Sorl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sorl1
Entrez Gene ID	300652
Full Name	sortilin related receptor 1
Synonyms	Lr11,RGD619914
General protein information	Preferred Names sortilin related receptor 1 Names sortilin-related receptor sortilin-related receptor, LDLR class A repeats-containing
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q22
Summary	may play a role in lipoprotein metabolism; increased expression occurs in response to balloon injury endothelial denudation in an experimental model for atherogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053519.1	NP_445971.1	sortilin-related receptor precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SORL1	NP_003096.1
Pan troglodytes (chimpanzee)	SORL1	XP_003313440.1
Macaca mulatta (Rhesus monkey)	SORL1	XP_001102178.2
Canis lupus familiaris (dog)	SORL1	XP_536545.2
Mus musculus (house mouse)	Sorl1	NP_035566.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010896	XP_309795.4
Bos taurus (cattle)	SORL1	NP_001179686.1
Gallus gallus (chicken)	SORL1	XP_001232946.3
Xenopus tropicalis (tropical clawed frog)	sorl1	XP_002941683.2
Rattus norvegicus (Norway rat)	Sorl1	NP_445971.1
Danio rerio (zebrafish)	sorl1	XP_005157607.1

Gene Ontology
Bibliography

Related articles in PubMed

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
Schmidt V, Schulz N, Yan X, Schürmann A, Kempa S, Kern M, Blüher M, Poy MN, Olivecrona G, Willnow TE
The Journal of clinical investigation126(7)2706-20(2016 07)

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.
Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H
Nature communications68951(2015 Nov)

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Caglayan S, Takagi-Niidome S, Liao F, Carlo AS, Schmidt V, Burgert T, Kitago Y, Füchtbauer EM, Füchtbauer A, Holtzman DM, Takagi J, Willnow TE
Science translational medicine6(223)223ra20(2014 Feb)

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
Burgert T, Schmidt V, Caglayan S, Lin F, Füchtbauer A, Füchtbauer EM, Nykjaer A, Carlo AS, Willnow TE
Molecular and cellular biology33(21)4308-20(2013 Nov)

SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Capsoni S, Carlo AS, Vignone D, Amato G, Criscuolo C, Willnow TE, Cattaneo A
Journal of Alzheimer's disease : JAD33(2)357-71(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sorl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sorl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09783	NM_053519.1 Latest version!	Rattus norvegicus sortilin related receptor 1 (Sorl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1091.30 $1559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sorl1 ( NM_053519.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445971.1 Rattus norvegicus sortilin related receptor 1 (Sorl1), mRNA.

