ATTGACAGCC TCACATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Upregulation of eIF6 inhibits cardiac hypertrophy induced by phenylephrine.
Biochemical and biophysical research communications495(1)601-606(2018 01)
Romano N,Ricciardi S,Gallo P,Ceci M

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.
Journal of thrombosis and haemostasis : JTH13(11)2108-18(2015 Nov)
Ricciardi S,Miluzio A,Brina D,Clarke K,Bonomo M,Aiolfi R,Guidotti LG,Falciani F,Biffo S

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Nature communications68261(2015 Sep)
Brina D,Miluzio A,Ricciardi S,Clarke K,Davidsen PK,Viero G,Tebaldi T,Offenhäuser N,Rozman J,Rathkolb B,Neschen S,Klingenspor M,Wolf E,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Quattrone A,Falciani F,Biffo S

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Genes & development25(9)917-29(2011 May)
Finch AJ,Hilcenko C,Basse N,Drynan LF,Goyenechea B,Menne TF,González Fernández A,Simpson P,D'Santos CS,Arends MJ,Donadieu J,Bellanné-Chantelot C,Costanzo M,Boone C,McKenzie AN,Freund SM,Warren AJ

Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation.
EMBO reports10(5)459-65(2009 May)
Miluzio A,Beugnet A,Volta V,Biffo S

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Eif6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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