Sdhb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sdhb
Entrez Gene ID	298596
Full Name	succinate dehydrogenase complex iron sulfur subunit B
General protein information	Preferred Names succinate dehydrogenase complex iron sulfur subunit B Names succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial ip iron-sulfur subunit of complex II succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
NM_001100539.1	NP_001094009.1	succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0E00683g	XP_453977.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007309	XP_308512.4
Eremothecium gossypii	AGOS_ACL065C	NP_983339.1
Macaca mulatta (Rhesus monkey)	SDHB	XP_001088349.1
Saccharomyces cerevisiae (baker's yeast)	SDH2	NP_013059.1
Neurospora crassa	NCU00959	XP_965152.1
Bos taurus (cattle)	SDHB	NP_001035573.1
Oryza sativa (rice)	Os08g0120000	NP_001060876.1
Homo sapiens (human)	SDHB	NP_002991.2
Mus musculus (house mouse)	Sdhb	NP_075863.2
Rattus norvegicus (Norway rat)	Sdhb	NP_001094009.1
Danio rerio (zebrafish)	sdhb	NP_001092210.1
Drosophila melanogaster (fruit fly)	SdhB	NP_477101.1
Arabidopsis thaliana (thale cress)	SDH2-1	NP_001118718.1
Arabidopsis thaliana (thale cress)	SDH2-2	NP_198881.1
Gallus gallus (chicken)	SDHB	XP_004950147.1
Xenopus tropicalis (tropical clawed frog)	sdhb	NP_001120000.1
Magnaporthe oryzae (rice blast fungus)	MGG_00167	XP_003718958.1
Schizosaccharomyces pombe (fission yeast)	sdh2	NP_593530.2
Pan troglodytes (chimpanzee)	SDHB	XP_003949355.1
Canis lupus familiaris (dog)	SDHB	NP_001239146.1
Caenorhabditis elegans (roundworm)	sdhb-1	NP_495992.1

Gene Ontology
Bibliography

Related articles in PubMed

Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage.
Peralta S, Torraco A, Wenz T, Garcia S, Diaz F, Moraes CT
Human molecular genetics23(6)1399-412(2014 Mar)

SDH mutations in cancer.
Bardella C, Pollard PJ, Tomlinson I
Biochimica et biophysica acta1807(11)1432-43(2011 Nov)

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Yang H, Brosel S, Acin-Perez R, Slavkovich V, Nishino I, Khan R, Goldberg IJ, Graziano J, Manfredi G, Schon EA
Human molecular genetics19(1)170-80(2010 Jan)

Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions.
Forner F, Kumar C, Luber CA, Fromme T, Klingenspor M, Mann M
Cell metabolism10(4)324-35(2009 Oct)

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells.
Cervera AM, Bayley JP, Devilee P, McCreath KJ
Molecular cancer889(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sdhb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sdhb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12023	NM_001100539.1 Latest version!	Rattus norvegicus succinate dehydrogenase complex iron sulfur subunit B (Sdhb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sdhb ( NM_001100539.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094009.1 Rattus norvegicus succinate dehydrogenase complex iron sulfur subunit B (Sdhb), mRNA.