Price & Availability↑

CloneID	ORa09783
Clone ID Related Accession (Same CDS sequence)	NM_053519.1
Accession Version	NM_053519.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570636800000
Organism	Rattus norvegicus(Norway rat)
Product	sortilin-related receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473975.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGACAC GGAGCAGCAG GAGGGAGTCG AGACTCCCTT TCCTATTCAC CCTGGTCGCT 
CTGCTGCCCC CCGGGGCTCT CGGCGGGGGC TGGACGCAGA GATTGCATGG TGGCGGAGCG 
CCCTTGCCCC AGGACCGCGG CTTCTTCGTG GTGCAGGGCG ACCCGCACGA GCTGCGGCTG 
GGAACGCACG GGGATGCCTG GGGGGCGAGC CCAGCGGCCA GGAAGCCACT CAGGACGCGG 
CGGAGCGCTG CTTTGCAGCC CCAGCCTATC CAGGTGTATG GACAGGTCAG CCTGAATGAC 
TCCCACAATC AGATGGTGGT GCACTGGGCT GGAGAGAAAA GCAACGTGAT CGTGGCATTA 
GCCCGAGACA GCCTGGCATT GACAAGGCCC AAGAGCAGTG ATGTATATGT GTCTTATGAC 
TATGGAAAAT CATTCAATAA GATTTCAGAG AAGCTGAACT TTGGTGTGGG AAACAGCAGT 
GAAGCCGTGA TCTCCCAATT CTACCACAGC CCTGCCGACA ACAAGAGGTA CATCTTTGTG 
GATGCTTATG CCCGATACCT CTGGATCACG TTTGACTTCG GCAGCACGAT CCATGGCTTC 
TCCATCCCAT TCCGGGCGGC TGATCTCCTC CTTCATAGCA AGGCCTCCAA CCTCCTCTTG 
GGCTTTGACA GCTCTCACCC CAACAAGCAG CTATGGAAGT CGGATGATTT TGGCCAGACC 
TGGATCATGA TTCAGGAACA TGTGAAGTCC TTTTCTTGGG GGATCGACCC CTATGACCAG 
CCGAACACTA TCTACATCGA GCGGCATGAA CCCTTTGGGT TCTCCACAGT GTTCCGCAGC 
ACAGACTTCT TCCAGTCCCG GGAAAACCAG GAAGTGATCC TGGAGGAAGT GAGAGACTTT 
CAGCTTCGGG ACAAGTACCT GTTTGCTACA AAGGTGGTGC ATCTTCCGGG CAGCCAGCAG 
CAGTCATCTG TCCAGCTCTG GGTCTCCTTT GGCCGGAAGC CTATGCGAGC AGCCCAGTTT 
GTCACAAAGC ATCCTATTAA CGAATACTAC ATCGCCGATG CCTCCGAAGA CCAGGTCTTC 
GTGTGCGTCA GCCACAGCAA CAATAGTACT AACCTGTACA TCTCAGAGGC GGAGGGGCTG 
AAATTCTCCC TATCCTTGGA GAATGTGCTG TATTATAGCC CAGGAGGGGC CGGCAGTGAC 
ACCCTGGTGA GGTATTTTGC AAACGAGCCG TTTGCCGACT TTCACCGAGT GGAGGGCTTA 
CAAGGAGTCT ACATTGCCAC CCTGATTAAT GGATCTATGA GTGAGGAGAA CATGAGGTCG 
GTCATCACCT TTGACAAAGG GGGAACCTGG GAATTTCTTC AGGCCCCGGC CTTCACAGGA 
TATGGAGAGA AAATCAATTG TGAGCTCTCT CAGGGCTGCT CCCTCCACCT GGCCCAGCGC 
CTCAGTCAAC TGCTCAACCT CCAACTTCGG AGGATGCCGA TCCTGTCCAA GGAGTCAGCC 
CCCGGCCTCA TCATCGCCAC CGGCTCTGTG GGAAAGAACT TGGCCAGCAA GACCAACGTG 
TACATCTCTA GCAGTGCCGG AGCCCGGTGG AGAGAGGCTC TTCCAGGACC TCATTACTAT 
ACTTGGGGTG ACCATGGAGG CATCATCATG GCCATTGCCC AGGGCATGGA GACCAACGAG 
CTGAAGTACA GCACCAATGA AGGCGAGACC TGGAAGACGT TCGTCTTCTC TGAGAAGCCT 
GTGTTTGTGT ATGGGCTTCT CACGGAACCT GGCGAGAAGA GCACCGTCTT CACCATCTTC 
GGCTCTAACA AGGAGAGTGT CCACAGCTGG CTCATCCTGC AGGTCAATGC CACCGACGCC 
TTGGGGGTTC CTTGCACGGA AAACGACTAC AAGCTGTGGT CCCCATCTGA TGAGCGGGGG 
