Crhbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crhbp
Entrez Gene ID	29625
Full Name	corticotropin releasing hormone binding protein
Synonyms	Crfbp
General protein information	Preferred Names corticotropin releasing hormone binding protein Names corticotropin-releasing factor-binding protein CRF-BP CRF-binding protein CRH-BP
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q12
Summary	binds corticotropin releasing hormone and modulates CRH action; may act as a reservoir of endogenous CRH in the brain [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_139183.2	NP_631922.1	corticotropin-releasing factor-binding protein precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	CRHBP	XP_001106453.1
Mus musculus (house mouse)	Crhbp	NP_940800.1
Gallus gallus (chicken)	CRHBP	XP_424801.3
Danio rerio (zebrafish)	crhbp	NP_001003459.1
Rattus norvegicus (Norway rat)	Crhbp	NP_631922.1
Drosophila melanogaster (fruit fly)	CG15537	NP_001097981.1
Xenopus tropicalis (tropical clawed frog)	crhbp	XP_002940913.1
Bos taurus (cattle)	CRHBP	NP_001094672.1
Homo sapiens (human)	CRHBP	NP_001873.2
Pan troglodytes (chimpanzee)	CRHBP	XP_001144864.1
Canis lupus familiaris (dog)	CRHBP	XP_853211.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000955	XP_309147.5

Gene Ontology
Bibliography

Related articles in PubMed

CRF binding protein facilitates the presence of CRF type 2α receptor on the cell surface.
Slater PG, Cerda CA, Pereira LA, Andrés ME, Gysling K
Proceedings of the National Academy of Sciences of the United States of America113(15)4075-80(2016 Apr)

Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area.
Slater PG, Noches V, Gysling K
The European journal of neuroscience43(2)220-9(2016 Jan)

Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons.
Blanco EH, Zúñiga JP, Andrés ME, Alvarez AR, Gysling K
Neuropeptides45(4)273-9(2011 Aug)

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.
Ray LA
Alcoholism, clinical and experimental research35(1)166-74(2011 Jan)

Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats.
Pan Y, Wang FM, Qiang LQ, Zhang DM, Kong LD
Psychoneuroendocrinology35(2)272-83(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Crhbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crhbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02228	NM_139183.2 Latest version!	Rattus norvegicus corticotropin releasing hormone binding protein (Crhbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crhbp ( NM_139183.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_631922.1 Rattus norvegicus corticotropin releasing hormone binding protein (Crhbp), mRNA.

Price & Availability↑

CloneID	ORa02228
Clone ID Related Accession (Same CDS sequence)	NM_139183.2
Accession Version	NM_139183.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	corticotropin-releasing factor-binding protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07007710.1. On Apr 25, 2008 this sequence version replaced NM_139183.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCACCGA ACTTCAAACT CCAATGCCAC TTCACTCTGA TCCTCCTGAC AGCTCTAAGG 
GGAGAGAGCC GCTACCTAGA GGTGCAAGAA GCCGCAGTCT ACGACCCTTT CCTGCTTTTC 
AGCGCCAATT TGAAGCGGAA CCTGGCAGAG GAGCAGCCCT ACCGACGGGC TCTGCGCTGC 
CTGGACATGC TGAGCCTCCC TGGCCAGTTC ACCTTCACCG CTGACCAGCC GCAGCTGCAC 
TGCGCCGCCT TCTTCATCGG CGAGCCGGAG GAGTTCATCA CCATCCACTT TGACCTGGTC 
TCCATCGACT GCCAGGGTGG GGATTTCCTG AAGGTATTTG ATGGTTGGAT CCTTAAGGGG 
GAGAAGTTCC CAAGTTCTCA GGATCACCCT CTGCCCACCA GGGAGAGGTA CACAGATTTC 
TGTGAGAGCG GTCTCACCAG AAGGAGTGTT ACATCTTCCC AGAATGTGGC CATGGTCTTC 
TTCCGGGTCC ATGAACCAGG AAATGGATTC ACGATAACCA TAAAGACAGA CCCCAACCTC 
TTCCCTTGCA ATATCATCTC TCAGACTCCG AGTGGAAGAT TTACTTTGGT GGTTCCATAC 
CAGCACCAAA ACTGCAGCTT TTCCATCATT TATCCGGTGA CCATCAAAAT CTCTGACCTC 
GCCCTGGGAC ACCTGCATGG CCTTCAGTTG AAGAAACCTG CGGCTGGCTG TGGTGGAACT 
GGAGACTTTG TGGAGCTGCT GGGAGGAACT GGACTGGACA CCTCCAAGAT GATGCTCTTA 
GTGGACCTGT GTTACCCCTT TCATGGCCCT GCCCAGATGA AAATTAGCTG CGACAATGCT 
GTGGTGAGGA TGGTCTCCAG TGGAAAACAC ATGAACCGTG TGACTTTTGA GTATCGTCAG 
CTGGAACCAC TCGAGCTGGA AACCTCGACC AGAAACAGCA TCCCGGAGTA CTGCTTGTCT 
AGTCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_631922.1
CDS	119..1087
Translation	MSPNFKLQCHFTLILLTALRGESRYLEVQEAAVYDPFLLFSANLKRNLAEEQPYRRALRCLDMLSLPGQFTFTADQPQLHCAAFFIGEPEEFITIHFDLVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPTRERYTDFCESGLTRRSVTSSQNVAMVFFRVHEPGNGFTITIKTDPNLFPCNIISQTPSGRFTLVVPYQHQNCSFSIIYPVTIKISDLALGHLHGLQLKKPAAGCGGTGDFVELLGGTGLDTSKMMLLVDLCYPFHGPAQMKISCDNAVVRMVSSGKHMNRVTFEYRQLEPLELETSTRNSIPEYCLSSL

