Ldlr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ldlr
Entrez Gene ID	300438
Full Name	low density lipoprotein receptor
Synonyms	LDLRA
General protein information	Preferred Names low density lipoprotein receptor Names low-density lipoprotein receptor LDL receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_175762.2	NP_786938.1	low-density lipoprotein receptor precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LDLR	NP_001160002.1
Danio rerio (zebrafish)	ldlra	NP_001025454.1
Homo sapiens (human)	LDLR	NP_000518.1
Macaca mulatta (Rhesus monkey)	LDLR	NP_001028078.1
Xenopus tropicalis (tropical clawed frog)	LOC100495826	XP_002942891.1
Canis lupus familiaris (dog)	LDLR	XP_005632926.1
Pan troglodytes (chimpanzee)	LDLR	XP_001167447.1
Mus musculus (house mouse)	Ldlr	NP_034830.2
Rattus norvegicus (Norway rat)	Ldlr	NP_786938.1

Gene Ontology
Bibliography

Related articles in PubMed

Up-regulation of PCSK9 gene expression and diminished level of LDL-receptor in rat liver as a potential cause of post-lipectomy hypercholesterolemia.
Dettlaff-Pokora A, Sucajtys-Szulc E, Sledzinski T
Molecular and cellular biochemistry455(1-2)207-217(2019 May)

Exercise training increased gene expression of LDL-R and PCSK9 in intestine: link to transintestinal cholesterol excretion.
Farahnak Z, Chapados N, Lavoie JM
General physiology and biophysics37(3)309-317(2018 May)

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.
Zhao Y, Yang Y, Xing R, Cui X, Xiao Y, Xie L, You P, Wang T, Zeng L, Peng W, Li D, Chen H, Liu M
Atherosclerosis27126-35(2018 04)

Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats.
Sithu SD, Malovichko MV, Riggs KA, Wickramasinghe NS, Winner MG, Agarwal A, Hamed-Berair RE, Kalani A, Riggs DW, Bhatnagar A, Srivastava S
JCI insight2(9)(2017 May)

Use of LDL receptor-targeting peptide vectors for
Molino Y, David M, Varini K, Jabès F, Gaudin N, Fortoul A, Bakloul K, Masse M, Bernard A, Drobecq L, Lécorché P, Temsamani J, Jacquot G, Khrestchatisky M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(5)1807-1827(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ldlr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ldlr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03954	NM_175762.2 Latest version!	Rattus norvegicus low density lipoprotein receptor (Ldlr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ldlr ( NM_175762.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_786938.1 Rattus norvegicus low density lipoprotein receptor (Ldlr), mRNA.