AACGAGTGTT TGCTAGGACA CAAGACAGTT TTCAAAAGGA GGACCCCTCA CGCAACGTGC 
TTTAATGGGG AAGACTTTGA CCGGCCGGTG GTCGTGTCCA ACTGCTCCTG CACCCGGGAG 
GACTACGAAT GTGACTTTGG CTTCAAGATG AGTGAAGATA TCTCCTTAGA GGTTTGTGTT 
CCAGACCCTG AGTTTTCTGG GAAGCCCTAC AGCCCTCCTG TGCCTTGTCC CGTGGGTTCT 
TCCTACAGGA GAACAAGAGG CTATCGGAAG ATTTCTGGGG ATACGTGCAG TGGAGGAGAT 
GTTGAGGCAC GGCTGGAGGG GGAGCTGGTC CCCTGTCCCC TGGCAGAAGA GAATGAGTTC 
ATCCTGTACG CCATGCGGAA ATCCATCTAC CGCTACGACT TGGCCTCGGG AGCCACGGAA 
CAGCTTCCTC TCTCGGGGCT GCGGGCAGCC GTGGCCCTGG ACTTTGACTA TGAGCACAAC 
TGCCTGTATT GGTCTGACCT GGCGCTGGAC ACCATCCAGC GTCTCTGCTT GAATGGGAGC 
ACAGGGCAAG AGGTGATCAT CAATTCTGGC CTGGAGACCG TGGAGGCTTT GGCCTTTGAA 
CCCCTCAGCC AGTTACTTTA CTGGGTGGAT GCCGGCTTTA AAAAGATCGA GGTAGCTAAT 
CCAGATGGTG ACTTCCGGCT GACAATCGTC AATTCCTCTG TGCTTGATCG ACCCAGGGCT 
CTAGTCCTTG TGCCCCAAGA GGGGGTGATG TTCTGGACTG ACTGGGGAGA CTTGAAGCCT 
GGAATTTACC GGAGCAACAT GGATGGGTCT GCTGCCTATC GCCTTGTGTC AGAGGACGTG 
AAGTGGCCTA ATGGCATCTC TGTGGACGGC CACTGGATTT ACTGGACGGA CGCTTACCTG 
GACTGTATCG AGCGCATCAC TTTCAGTGGC CAGCAGCGTT CAGTCATCCT TGACAACCTC 
CCACACCCTT ACGCCATTGC CGTCTTTAAG AACGAGATCT ACTGGGACGA CTGGTCGCAG 
CTCAGTATCT TCAGAGCTTC CAAGTACAGC AGGTCCCAGG TGGAGACCCT AGCGAGCCAG 
CTCACCGGCC TGATGGACAT GAAGATCTTC TACAAAGGAA AGAACGCCGG AAGCAATGCC 
TGCATTCCTC AGCCCTGCAG TCTACTGTGC CTCCCTAAGG CCAACAACAG CAAAAGCTGC 
AGGTGTCCAG AAGGCGTGGC CAGCAGTGTC CTCCCCTCTG GGTACCTGAT GTGTGACTGC 
CCTCAGGGCT ACGAGAGGAA GAACAACACC TGTGTCAAAG AAGAGAACAC CTGTCTTCGC 
AACCAGTACC ACTGCAGCAA CGGCAACTGT ATCAACAGCA TTTGGTGGTG TGATTTCGAC 
AACGACTGTG GCGATATGAG TGACGAGAGG AATTGCCCCA CGACCATCTG TGATGCAGAC 
ACTCAGTTCC GGTGCCAGGA GTCGGGGACT TGTATTCCAC TCTCCTATAA GTGTGACCTT 
GAAGATGACT GTGGAGATAA CAGTGATGAG AGTCACTGTG AGATGCACCA GTGTCGCAGC 
GACGAGTTCA ACTGTAGCTC TGGGATGTGC ATCCGGTCCT CCTGGGTGTG CGACGGAGAC 
AACGACTGTC GGGACTGGTC TGATGAAGCC AACTGCACCG CCATCTACCA CACCTGTGAG 
GCCTCCAACT TCCAATGCCA CAATGGCCAC TGCATCCCCC AGCGATGGGC ATGTGACGGT 
GACGCGGATT GCCAGGACGG CTCTGATGAA GATCCCATCA GCTGTGAGAA AAAGTGCAAT 
GGATTCCACT GCCCAAACGG CACGTGCATC CCATCCAGCA AGCATTGTGA CGGGCTGCGG 
GACTGCCCCG ACGGCTCTGA CGAGCAGCAC TGTGAGCCCT TCTGCACACG TTTCATGGAC 
TTTGTGTGTA AGAACCGTCA GCAGTGTCTG TTCCACTCCA TGGTGTGTGA CGGGATCATC 
CAGTGCCGAG ATGGCTCTGA TGAGGATGCC ACCTTCGCCG GATGCTCCCA AGACCCGGAG 
TTCCACAAGG AGTGTGACGA GTTCGGCTTC CAGTGTCAGA ACGGAGTGTG CATCAGCTTG 
ATTTGGAAAT GCGATGGGAT GGATGACTGC GGAGACTACT CTGACGAGGC CAACTGTGAA 
AACCCCACAG AAGCCCCGAA CTGCTCCCGC TACTTCCAGT TCCACTGTGA GAATGGCCGC 
TGCATCCCCA ACAGGTGGAA ATGTGACAGA GAGAATGACT GCGGGGACTG GTCTGATGAG 
