Txk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Txk
Entrez Gene ID	305311
Full Name	TXK tyrosine kinase
General protein information	Preferred Names TXK tyrosine kinase Names tyrosine-protein kinase TXK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p11

mRNA and Protein(s)

mRNA	Protein	Name
XM_008770141.2	XP_008768363.1	tyrosine-protein kinase TXK isoform X1
XM_008770142.2	XP_008768364.1	tyrosine-protein kinase TXK isoform X2
NM_001024255.1	NP_001019426.1	tyrosine-protein kinase TXK

Pathways from BioSystems

Homologies

Homo sapiens (human)	TXK	NP_003319.2
Mus musculus (house mouse)	Txk	NP_038726.2
Rattus norvegicus (Norway rat)	Txk	NP_001019426.1
Canis lupus familiaris (dog)	TXK	XP_539258.3
Bos taurus (cattle)	TXK	NP_001193077.1
Danio rerio (zebrafish)	LOC100534735	XP_003201292.2
Pan troglodytes (chimpanzee)	TXK	XP_517311.3
Macaca mulatta (Rhesus monkey)	TXK	XP_001103052.1
Gallus gallus (chicken)	TXK	XP_004936109.1

Gene Ontology
Bibliography

Related articles in PubMed

The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Felices M, Berg LJ
Journal of immunology (Baltimore, Md. : 1950)180(5)3007-18(2008 Mar)

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Maruyama T, Nara K, Yoshikawa H, Suzuki N
Clinical and experimental immunology147(1)164-75(2007 Jan)

Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.
Kashiwakura J, Suzuki N, Takeno M, Itoh S, Oku T, Sakane T, Nakajin S, Toyoshima S
Biological & pharmaceutical bulletin25(6)718-21(2002 Jun)

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
Takeba Y, Nagafuchi H, Takeno M, Kashiwakura J, Suzuki N
Journal of immunology (Baltimore, Md. : 1950)168(5)2365-70(2002 Mar)

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes.
Kashiwakura J, Suzuki N, Nagafuchi H, Takeno M, Takeba Y, Shimoyama Y, Sakane T
The Journal of experimental medicine190(8)1147-54(1999 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Txk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Txk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa06090	NM_001024255.1 Latest version!	Rattus norvegicus TXK tyrosine kinase (Txk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa46256	XM_008770141.2 Latest version!	Rattus norvegicus TXK tyrosine kinase (Txk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa46257	XM_008770142.2 Latest version!	Rattus norvegicus TXK tyrosine kinase (Txk), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Txk ( NM_001024255.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001019426.1 Rattus norvegicus TXK tyrosine kinase (Txk), mRNA.

