Sirt7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sirt7
Entrez Gene ID	303745
Full Name	sirtuin 7
General protein information	Preferred Names sirtuin 7 Names NAD-dependent protein deacetylase sirtuin-7 NAD-dependent deacetylase sirtuin-7 SIR2-like protein 7 regulatory protein SIR2 homolog 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006247889.3	XP_006247951.1	NAD-dependent protein deacetylase sirtuin-7 isoform X2
XM_008768477.2	XP_008766699.1	NAD-dependent protein deacetylase sirtuin-7 isoform X1
NM_001107073.1	NP_001100543.1	NAD-dependent protein deacetylase sirtuin-7

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sirt7	NP_694696.2
Gallus gallus (chicken)	PCYT2	NP_001026277.1
Homo sapiens (human)	SIRT7	NP_057622.1
Pan troglodytes (chimpanzee)	SIRT7	XP_511750.2
Macaca mulatta (Rhesus monkey)	SIRT7	XP_001112687.1
Canis lupus familiaris (dog)	SIRT7	XP_540490.2
Bos taurus (cattle)	SIRT7	NP_001068685.1
Danio rerio (zebrafish)	LOC796135	XP_001336438.3
Drosophila melanogaster (fruit fly)	Sirt7	NP_651664.2
Rattus norvegicus (Norway rat)	Sirt7	NP_001100543.1
Xenopus tropicalis (tropical clawed frog)	sirt7	NP_001015815.1

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of microRNA-142-5p attenuates hypoxia-induced apoptosis through targeting SIRT7.
Zhan L, Lei S, Li W, Zhang Y, Wang H, Shi Y, Tian Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie94394-401(2017 Oct)

Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin signaling pathway.
Chen EEM, Zhang W, Ye CCY, Gao X, Jiang LLJ, Zhao TTF, Pan ZZJ, Xue DDT
Cell death & disease8(9)e3042(2017 09)

Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation.
Wang H, Liu S, Liu S, Wei W, Zhou X, Lin F, Wang J, Chen J, Zhang G, Pang Y
PloS one12(6)e0178530(2017)

Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats.
Reddy BR, Maitra S, Jhelum P, Kumar KP, Bagul PK, Kaur G, Banerjee SK, Kumar A, Chakravarty S
Journal of biosciences41(3)407-17(2016 Sep)

NAD⁺ in aging, metabolism, and neurodegeneration.
Verdin E
Science (New York, N.Y.)350(6265)1208-13(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sirt7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sirt7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa02827	NM_001107073.1 Latest version!	Rattus norvegicus sirtuin 7 (Sirt7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa34032	XM_006247889.3 Latest version!	Rattus norvegicus sirtuin 7 (Sirt7), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa46070	XM_008768477.2 Latest version!	Rattus norvegicus sirtuin 7 (Sirt7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sirt7 ( NM_001107073.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100543.1 Rattus norvegicus sirtuin 7 (Sirt7), mRNA.