AAGGACTGTG GAGATTCACA CATTTTCCCC TCCCCCACCC CCGGACCGTC CACATGTCTG 
CCCAATTACT TCCGATGCAG CAGCGGGGCC TGCGTGATGG GCACCTGGGT GTGCGACGGC 
TACAGGGACT GTGCTGATGG CTCAGATGAG GAAGCCTGCC CCTCTCTAGC AAACTCCACT 
GCCGCCTCCA CTCCCACCCA GCTTGGGCAG TGTGACCGAT TTGAGTTCGA GTGCCGCCAA 
CCAAAGAAAT GTATCCCCAA CTGGAAGCGC TGTGATGGCC ACCAGGATTG CCAAGACGGC 
CAGGACGAAG CCAACTGCCC CACTCACAGC ACCTTGACGT GTATGAGCAG GGAGTTCAAG 
TGTGAGGACG GCGAGGCGTG CATTGTGCTC TCGGAGCGCT GTGACGGCTT CCTGGATTGC 
TCTGATGAGA GTGATGAGAA GGCCTGCAGC GATGAGTTAA CAGTATATAA AGTCCAGAAT 
CTTCAATGGA TAGCTGATTT CTCTGGGGAT GTGACTTTGA CCTGGACGCG ACCAAAAAAA 
ATGCCATCTG CTTCTTGTGT ATACAATGTG TACTACAGGG TGGTTGGAGA GAGCATATGG 
AAGACCCTGG AAACCCATAG CAATAAAACA AGCACTGTGC TGAAGGTCCT GAAGCCAGAC 
ACCACGTACC AGGTTAAGGT CCAGGTGCAC TGCCTTAGCA AGGTGCACAA CACCAATGAC 
TTTGTGACCC TGAGGACTCC AGAGGGGTTG CCGGATGCCC CTCGGAATCT CCAGCTCTCC 
CTAAACAGTG AAGAGGAAGG TGTGATTCTT GGGCACTGGG CTCCTCCCGT CCACACCCAT 
GGCCTCATCC GTGAGTACAT TGTGGAATAC AGCCGGAGTG GATCCAAGAT GTGGGCCTCC 
CAGAGAGCTG CCAGCAACTC TACAGAGATA AAGAACTTAC TGCTCAATGC CCTCTACACC 
GTCCGAGTGG CTGCGGTGAC TAGTCGGGGA ATAGGAAACT GGAGTGATTC CAAATCCATC 
ACCACCACAA AAGGAAAAGT GATCCAAGCA CCAAATATCC ACATTGACAG CTACGATGAA 
AATTCTCTCA GCTTTACCCT GACCATGGAC GGTGACATCA AGGTCAATGG CTATGTGGTG 
AACCTTTTCT GGTCATTTGA TGCCCACAAA CAAGAAAAGA AAACCTTGAA CTTCCGAGGA 
GGAAGCTCGC TGTCACACAA AGTGAGCAAT CTGACAGCTC ATACGTCCTA TGAGGTTTCT 
GCCTGGGCCA AGACAGACTT GGGGGACAGT CCTCTGGCCT TTGAGCACAT CTTGACCAGA 
GGCATCAGTC CACCTGCTCC TAGTCTCAAA GCCAAGGCCA TCAATCAGAC TGCAGTGGAG 
TGCATCTGGA CTGGCCCCAA GAATGTGGTG TATGGTATTT TCTACGCCAC ATCCTTCCTC 
GACCTCTACC GAAACCCTAA GAGTTTAACT ACTTCACTCC ACAATAAGAC AGTCATTGTC 
AGCAAGGATG AGCAGTATTT GTTTCTGGTC CGGGTGTTGA TCCCTTACCA AGGGCCGTCC 
TCCGACTACG TTGTGGTGAA GATGATCCCA GACAGCAGGC TTCCACCTCG GCACCTACAT 
GCCGTCCAAA TAGGCAAGAC CTCAGCAGTC ATCAAGTGGG AGTCACCCTA CGACTCTCCT 
GACCAGGACC TGTTCTACGC CATTGCAGTG AAAGATCTGA TCCGAAAGAC GGACAGGAGC 
TACAAAGTCA GATCCCGCAA CAGTACTGTG GAGTACAGCC TTAGCAAGCT GGAGCCTGGA 
GGGAAATACC ATATCATTGT CCAGCTGGGA AACATGAGCA AGGACTCCAG CATAAAAATC 
ACCACCGTCT CATTGTCAGC ACCTGATGCC TTAAAAATCA TAACCGAAAA CGACCACGTT 
CTCCTCTTTT GGAAAAGTCT AGCTTTAAAG GAAAAGCAGT TCAATGAAAC CAGGGGCTAC 
GAGATACACA TGTTTGACAG TGCCGTGAAT CTCACCGCTT ACCTTGGGAA TACTACTGAC 
AATTTCTTTA AAGTGTCCAA CCTGAAGATG GGTCACAATT ACACTTTCAC GGTCCAGGCT 
CGATGTCTCT TTGGTAGCCA GATCTGCGGG GAGCCTGCCG TGCTGCTGTA TGACGAACTG 
AGCTCAGGTG GAGATGCCAC AGTGGTCCAG ACTGCCAGGT CTACTGACGT CGCGGCCGTG 
GTGGTTCCTA TCTTGTTCCT GATCCTGCTG AGCCTGGGAG TCGGCTTTGC CGTCCTCTAC 