Price & Availability↑

CloneID	ORa06090
Clone ID Related Accession (Same CDS sequence)	NM_001024255.1
Accession Version	NM_001024255.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527350400000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase TXK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC095847.1. On May 27, 2005 this sequence version replaced XM_223365.3. ##Evidence-Data-START## Transcript exon combination :: BC095847.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGATCTCCT TTTCAGACAG CACCTTCCAG TCTATCCTCT GTTGCTGCTG TTGCTGCTCA 
GTGCAGGGGA GACGAGTGAC AACACGGATC AGCCTAAGCA GAGAGGAAGA ACTCTCAGAA 
AAGCATTCCC AGCGTCAGAG GCAGTGGTTC TCCAAACTGA TGGGCAAAAG TCAATCCAGC 
AGAGGTGGGG TGCAACCCTC AAAGCGTAGG CCACTGCCTC CCCTCCCGCA GGAGTTTACA 
GAAGAGAGAA TCCGGGTCAA GGCTCTTTAT GACTTCCTGC CTCGGGAGCC CTGTAATTTG 
GCACTGAAGA GAGCAGAGGA ATATCTGATA TTGGAGAGGT GTGACCCTCA CTGGTGGAGG 
GCCAGAGACC GCCTCGGGAA TGAAGGCTTA ATCCCAAGCA ACTATGTGAC AGAAAACAGA 
CTCACCAATT TAGAAACATA TGAATGGTAT CATAAGAACA TCACTAGAGA CCAGACGGAA 
CGCCTGTTGA GGCAGGAGGC TAAAGAAGGT GCATTTATCG TGAGAGATTC GAGACATTTG 
GGGTCTTACA CAATCTCTGT GTTTACAAGA GCTAGAAGGC ATACACAGTC TTCAATAAAA 
CATTATCAGA TTAAAAAGAA TGACTCAGGA CAATGGTACG TCACCGAAAG ACACCTCTTT 
CCCTCGGTTC CCGAGTTGAT CCAGTATCAC CAGTACAATG CAGCTGGTCT CATGTCCCGT 
CTCCGCTATC CTGTTGGGCT CCTGGGCAGC TGTTTACCAG CCACATCTGG TTTTAGCTAT 
GAAAAGTGGG AAATAGATCC GTCTGAGTTG ACTTTTGTCA AGGAGATCGG AAGTGGTCAG 
TTTGGGGTAG TCTACTTAGG AGAGTGGAGA GCACGTATCC GGGTCGCCAT CAAGGCCATC 
AATGAAGGCT CCATGTCTGA AGAAGATTTC ATTGAGGAAG CCAAGGTGAT GATGAAGCTG 
TCACACTCGA GGTTAGTTCA ACTTTATGGG GTGTGCATAC AGCAGAAGCC CCTCTACATA 
GTGACGGAGT TCATGGAAAA TGGCTGCCTG CTCGACTATC TCAGGGAGAG AAAAGGCAAG 
CTTCCGAAGG CATTGCTTTT GAGCATGTGC CAGGACATAT GTGAAGGGAT GGCGTACCTG 
GAGAAGAGCT GCTATATCCA CAGGGATCTG GCTGCCAGGA ACTGTTTGGT CAGTTCTGCC 
TGCGTAGTAA AGATCTCGGA CTTTGGGATG GCGAGGTACG TTTTGGACGA TGAATATATC 
AGTTCTTCTG GAGCTAAGTT CCCAGTCAAG TGGTCCCCAC CTGAAGTTTT TCATTTCAAC 
AAGTACAGTA GCAAGTCTGA CGTCTGGTCA TTCGGAGTTT TAATGTGGGA AGTTTTTACA 
GAAGGAAAAA TGCCCTTTGA GAATAAGTCC AATTTGCAAG TGGTGGAAGC CATTTCTAAA 
GGTTTCCGGC TCTATCGTCC TCACCTGGCC CCCATGTCCA TATACGGAGT TATGTACAGT 
TGCTGGCATG AGAGCCCTAA AGGCCGTCCG ACATTTGCTG AGTTGCTTCA GGTTCTCGCA 
GAGATCGCGG AAACCTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019426.1
CDS	167..1747
Translation	MISFSDSTFQSILCCCCCCSVQGRRVTTRISLSREEELSEKHSQRQRQWFSKLMGKSQSSRGGVQPSKRRPLPPLPQEFTEERIRVKALYDFLPREPCNLALKRAEEYLILERCDPHWWRARDRLGNEGLIPSNYVTENRLTNLETYEWYHKNITRDQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYVTERHLFPSVPELIQYHQYNAAGLMSRLRYPVGLLGSCLPATSGFSYEKWEIDPSELTFVKEIGSGQFGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGKLPKALLLSMCQDICEGMAYLEKSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPKGRPTFAELLQVLAEIAETW

Target ORF information:

RefSeq Version	NM_001024255.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TXK tyrosine kinase (Txk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024255.1

ORF Insert Sequence:

ATGATCTCCT TTTCAGACAG CACCTTCCAG TCTATCCTCT GTTGCTGCTG TTGCTGCTCA 
GTGCAGGGGA GACGAGTGAC AACACGGATC AGCCTAAGCA GAGAGGAAGA ACTCTCAGAA 
AAGCATTCCC AGCGTCAGAG GCAGTGGTTC TCCAAACTGA TGGGCAAAAG TCAATCCAGC 
AGAGGTGGGG TGCAACCCTC AAAGCGTAGG CCACTGCCTC CCCTCCCGCA GGAGTTTACA 
GAAGAGAGAA TCCGGGTCAA GGCTCTTTAT GACTTCCTGC CTCGGGAGCC CTGTAATTTG 
GCACTGAAGA GAGCAGAGGA ATATCTGATA TTGGAGAGGT GTGACCCTCA CTGGTGGAGG 
GCCAGAGACC GCCTCGGGAA TGAAGGCTTA ATCCCAAGCA ACTATGTGAC AGAAAACAGA 
CTCACCAATT TAGAAACATA TGAATGGTAT CATAAGAACA TCACTAGAGA CCAGACGGAA 
CGCCTGTTGA GGCAGGAGGC TAAAGAAGGT GCATTTATCG TGAGAGATTC GAGACATTTG 
GGGTCTTACA CAATCTCTGT GTTTACAAGA GCTAGAAGGC ATACACAGTC TTCAATAAAA 
CATTATCAGA TTAAAAAGAA TGACTCAGGA CAATGGTACG TCACCGAAAG ACACCTCTTT 
CCCTCGGTTC CCGAGTTGAT CCAGTATCAC CAGTACAATG CAGCTGGTCT CATGTCCCGT 
CTCCGCTATC CTGTTGGGCT CCTGGGCAGC TGTTTACCAG CCACATCTGG TTTTAGCTAT 
GAAAAGTGGG AAATAGATCC GTCTGAGTTG ACTTTTGTCA AGGAGATCGG AAGTGGTCAG 
TTTGGGGTAG TCTACTTAGG AGAGTGGAGA GCACGTATCC GGGTCGCCAT CAAGGCCATC 
AATGAAGGCT CCATGTCTGA AGAAGATTTC ATTGAGGAAG CCAAGGTGAT GATGAAGCTG 
TCACACTCGA GGTTAGTTCA ACTTTATGGG GTGTGCATAC AGCAGAAGCC CCTCTACATA 
GTGACGGAGT TCATGGAAAA TGGCTGCCTG CTCGACTATC TCAGGGAGAG AAAAGGCAAG 
CTTCCGAAGG CATTGCTTTT GAGCATGTGC CAGGACATAT GTGAAGGGAT GGCGTACCTG 
GAGAAGAGCT GCTATATCCA CAGGGATCTG GCTGCCAGGA ACTGTTTGGT CAGTTCTGCC 
TGCGTAGTAA AGATCTCGGA CTTTGGGATG GCGAGGTACG TTTTGGACGA TGAATATATC 
AGTTCTTCTG GAGCTAAGTT CCCAGTCAAG TGGTCCCCAC CTGAAGTTTT TCATTTCAAC 
AAGTACAGTA GCAAGTCTGA CGTCTGGTCA TTCGGAGTTT TAATGTGGGA AGTTTTTACA 
GAAGGAAAAA TGCCCTTTGA GAATAAGTCC AATTTGCAAG TGGTGGAAGC CATTTCTAAA 
GGTTTCCGGC TCTATCGTCC TCACCTGGCC CCCATGTCCA TATACGGAGT TATGTACAGT 
TGCTGGCATG AGAGCCCTAA AGGCCGTCCG ACATTTGCTG AGTTGCTTCA GGTTCTCGCA 
GAGATCGCGG AAACCTGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txk ( XM_008770141.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768363.1 Rattus norvegicus TXK tyrosine kinase (Txk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa46256
Clone ID Related Accession (Same CDS sequence)	XM_008770141.2
Accession Version	XM_008770141.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1596bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase TXK isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770141.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTTACT GTGAATGGAA CACAGCTGAA GAACCAAGGC TTCTGTGTGT GCCCAGCCAA 
