S1pr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	S1pr1
Entrez Gene ID	29733
Full Name	sphingosine-1-phosphate receptor 1
Synonyms	Edg1
General protein information	Preferred Names sphingosine-1-phosphate receptor 1 Names sphingosine 1-phosphate receptor 1 EDG1 (Edg1) S1P receptor 1 S1P receptor Edg-1 S1P1 endothelial differentiation G-protein coupled receptor 1 endothelial differentiation sphingolipid G-protein-coupled receptor 1 sphingosine 1-phosphate receptor Edg-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q41
Summary	G-protein-coupled receptor homolog; may mediate neurotransmission and endothelial cell differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008761459.2	XP_008759681.1	sphingosine 1-phosphate receptor 1 isoform X1
NM_017301.2	NP_058997.1	sphingosine 1-phosphate receptor 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	S1PR1	NP_001013603.2
Xenopus tropicalis (tropical clawed frog)	s1pr1	NP_001072893.1
Pan troglodytes (chimpanzee)	S1PR1	XP_001138743.2
Mus musculus (house mouse)	S1pr1	NP_031927.2
Gallus gallus (chicken)	S1PR1	XP_004936607.1
Homo sapiens (human)	S1PR1	NP_001391.2
Canis lupus familiaris (dog)	S1PR1	XP_005621915.1
Rattus norvegicus (Norway rat)	S1pr1	NP_058997.1
Macaca mulatta (Rhesus monkey)	S1PR1	XP_001107778.2
Danio rerio (zebrafish)	s1pr1	NP_571766.2

Gene Ontology
Bibliography

Related articles in PubMed

Testosterone regulates the expression and functional activity of sphingosine-1-phosphate receptors in the rat corpus cavernosum.
Yin J, Guo YM, Chen P, Xiao H, Wang XH, DiSanto ME, Zhang XH
Journal of cellular and molecular medicine22(3)1507-1516(2018 03)

The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices.
St-Cyr Giguère F, Attiori Essis S, Chagniel L, Germain M, Cyr M, Massicotte G
Brain research165851-59(2017 03)

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization.
Lee MH, Appleton KM, El-Shewy HM, Sorci-Thomas MG, Thomas MJ, Lopes-Virella MF, Luttrell LM, Hammad SM, Klein RL
Journal of lipid research58(2)325-338(2017 02)

The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis.
Al-Jarallah A, Oriowo M
PloS one12(5)e0170792(2017)

Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway.
Ye Y, Zhao Z, Xu H, Zhang X, Su X, Yang Y, Yu X, He X
Neural plasticity20168072156(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following S1pr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S1pr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12443	NM_017301.2 Latest version!	Rattus norvegicus sphingosine-1-phosphate receptor 1 (S1pr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa12443	XM_008761459.2 Latest version!	Rattus norvegicus sphingosine-1-phosphate receptor 1 (S1pr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S1pr1 ( NM_017301.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058997.1 Rattus norvegicus sphingosine-1-phosphate receptor 1 (S1pr1), mRNA.

Price & Availability↑

CloneID	ORa12443
Clone ID Related Accession (Same CDS sequence)	XM_008761459.2 , NM_017301.2
Accession Version	NM_017301.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570896000000
Organism	Rattus norvegicus(Norway rat)
Product	sphingosine 1-phosphate receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097938.1. On Jun 12, 2005 this sequence version replaced NM_017301.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC097938.1, FQ120434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTCCT CCACCAGCAT CCCAGTGGTT AAGGCTCTCC GCAGCCAAGT CTCCGACTAT 
GGCAACTATG ATATCATAGT CCGGCATTAC AACTACACAG GCAAGCTGAA CATCGGAGTG 
GAGAAGGACC ATGGCATTAA ACTGACTTCA GTGGTGTTCA TTCTCATCTG CTGCTTGATC 
ATCCTAGAGA ATATATTTGT CTTGCTAACT ATTTGGAAAA CCAAGAAGTT CCACCGGCCC 
ATGTACTATT TCATAGGCAA CCTAGCCCTC TCGGACCTGT TAGCAGGAGT GGCTTACACA 
GCTAACCTGC TGTTGTCTGG GGCCACCACC TACAAGCTCA CACCTGCCCA GTGGTTTCTG 
CGGGAAGGAA GTATGTTTGT GGCTCTGTCT GCCTCAGTCT TCAGCCTCCT TGCTATCGCC 
ATTGAGCGCT ACATCACCAT GCTGAAGATG AAACTACACA ACGGCAGCAA CAGCTCGCGC 
TCCTTTCTGC TGATCAGTGC CTGCTGGGTC ATCTCCCTCA TCCTGGGTGG GCTGCCCATC 
ATGGGCTGGA ACTGCATCAG CTCGCTGTCC AGCTGCTCCA CCGTGCTCCC GCTCTACCAC 
AAGCACTATA TTCTCTTCTG CACCACCGTC TTCACCCTGC TCCTGCTTTC CATCGTCATC 
CTCTACTGCA GGATCTACTC CTTGGTGAGG ACTCGAAGCC GCCGCCTGAC CTTCCGCAAG 
AACATCTCCA AGGCCAGCCG CAGTTCCGAG AAGTCTCTGG CCTTGCTGAA GACAGTGATC 
ATTGTCCTGA GTGTCTTCAT TGCCTGCTGG GCCCCTCTCT TCATCCTACT ACTTTTAGAT 
GTGGGGTGCA AGGCGAAGAC CTGTGACATC CTGTACAAAG CAGAGTACTT CCTGGTTCTG 
GCTGTGCTGA ACTCAGGTAC CAACCCCATC ATCTACACTC TGACCAATAA GGAGATGCGC 
CGGGCCTTCA TCAGGATCAT ATCTTGTTGC AAATGCCCCA ACGGAGACTC CGCTGGCAAA 
TTCAAGAGGC CCATCATCCC GGGCATGGAA TTTAGCCGCA GCAAATCAGA CAACTCCTCC 
CACCCCCAGA AGGATGATGG GGACAATCCA GAGACCATTA TGTCTTCTGG AAACGTCAAT 
TCTTCTTCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058997.1
CDS	227..1378
Translation	MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS

Target ORF information:

RefSeq Version	NM_017301.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sphingosine-1-phosphate receptor 1 (S1pr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017301.2

ORF Insert Sequence:

ATGGTGTCCT CCACCAGCAT CCCAGTGGTT AAGGCTCTCC GCAGCCAAGT CTCCGACTAT 
GGCAACTATG ATATCATAGT CCGGCATTAC AACTACACAG GCAAGCTGAA CATCGGAGTG 
GAGAAGGACC ATGGCATTAA ACTGACTTCA GTGGTGTTCA TTCTCATCTG CTGCTTGATC 
ATCCTAGAGA ATATATTTGT CTTGCTAACT ATTTGGAAAA CCAAGAAGTT CCACCGGCCC 
ATGTACTATT TCATAGGCAA CCTAGCCCTC TCGGACCTGT TAGCAGGAGT GGCTTACACA 
GCTAACCTGC TGTTGTCTGG GGCCACCACC TACAAGCTCA CACCTGCCCA GTGGTTTCTG 
CGGGAAGGAA GTATGTTTGT GGCTCTGTCT GCCTCAGTCT TCAGCCTCCT TGCTATCGCC 
ATTGAGCGCT ACATCACCAT GCTGAAGATG AAACTACACA ACGGCAGCAA CAGCTCGCGC 
TCCTTTCTGC TGATCAGTGC CTGCTGGGTC ATCTCCCTCA TCCTGGGTGG GCTGCCCATC 
ATGGGCTGGA ACTGCATCAG CTCGCTGTCC AGCTGCTCCA CCGTGCTCCC GCTCTACCAC 
AAGCACTATA TTCTCTTCTG CACCACCGTC TTCACCCTGC TCCTGCTTTC CATCGTCATC 
CTCTACTGCA GGATCTACTC CTTGGTGAGG ACTCGAAGCC GCCGCCTGAC CTTCCGCAAG 
AACATCTCCA AGGCCAGCCG CAGTTCCGAG AAGTCTCTGG CCTTGCTGAA GACAGTGATC 
ATTGTCCTGA GTGTCTTCAT TGCCTGCTGG GCCCCTCTCT TCATCCTACT ACTTTTAGAT 
GTGGGGTGCA AGGCGAAGAC CTGTGACATC CTGTACAAAG CAGAGTACTT CCTGGTTCTG 
GCTGTGCTGA ACTCAGGTAC CAACCCCATC ATCTACACTC TGACCAATAA GGAGATGCGC 
CGGGCCTTCA TCAGGATCAT ATCTTGTTGC AAATGCCCCA ACGGAGACTC CGCTGGCAAA 
TTCAAGAGGC CCATCATCCC GGGCATGGAA TTTAGCCGCA GCAAATCAGA CAACTCCTCC 
CACCCCCAGA AGGATGATGG GGACAATCCA GAGACCATTA TGTCTTCTGG AAACGTCAAT 
TCTTCTTCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S1pr1 ( XM_008761459.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008759681.1 Rattus norvegicus sphingosine-1-phosphate receptor 1 (S1pr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12443
Clone ID Related Accession (Same CDS sequence)	XM_008761459.2 , NM_017301.2
Accession Version	XM_008761459.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	sphingosine 1-phosphate receptor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008761459.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTCCT CCACCAGCAT CCCAGTGGTT AAGGCTCTCC GCAGCCAAGT CTCCGACTAT 
GGCAACTATG ATATCATAGT CCGGCATTAC AACTACACAG GCAAGCTGAA CATCGGAGTG 
GAGAAGGACC ATGGCATTAA ACTGACTTCA GTGGTGTTCA TTCTCATCTG CTGCTTGATC 
ATCCTAGAGA ATATATTTGT CTTGCTAACT ATTTGGAAAA CCAAGAAGTT CCACCGGCCC 
ATGTACTATT TCATAGGCAA CCTAGCCCTC TCGGACCTGT TAGCAGGAGT GGCTTACACA 
GCTAACCTGC TGTTGTCTGG GGCCACCACC TACAAGCTCA CACCTGCCCA GTGGTTTCTG 
CGGGAAGGAA GTATGTTTGT GGCTCTGTCT GCCTCAGTCT TCAGCCTCCT TGCTATCGCC 
ATTGAGCGCT ACATCACCAT GCTGAAGATG AAACTACACA ACGGCAGCAA CAGCTCGCGC 
TCCTTTCTGC TGATCAGTGC CTGCTGGGTC ATCTCCCTCA TCCTGGGTGG GCTGCCCATC 
ATGGGCTGGA ACTGCATCAG CTCGCTGTCC AGCTGCTCCA CCGTGCTCCC GCTCTACCAC 
AAGCACTATA TTCTCTTCTG CACCACCGTC TTCACCCTGC TCCTGCTTTC CATCGTCATC 
CTCTACTGCA GGATCTACTC CTTGGTGAGG ACTCGAAGCC GCCGCCTGAC CTTCCGCAAG 
AACATCTCCA AGGCCAGCCG CAGTTCCGAG AAGTCTCTGG CCTTGCTGAA GACAGTGATC 
ATTGTCCTGA GTGTCTTCAT TGCCTGCTGG GCCCCTCTCT TCATCCTACT ACTTTTAGAT 
GTGGGGTGCA AGGCGAAGAC CTGTGACATC CTGTACAAAG CAGAGTACTT CCTGGTTCTG 
GCTGTGCTGA ACTCAGGTAC CAACCCCATC ATCTACACTC TGACCAATAA GGAGATGCGC 
CGGGCCTTCA TCAGGATCAT ATCTTGTTGC AAATGCCCCA ACGGAGACTC CGCTGGCAAA 
TTCAAGAGGC CCATCATCCC GGGCATGGAA TTTAGCCGCA GCAAATCAGA CAACTCCTCC 
CACCCCCAGA AGGATGATGG GGACAATCCA GAGACCATTA TGTCTTCTGG AAACGTCAAT 
TCTTCTTCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008759681.1
CDS	1386..2537
Translation	MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIMGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSHPQKDDGDNPETIMSSGNVNSSS

