Btg2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Btg2
Entrez Gene ID	29619
Full Name	BTG anti-proliferation factor 2
Synonyms	Agl,An,Pc3,Tis21,an-1
General protein information	Preferred Names BTG anti-proliferation factor 2 Names protein BTG2 B-cell translocation gene 2, anti-proliferative BTG family, member 2 Early induced gene B-cell translocation gene 2 NGF-inducible anti-proliferative protein PC3 NGF-inducible anti-proliferative putative secreted protein cell surface alloantigen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	an anti-proliferative protein; interacts with Pick1 and may have a role in PKC-mediated extracellular signal transduction and cellular differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017259.1	NP_058955.1	protein BTG2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	BTG2	NP_006754.1
Gallus gallus (chicken)	BTG2	XP_418053.3
Xenopus tropicalis (tropical clawed frog)	btg2	NP_001011013.1
Canis lupus familiaris (dog)	BTG2	XP_545676.3
Bos taurus (cattle)	BTG2	XP_002693925.2
Danio rerio (zebrafish)	btg2	NP_570997.1
Rattus norvegicus (Norway rat)	Btg2	NP_058955.1
Pan troglodytes (chimpanzee)	BTG2	XP_001155267.1
Macaca mulatta (Rhesus monkey)	BTG2	XP_001102745.1
Mus musculus (house mouse)	Btg2	NP_031596.1

Gene Ontology
Bibliography

Related articles in PubMed

HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.
Micheli L, D'Andrea G, Leonardi L, Tirone F
Journal of cellular physiology232(7)1696-1707(2017 Jul)

Female-specific hypertension loci on rat chromosome 13.
Hoffman MJ, Flister MJ, Nunez L, Xiao B, Greene AS, Jacob HJ, Moreno C
Hypertension (Dallas, Tex. : 1979)62(3)557-63(2013 Sep)

B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic β-cells.
Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
Experimental & molecular medicine45e25(2013 May)

B-cell translocation gene 2: expression in the rat ovary and potential association with adenine nucleotide translocase 2 in mitochondria.
Park JI, Kim SG, Baek MW, Park TJ, Lim IK, Seo YW, Chun SY
Molecular and cellular endocrinology367(1-2)31-40(2013 Mar)

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
Doidge R, Mittal S, Aslam A, Winkler GS
PloS one7(12)e51331(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Btg2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Btg2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03434	NM_017259.1 Latest version!	Rattus norvegicus BTG anti-proliferation factor 2 (Btg2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Btg2 ( NM_017259.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058955.1 Rattus norvegicus BTG anti-proliferation factor 2 (Btg2), mRNA.

Price & Availability↑

CloneID	ORa03434
Clone ID Related Accession (Same CDS sequence)	NM_017259.1
Accession Version	NM_017259.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	protein BTG2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M60921.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M60921.1, BC072493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906347 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCACG GGAAGAGAAC CGACATGCTC CCGGAGATCG CCGCCGCCGT AGGTTTCCTC 
ACCAGTCTCC TGAGGACTCG GGGCTGCGTG AGCGAGCAGA GACTCAAGGT TTTCAGTAGG 
GCGCTCCAGG ACGCACTGAC CGATCATTAC AAACACCACT GGTTTCCAGA AAAGCCATCC 
AAGGGCTCCG GCTATCGCTG TATCCGCATC AACCACAAGA TGGACCCCAT CATCAGCAAG 
GTGGCCAGCC AGATCGGACT CAGCCAGCCC CAGCTGCACC AGCTCCTGCC CAGCGAGCTG 
ACCCTGTGGG TCGATCCCTA CGAAGTGTCC TACCGCATCG GGGAAGATGG ATCCATCTGC 
GTGCTGTATG AGGAGGCGCC GGTGGCCACC TCCTACGGGC TCCTCACCTG CAAGAACCAG 
ATGATGCTGG GCAGGAGCAG TCCATCGAAG AACTACGTGA TGACTGTCTC CAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058955.1
CDS	65..541
Translation	MSHGKRTDMLPEIAAAVGFLTSLLRTRGCVSEQRLKVFSRALQDALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHQLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVATSYGLLTCKNQMMLGRSSPSKNYVMTVSS

Target ORF information:

RefSeq Version	NM_017259.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BTG anti-proliferation factor 2 (Btg2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017259.1

ORF Insert Sequence:

ATGAGCCACG GGAAGAGAAC CGACATGCTC CCGGAGATCG CCGCCGCCGT AGGTTTCCTC 
ACCAGTCTCC TGAGGACTCG GGGCTGCGTG AGCGAGCAGA GACTCAAGGT TTTCAGTAGG 
GCGCTCCAGG ACGCACTGAC CGATCATTAC AAACACCACT GGTTTCCAGA AAAGCCATCC 
AAGGGCTCCG GCTATCGCTG TATCCGCATC AACCACAAGA TGGACCCCAT CATCAGCAAG 
GTGGCCAGCC AGATCGGACT CAGCCAGCCC CAGCTGCACC AGCTCCTGCC CAGCGAGCTG 
ACCCTGTGGG TCGATCCCTA CGAAGTGTCC TACCGCATCG GGGAAGATGG ATCCATCTGC 
GTGCTGTATG AGGAGGCGCC GGTGGCCACC TCCTACGGGC TCCTCACCTG CAAGAACCAG 
ATGATGCTGG GCAGGAGCAG TCCATCGAAG AACTACGTGA TGACTGTCTC CAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.
Journal of cellular physiology232(7)1696-1707(2017 Jul)
Micheli L,D'Andrea G,Leonardi L,Tirone F

Female-specific hypertension loci on rat chromosome 13.
Hypertension (Dallas, Tex. : 1979)62(3)557-63(2013 Sep)
Hoffman MJ,Flister MJ,Nunez L,Xiao B,Greene AS,Jacob HJ,Moreno C

B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic β-cells.
Experimental & molecular medicine45e25(2013 May)
Hwang SL,Kwon O,Kim SG,Lee IK,Kim YD

B-cell translocation gene 2: expression in the rat ovary and potential association with adenine nucleotide translocase 2 in mitochondria.
Molecular and cellular endocrinology367(1-2)31-40(2013 Mar)
Park JI,Kim SG,Baek MW,Park TJ,Lim IK,Seo YW,Chun SY

The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
PloS one7(12)e51331(2012)
Doidge R,Mittal S,Aslam A,Winkler GS