CAGGGTAGCC ATGATCCTGT CCTCTTACGA GTGACAACAC GGATCAGCCT AAGCAGAGAG 
GAAGAACTCT CAGAAAAGCA TTCCCAGCGT CAGAGGCAGT GGTTCTCCAA ACTGATGGGC 
AAAAGTCAAT CCAGCAGAGG TGGGGTGCAA CCCTCAAAGC GTAGGCCACT GCCTCCCCTC 
CCGCAGGAGT TTACAGAAGA GAGAATCCGG GTCAAGGCTC TTTATGACTT CCTGCCTCGG 
GAGCCCTGTA ATTTGGCACT GAAGAGAGCA GAGGAATATC TGATATTGGA GAGGTGTGAC 
CCTCACTGGT GGAGGGCCAG AGACCGCCTC GGGAATGAAG GCTTAATCCC AAGCAACTAT 
GTGACAGAAA ACAGACTCAC CAATTTAGAA ACATATGAAT GGTATCATAA GAACATCACT 
AGAGACCAGA CGGAACGCCT GTTGAGGCAG GAGGCTAAAG AAGGTGCATT TATCGTGAGA 
GATTCGAGAC ATTTGGGGTC TTACACAATC TCTGTGTTTA CAAGAGCTAG AAGGCATACA 
CAGTCTTCAA TAAAACATTA TCAGATTAAA AAGAATGACT CAGGACAATG GTACGTCACC 
GAAAGACACC TCTTTCCCTC GGTTCCCGAG TTGATCCAGT ATCACCAGTA CAATGCAGCT 
GGTCTCATGT CCCGTCTCCG CTATCCTGTT GGGCTCCTGG GCAGCTGTTT ACCAGCCACA 
TCTGGTTTTA GCTATGAAAA GTGGGAAATA GATCCGTCTG AGTTGACTTT TGTCAAGGAG 
ATCGGAAGTG GTCAGTTTGG GGTAGTCTAC TTAGGAGAGT GGAGAGCACG TATCCGGGTC 
GCCATCAAGG CCATCAATGA AGGCTCCATG TCTGAAGAAG ATTTCATTGA GGAAGCCAAG 
GTGATGATGA AGCTGTCACA CTCGAGGTTA GTTCAACTTT ATGGGGTGTG CATACAGCAG 
AAGCCCCTCT ACATAGTGAC GGAGTTCATG GAAAATGGCT GCCTGCTCGA CTATCTCAGG 
GAGAGAAAAG GCAAGCTTCC GAAGGCATTG CTTTTGAGCA TGTGCCAGGA CATATGTGAA 
GGGATGGCGT ACCTGGAGAA GAGCTGCTAT ATCCACAGGG ATCTGGCTGC CAGGAACTGT 
TTGGTCAGTT CTGCCTGCGT AGTAAAGATC TCGGACTTTG GGATGGCGAG GTACGTTTTG 
GACGATGAAT ATATCAGTTC TTCTGGAGCT AAGTTCCCAG TCAAGTGGTC CCCACCTGAA 
GTTTTTCATT TCAACAAGTA CAGTAGCAAG TCTGACGTCT GGTCATTCGG AGTTTTAATG 
TGGGAAGTTT TTACAGAAGG AAAAATGCCC TTTGAGAATA AGTCCAATTT GCAAGTGGTG 
GAAGCCATTT CTAAAGGTTT CCGGCTCTAT CGTCCTCACC TGGCCCCCAT GTCCATATAC 
GGAGTTATGT ACAGTTGCTG GCATGAGAGC CCTAAAGGCC GTCCGACATT TGCTGAGTTG 
CTTCAGGTTC TCGCAGAGAT CGCGGAAACC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768363.1
CDS	480..2075
Translation	MCYCEWNTAEEPRLLCVPSQQGSHDPVLLRVTTRISLSREEELSEKHSQRQRQWFSKLMGKSQSSRGGVQPSKRRPLPPLPQEFTEERIRVKALYDFLPREPCNLALKRAEEYLILERCDPHWWRARDRLGNEGLIPSNYVTENRLTNLETYEWYHKNITRDQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYVTERHLFPSVPELIQYHQYNAAGLMSRLRYPVGLLGSCLPATSGFSYEKWEIDPSELTFVKEIGSGQFGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGKLPKALLLSMCQDICEGMAYLEKSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPKGRPTFAELLQVLAEIAETW

Target ORF information:

RefSeq Version	XM_008770141.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TXK tyrosine kinase (Txk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770141.2

ORF Insert Sequence:

ATGTGTTACT GTGAATGGAA CACAGCTGAA GAACCAAGGC TTCTGTGTGT GCCCAGCCAA 
CAGGGTAGCC ATGATCCTGT CCTCTTACGA GTGACAACAC GGATCAGCCT AAGCAGAGAG 
GAAGAACTCT CAGAAAAGCA TTCCCAGCGT CAGAGGCAGT GGTTCTCCAA ACTGATGGGC 
AAAAGTCAAT CCAGCAGAGG TGGGGTGCAA CCCTCAAAGC GTAGGCCACT GCCTCCCCTC 
CCGCAGGAGT TTACAGAAGA GAGAATCCGG GTCAAGGCTC TTTATGACTT CCTGCCTCGG 
GAGCCCTGTA ATTTGGCACT GAAGAGAGCA GAGGAATATC TGATATTGGA GAGGTGTGAC 
CCTCACTGGT GGAGGGCCAG AGACCGCCTC GGGAATGAAG GCTTAATCCC AAGCAACTAT 
GTGACAGAAA ACAGACTCAC CAATTTAGAA ACATATGAAT GGTATCATAA GAACATCACT 
AGAGACCAGA CGGAACGCCT GTTGAGGCAG GAGGCTAAAG AAGGTGCATT TATCGTGAGA 
GATTCGAGAC ATTTGGGGTC TTACACAATC TCTGTGTTTA CAAGAGCTAG AAGGCATACA 
CAGTCTTCAA TAAAACATTA TCAGATTAAA AAGAATGACT CAGGACAATG GTACGTCACC 
GAAAGACACC TCTTTCCCTC GGTTCCCGAG TTGATCCAGT ATCACCAGTA CAATGCAGCT 
GGTCTCATGT CCCGTCTCCG CTATCCTGTT GGGCTCCTGG GCAGCTGTTT ACCAGCCACA 
TCTGGTTTTA GCTATGAAAA GTGGGAAATA GATCCGTCTG AGTTGACTTT TGTCAAGGAG 
ATCGGAAGTG GTCAGTTTGG GGTAGTCTAC TTAGGAGAGT GGAGAGCACG TATCCGGGTC 
GCCATCAAGG CCATCAATGA AGGCTCCATG TCTGAAGAAG ATTTCATTGA GGAAGCCAAG 
GTGATGATGA AGCTGTCACA CTCGAGGTTA GTTCAACTTT ATGGGGTGTG CATACAGCAG 
AAGCCCCTCT ACATAGTGAC GGAGTTCATG GAAAATGGCT GCCTGCTCGA CTATCTCAGG 
GAGAGAAAAG GCAAGCTTCC GAAGGCATTG CTTTTGAGCA TGTGCCAGGA CATATGTGAA 
GGGATGGCGT ACCTGGAGAA GAGCTGCTAT ATCCACAGGG ATCTGGCTGC CAGGAACTGT 
TTGGTCAGTT CTGCCTGCGT AGTAAAGATC TCGGACTTTG GGATGGCGAG GTACGTTTTG 
GACGATGAAT ATATCAGTTC TTCTGGAGCT AAGTTCCCAG TCAAGTGGTC CCCACCTGAA 
GTTTTTCATT TCAACAAGTA CAGTAGCAAG TCTGACGTCT GGTCATTCGG AGTTTTAATG 
TGGGAAGTTT TTACAGAAGG AAAAATGCCC TTTGAGAATA AGTCCAATTT GCAAGTGGTG 
GAAGCCATTT CTAAAGGTTT CCGGCTCTAT CGTCCTCACC TGGCCCCCAT GTCCATATAC 
GGAGTTATGT ACAGTTGCTG GCATGAGAGC CCTAAAGGCC GTCCGACATT TGCTGAGTTG 
CTTCAGGTTC TCGCAGAGAT CGCGGAAACC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Txk ( XM_008770142.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008768364.1 Rattus norvegicus TXK tyrosine kinase (Txk), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa46257
Clone ID Related Accession (Same CDS sequence)	XM_008770142.2