Target ORF information:

RefSeq Version	XM_008761459.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sphingosine-1-phosphate receptor 1 (S1pr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008761459.2

ORF Insert Sequence:

ATGGTGTCCT CCACCAGCAT CCCAGTGGTT AAGGCTCTCC GCAGCCAAGT CTCCGACTAT 
GGCAACTATG ATATCATAGT CCGGCATTAC AACTACACAG GCAAGCTGAA CATCGGAGTG 
GAGAAGGACC ATGGCATTAA ACTGACTTCA GTGGTGTTCA TTCTCATCTG CTGCTTGATC 
ATCCTAGAGA ATATATTTGT CTTGCTAACT ATTTGGAAAA CCAAGAAGTT CCACCGGCCC 
ATGTACTATT TCATAGGCAA CCTAGCCCTC TCGGACCTGT TAGCAGGAGT GGCTTACACA 
GCTAACCTGC TGTTGTCTGG GGCCACCACC TACAAGCTCA CACCTGCCCA GTGGTTTCTG 
CGGGAAGGAA GTATGTTTGT GGCTCTGTCT GCCTCAGTCT TCAGCCTCCT TGCTATCGCC 
ATTGAGCGCT ACATCACCAT GCTGAAGATG AAACTACACA ACGGCAGCAA CAGCTCGCGC 
TCCTTTCTGC TGATCAGTGC CTGCTGGGTC ATCTCCCTCA TCCTGGGTGG GCTGCCCATC 
ATGGGCTGGA ACTGCATCAG CTCGCTGTCC AGCTGCTCCA CCGTGCTCCC GCTCTACCAC 
AAGCACTATA TTCTCTTCTG CACCACCGTC TTCACCCTGC TCCTGCTTTC CATCGTCATC 
CTCTACTGCA GGATCTACTC CTTGGTGAGG ACTCGAAGCC GCCGCCTGAC CTTCCGCAAG 
AACATCTCCA AGGCCAGCCG CAGTTCCGAG AAGTCTCTGG CCTTGCTGAA GACAGTGATC 
ATTGTCCTGA GTGTCTTCAT TGCCTGCTGG GCCCCTCTCT TCATCCTACT ACTTTTAGAT 
GTGGGGTGCA AGGCGAAGAC CTGTGACATC CTGTACAAAG CAGAGTACTT CCTGGTTCTG 
GCTGTGCTGA ACTCAGGTAC CAACCCCATC ATCTACACTC TGACCAATAA GGAGATGCGC 
CGGGCCTTCA TCAGGATCAT ATCTTGTTGC AAATGCCCCA ACGGAGACTC CGCTGGCAAA 
TTCAAGAGGC CCATCATCCC GGGCATGGAA TTTAGCCGCA GCAAATCAGA CAACTCCTCC 
CACCCCCAGA AGGATGATGG GGACAATCCA GAGACCATTA TGTCTTCTGG AAACGTCAAT 
TCTTCTTCTT AA