Target ORF information:

RefSeq Version	NM_139183.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus corticotropin releasing hormone binding protein (Crhbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139183.2

ORF Insert Sequence:

ATGTCACCGA ACTTCAAACT CCAATGCCAC TTCACTCTGA TCCTCCTGAC AGCTCTAAGG 
GGAGAGAGCC GCTACCTAGA GGTGCAAGAA GCCGCAGTCT ACGACCCTTT CCTGCTTTTC 
AGCGCCAATT TGAAGCGGAA CCTGGCAGAG GAGCAGCCCT ACCGACGGGC TCTGCGCTGC 
CTGGACATGC TGAGCCTCCC TGGCCAGTTC ACCTTCACCG CTGACCAGCC GCAGCTGCAC 
TGCGCCGCCT TCTTCATCGG CGAGCCGGAG GAGTTCATCA CCATCCACTT TGACCTGGTC 
TCCATCGACT GCCAGGGTGG GGATTTCCTG AAGGTATTTG ATGGTTGGAT CCTTAAGGGG 
GAGAAGTTCC CAAGTTCTCA GGATCACCCT CTGCCCACCA GGGAGAGGTA CACAGATTTC 
TGTGAGAGCG GTCTCACCAG AAGGAGTGTT ACATCTTCCC AGAATGTGGC CATGGTCTTC 
TTCCGGGTCC ATGAACCAGG AAATGGATTC ACGATAACCA TAAAGACAGA CCCCAACCTC 
TTCCCTTGCA ATATCATCTC TCAGACTCCG AGTGGAAGAT TTACTTTGGT GGTTCCATAC 
CAGCACCAAA ACTGCAGCTT TTCCATCATT TATCCGGTGA CCATCAAAAT CTCTGACCTC 
GCCCTGGGAC ACCTGCATGG CCTTCAGTTG AAGAAACCTG CGGCTGGCTG TGGTGGAACT 
GGAGACTTTG TGGAGCTGCT GGGAGGAACT GGACTGGACA CCTCCAAGAT GATGCTCTTA 
GTGGACCTGT GTTACCCCTT TCATGGCCCT GCCCAGATGA AAATTAGCTG CGACAATGCT 
GTGGTGAGGA TGGTCTCCAG TGGAAAACAC ATGAACCGTG TGACTTTTGA GTATCGTCAG 
CTGGAACCAC TCGAGCTGGA AACCTCGACC AGAAACAGCA TCCCGGAGTA CTGCTTGTCT 
AGTCTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRF binding protein facilitates the presence of CRF type 2α receptor on the cell surface.
Proceedings of the National Academy of Sciences of the United States of America113(15)4075-80(2016 Apr)
Slater PG,Cerda CA,Pereira LA,Andrés ME,Gysling K

Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area.
The European journal of neuroscience43(2)220-9(2016 Jan)
Slater PG,Noches V,Gysling K

Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons.
Neuropeptides45(4)273-9(2011 Aug)
Blanco EH,Zúñiga JP,Andrés ME,Alvarez AR,Gysling K

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.
Alcoholism, clinical and experimental research35(1)166-74(2011 Jan)
Ray LA

Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats.
Psychoneuroendocrinology35(2)272-83(2010 Feb)
Pan Y,Wang FM,Qiang LQ,Zhang DM,Kong LD