Price & Availability↑

CloneID	ORa02827
Clone ID Related Accession (Same CDS sequence)	NM_001107073.1
Accession Version	NM_001107073.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1209bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571414400000
Organism	Rattus norvegicus(Norway rat)
Product	NAD-dependent protein deacetylase sirtuin-7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_221204.4, XM_001081828.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC167031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCCG GTGGCGGTCT GAGCCGCTCG GAGCGCAAAG CGGCTGAGCG GGTCCGGAGG 
TTGCGGGAGG AGCAGCAGCG GGAGCGCCTC CGTCAGGTGT CACGCATCCT GAGGAAGGCG 
GCTGCAGAGC GCAGCGCGGA GGAGGGCCGG CTTCTAGCTG AGAGTGAGGA TCTGGTGACC 
GAGCTTCAGG GTCGGAGCCG GCGGCGTGAG GGCCTCAAGC GCCGCCAGGA GGAGGTGTGT 
GATGACCCAG AGGAGTTGCG GAGGAAGGTC CGCGAACTAG CCGGAGCTGT CCGAAGTGCC 
AGACACTTGG TTGTCTACAC AGGCGCTGGG ATCAGCACGG CAGCCTCTAT CCCAGATTAC 
CGGGGTCCTA ATGGAGTGTG GACACTGCTC CAGAAAGGAA GGCCTGTGAG TGCTGCCGAC 
CTAAGCGAAG CAGAGCCTAC CCTCACCCAC ATGAGCATCA CCCAGCTGCA CAAGCATAAG 
CTGGTGCAAC ACGTGGTGTC TCAGAACTGC GACGGGCTCC ACCTGCGCAG TGGGCTGCCA 
CGGACCGCCA TCTCTGAGCT CCATGGGAAT ATGTATATTG AAGTCTGCAC CTCCTGCATC 
CCTAACAGAG AGTACGTCCG AGTGTTTGAC GTGACGGAGC GTACCGCCCT TCACCGACAC 
CTGACAGGCC GGACGTGCCA CAAGTGTGGG ACTCAGCTTC GGGACACCAT TGTGCACTTT 
GGGGAGAGGG GGACGCTAGG GCAGCCCCTG AACTGGGAGG CAGCGACTGA GGCCGCTAGC 
AAAGCAGACA CAATCCTGTG TTTAGGGTCC AGCTTGAAGG TACTGAAGAA GTACCCCCGT 
CTCTGGTGCA TGACGAAGCC CCCAAGCCGT CGGCCCAAAC TCTACATTGT GAACCTGCAG 
TGGACCCCGA AGGATGACTG GGCTGCCCTG AAGCTTCATG GGAAATGTGA TGATGTAATG 
CGGCTCCTCA TGGACGAACT GGGCCTGGAG ATCCCTGTCT ACAACCGGTG GCAGGACCCA 
ATCTTCTCCT TGGCAACTCC ACTCCGTGCT GGCGAAGAAG GTAGCCACAG TAGGAAGTCA 
CTGTGCAGGA GCAGAGAAGA GCCCCCACCC GGGGACCAGA GTGCCCCTCT TGCCTCAGCC 
ACCCCCATCC TAGGAGGCTG GTTCGGCAGG GGCTGTGCTA AGCGTGCAAA AAGGAAGAAA 
GCGGCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100543.1
CDS	21..1229
Translation	MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDELGLEIPVYNRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEPPPGDQSAPLASATPILGGWFGRGCAKRAKRKKAA

Target ORF information:

RefSeq Version	NM_001107073.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sirtuin 7 (Sirt7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107073.1

ORF Insert Sequence:

ATGGCAGCCG GTGGCGGTCT GAGCCGCTCG GAGCGCAAAG CGGCTGAGCG GGTCCGGAGG 
TTGCGGGAGG AGCAGCAGCG GGAGCGCCTC CGTCAGGTGT CACGCATCCT GAGGAAGGCG 
GCTGCAGAGC GCAGCGCGGA GGAGGGCCGG CTTCTAGCTG AGAGTGAGGA TCTGGTGACC 
GAGCTTCAGG GTCGGAGCCG GCGGCGTGAG GGCCTCAAGC GCCGCCAGGA GGAGGTGTGT 
GATGACCCAG AGGAGTTGCG GAGGAAGGTC CGCGAACTAG CCGGAGCTGT CCGAAGTGCC 
AGACACTTGG TTGTCTACAC AGGCGCTGGG ATCAGCACGG CAGCCTCTAT CCCAGATTAC 
CGGGGTCCTA ATGGAGTGTG GACACTGCTC CAGAAAGGAA GGCCTGTGAG TGCTGCCGAC 
CTAAGCGAAG CAGAGCCTAC CCTCACCCAC ATGAGCATCA CCCAGCTGCA CAAGCATAAG 
CTGGTGCAAC ACGTGGTGTC TCAGAACTGC GACGGGCTCC ACCTGCGCAG TGGGCTGCCA 
CGGACCGCCA TCTCTGAGCT CCATGGGAAT ATGTATATTG AAGTCTGCAC CTCCTGCATC 
CCTAACAGAG AGTACGTCCG AGTGTTTGAC GTGACGGAGC GTACCGCCCT TCACCGACAC 
CTGACAGGCC GGACGTGCCA CAAGTGTGGG ACTCAGCTTC GGGACACCAT TGTGCACTTT 
GGGGAGAGGG GGACGCTAGG GCAGCCCCTG AACTGGGAGG CAGCGACTGA GGCCGCTAGC 
AAAGCAGACA CAATCCTGTG TTTAGGGTCC AGCTTGAAGG TACTGAAGAA GTACCCCCGT 
CTCTGGTGCA TGACGAAGCC CCCAAGCCGT CGGCCCAAAC TCTACATTGT GAACCTGCAG 
TGGACCCCGA AGGATGACTG GGCTGCCCTG AAGCTTCATG GGAAATGTGA TGATGTAATG 
CGGCTCCTCA TGGACGAACT GGGCCTGGAG ATCCCTGTCT ACAACCGGTG GCAGGACCCA 
ATCTTCTCCT TGGCAACTCC ACTCCGTGCT GGCGAAGAAG GTAGCCACAG TAGGAAGTCA 
CTGTGCAGGA GCAGAGAAGA GCCCCCACCC GGGGACCAGA GTGCCCCTCT TGCCTCAGCC 
ACCCCCATCC TAGGAGGCTG GTTCGGCAGG GGCTGTGCTA AGCGTGCAAA AAGGAAGAAA 
GCGGCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sirt7 ( XM_006247889.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006247951.1 Rattus norvegicus sirtuin 7 (Sirt7), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa34032
Clone ID Related Accession (Same CDS sequence)	XM_006247889.3
Accession Version	XM_006247889.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	NAD-dependent protein deacetylase sirtuin-7 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006247889.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCCG GTGGCGGTCT GAGCCGCTCG GAGCGCAAAG CGGCTGAGCG GGTCCGGAGG 
TTGCGGGAGG AGCAGCAGCG GGAGCGCCTC CGTCAGGTGT CACGCATCCT GAGGAAGGCG 
GCTGCAGAGC GCAGCGCGGA GGAGGGCCGG CTTCTAGCTG AGAGTGAGGA TCTGGTGACC 
GAGCTTCAGG GTCGGAGCCG GCGGCGTGAG GGCCTCAAGC GCCGCCAGGA GGAGGTGTGT 
GATGACCCAG AGGAGTTGCG GAGGAAGGTC CGCGAACTAG CCGGAGCTGT CCGAAGTGCC 
AGACACTTGG TTGTCTACAC AGGCGCTGGG ATCAGCACGG CAGCCTCTAT CCCAGATTAC 
CGGGGTCCTA ATGGAGTGTG GACACTGCTC CAGAAAGGAA GGCCTGTGAG TGCTGCCGAC 
CTAAGCGAAG CAGAGCCTAC CCTCACCCAC ATGAGCATCA CCCAGCTGCA CAAGCATAAG 
CTGGTGCAAC ACGTGGTGTC TCAGAACTGC GACGGGCTCC ACCTGCGCAG TGGGCTGCCA 
CGGACCGCCA TCTCTGAGCT CCATGGGAAT ATGTATATTG AAGTCTGCAC CTCCTGCATC 
CCTAACAGAG AGTACGTCCG AGTGTTTGAC GTGACGGAGC GTACCGCCCT TCACCGACAC 
CTGACAGGCC GGACGTGCCA CAAGTGTGGG ACTCAGCTTC GGGACACCAT TGTGCACTTT 
GGGGAGAGGG GGACGCTAGG GCAGCCCCTG AACTGGGAGG CAGCGACTGA GGCCGCTAGC 
AAAGCAGACA CAATCCTGTG TTTAGGGTCC AGCTTGAAGG TACTGAAGAA GTACCCCCGT 
CTCTGGTGCA TGACGAAGCC CCCAAGCCGT CGGCCCAAAC TCTACATTGT GAACCTGCAG 
TGGACCCCGA AGGATGACTG GGCTGCCCTG AAGCTTCATG GGAAATGTGA TGATGTAATG 
CGGCTCCTCA TGGACGAACT GGGCCTGGAG ATCCCTGTCT ACAACCGGGT CTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006247951.1
CDS	100..1116
Translation	MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDELGLEIPVYNRVL

Target ORF information:

RefSeq Version	XM_006247889.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sirtuin 7 (Sirt7), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006247889.3

ORF Insert Sequence:

ATGGCAGCCG GTGGCGGTCT GAGCCGCTCG GAGCGCAAAG CGGCTGAGCG GGTCCGGAGG 
TTGCGGGAGG AGCAGCAGCG GGAGCGCCTC CGTCAGGTGT CACGCATCCT GAGGAAGGCG 
GCTGCAGAGC GCAGCGCGGA GGAGGGCCGG CTTCTAGCTG AGAGTGAGGA TCTGGTGACC 
GAGCTTCAGG GTCGGAGCCG GCGGCGTGAG GGCCTCAAGC GCCGCCAGGA GGAGGTGTGT 
GATGACCCAG AGGAGTTGCG GAGGAAGGTC CGCGAACTAG CCGGAGCTGT CCGAAGTGCC 
AGACACTTGG TTGTCTACAC AGGCGCTGGG ATCAGCACGG CAGCCTCTAT CCCAGATTAC 
CGGGGTCCTA ATGGAGTGTG GACACTGCTC CAGAAAGGAA GGCCTGTGAG TGCTGCCGAC 
CTAAGCGAAG CAGAGCCTAC CCTCACCCAC ATGAGCATCA CCCAGCTGCA CAAGCATAAG 
CTGGTGCAAC ACGTGGTGTC TCAGAACTGC GACGGGCTCC ACCTGCGCAG TGGGCTGCCA 
CGGACCGCCA TCTCTGAGCT CCATGGGAAT ATGTATATTG AAGTCTGCAC CTCCTGCATC 
CCTAACAGAG AGTACGTCCG AGTGTTTGAC GTGACGGAGC GTACCGCCCT TCACCGACAC 
CTGACAGGCC GGACGTGCCA CAAGTGTGGG ACTCAGCTTC GGGACACCAT TGTGCACTTT 
GGGGAGAGGG GGACGCTAGG GCAGCCCCTG AACTGGGAGG CAGCGACTGA GGCCGCTAGC 
AAAGCAGACA CAATCCTGTG TTTAGGGTCC AGCTTGAAGG TACTGAAGAA GTACCCCCGT 
CTCTGGTGCA TGACGAAGCC CCCAAGCCGT CGGCCCAAAC TCTACATTGT GAACCTGCAG 
TGGACCCCGA AGGATGACTG GGCTGCCCTG AAGCTTCATG GGAAATGTGA TGATGTAATG 
CGGCTCCTCA TGGACGAACT GGGCCTGGAG ATCCCTGTCT ACAACCGGGT CTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sirt7 ( XM_008768477.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008766699.1 Rattus norvegicus sirtuin 7 (Sirt7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa46070
Clone ID Related Accession (Same CDS sequence)	XM_008768477.2
Accession Version	XM_008768477.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1281bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	NAD-dependent protein deacetylase sirtuin-7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768477.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCCG GTGGCGGTCT GAGCCGCTCG GAGCGCAAAG CGGCTGAGCG GGTCCGGAGG 
TTGCGGGAGG AGCAGCAGCG GGAGCGCCTC CGTCAGGTGT CACGCATCCT GAGGAAGGCG 
GCTGCAGAGC GCAGCGCGGA GGAGGGCCGG CTTCTAGCTG AGAGTGAGGA TCTGGTGACC 
GAGCTTCAGG GTCGGAGCCG GCGGCGTGAG GGCCTCAAGC GCCGCCAGGA GGAGGTGTGT 
GATGACCCAG AGGAGTTGCG GAGGAAGGTC CGCGAACTAG CCGGAGCTGT CCGAAGTGCC 
AGACACTTGG TTGTCTACAC AGGCGCTGGG ATCAGCACGG CAGCCTCTAT CCCAGATTAC 
CGGGGTCCTA ATGGAGTGTG GACACTGCTC CAGAAAGGAA GGCCTGTGAG TGCTGCCGAC 
CTAAGCGAAG CAGAGCCTAC CCTCACCCAC ATGAGCATCA CCCAGCTGCA CAAGCATAAG 
CTGGTGCAAC ACGTGGTGTC TCAGAACTGC GACGGGCTCC ACCTGCGCAG TGGGCTGCCA 
CGGACCGCCA TCTCTGAGCT CCATGGGAAT ATGTATATTG AAGTGAGCAG TGCCCAGAGG 
ACTCAGGGCC TGGGGGACAA GCAGATGTCA CTCACTGTGC CCTCTCTTCC TCAGGTCTGC 
ACCTCCTGCA TCCCTAACAG AGAGTACGTC CGAGTGTTTG ACGTGACGGA GCGTACCGCC 
CTTCACCGAC ACCTGACAGG CCGGACGTGC CACAAGTGTG GGACTCAGCT TCGGGACACC 
ATTGTGCACT TTGGGGAGAG GGGGACGCTA GGGCAGCCCC TGAACTGGGA GGCAGCGACT 
GAGGCCGCTA GCAAAGCAGA CACAATCCTG TGTTTAGGGT CCAGCTTGAA GGTACTGAAG 
AAGTACCCCC GTCTCTGGTG CATGACGAAG CCCCCAAGCC GTCGGCCCAA ACTCTACATT 
GTGAACCTGC AGTGGACCCC GAAGGATGAC TGGGCTGCCC TGAAGCTTCA TGGGAAATGT 
GATGATGTAA TGCGGCTCCT CATGGACGAA CTGGGCCTGG AGATCCCTGT CTACAACCGG 
TGGCAGGACC CAATCTTCTC CTTGGCAACT CCACTCCGTG CTGGCGAAGA AGGTAGCCAC 
AGTAGGAAGT CACTGTGCAG GAGCAGAGAA GAGCCCCCAC CCGGGGACCA GAGTGCCCCT 
CTTGCCTCAG CCACCCCCAT CCTAGGAGGC TGGTTCGGCA GGGGCTGTGC TAAGCGTGCA 
AAAAGGAAGA AAGCGGCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008766699.1
CDS	100..1380
Translation	MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAERSAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRPVSAADLSEAEPTLTHMSITQLHKHKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVSSAQRTQGLGDKQMSLTVPSLPQVCTSCIPNREYVRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMRLLMDELGLEIPVYNRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEPPPGDQSAPLASATPILGGWFGRGCAKRAKRKKAA

