Mbtps2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mbtps2
Entrez Gene ID	302705
Full Name	membrane-bound transcription factor peptidase, site 2
Synonyms	LRRGT00063
General protein information	Preferred Names membrane-bound transcription factor peptidase, site 2 Names membrane-bound transcription factor site-2 protease membrane-bound transcription factor protease, site 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001035007.1	NP_001030179.1	membrane-bound transcription factor site-2 protease
XM_006256944.3	XP_006257006.1	membrane-bound transcription factor site-2 protease isoform X1

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	MBTPS2	XP_001087019.2
Canis lupus familiaris (dog)	MBTPS2	XP_548891.3
Danio rerio (zebrafish)	mbtps2	NP_001020632.1
Drosophila melanogaster (fruit fly)	S2P	NP_610705.1
Arabidopsis thaliana (thale cress)	AT4G20310	NP_001154255.1
Caenorhabditis elegans (roundworm)	Y56A3A.2	NP_499537.2
Mus musculus (house mouse)	Mbtps2	NP_758511.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011819	XP_320696.4
Bos taurus (cattle)	MBTPS2	NP_001069449.1
Xenopus tropicalis (tropical clawed frog)	mbtps2	NP_001017061.1
Homo sapiens (human)	MBTPS2	NP_056968.1
Pan troglodytes (chimpanzee)	MBTPS2	XP_003953992.1
Rattus norvegicus (Norway rat)	Mbtps2	NP_001030179.1
Gallus gallus (chicken)	MBTPS2	XP_425566.3

Gene Ontology
Bibliography

Related articles in PubMed

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta.
Lindert U, Cabral WA, Ausavarat S, Tongkobpetch S, Ludin K, Barnes AM, Yeetong P, Weis M, Krabichler B, Srichomthong C, Makareeva EN, Janecke AR, Leikin S, Röthlisberger B, Rohrbach M, Kennerknecht I, Eyre DR, Suphapeetiporn K, Giunta C, Marini JC, Shotelersuk V
Nature communications711920(2016 07)

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.
Osborne TF, Espenshade PJ
Genes & development23(22)2578-91(2009 Nov)

IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response.
Oeffner F, Fischer G, Happle R, König A, Betz RC, Bornholdt D, Neidel U, Boente Mdel C, Redler S, Romero-Gomez J, Salhi A, Vera-Casaño A, Weirich C, Grzeschik KH
American journal of human genetics84(4)459-67(2009 Apr)

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL
Molecular cell6(6)1355-64(2000 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mbtps2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mbtps2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa39737	XM_006256944.3 Latest version!	Rattus norvegicus membrane-bound transcription factor peptidase, site 2 (Mbtps2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa09160	NM_001035007.1 Latest version!	Rattus norvegicus membrane-bound transcription factor peptidase, site 2 (Mbtps2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mbtps2 ( XM_006256944.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006257006.1 Rattus norvegicus membrane-bound transcription factor peptidase, site 2 (Mbtps2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa39737
Clone ID Related Accession (Same CDS sequence)	XM_006256944.3
Accession Version	XM_006256944.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	membrane-bound transcription factor site-2 protease isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006256944.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTTTG GTGTGATTGC CATGTTCAGC TCTTTTTTTC TCCTTGGAAA AACACTGATG 
CAGACTTTGG CACAAATGAT GGCTGACTCT CCCTCTCCTT ATTCTTCCTC TTCTTCCTCT 
TCCTCTTCCT CTTCCTCTTC CTCTTCCTCT TCTTCTTCCT CCTCCTCCTC TCTTCACAAT 
GATCAGGTGT TGCAAGTTGT GGTTCCTGGT ATAAATTTAC CTGTCAATCA GCTGACTTAC 
TTCTTCGCTG CAGTCCTCAT TAGTGGTGTT GTACATGAAA TTGGACACGG TATAGCAGCC 
ATTAGGGAAC AAGTTCGATT TAATGGCTTT GGAATTTTCC TCTTCATTAT TTATCCTGGA 
GCATTTGTTG ATCTGTTCAC CACCCATTTG CAACTTATAT CACCAGTCCA GCAGCTAAGG 
ATATTTTGTG CAGGTATATG GCATAATTTT GTCCTTGCTC TCCTTGGTAT TTTAGCTCTT 
GTTCTCCTCC CAGTAATCCT CTTGCCTTTT TACTACACTG GAGTTGGGGT ACTTATCACT 
GAAGTCGCAG AGGACTCACC TGCCATTGGA CCCAGAGGCC TTTTTGTGGG AGACCTTGTT 
ACTCATCTAC AGGATTGTCC CGTTACTAAT GTGCAAGATT GGAACGAATG TTTAGACACC 
ATTGCATATG AGCCCCAAAT TGGGTACTGT ATAAGTGCAT CAACGTTACA ACAATTAAGC 
TTCCCAGTTA GAGCATACAA ACGACTAGAT GGTTCTACTG AATGCTGTAA CAATCACAGC 
CTCACAGATG TGTGCTTTTC CTACAGAAAT AATTTTAATA AACGTTTGCA TACATGTCTA 
CCTGCCCGGA AAGCAGTTGA AGCCACTCAA GTTTGTAGAA GCAATAAAGA TTGCAAAAGC 
AGCTCAAGCT CAAGCTTCTG TATAGTGCCA TCCTTGGAAA CTCACACTCG GTTAATAAAG 
GTGAAACACC CCCCACAGAT TGATATGCTC TATGTAGGGC ACCCACTGCA CCTTCACTAC 
ACAGTGAGCA TTACAAGTTT TATCCCACGT TTCAACTTTC TAAGCATAGA TCTGCCAGTA 
ATTGTGGAGA CATTTGTCAA ATACCTGATT TCTCTTTCTG GAGCCCTGGC TATTGTTAAT 
GCAGTGCCCT GCTTTGCCTT GGACGGTCAA TGGATTTTAA ACTCTTTCCT GGATGCTACC 
CTGACTTCAG TGATTGGAGA CAACGATGTC AAAGATCTAA TAGGATTTTT CATCCTGCTT 
GGTGGCAGTG TACTTTTGGC TGCCAATGTG ACACTGGGAC TCTGGATGGT TACAGCACGG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006257006.1
CDS	101..1423
Translation	MVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSPYSSSSSSSSSSSSSSSSSSSSSSSLHNDQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSSSSSSFCIVPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR

Target ORF information:

RefSeq Version	XM_006256944.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus membrane-bound transcription factor peptidase, site 2 (Mbtps2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006256944.3

ORF Insert Sequence:

ATGGTGTTTG GTGTGATTGC CATGTTCAGC TCTTTTTTTC TCCTTGGAAA AACACTGATG 
CAGACTTTGG CACAAATGAT GGCTGACTCT CCCTCTCCTT ATTCTTCCTC TTCTTCCTCT 
TCCTCTTCCT CTTCCTCTTC CTCTTCCTCT TCTTCTTCCT CCTCCTCCTC TCTTCACAAT 
GATCAGGTGT TGCAAGTTGT GGTTCCTGGT ATAAATTTAC CTGTCAATCA GCTGACTTAC 
TTCTTCGCTG CAGTCCTCAT TAGTGGTGTT GTACATGAAA TTGGACACGG TATAGCAGCC 
ATTAGGGAAC AAGTTCGATT TAATGGCTTT GGAATTTTCC TCTTCATTAT TTATCCTGGA 
GCATTTGTTG ATCTGTTCAC CACCCATTTG CAACTTATAT CACCAGTCCA GCAGCTAAGG 
ATATTTTGTG CAGGTATATG GCATAATTTT GTCCTTGCTC TCCTTGGTAT TTTAGCTCTT 
GTTCTCCTCC CAGTAATCCT CTTGCCTTTT TACTACACTG GAGTTGGGGT ACTTATCACT 
GAAGTCGCAG AGGACTCACC TGCCATTGGA CCCAGAGGCC TTTTTGTGGG AGACCTTGTT 
ACTCATCTAC AGGATTGTCC CGTTACTAAT GTGCAAGATT GGAACGAATG TTTAGACACC 
ATTGCATATG AGCCCCAAAT TGGGTACTGT ATAAGTGCAT CAACGTTACA ACAATTAAGC 
TTCCCAGTTA GAGCATACAA ACGACTAGAT GGTTCTACTG AATGCTGTAA CAATCACAGC 
CTCACAGATG TGTGCTTTTC CTACAGAAAT AATTTTAATA AACGTTTGCA TACATGTCTA 
CCTGCCCGGA AAGCAGTTGA AGCCACTCAA GTTTGTAGAA GCAATAAAGA TTGCAAAAGC 
AGCTCAAGCT CAAGCTTCTG TATAGTGCCA TCCTTGGAAA CTCACACTCG GTTAATAAAG 
GTGAAACACC CCCCACAGAT TGATATGCTC TATGTAGGGC ACCCACTGCA CCTTCACTAC 
ACAGTGAGCA TTACAAGTTT TATCCCACGT TTCAACTTTC TAAGCATAGA TCTGCCAGTA 
ATTGTGGAGA CATTTGTCAA ATACCTGATT TCTCTTTCTG GAGCCCTGGC TATTGTTAAT 
GCAGTGCCCT GCTTTGCCTT GGACGGTCAA TGGATTTTAA ACTCTTTCCT GGATGCTACC 
CTGACTTCAG TGATTGGAGA CAACGATGTC AAAGATCTAA TAGGATTTTT CATCCTGCTT 
GGTGGCAGTG TACTTTTGGC TGCCAATGTG ACACTGGGAC TCTGGATGGT TACAGCACGG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mbtps2 ( NM_001035007.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001030179.1 Rattus norvegicus membrane-bound transcription factor peptidase, site 2 (Mbtps2), mRNA.