Price & Availability↑

CloneID	ORa12023
Clone ID Related Accession (Same CDS sequence)	NM_001100539.1
Accession Version	NM_001100539.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550505600000
Organism	Rattus norvegicus(Norway rat)
Product	succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC158620.1. On or before Oct 24, 2008 this sequence version replaced XM_216558.3, XM_001071846.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC158620.1, FQ215046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCGGCGG TGGTCGGGGT CTCCTTGAAG CGCGGCTTTT CGGCTACGGC TCTCGGCAGA 
GTCGGCCTGC AGTTTCAGGC CTGCCGAGAG GCACAGACAG CTGCTGCTGC AGCTCCCAGA 
ATCAAAACCT TCGCCATTTA CCGATGGGAC CCGGACAAGG CTGGAGATAA ACCTCGAATG 
CAGACATACA AGGTGGATCT GAATAAGTGT GGACCGATGG TGCTGGATGC TCTAATCAAG 
ATTAAGAATG AAATCGATTC TACTTTGACC TTCCGAAGAT CATGCAGAGA AGGGATCTGT 
GGCTCTTGTG CCATGAACAT CAACGGAGGC AACACGCTGG CATGCACGCG CAGGATCGAC 
ACAGACCTTG GCAAAGTCTC GAAAATATAC CCTCTTCCGC ATATGTATGT GATCAAGGAT 
CTAGTCCCTG ACTTGAGTAA CTTCTATGCA CAATACAAAT CCATTGAGCC CTATCTGAAG 
AAGAAGGATG AGTCCCAGGA GGGCAAGCAA CAGTATCTGC AATCCATCGA GGACCGGGAG 
AAGCTGGACG GATTGTATGA GTGCATCCTG TGTGCCTGCT GCAGCACCAG CTGTCCCAGT 
TACTGGTGGA ACGGAGACAA GTACCTGGGG CCTGCAGTTC TCATGCAGGC TTATCGCTGG 
ATGATCGACT CCAGAGATGA ATTCACAGAG GAGCGCCTGG CCAAGCTGCA GGACCCCTTC 
TCTCTCTACC GCTGCCACAC CATCATGAAC TGTACACAGA CCTGCCCCAA GGGTCTGAAT 
CCAGGAAAAG CAATTGCAGA AATCAAGAAG ATGATGGCGA CCTACAAGGA GAAGCGGGCA 
TTGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094009.1
CDS	21..869
Translation	MAAVVGVSLKRGFSATALGRVGLQFQACREAQTAAAAAPRIKTFAIYRWDPDKAGDKPRMQTYKVDLNKCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLGKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDEFTEERLAKLQDPFSLYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA

Target ORF information:

RefSeq Version	NM_001100539.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus succinate dehydrogenase complex iron sulfur subunit B (Sdhb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100539.1

ORF Insert Sequence:

ATGGCGGCGG TGGTCGGGGT CTCCTTGAAG CGCGGCTTTT CGGCTACGGC TCTCGGCAGA 
GTCGGCCTGC AGTTTCAGGC CTGCCGAGAG GCACAGACAG CTGCTGCTGC AGCTCCCAGA 
ATCAAAACCT TCGCCATTTA CCGATGGGAC CCGGACAAGG CTGGAGATAA ACCTCGAATG 
CAGACATACA AGGTGGATCT GAATAAGTGT GGACCGATGG TGCTGGATGC TCTAATCAAG 
ATTAAGAATG AAATCGATTC TACTTTGACC TTCCGAAGAT CATGCAGAGA AGGGATCTGT 
GGCTCTTGTG CCATGAACAT CAACGGAGGC AACACGCTGG CATGCACGCG CAGGATCGAC 
ACAGACCTTG GCAAAGTCTC GAAAATATAC CCTCTTCCGC ATATGTATGT GATCAAGGAT 
CTAGTCCCTG ACTTGAGTAA CTTCTATGCA CAATACAAAT CCATTGAGCC CTATCTGAAG 
AAGAAGGATG AGTCCCAGGA GGGCAAGCAA CAGTATCTGC AATCCATCGA GGACCGGGAG 
AAGCTGGACG GATTGTATGA GTGCATCCTG TGTGCCTGCT GCAGCACCAG CTGTCCCAGT 
TACTGGTGGA ACGGAGACAA GTACCTGGGG CCTGCAGTTC TCATGCAGGC TTATCGCTGG 
ATGATCGACT CCAGAGATGA ATTCACAGAG GAGCGCCTGG CCAAGCTGCA GGACCCCTTC 
TCTCTCTACC GCTGCCACAC CATCATGAAC TGTACACAGA CCTGCCCCAA GGGTCTGAAT 
CCAGGAAAAG CAATTGCAGA AATCAAGAAG ATGATGGCGA CCTACAAGGA GAAGCGGGCA 
TTGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage.
Human molecular genetics23(6)1399-412(2014 Mar)
Peralta S,Torraco A,Wenz T,Garcia S,Diaz F,Moraes CT

SDH mutations in cancer.
Biochimica et biophysica acta1807(11)1432-43(2011 Nov)
Bardella C,Pollard PJ,Tomlinson I

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Human molecular genetics19(1)170-80(2010 Jan)
Yang H,Brosel S,Acin-Perez R,Slavkovich V,Nishino I,Khan R,Goldberg IJ,Graziano J,Manfredi G,Schon EA

Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions.
Cell metabolism10(4)324-35(2009 Oct)
Forner F,Kumar C,Luber CA,Fromme T,Klingenspor M,Mann M

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells.
Molecular cancer889(2009 Oct)
Cervera AM,Bayley JP,Devilee P,McCreath KJ

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Sdhb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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