ACGAAGCACC GCCGCTTACA AAGCAGCTTC ACTGCCTTTG CCAACAGCCA CTACAGCTCC 
AGGCTGGGCT CCGCCATCTT CTCTTCCGGG GATGACCTAG GAGAGGACGA CGAAGATGCT 
CCCATGATTA CCGGATTCTC AGACGATGTC CCCATGGTGA TAGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445971.1
CDS	1..6648
Translation	MATRSSRRESRLPFLFTLVALLPPGALGGGWTQRLHGGGAPLPQDRGFFVVQGDPHELRLGTHGDAWGASPAARKPLRTRRSAALQPQPIQVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALTRPKSSDVYVSYDYGKSFNKISEKLNFGVGNSSEAVISQFYHSPADNKRYIFVDAYARYLWITFDFGSTIHGFSIPFRAADLLLHSKASNLLLGFDSSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDQPNTIYIERHEPFGFSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYLFATKVVHLPGSQQQSSVQLWVSFGRKPMRAAQFVTKHPINEYYIADASEDQVFVCVSHSNNSTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMSEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIIMAIAQGMETNELKYSTNEGETWKTFVFSEKPVFVYGLLTEPGEKSTVFTIFGSNKESVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDISLEVCVPDPEFSGKPYSPPVPCPVGSSYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAMRKSIYRYDLASGATEQLPLSGLRAAVALDFDYEHNCLYWSDLALDTIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYRLVSEDVKWPNGISVDGHWIYWTDAYLDCIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSRSQVETLASQLTGLMDMKIFYKGKNAGSNACIPQPCSLLCLPKANNSKSCRCPEGVASSVLPSGYLMCDCPQGYERKNNTCVKEENTCLRNQYHCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDADTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCHNGHCIPQRWACDGDADCQDGSDEDPISCEKKCNGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHCEPFCTRFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDATFAGCSQDPEFHKECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFHCENGRCIPNRWKCDRENDCGDWSDEKDCGDSHIFPSPTPGPSTCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEACPSLANSTAASTPTQLGQCDRFEFECRQPKKCIPNWKRCDGHQDCQDGQDEANCPTHSTLTCMSREFKCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWIADFSGDVTLTWTRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQVHCLSKVHNTNDFVTLRTPEGLPDAPRNLQLSLNSEEEGVILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLLNALYTVRVAAVTSRGIGNWSDSKSITTTKGKVIQAPNIHIDSYDENSLSFTLTMDGDIKVNGYVVNLFWSFDAHKQEKKTLNFRGGSSLSHKVSNLTAHTSYEVSAWAKTDLGDSPLAFEHILTRGISPPAPSLKAKAINQTAVECIWTGPKNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVLIPYQGPSSDYVVVKMIPDSRLPPRHLHAVQIGKTSAVIKWESPYDSPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTVEYSLSKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKQFNETRGYEIHMFDSAVNLTAYLGNTTDNFFKVSNLKMGHNYTFTVQARCLFGSQICGEPAVLLYDELSSGGDATVVQTARSTDVAAVVVPILFLILLSLGVGFAVLYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA

Target ORF information:

RefSeq Version	NM_053519.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sortilin related receptor 1 (Sorl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053519.1

ORF Insert Sequence:

ATGGCGACAC GGAGCAGCAG GAGGGAGTCG AGACTCCCTT TCCTATTCAC CCTGGTCGCT 
CTGCTGCCCC CCGGGGCTCT CGGCGGGGGC TGGACGCAGA GATTGCATGG TGGCGGAGCG 
CCCTTGCCCC AGGACCGCGG CTTCTTCGTG GTGCAGGGCG ACCCGCACGA GCTGCGGCTG 
GGAACGCACG GGGATGCCTG GGGGGCGAGC CCAGCGGCCA GGAAGCCACT CAGGACGCGG 
CGGAGCGCTG CTTTGCAGCC CCAGCCTATC CAGGTGTATG GACAGGTCAG CCTGAATGAC 
TCCCACAATC AGATGGTGGT GCACTGGGCT GGAGAGAAAA GCAACGTGAT CGTGGCATTA 
GCCCGAGACA GCCTGGCATT GACAAGGCCC AAGAGCAGTG ATGTATATGT GTCTTATGAC 
TATGGAAAAT CATTCAATAA GATTTCAGAG AAGCTGAACT TTGGTGTGGG AAACAGCAGT 
GAAGCCGTGA TCTCCCAATT CTACCACAGC CCTGCCGACA ACAAGAGGTA CATCTTTGTG 
GATGCTTATG CCCGATACCT CTGGATCACG TTTGACTTCG GCAGCACGAT CCATGGCTTC 
TCCATCCCAT TCCGGGCGGC TGATCTCCTC CTTCATAGCA AGGCCTCCAA CCTCCTCTTG 
GGCTTTGACA GCTCTCACCC CAACAAGCAG CTATGGAAGT CGGATGATTT TGGCCAGACC 
TGGATCATGA TTCAGGAACA TGTGAAGTCC TTTTCTTGGG GGATCGACCC CTATGACCAG 
CCGAACACTA TCTACATCGA GCGGCATGAA CCCTTTGGGT TCTCCACAGT GTTCCGCAGC 
ACAGACTTCT TCCAGTCCCG GGAAAACCAG GAAGTGATCC TGGAGGAAGT GAGAGACTTT 
CAGCTTCGGG ACAAGTACCT GTTTGCTACA AAGGTGGTGC ATCTTCCGGG CAGCCAGCAG 
CAGTCATCTG TCCAGCTCTG GGTCTCCTTT GGCCGGAAGC CTATGCGAGC AGCCCAGTTT 
GTCACAAAGC ATCCTATTAA CGAATACTAC ATCGCCGATG CCTCCGAAGA CCAGGTCTTC 
GTGTGCGTCA GCCACAGCAA CAATAGTACT AACCTGTACA TCTCAGAGGC GGAGGGGCTG 
AAATTCTCCC TATCCTTGGA GAATGTGCTG TATTATAGCC CAGGAGGGGC CGGCAGTGAC 
ACCCTGGTGA GGTATTTTGC AAACGAGCCG TTTGCCGACT TTCACCGAGT GGAGGGCTTA 
CAAGGAGTCT ACATTGCCAC CCTGATTAAT GGATCTATGA GTGAGGAGAA CATGAGGTCG 
GTCATCACCT TTGACAAAGG GGGAACCTGG GAATTTCTTC AGGCCCCGGC CTTCACAGGA 
TATGGAGAGA AAATCAATTG TGAGCTCTCT CAGGGCTGCT CCCTCCACCT GGCCCAGCGC 
CTCAGTCAAC TGCTCAACCT CCAACTTCGG AGGATGCCGA TCCTGTCCAA GGAGTCAGCC 
CCCGGCCTCA TCATCGCCAC CGGCTCTGTG GGAAAGAACT TGGCCAGCAA GACCAACGTG 
TACATCTCTA GCAGTGCCGG AGCCCGGTGG AGAGAGGCTC TTCCAGGACC TCATTACTAT 
ACTTGGGGTG ACCATGGAGG CATCATCATG GCCATTGCCC AGGGCATGGA GACCAACGAG 
CTGAAGTACA GCACCAATGA AGGCGAGACC TGGAAGACGT TCGTCTTCTC TGAGAAGCCT 
GTGTTTGTGT ATGGGCTTCT CACGGAACCT GGCGAGAAGA GCACCGTCTT CACCATCTTC 
GGCTCTAACA AGGAGAGTGT CCACAGCTGG CTCATCCTGC AGGTCAATGC CACCGACGCC 
TTGGGGGTTC CTTGCACGGA AAACGACTAC AAGCTGTGGT CCCCATCTGA TGAGCGGGGG 
AACGAGTGTT TGCTAGGACA CAAGACAGTT TTCAAAAGGA GGACCCCTCA CGCAACGTGC 
TTTAATGGGG AAGACTTTGA CCGGCCGGTG GTCGTGTCCA ACTGCTCCTG CACCCGGGAG 
GACTACGAAT GTGACTTTGG CTTCAAGATG AGTGAAGATA TCTCCTTAGA GGTTTGTGTT 
CCAGACCCTG AGTTTTCTGG GAAGCCCTAC AGCCCTCCTG TGCCTTGTCC CGTGGGTTCT 
TCCTACAGGA GAACAAGAGG CTATCGGAAG ATTTCTGGGG ATACGTGCAG TGGAGGAGAT 
GTTGAGGCAC GGCTGGAGGG GGAGCTGGTC CCCTGTCCCC TGGCAGAAGA GAATGAGTTC 
ATCCTGTACG CCATGCGGAA ATCCATCTAC CGCTACGACT TGGCCTCGGG AGCCACGGAA 
CAGCTTCCTC TCTCGGGGCT GCGGGCAGCC GTGGCCCTGG ACTTTGACTA TGAGCACAAC 
TGCCTGTATT GGTCTGACCT GGCGCTGGAC ACCATCCAGC GTCTCTGCTT GAATGGGAGC 