Price & Availability↑

CloneID	ORa03954
Clone ID Related Accession (Same CDS sequence)	NM_175762.2
Accession Version	NM_175762.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2640bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	low-density lipoprotein receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X13722.1. On or before Dec 17, 2003 this sequence version replaced XM_217091.1, NM_175762.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X13722.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCACCG CGGATCTGAT GCTACGCTGG GCCATCGCCC TGCTCCTGGC TGCTGCTGGA 
GTTGCAGCAG AAGATTCATG TGGCAAGAAC GAGTTCCAGT GTAGAGACGG AAAATGCATC 
GTCAGCAAGT GGGTGTGTGA CGGCAGCCGC GAGTGCCCGG ATGGCTCCGA TGAGTCCCCT 
GAGACATGCA TGTCTGTCAC CTGTCGATCC GGTGAGTTCA GCTGTGGAGG CCGCGTCAGC 
CGATGCATTC CTGACTCCTG GAGATGTGAT GGGCGGACCG ACTGTGAAAA TGGCTCGGAT 
GAACTAGACT GCTCCCCCAA GACGTGCTCC CTGGATGAGT TCCGCTGCCA GGATGGCAAG 
TGCATCTCCC GGCAGTTTGT GTGTGACCAA GACTGGGATT GCCTGGATGG CTCTGACGAG 
GCCCACTGTG CGGCCACCAC TTGTGGCCCT GCTCACTTCC GCTGCAACTC CTCTTCCTGC 
ATCCCCAGCC TGTGGGCCTG CGACGGGGAC CGGGACTGTG ACGATGGCTC CGATGAGTGG 
CCGCAGAACT GCGGGGCCGA AGACACGGCC GCTGAGGTGG TCAGCAGCCC CTGCTCCTCC 
CTCGAGTTCC ACTGTGGCAG TAGTGAGTGT ATCCATCGCA GCTGGGTCTG TGACGGTGCG 
GCTGACTGCA AGGACAAGTC GGACGAGGAG AACTGCGCGG TGACCACCTG CCGACCTGAC 
GAATTCCAGT GTGCAGATGG CTCCTGTATT CACGGTAGCC GCCAGTGTGA CCGTGAACAT 
GACTGCAAAG ACATGAGCGA CGAGCTTGGC TGCATCAATG TGACCCAGTG CGATGGCCCT 
AACAAATTCA AGTGCCACAG TGGGGAGTGC ATCAGCTTGG ACAAGGTGTG CAACTCCGCC 
CGGGACTGTC GTGACTGGTC GGATGAGCCC ATCAAGGAGT GCAAGACCAA CGAGTGCTTG 
GACAACAATG GTGGCTGTTC CCACATCTGC AAGGACCTCA AGATTGGCTA TGAGTGCCTA 
TGTCCCAGCG GTTTCCGGTT GGTGGACGGC CACCAGTGTG AAGATATTGA CGAGTGTCAG 
GAGCCAGACA CCTGCAGCCA GCTCTGTGTG AACCTGGAGG GCAGCTTCAA GTGCGAGTGT 
CGGGCCGGCT TCCACATGGA CCCTCACACC AGGGTCTGCA AGGCTGTGGG TTCCATAGGG 
TTTCTGCTCT TCACCAACCG CCATGAGGTA CGTAAGATGA CCCTGGACCG CAGCGAGTAT 
ACCAGCCTGA TCCCCAACCT GAAGAATGTG GTGGCGCTGG ACACTGAGGT GGCCAACAAT 
AGAATTTACT GGTCTGACCT GTCCCAGAGA AAGATCTACA GCGCCGTGAT GGACCAGGGC 
ACCAGCTTGT CCTATGATGC CATCATCAGT GGGGACCTGC ACGCCCCTGA CGGGCTGGCG 
GTAGACTGGA TCCATGGCAA CATCTACTGG ACGGATTCAG TTCCGGGCAC TGTTTCCGTG 
GCTGACACCA AGGGTGTCAG GAGGAGAACT CTGTTCCGAG AGAAAGGGTC CAGACCCAGA 
GCCATCGTAG TGGACCCTGT GCATGGCTTC ATGTACTGGA CAGATTGGGG GACACCTGCC 
AAGATCAAGA AAGGGGGTTT GAATGGTGTA GACATCTACT CTCTGGTGAC CGAGGACATC 
CAGTGGCCAA ATGGCATCAC ACTAGATCTT CCCAGTGGCC GCCTCTATTG GGTTGATTCC 
AAACTCCACT CCATCTCCAG CATCGATGTC AATGGGGGTG GTCGGAAAAC CATTTTGGAG 
GATGAGAAGC AGCTAGCTCA CCCCTTCTCC TTGGCCATCT ATGAGGACAA AGTGTATTGG 
ACAGATGTCT TAAATGAAGC CATTTTCAGT GCCAACCGCC TCACGGGTTC AGATGTGAAT 
TTGGTGGCTA AAAACCTCAT GTCCCCGGAG GACATTGTCC TGTTTCACAA CGTCACGCAG 
CCTAGAGGGG TAAACTGGTG TGAGGCAACG GTTCTCCCCA ACGGTGGCTG CCAGTACATG 
TGCCTGCCTG CCCCTCAGAT CAGTGCCCAC TCACCCAAGT TCACCTGCGC TTGCCCTGAT 
GGTATGCTAC TGGCCAAGGA CATGAGGAGC TGCCTCCCAG AAGTCGACAC TGTACCGACC 
ACCCAGGGGA CATCCACCAT TGGGCCTGTG GTCACCACAT CAGCTGCTGT GTCACTGAAG 
CGCAAGGAGG ATCCCTCAGC TACTAGGCAC AAGGAGGATC CCTCAGCTAC TAGGCACAAT 
GAGGATCCCT CAGCTACCAG CACCTCTAGG CAGCCTGGGG ATACCCCAGA GCTCAGCACA 
GTGGAGTCGG TGACAGTGTC CTCCCAAGTC CAAGGTGACA TGGCTGGCAG AGGGGACGAG 
GTGCAGCGGC ACGGTGTGGG GTTCTTGTCC ATCTTCCTCC CCATTGCACT GGTGGCCCTC 
CTTGTCTTCG GAGCCATCCT CCTGTGGAGG AACTGGCGGC TGAGGAACAT TAACAGCATA 
AACTTTGACA ACCCAGTCTA CCAGAAGACC ACGGAGGACG AGATCCACAT TTGCCGCAGC 
CAGGATGGCT ATACCTACCC CTCGAGACAG ATGGTCAGCC TGGAGGATGA TGTGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_786938.1
CDS	154..2793
Translation	MSTADLMLRWAIALLLAAAGVAAEDSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWRCDGRTDCENGSDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCAATTCGPAHFRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGAEDTAAEVVSSPCSSLEFHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKDLKIGYECLCPSGFRLVDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVCKAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQGTSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIVLFHNVTQPRGVNWCEATVLPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGTSTIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHNEDPSATSTSRQPGDTPELSTVESVTVSSQVQGDMAGRGDEVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKTTEDEIHICRSQDGYTYPSRQMVSLEDDVA