Target ORF information:

RefSeq Version	XM_008768477.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sirtuin 7 (Sirt7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768477.2

ORF Insert Sequence:

ATGGCAGCCG GTGGCGGTCT GAGCCGCTCG GAGCGCAAAG CGGCTGAGCG GGTCCGGAGG 
TTGCGGGAGG AGCAGCAGCG GGAGCGCCTC CGTCAGGTGT CACGCATCCT GAGGAAGGCG 
GCTGCAGAGC GCAGCGCGGA GGAGGGCCGG CTTCTAGCTG AGAGTGAGGA TCTGGTGACC 
GAGCTTCAGG GTCGGAGCCG GCGGCGTGAG GGCCTCAAGC GCCGCCAGGA GGAGGTGTGT 
GATGACCCAG AGGAGTTGCG GAGGAAGGTC CGCGAACTAG CCGGAGCTGT CCGAAGTGCC 
AGACACTTGG TTGTCTACAC AGGCGCTGGG ATCAGCACGG CAGCCTCTAT CCCAGATTAC 
CGGGGTCCTA ATGGAGTGTG GACACTGCTC CAGAAAGGAA GGCCTGTGAG TGCTGCCGAC 
CTAAGCGAAG CAGAGCCTAC CCTCACCCAC ATGAGCATCA CCCAGCTGCA CAAGCATAAG 
CTGGTGCAAC ACGTGGTGTC TCAGAACTGC GACGGGCTCC ACCTGCGCAG TGGGCTGCCA 
CGGACCGCCA TCTCTGAGCT CCATGGGAAT ATGTATATTG AAGTGAGCAG TGCCCAGAGG 
ACTCAGGGCC TGGGGGACAA GCAGATGTCA CTCACTGTGC CCTCTCTTCC TCAGGTCTGC 
ACCTCCTGCA TCCCTAACAG AGAGTACGTC CGAGTGTTTG ACGTGACGGA GCGTACCGCC 
CTTCACCGAC ACCTGACAGG CCGGACGTGC CACAAGTGTG GGACTCAGCT TCGGGACACC 
ATTGTGCACT TTGGGGAGAG GGGGACGCTA GGGCAGCCCC TGAACTGGGA GGCAGCGACT 
GAGGCCGCTA GCAAAGCAGA CACAATCCTG TGTTTAGGGT CCAGCTTGAA GGTACTGAAG 
AAGTACCCCC GTCTCTGGTG CATGACGAAG CCCCCAAGCC GTCGGCCCAA ACTCTACATT 
GTGAACCTGC AGTGGACCCC GAAGGATGAC TGGGCTGCCC TGAAGCTTCA TGGGAAATGT 
GATGATGTAA TGCGGCTCCT CATGGACGAA CTGGGCCTGG AGATCCCTGT CTACAACCGG 
TGGCAGGACC CAATCTTCTC CTTGGCAACT CCACTCCGTG CTGGCGAAGA AGGTAGCCAC 
AGTAGGAAGT CACTGTGCAG GAGCAGAGAA GAGCCCCCAC CCGGGGACCA GAGTGCCCCT 
CTTGCCTCAG CCACCCCCAT CCTAGGAGGC TGGTTCGGCA GGGGCTGTGC TAAGCGTGCA 
AAAAGGAAGA AAGCGGCGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of microRNA-142-5p attenuates hypoxia-induced apoptosis through targeting SIRT7.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie94394-401(2017 Oct)
Zhan L,Lei S,Li W,Zhang Y,Wang H,Shi Y,Tian Y

Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin signaling pathway.
Cell death & disease8(9)e3042(2017 09)
Chen EEM,Zhang W,Ye CCY,Gao X,Jiang LLJ,Zhao TTF,Pan ZZJ,Xue DDT

Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation.
PloS one12(6)e0178530(2017)
Wang H,Liu S,Liu S,Wei W,Zhou X,Lin F,Wang J,Chen J,Zhang G,Pang Y

Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats.
Journal of biosciences41(3)407-17(2016 Sep)
Reddy BR,Maitra S,Jhelum P,Kumar KP,Bagul PK,Kaur G,Banerjee SK,Kumar A,Chakravarty S

NAD⁺ in aging, metabolism, and neurodegeneration.
Science (New York, N.Y.)350(6265)1208-13(2015 Dec)
Verdin E

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