| Gene Symbol | S1pr1 |
| Entrez Gene ID | 13609 |
| Full Name | sphingosine-1-phosphate receptor 1 |
| Synonyms | AI849002,Edg1,Lpb1,S1p,S1p1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]. |
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S1pr1 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following S1pr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S1pr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu20424 Clone ID Related Accession (Same CDS sequence) NM_007901.5 Accession Version NM_007901.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1149bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577030400000 Organism Mus musculus(house mouse) Product sphingosine 1-phosphate receptor 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC126932.4 and AK004591.2. On Jan 22, 2010 this sequence version replaced NM_007901.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004591.2, AK138316.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141ATGGTGTCCA CTAGCATCCC GGAGGTTAAA GCTCTCCGCA GCTCAGTCTC TGACTATGGG
AACTATGATA TCATAGTCCG GCATTACAAC TACACAGGCA AGTTGAACAT CGGGGCGGAG
AAGGACCATG GCATTAAACT GACTTCAGTG GTGTTCATTC TCATCTGCTG CTTCATCATC
CTAGAGAATA TATTTGTCTT GCTAACTATT TGGAAAACCA AGAAGTTCCA CCGGCCCATG
TACTATTTCA TAGGCAACCT AGCCCTCTCG GACCTATTAG CAGGCGTGGC TTACACAGCT
AACCTGCTGT TGTCTGGGGC CACCACTTAC AAGCTCACAC CTGCCCAGTG GTTTCTGCGG
GAAGGGAGTA TGTTTGTGGC TCTCTCTGCA TCAGTCTTCA GCCTCCTTGC CATCGCCATT
GAGCGCTACA TCACCATGCT GAAGATGAAA CTACACAACG GGAGCAACAG CTCGCGCTCC
TTTCTGCTGA TCAGCGCCTG CTGGGTCATC TCCCTCATCC TGGGGGGCCT GCCCATCATG
GGCTGGAACT GCATCAGCTC GCTGTCTAGC TGCTCCACCG TGCTCCCGCT CTACCACAAG
CACTATATTC TCTTCTGCAC CACCGTCTTC ACTCTGCTCC TGCTTTCCAT CGTCATCCTC
TACTGCAGGA TCTACTCCTT GGTCAGGACT CGAAGCCGCC GCCTGACCTT CCGCAAGAAC
ATCTCCAAGG CCAGTCGCAG TTCTGAGAAG TCTCTGGCCT TGCTGAAGAC GGTGATCATT
GTCCTGAGTG TCTTCATTGC CTGCTGGGCC CCTCTCTTCA TCCTACTACT GTTAGATGTG
GGCTGCAAGG CGAAGACCTG TGACATCCTG TACAAAGCAG AGTACTTCCT GGTTCTGGCT
GTGCTGAACT CAGGTACCAA CCCCATCATC TACACTCTGA CCAACAAGGA GATGCGCCGG
GCCTTCATCC GGATCGTATC TTGTTGCAAA TGCCCCAACG GAGACTCTGC TGGCAAATTC
AAGAGGCCCA TCATCCCAGG CATGGAATTT AGCCGCAGCA AATCAGACAA CTCCTCTCAC
CCCCAGAAGG ACGATGGGGA CAACCCAGAG ACCATTATGT CGTCTGGAAA CGTCAATTCT
TCTTCCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_031927.2 CDS 519..1667 Translation 
Target ORF information:
RefSeq Version NM_007901.5 Organism Mus musculus(house mouse) Definition Mus musculus sphingosine-1-phosphate receptor 1 (S1pr1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_007901.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141ATGGTGTCCA CTAGCATCCC GGAGGTTAAA GCTCTCCGCA GCTCAGTCTC TGACTATGGG
AACTATGATA TCATAGTCCG GCATTACAAC TACACAGGCA AGTTGAACAT CGGGGCGGAG
AAGGACCATG GCATTAAACT GACTTCAGTG GTGTTCATTC TCATCTGCTG CTTCATCATC
CTAGAGAATA TATTTGTCTT GCTAACTATT TGGAAAACCA AGAAGTTCCA CCGGCCCATG
TACTATTTCA TAGGCAACCT AGCCCTCTCG GACCTATTAG CAGGCGTGGC TTACACAGCT
AACCTGCTGT TGTCTGGGGC CACCACTTAC AAGCTCACAC CTGCCCAGTG GTTTCTGCGG
GAAGGGAGTA TGTTTGTGGC TCTCTCTGCA TCAGTCTTCA GCCTCCTTGC CATCGCCATT
GAGCGCTACA TCACCATGCT GAAGATGAAA CTACACAACG GGAGCAACAG CTCGCGCTCC
TTTCTGCTGA TCAGCGCCTG CTGGGTCATC TCCCTCATCC TGGGGGGCCT GCCCATCATG
GGCTGGAACT GCATCAGCTC GCTGTCTAGC TGCTCCACCG TGCTCCCGCT CTACCACAAG
CACTATATTC TCTTCTGCAC CACCGTCTTC ACTCTGCTCC TGCTTTCCAT CGTCATCCTC
TACTGCAGGA TCTACTCCTT GGTCAGGACT CGAAGCCGCC GCCTGACCTT CCGCAAGAAC
ATCTCCAAGG CCAGTCGCAG TTCTGAGAAG TCTCTGGCCT TGCTGAAGAC GGTGATCATT
GTCCTGAGTG TCTTCATTGC CTGCTGGGCC CCTCTCTTCA TCCTACTACT GTTAGATGTG
GGCTGCAAGG CGAAGACCTG TGACATCCTG TACAAAGCAG AGTACTTCCT GGTTCTGGCT
GTGCTGAACT CAGGTACCAA CCCCATCATC TACACTCTGA CCAACAAGGA GATGCGCCGG
GCCTTCATCC GGATCGTATC TTGTTGCAAA TGCCCCAACG GAGACTCTGC TGGCAAATTC
AAGAGGCCCA TCATCCCAGG CATGGAATTT AGCCGCAGCA AATCAGACAA CTCCTCTCAC
CCCCAGAAGG ACGATGGGGA CAACCCAGAG ACCATTATGT CGTCTGGAAA CGTCAATTCT
TCTTCCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cells.
Biochimica et biophysica acta. General subjects1863(6)1079-1087(2019 06)
Shi X,Wang W,Li J,Wang T,Lin Y,Huang S,Kuver A,Chen C,Hla T,Li X,Dai K
Sphigosine-1-phosphate receptor 1 promotes neointimal hyperplasia in a mouse model of carotid artery injury.
Biochemical and biophysical research communications511(1)179-184(2019 03)
Kitano T,Usui S,Takashima SI,Inoue O,Goten C,Nomura A,Yoshioka K,Okajima M,Kaneko S,Takuwa Y,Takamura M
Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways.
Molecular medicine reports19(2)1272-1283(2019 Feb)
Wang M,Luo GH,Liu H,Zhang YP,Wang B,Di DM,Zhan XH,Yu Y,Yao S,Zhang XY,Xu N
Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation.
The American journal of pathology188(12)2811-2825(2018 12)
Montrose DC,Zhou XK,McNally EM,Sue E,Wang H,Nishiguchi R,Verma A,Elemento O,Simpson KW,Yang P,Hla T,Dannenberg AJ
A Functionally Defined
eNeuro5(5)(2018 Sep-Oct)
Groves A,Kihara Y,Jonnalagadda D,Rivera R,Kennedy G,Mayford M,Chun J
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