Target ORF information:

RefSeq Version	NM_175762.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus low density lipoprotein receptor (Ldlr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175762.2

ORF Insert Sequence:

ATGAGCACCG CGGATCTGAT GCTACGCTGG GCCATCGCCC TGCTCCTGGC TGCTGCTGGA 
GTTGCAGCAG AAGATTCATG TGGCAAGAAC GAGTTCCAGT GTAGAGACGG AAAATGCATC 
GTCAGCAAGT GGGTGTGTGA CGGCAGCCGC GAGTGCCCGG ATGGCTCCGA TGAGTCCCCT 
GAGACATGCA TGTCTGTCAC CTGTCGATCC GGTGAGTTCA GCTGTGGAGG CCGCGTCAGC 
CGATGCATTC CTGACTCCTG GAGATGTGAT GGGCGGACCG ACTGTGAAAA TGGCTCGGAT 
GAACTAGACT GCTCCCCCAA GACGTGCTCC CTGGATGAGT TCCGCTGCCA GGATGGCAAG 
TGCATCTCCC GGCAGTTTGT GTGTGACCAA GACTGGGATT GCCTGGATGG CTCTGACGAG 
GCCCACTGTG CGGCCACCAC TTGTGGCCCT GCTCACTTCC GCTGCAACTC CTCTTCCTGC 
ATCCCCAGCC TGTGGGCCTG CGACGGGGAC CGGGACTGTG ACGATGGCTC CGATGAGTGG 
CCGCAGAACT GCGGGGCCGA AGACACGGCC GCTGAGGTGG TCAGCAGCCC CTGCTCCTCC 
CTCGAGTTCC ACTGTGGCAG TAGTGAGTGT ATCCATCGCA GCTGGGTCTG TGACGGTGCG 
GCTGACTGCA AGGACAAGTC GGACGAGGAG AACTGCGCGG TGACCACCTG CCGACCTGAC 
GAATTCCAGT GTGCAGATGG CTCCTGTATT CACGGTAGCC GCCAGTGTGA CCGTGAACAT 
GACTGCAAAG ACATGAGCGA CGAGCTTGGC TGCATCAATG TGACCCAGTG CGATGGCCCT 
AACAAATTCA AGTGCCACAG TGGGGAGTGC ATCAGCTTGG ACAAGGTGTG CAACTCCGCC 
CGGGACTGTC GTGACTGGTC GGATGAGCCC ATCAAGGAGT GCAAGACCAA CGAGTGCTTG 
GACAACAATG GTGGCTGTTC CCACATCTGC AAGGACCTCA AGATTGGCTA TGAGTGCCTA 
TGTCCCAGCG GTTTCCGGTT GGTGGACGGC CACCAGTGTG AAGATATTGA CGAGTGTCAG 
GAGCCAGACA CCTGCAGCCA GCTCTGTGTG AACCTGGAGG GCAGCTTCAA GTGCGAGTGT 
CGGGCCGGCT TCCACATGGA CCCTCACACC AGGGTCTGCA AGGCTGTGGG TTCCATAGGG 
TTTCTGCTCT TCACCAACCG CCATGAGGTA CGTAAGATGA CCCTGGACCG CAGCGAGTAT 
ACCAGCCTGA TCCCCAACCT GAAGAATGTG GTGGCGCTGG ACACTGAGGT GGCCAACAAT 
AGAATTTACT GGTCTGACCT GTCCCAGAGA AAGATCTACA GCGCCGTGAT GGACCAGGGC 
ACCAGCTTGT CCTATGATGC CATCATCAGT GGGGACCTGC ACGCCCCTGA CGGGCTGGCG 
GTAGACTGGA TCCATGGCAA CATCTACTGG ACGGATTCAG TTCCGGGCAC TGTTTCCGTG 
GCTGACACCA AGGGTGTCAG GAGGAGAACT CTGTTCCGAG AGAAAGGGTC CAGACCCAGA 
GCCATCGTAG TGGACCCTGT GCATGGCTTC ATGTACTGGA CAGATTGGGG GACACCTGCC 
AAGATCAAGA AAGGGGGTTT GAATGGTGTA GACATCTACT CTCTGGTGAC CGAGGACATC 
CAGTGGCCAA ATGGCATCAC ACTAGATCTT CCCAGTGGCC GCCTCTATTG GGTTGATTCC 
AAACTCCACT CCATCTCCAG CATCGATGTC AATGGGGGTG GTCGGAAAAC CATTTTGGAG 