ACAGGGCAAG AGGTGATCAT CAATTCTGGC CTGGAGACCG TGGAGGCTTT GGCCTTTGAA 
CCCCTCAGCC AGTTACTTTA CTGGGTGGAT GCCGGCTTTA AAAAGATCGA GGTAGCTAAT 
CCAGATGGTG ACTTCCGGCT GACAATCGTC AATTCCTCTG TGCTTGATCG ACCCAGGGCT 
CTAGTCCTTG TGCCCCAAGA GGGGGTGATG TTCTGGACTG ACTGGGGAGA CTTGAAGCCT 
GGAATTTACC GGAGCAACAT GGATGGGTCT GCTGCCTATC GCCTTGTGTC AGAGGACGTG 
AAGTGGCCTA ATGGCATCTC TGTGGACGGC CACTGGATTT ACTGGACGGA CGCTTACCTG 
GACTGTATCG AGCGCATCAC TTTCAGTGGC CAGCAGCGTT CAGTCATCCT TGACAACCTC 
CCACACCCTT ACGCCATTGC CGTCTTTAAG AACGAGATCT ACTGGGACGA CTGGTCGCAG 
CTCAGTATCT TCAGAGCTTC CAAGTACAGC AGGTCCCAGG TGGAGACCCT AGCGAGCCAG 
CTCACCGGCC TGATGGACAT GAAGATCTTC TACAAAGGAA AGAACGCCGG AAGCAATGCC 
TGCATTCCTC AGCCCTGCAG TCTACTGTGC CTCCCTAAGG CCAACAACAG CAAAAGCTGC 
AGGTGTCCAG AAGGCGTGGC CAGCAGTGTC CTCCCCTCTG GGTACCTGAT GTGTGACTGC 
CCTCAGGGCT ACGAGAGGAA GAACAACACC TGTGTCAAAG AAGAGAACAC CTGTCTTCGC 
AACCAGTACC ACTGCAGCAA CGGCAACTGT ATCAACAGCA TTTGGTGGTG TGATTTCGAC 
AACGACTGTG GCGATATGAG TGACGAGAGG AATTGCCCCA CGACCATCTG TGATGCAGAC 
ACTCAGTTCC GGTGCCAGGA GTCGGGGACT TGTATTCCAC TCTCCTATAA GTGTGACCTT 
GAAGATGACT GTGGAGATAA CAGTGATGAG AGTCACTGTG AGATGCACCA GTGTCGCAGC 
GACGAGTTCA ACTGTAGCTC TGGGATGTGC ATCCGGTCCT CCTGGGTGTG CGACGGAGAC 
AACGACTGTC GGGACTGGTC TGATGAAGCC AACTGCACCG CCATCTACCA CACCTGTGAG 
GCCTCCAACT TCCAATGCCA CAATGGCCAC TGCATCCCCC AGCGATGGGC ATGTGACGGT 
GACGCGGATT GCCAGGACGG CTCTGATGAA GATCCCATCA GCTGTGAGAA AAAGTGCAAT 
GGATTCCACT GCCCAAACGG CACGTGCATC CCATCCAGCA AGCATTGTGA CGGGCTGCGG 
GACTGCCCCG ACGGCTCTGA CGAGCAGCAC TGTGAGCCCT TCTGCACACG TTTCATGGAC 
TTTGTGTGTA AGAACCGTCA GCAGTGTCTG TTCCACTCCA TGGTGTGTGA CGGGATCATC 
CAGTGCCGAG ATGGCTCTGA TGAGGATGCC ACCTTCGCCG GATGCTCCCA AGACCCGGAG 
TTCCACAAGG AGTGTGACGA GTTCGGCTTC CAGTGTCAGA ACGGAGTGTG CATCAGCTTG 
ATTTGGAAAT GCGATGGGAT GGATGACTGC GGAGACTACT CTGACGAGGC CAACTGTGAA 
AACCCCACAG AAGCCCCGAA CTGCTCCCGC TACTTCCAGT TCCACTGTGA GAATGGCCGC 
TGCATCCCCA ACAGGTGGAA ATGTGACAGA GAGAATGACT GCGGGGACTG GTCTGATGAG 
AAGGACTGTG GAGATTCACA CATTTTCCCC TCCCCCACCC CCGGACCGTC CACATGTCTG 
CCCAATTACT TCCGATGCAG CAGCGGGGCC TGCGTGATGG GCACCTGGGT GTGCGACGGC 
TACAGGGACT GTGCTGATGG CTCAGATGAG GAAGCCTGCC CCTCTCTAGC AAACTCCACT 
GCCGCCTCCA CTCCCACCCA GCTTGGGCAG TGTGACCGAT TTGAGTTCGA GTGCCGCCAA 
CCAAAGAAAT GTATCCCCAA CTGGAAGCGC TGTGATGGCC ACCAGGATTG CCAAGACGGC 
CAGGACGAAG CCAACTGCCC CACTCACAGC ACCTTGACGT GTATGAGCAG GGAGTTCAAG 
TGTGAGGACG GCGAGGCGTG CATTGTGCTC TCGGAGCGCT GTGACGGCTT CCTGGATTGC 
TCTGATGAGA GTGATGAGAA GGCCTGCAGC GATGAGTTAA CAGTATATAA AGTCCAGAAT 
CTTCAATGGA TAGCTGATTT CTCTGGGGAT GTGACTTTGA CCTGGACGCG ACCAAAAAAA 
ATGCCATCTG CTTCTTGTGT ATACAATGTG TACTACAGGG TGGTTGGAGA GAGCATATGG 
AAGACCCTGG AAACCCATAG CAATAAAACA AGCACTGTGC TGAAGGTCCT GAAGCCAGAC 
ACCACGTACC AGGTTAAGGT CCAGGTGCAC TGCCTTAGCA AGGTGCACAA CACCAATGAC 
TTTGTGACCC TGAGGACTCC AGAGGGGTTG CCGGATGCCC CTCGGAATCT CCAGCTCTCC 
CTAAACAGTG AAGAGGAAGG TGTGATTCTT GGGCACTGGG CTCCTCCCGT CCACACCCAT 
GGCCTCATCC GTGAGTACAT TGTGGAATAC AGCCGGAGTG GATCCAAGAT GTGGGCCTCC 
CAGAGAGCTG CCAGCAACTC TACAGAGATA AAGAACTTAC TGCTCAATGC CCTCTACACC 
GTCCGAGTGG CTGCGGTGAC TAGTCGGGGA ATAGGAAACT GGAGTGATTC CAAATCCATC 
ACCACCACAA AAGGAAAAGT GATCCAAGCA CCAAATATCC ACATTGACAG CTACGATGAA 
AATTCTCTCA GCTTTACCCT GACCATGGAC GGTGACATCA AGGTCAATGG CTATGTGGTG 
AACCTTTTCT GGTCATTTGA TGCCCACAAA CAAGAAAAGA AAACCTTGAA CTTCCGAGGA 
GGAAGCTCGC TGTCACACAA AGTGAGCAAT CTGACAGCTC ATACGTCCTA TGAGGTTTCT 
GCCTGGGCCA AGACAGACTT GGGGGACAGT CCTCTGGCCT TTGAGCACAT CTTGACCAGA 
GGCATCAGTC CACCTGCTCC TAGTCTCAAA GCCAAGGCCA TCAATCAGAC TGCAGTGGAG 
TGCATCTGGA CTGGCCCCAA GAATGTGGTG TATGGTATTT TCTACGCCAC ATCCTTCCTC 
GACCTCTACC GAAACCCTAA GAGTTTAACT ACTTCACTCC ACAATAAGAC AGTCATTGTC 
AGCAAGGATG AGCAGTATTT GTTTCTGGTC CGGGTGTTGA TCCCTTACCA AGGGCCGTCC 
TCCGACTACG TTGTGGTGAA GATGATCCCA GACAGCAGGC TTCCACCTCG GCACCTACAT 
GCCGTCCAAA TAGGCAAGAC CTCAGCAGTC ATCAAGTGGG AGTCACCCTA CGACTCTCCT 
GACCAGGACC TGTTCTACGC CATTGCAGTG AAAGATCTGA TCCGAAAGAC GGACAGGAGC 
TACAAAGTCA GATCCCGCAA CAGTACTGTG GAGTACAGCC TTAGCAAGCT GGAGCCTGGA 
GGGAAATACC ATATCATTGT CCAGCTGGGA AACATGAGCA AGGACTCCAG CATAAAAATC 
ACCACCGTCT CATTGTCAGC ACCTGATGCC TTAAAAATCA TAACCGAAAA CGACCACGTT 
CTCCTCTTTT GGAAAAGTCT AGCTTTAAAG GAAAAGCAGT TCAATGAAAC CAGGGGCTAC 
GAGATACACA TGTTTGACAG TGCCGTGAAT CTCACCGCTT ACCTTGGGAA TACTACTGAC 
AATTTCTTTA AAGTGTCCAA CCTGAAGATG GGTCACAATT ACACTTTCAC GGTCCAGGCT 
CGATGTCTCT TTGGTAGCCA GATCTGCGGG GAGCCTGCCG TGCTGCTGTA TGACGAACTG 
AGCTCAGGTG GAGATGCCAC AGTGGTCCAG ACTGCCAGGT CTACTGACGT CGCGGCCGTG 
GTGGTTCCTA TCTTGTTCCT GATCCTGCTG AGCCTGGGAG TCGGCTTTGC CGTCCTCTAC 
ACGAAGCACC GCCGCTTACA AAGCAGCTTC ACTGCCTTTG CCAACAGCCA CTACAGCTCC 
AGGCTGGGCT CCGCCATCTT CTCTTCCGGG GATGACCTAG GAGAGGACGA CGAAGATGCT 
CCCATGATTA CCGGATTCTC AGACGATGTC CCCATGGTGA TAGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
The Journal of clinical investigation126(7)2706-20(2016 07)
Schmidt V,Schulz N,Yan X,Schürmann A,Kempa S,Kern M,Blüher M,Poy MN,Olivecrona G,Willnow TE

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.
Nature communications68951(2015 Nov)
Whittle AJ,Jiang M,Peirce V,Relat J,Virtue S,Ebinuma H,Fukamachi I,Yamaguchi T,Takahashi M,Murano T,Tatsuno I,Takeuchi M,Nakaseko C,Jin W,Jin Z,Campbell M,Schneider WJ,Vidal-Puig A,Bujo H

Lysosomal sorting of amyloid-β by the SORLA receptor is impaired by a familial Alzheimer's disease mutation.
Science translational medicine6(223)223ra20(2014 Feb)
Caglayan S,Takagi-Niidome S,Liao F,Carlo AS,Schmidt V,Burgert T,Kitago Y,Füchtbauer EM,Füchtbauer A,Holtzman DM,Takagi J,Willnow TE

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
Molecular and cellular biology33(21)4308-20(2013 Nov)
Burgert T,Schmidt V,Caglayan S,Lin F,Füchtbauer A,Füchtbauer EM,Nykjaer A,Carlo AS,Willnow TE

SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD33(2)357-71(2013)
Capsoni S,Carlo AS,Vignone D,Amato G,Criscuolo C,Willnow TE,Cattaneo A

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Sorl1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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