Price & Availability↑

CloneID	ORa09160
Clone ID Related Accession (Same CDS sequence)	NM_001035007.1
Accession Version	NM_001035007.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555516800000
Organism	Rattus norvegicus(Norway rat)
Product	membrane-bound transcription factor site-2 protease
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07038108.1, AABR07038109.1 and AABR07038110.1. On Oct 22, 2005 this sequence version replaced XM_228964.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGTT GGACTGCCGT CTACCTGGCC 
GACTTGGTGT TGAAGTCATC TGTGTATTTT AAACATTCTT ATGAAGACTG GCTGGAAAAC 
AATGGATTGA GCATCTCTCC TTTTCATATA AGATGGCAAA CTTCAATTTT TAATCGTGCC 
TTTTACAGTT GGGGACGGCG GAAAGCAAGG ATGCTTTACC AATGGTTCAA TTTTGGAATG 
GTGTTTGGTG TGATTGCCAT GTTCAGCTCT TTTTTTCTCC TTGGAAAAAC ACTGATGCAG 
ACTTTGGCAC AAATGATGGC TGACTCTCCC TCTCCTTATT CTTCCTCTTC TTCCTCTTCC 
TCTTCCTCTT CCTCTTCCTC TTCCTCTTCT TCTTCCTCCT CCTCCTCTCT TCACAATGAT 
CAGGTGTTGC AAGTTGTGGT TCCTGGTATA AATTTACCTG TCAATCAGCT GACTTACTTC 
TTCGCTGCAG TCCTCATTAG TGGTGTTGTA CATGAAATTG GACACGGTAT AGCAGCCATT 
AGGGAACAAG TTCGATTTAA TGGCTTTGGA ATTTTCCTCT TCATTATTTA TCCTGGAGCA 
TTTGTTGATC TGTTCACCAC CCATTTGCAA CTTATATCAC CAGTCCAGCA GCTAAGGATA 
TTTTGTGCAG GTATATGGCA TAATTTTGTC CTTGCTCTCC TTGGTATTTT AGCTCTTGTT 
CTCCTCCCAG TAATCCTCTT GCCTTTTTAC TACACTGGAG TTGGGGTACT TATCACTGAA 
GTCGCAGAGG ACTCACCTGC CATTGGACCC AGAGGCCTTT TTGTGGGAGA CCTTGTTACT 
CATCTACAGG ATTGTCCCGT TACTAATGTG CAAGATTGGA ACGAATGTTT AGACACCATT 
GCATATGAGC CCCAAATTGG GTACTGTATA AGTGCATCAA CGTTACAACA ATTAAGCTTC 
CCAGTTAGAG CATACAAACG ACTAGATGGT TCTACTGAAT GCTGTAACAA TCACAGCCTC 
ACAGATGTGT GCTTTTCCTA CAGAAATAAT TTTAATAAAC GTTTGCATAC ATGTCTACCT 
GCCCGGAAAG CAGTTGAAGC CACTCAAGTT TGTAGAAGCA ATAAAGATTG CAAAAGCAGC 
TCAAGCTCAA GCTTCTGTAT AGTGCCATCC TTGGAAACTC ACACTCGGTT AATAAAGGTG 
AAACACCCCC CACAGATTGA TATGCTCTAT GTAGGGCACC CACTGCACCT TCACTACACA 
GTGAGCATTA CAAGTTTTAT CCCACGTTTC AACTTTCTAA GCATAGATCT GCCAGTAATT 
GTGGAGACAT TTGTCAAATA CCTGATTTCT CTTTCTGGAG CCCTGGCTAT TGTTAATGCA 
GTGCCCTGCT TTGCCTTGGA CGGTCAATGG ATTTTAAACT CTTTCCTGGA TGCTACCCTG 
ACTTCAGTGA TTGGAGACAA CGATGTCAAA GATCTAATAG GATTTTTCAT CCTGCTTGGT 
GGCAGTGTAC TTTTGGCTGC CAATGTGACA CTGGGACTCT GGATGGTTAC AGCACGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001030179.1
CDS	93..1652
Translation	MIPVSLVVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTSIFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTLAQMMADSPSPYSSSSSSSSSSSSSSSSSSSSSSSLHNDQVLQVVVPGINLPVNQLTYFFAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQLRIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVGDLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTECCNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSSSSSSFCIVPSLETHTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLISLSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAANVTLGLWMVTAR

Target ORF information:

RefSeq Version	NM_001035007.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus membrane-bound transcription factor peptidase, site 2 (Mbtps2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001035007.1

ORF Insert Sequence:

ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGTT GGACTGCCGT CTACCTGGCC 
GACTTGGTGT TGAAGTCATC TGTGTATTTT AAACATTCTT ATGAAGACTG GCTGGAAAAC 
AATGGATTGA GCATCTCTCC TTTTCATATA AGATGGCAAA CTTCAATTTT TAATCGTGCC 
TTTTACAGTT GGGGACGGCG GAAAGCAAGG ATGCTTTACC AATGGTTCAA TTTTGGAATG 
GTGTTTGGTG TGATTGCCAT GTTCAGCTCT TTTTTTCTCC TTGGAAAAAC ACTGATGCAG 
ACTTTGGCAC AAATGATGGC TGACTCTCCC TCTCCTTATT CTTCCTCTTC TTCCTCTTCC 
TCTTCCTCTT CCTCTTCCTC TTCCTCTTCT TCTTCCTCCT CCTCCTCTCT TCACAATGAT 
CAGGTGTTGC AAGTTGTGGT TCCTGGTATA AATTTACCTG TCAATCAGCT GACTTACTTC 
TTCGCTGCAG TCCTCATTAG TGGTGTTGTA CATGAAATTG GACACGGTAT AGCAGCCATT 
AGGGAACAAG TTCGATTTAA TGGCTTTGGA ATTTTCCTCT TCATTATTTA TCCTGGAGCA 
TTTGTTGATC TGTTCACCAC CCATTTGCAA CTTATATCAC CAGTCCAGCA GCTAAGGATA 
TTTTGTGCAG GTATATGGCA TAATTTTGTC CTTGCTCTCC TTGGTATTTT AGCTCTTGTT 
CTCCTCCCAG TAATCCTCTT GCCTTTTTAC TACACTGGAG TTGGGGTACT TATCACTGAA 
GTCGCAGAGG ACTCACCTGC CATTGGACCC AGAGGCCTTT TTGTGGGAGA CCTTGTTACT 
CATCTACAGG ATTGTCCCGT TACTAATGTG CAAGATTGGA ACGAATGTTT AGACACCATT 
GCATATGAGC CCCAAATTGG GTACTGTATA AGTGCATCAA CGTTACAACA ATTAAGCTTC 
CCAGTTAGAG CATACAAACG ACTAGATGGT TCTACTGAAT GCTGTAACAA TCACAGCCTC 
ACAGATGTGT GCTTTTCCTA CAGAAATAAT TTTAATAAAC GTTTGCATAC ATGTCTACCT 
GCCCGGAAAG CAGTTGAAGC CACTCAAGTT TGTAGAAGCA ATAAAGATTG CAAAAGCAGC 
TCAAGCTCAA GCTTCTGTAT AGTGCCATCC TTGGAAACTC ACACTCGGTT AATAAAGGTG 
AAACACCCCC CACAGATTGA TATGCTCTAT GTAGGGCACC CACTGCACCT TCACTACACA 
GTGAGCATTA CAAGTTTTAT CCCACGTTTC AACTTTCTAA GCATAGATCT GCCAGTAATT 
GTGGAGACAT TTGTCAAATA CCTGATTTCT CTTTCTGGAG CCCTGGCTAT TGTTAATGCA 
GTGCCCTGCT TTGCCTTGGA CGGTCAATGG ATTTTAAACT CTTTCCTGGA TGCTACCCTG 
ACTTCAGTGA TTGGAGACAA CGATGTCAAA GATCTAATAG GATTTTTCAT CCTGCTTGGT 
GGCAGTGTAC TTTTGGCTGC CAATGTGACA CTGGGACTCT GGATGGTTAC AGCACGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta.
Nature communications711920(2016 07)
Lindert U,Cabral WA,Ausavarat S,Tongkobpetch S,Ludin K,Barnes AM,Yeetong P,Weis M,Krabichler B,Srichomthong C,Makareeva EN,Janecke AR,Leikin S,Röthlisberger B,Rohrbach M,Kennerknecht I,Eyre DR,Suphapeetiporn K,Giunta C,Marini JC,Shotelersuk V

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.
Genes & development23(22)2578-91(2009 Nov)
Osborne TF,Espenshade PJ

IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response.
American journal of human genetics84(4)459-67(2009 Apr)
Oeffner F,Fischer G,Happle R,König A,Betz RC,Bornholdt D,Neidel U,Boente Mdel C,Redler S,Romero-Gomez J,Salhi A,Vera-Casaño A,Weirich C,Grzeschik KH

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs.
Molecular cell6(6)1355-64(2000 Dec)
Ye J,Rawson RB,Komuro R,Chen X,Davé UP,Prywes R,Brown MS,Goldstein JL

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Mbtps2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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