GATGAGAAGC AGCTAGCTCA CCCCTTCTCC TTGGCCATCT ATGAGGACAA AGTGTATTGG 
ACAGATGTCT TAAATGAAGC CATTTTCAGT GCCAACCGCC TCACGGGTTC AGATGTGAAT 
TTGGTGGCTA AAAACCTCAT GTCCCCGGAG GACATTGTCC TGTTTCACAA CGTCACGCAG 
CCTAGAGGGG TAAACTGGTG TGAGGCAACG GTTCTCCCCA ACGGTGGCTG CCAGTACATG 
TGCCTGCCTG CCCCTCAGAT CAGTGCCCAC TCACCCAAGT TCACCTGCGC TTGCCCTGAT 
GGTATGCTAC TGGCCAAGGA CATGAGGAGC TGCCTCCCAG AAGTCGACAC TGTACCGACC 
ACCCAGGGGA CATCCACCAT TGGGCCTGTG GTCACCACAT CAGCTGCTGT GTCACTGAAG 
CGCAAGGAGG ATCCCTCAGC TACTAGGCAC AAGGAGGATC CCTCAGCTAC TAGGCACAAT 
GAGGATCCCT CAGCTACCAG CACCTCTAGG CAGCCTGGGG ATACCCCAGA GCTCAGCACA 
GTGGAGTCGG TGACAGTGTC CTCCCAAGTC CAAGGTGACA TGGCTGGCAG AGGGGACGAG 
GTGCAGCGGC ACGGTGTGGG GTTCTTGTCC ATCTTCCTCC CCATTGCACT GGTGGCCCTC 
CTTGTCTTCG GAGCCATCCT CCTGTGGAGG AACTGGCGGC TGAGGAACAT TAACAGCATA 
AACTTTGACA ACCCAGTCTA CCAGAAGACC ACGGAGGACG AGATCCACAT TTGCCGCAGC 
CAGGATGGCT ATACCTACCC CTCGAGACAG ATGGTCAGCC TGGAGGATGA TGTGGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Up-regulation of PCSK9 gene expression and diminished level of LDL-receptor in rat liver as a potential cause of post-lipectomy hypercholesterolemia.
Molecular and cellular biochemistry455(1-2)207-217(2019 May)
Dettlaff-Pokora A,Sucajtys-Szulc E,Sledzinski T

Exercise training increased gene expression of LDL-R and PCSK9 in intestine: link to transintestinal cholesterol excretion.
General physiology and biophysics37(3)309-317(2018 May)
Farahnak Z,Chapados N,Lavoie JM

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.
Atherosclerosis27126-35(2018 04)
Zhao Y,Yang Y,Xing R,Cui X,Xiao Y,Xie L,You P,Wang T,Zeng L,Peng W,Li D,Chen H,Liu M

Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats.
JCI insight2(9)(2017 May)
Sithu SD,Malovichko MV,Riggs KA,Wickramasinghe NS,Winner MG,Agarwal A,Hamed-Berair RE,Kalani A,Riggs DW,Bhatnagar A,Srivastava S

Use of LDL receptor-targeting peptide vectors for
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(5)1807-1827(2017 05)
Molino Y,David M,Varini K,Jabès F,Gaudin N,Fortoul A,Bakloul K,Masse M,Bernard A,Drobecq L,Lécorché P,Temsamani J,Jacquot G,Khrestchatisky M

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Ldlr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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