Accession Version	XM_008770142.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase TXK isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770142.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGTTACT GTGAATGGAA CACAGCTGAA GAACCAAGGC TTCTGTGTGT GCCCAGCCAA 
CAGGGTAGCC ATGATCCTGT CCTCTTACGA GTGACAACAC GGATCAGCCT AAGCAGAGAG 
GAAGAACTCT CAGAAAAGCA TTCCCAGCGT CAGAGGCAGT GGTTCTCCAA ACTGATGGGC 
AAAAGTCAAG AGTTTACAGA AGAGAGAATC CGGGTCAAGG CTCTTTATGA CTTCCTGCCT 
CGGGAGCCCT GTAATTTGGC ACTGAAGAGA GCAGAGGAAT ATCTGATATT GGAGAGGTGT 
GACCCTCACT GGTGGAGGGC CAGAGACCGC CTCGGGAATG AAGGCTTAAT CCCAAGCAAC 
TATGTGACAG AAAACAGACT CACCAATTTA GAAACATATG AATGGTATCA TAAGAACATC 
ACTAGAGACC AGACGGAACG CCTGTTGAGG CAGGAGGCTA AAGAAGGTGC ATTTATCGTG 
AGAGATTCGA GACATTTGGG GTCTTACACA ATCTCTGTGT TTACAAGAGC TAGAAGGCAT 
ACACAGTCTT CAATAAAACA TTATCAGATT AAAAAGAATG ACTCAGGACA ATGGTACGTC 
ACCGAAAGAC ACCTCTTTCC CTCGGTTCCC GAGTTGATCC AGTATCACCA GTACAATGCA 
GCTGGTCTCA TGTCCCGTCT CCGCTATCCT GTTGGGCTCC TGGGCAGCTG TTTACCAGCC 
ACATCTGGTT TTAGCTATGA AAAGTGGGAA ATAGATCCGT CTGAGTTGAC TTTTGTCAAG 
GAGATCGGAA GTGGTCAGTT TGGGGTAGTC TACTTAGGAG AGTGGAGAGC ACGTATCCGG 
GTCGCCATCA AGGCCATCAA TGAAGGCTCC ATGTCTGAAG AAGATTTCAT TGAGGAAGCC 
AAGGTGATGA TGAAGCTGTC ACACTCGAGG TTAGTTCAAC TTTATGGGGT GTGCATACAG 
CAGAAGCCCC TCTACATAGT GACGGAGTTC ATGGAAAATG GCTGCCTGCT CGACTATCTC 
AGGGAGAGAA AAGGCAAGCT TCCGAAGGCA TTGCTTTTGA GCATGTGCCA GGACATATGT 
GAAGGGATGG CGTACCTGGA GAAGAGCTGC TATATCCACA GGGATCTGGC TGCCAGGAAC 
TGTTTGGTCA GTTCTGCCTG CGTAGTAAAG ATCTCGGACT TTGGGATGGC GAGGTACGTT 
TTGGACGATG AATATATCAG TTCTTCTGGA GCTAAGTTCC CAGTCAAGTG GTCCCCACCT 
GAAGTTTTTC ATTTCAACAA GTACAGTAGC AAGTCTGACG TCTGGTCATT CGGAGTTTTA 
ATGTGGGAAG TTTTTACAGA AGGAAAAATG CCCTTTGAGA ATAAGTCCAA TTTGCAAGTG 
GTGGAAGCCA TTTCTAAAGG TTTCCGGCTC TATCGTCCTC ACCTGGCCCC CATGTCCATA 
TACGGAGTTA TGTACAGTTG CTGGCATGAG AGCCCTAAAG GCCGTCCGAC ATTTGCTGAG 
TTGCTTCAGG TTCTCGCAGA GATCGCGGAA ACCTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008768364.1
CDS	480..2018
Translation	MCYCEWNTAEEPRLLCVPSQQGSHDPVLLRVTTRISLSREEELSEKHSQRQRQWFSKLMGKSQEFTEERIRVKALYDFLPREPCNLALKRAEEYLILERCDPHWWRARDRLGNEGLIPSNYVTENRLTNLETYEWYHKNITRDQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYVTERHLFPSVPELIQYHQYNAAGLMSRLRYPVGLLGSCLPATSGFSYEKWEIDPSELTFVKEIGSGQFGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGKLPKALLLSMCQDICEGMAYLEKSCYIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPKGRPTFAELLQVLAEIAETW

Target ORF information:

RefSeq Version	XM_008770142.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TXK tyrosine kinase (Txk), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008770142.2

ORF Insert Sequence:

ATGTGTTACT GTGAATGGAA CACAGCTGAA GAACCAAGGC TTCTGTGTGT GCCCAGCCAA 
CAGGGTAGCC ATGATCCTGT CCTCTTACGA GTGACAACAC GGATCAGCCT AAGCAGAGAG 
GAAGAACTCT CAGAAAAGCA TTCCCAGCGT CAGAGGCAGT GGTTCTCCAA ACTGATGGGC 
AAAAGTCAAG AGTTTACAGA AGAGAGAATC CGGGTCAAGG CTCTTTATGA CTTCCTGCCT 
CGGGAGCCCT GTAATTTGGC ACTGAAGAGA GCAGAGGAAT ATCTGATATT GGAGAGGTGT 
GACCCTCACT GGTGGAGGGC CAGAGACCGC CTCGGGAATG AAGGCTTAAT CCCAAGCAAC 
TATGTGACAG AAAACAGACT CACCAATTTA GAAACATATG AATGGTATCA TAAGAACATC 
ACTAGAGACC AGACGGAACG CCTGTTGAGG CAGGAGGCTA AAGAAGGTGC ATTTATCGTG 
AGAGATTCGA GACATTTGGG GTCTTACACA ATCTCTGTGT TTACAAGAGC TAGAAGGCAT 
ACACAGTCTT CAATAAAACA TTATCAGATT AAAAAGAATG ACTCAGGACA ATGGTACGTC 
ACCGAAAGAC ACCTCTTTCC CTCGGTTCCC GAGTTGATCC AGTATCACCA GTACAATGCA 
GCTGGTCTCA TGTCCCGTCT CCGCTATCCT GTTGGGCTCC TGGGCAGCTG TTTACCAGCC 
ACATCTGGTT TTAGCTATGA AAAGTGGGAA ATAGATCCGT CTGAGTTGAC TTTTGTCAAG 
GAGATCGGAA GTGGTCAGTT TGGGGTAGTC TACTTAGGAG AGTGGAGAGC ACGTATCCGG 
GTCGCCATCA AGGCCATCAA TGAAGGCTCC ATGTCTGAAG AAGATTTCAT TGAGGAAGCC 
AAGGTGATGA TGAAGCTGTC ACACTCGAGG TTAGTTCAAC TTTATGGGGT GTGCATACAG 
CAGAAGCCCC TCTACATAGT GACGGAGTTC ATGGAAAATG GCTGCCTGCT CGACTATCTC 
AGGGAGAGAA AAGGCAAGCT TCCGAAGGCA TTGCTTTTGA GCATGTGCCA GGACATATGT 
GAAGGGATGG CGTACCTGGA GAAGAGCTGC TATATCCACA GGGATCTGGC TGCCAGGAAC 
TGTTTGGTCA GTTCTGCCTG CGTAGTAAAG ATCTCGGACT TTGGGATGGC GAGGTACGTT 
TTGGACGATG AATATATCAG TTCTTCTGGA GCTAAGTTCC CAGTCAAGTG GTCCCCACCT 
GAAGTTTTTC ATTTCAACAA GTACAGTAGC AAGTCTGACG TCTGGTCATT CGGAGTTTTA 
ATGTGGGAAG TTTTTACAGA AGGAAAAATG CCCTTTGAGA ATAAGTCCAA TTTGCAAGTG 
GTGGAAGCCA TTTCTAAAGG TTTCCGGCTC TATCGTCCTC ACCTGGCCCC CATGTCCATA 
TACGGAGTTA TGTACAGTTG CTGGCATGAG AGCCCTAAAG GCCGTCCGAC ATTTGCTGAG 
TTGCTTCAGG TTCTCGCAGA GATCGCGGAA ACCTGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Journal of immunology (Baltimore, Md. : 1950)180(5)3007-18(2008 Mar)
Felices M,Berg LJ

Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Clinical and experimental immunology147(1)164-75(2007 Jan)
Maruyama T,Nara K,Yoshikawa H,Suzuki N

Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.
Biological & pharmaceutical bulletin25(6)718-21(2002 Jun)
Kashiwakura J,Suzuki N,Takeno M,Itoh S,Oku T,Sakane T,Nakajin S,Toyoshima S

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription.
Journal of immunology (Baltimore, Md. : 1950)168(5)2365-70(2002 Mar)
Takeba Y,Nagafuchi H,Takeno M,Kashiwakura J,Suzuki N

Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes.
The Journal of experimental medicine190(8)1147-54(1999 Oct)
Kashiwakura J,Suzuki N,Nagafuchi H,Takeno M,Takeba Y,Shimoyama Y,Sakane T

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

Txk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM