Rgs4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rgs4
Entrez Gene ID	29480
Full Name	regulator of G-protein signaling 4
General protein information	Preferred Names regulator of G-protein signaling 4 Names regulator of G-protein signaling 4 RGP4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q24
Summary	regulates G-protein coupled receptor signaling by accelerating the inactivation of active G-proteins; may regulate dopamine D2 receptor signaling [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017214.1	NP_058910.1	regulator of G-protein signaling 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RGS4	NP_001040065.1
Macaca mulatta (Rhesus monkey)	RGS4	XP_001082467.1
Canis lupus familiaris (dog)	RGS4	XP_545783.2
Gallus gallus (chicken)	RGS4	NP_989716.1
Danio rerio (zebrafish)	rgs4	NP_954968.1
Pan troglodytes (chimpanzee)	RGS4	XP_513957.2
Mus musculus (house mouse)	Rgs4	NP_033088.2
Rattus norvegicus (Norway rat)	Rgs4	NP_058910.1
Xenopus tropicalis (tropical clawed frog)	rgs4	NP_989295.2
Homo sapiens (human)	RGS4	NP_001095915.1

Gene Ontology
Bibliography

Related articles in PubMed

Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex.
Luessen DJ, Sun H, McGinnis MM, McCool BA, Chen R
Brain research1672106-112(2017 Oct)

The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat.
Namvar S, Fathollahi Y, Javan M, Zeraati M, Mohammad-Zadeh M, Shojaei A, Mirnajafi-Zadeh J
Journal of the neurological sciences375450-459(2017 Apr)

Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells.
Bodle CR, Hayes MP, O'Brien JB, Roman DL
Analytical biochemistry52210-17(2017 Apr)

A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity.
Taccola G, Doyen PJ, Damblon J, Dingu N, Ballarin B, Steyaert A, Rieux AD, Forget P, Hermans E, Bosier B, Deumens R
Experimental neurology2861-11(2016 Dec)

Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.
Bosier B, Doyen PJ, Brolet A, Muccioli GG, Ahmed E, Desmet N, Hermans E, Deumens R
British journal of pharmacology172(22)5333-46(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rgs4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgs4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03260	NM_017214.1 Latest version!	Rattus norvegicus regulator of G-protein signaling 4 (Rgs4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rgs4 ( NM_017214.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058910.1 Rattus norvegicus regulator of G-protein signaling 4 (Rgs4), mRNA.

Price & Availability↑

CloneID	ORa03260
Clone ID Related Accession (Same CDS sequence)	NM_017214.1
Accession Version	NM_017214.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	regulator of G-protein signaling 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF117211.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF117211.1, U27767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTGCAAAG GACTCGCTGG TCTGCCGGCT TCCTGCCTGA GGAGCGCAAA GGATATGAAA 
CATCGGCTGG GATTTCTGCT GCAGAAATCA GATTCCTGTG AACATAGTTC TTCACACAGC 
AAGAAGGACA AAGTAGTAAC TTGCCAGAGG GTGAGCCAAG AAGAAGTCAA GAAATGGGCT 
GAATCGCTGG AAAACCTGAT TAACCATGAA TGTGGACTGG CAGCTTTCAA AGCTTTCCTG 
AAGTCAGAAT ACAGTGAGGA GAACATTGAC TTCTGGATCA GCTGTGAGGA GTACAAGAAA 
ATCAAATCAC CTTCTAAACT AAGTCCCAAG GCCAAGAAGA TCTACAATGA GTTCATCTCT 
GTGCAGGCAA CAAAAGAGGT GAACCTGGAT TCTTGCACCA GAGAGGAGAC AAGCCGGAAC 
ATGTTAGAGC CCACGATAAC CTGTTTTGAT GAAGCCCAGA AGAAGATTTT CAACCTGATG 
GAAAAGGATT CATACCGTCG TTTCCTCAAG TCTCGATTCT ATCTTGACCT GACCAATCCT 
TCCAGCTGCG GGGCAGAGAA GCAGAAAGGA GCCAAGAGTT CTGCAGACTG CACTTCCCTA 
GTCCCTCAGT GTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058910.1
CDS	110..727
Translation	MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDKVVTCQRVSQEEVKKWAESLENLINHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLTNPSSCGAEKQKGAKSSADCTSLVPQCA

Target ORF information:

RefSeq Version	NM_017214.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus regulator of G-protein signaling 4 (Rgs4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017214.1

ORF Insert Sequence:

ATGTGCAAAG GACTCGCTGG TCTGCCGGCT TCCTGCCTGA GGAGCGCAAA GGATATGAAA 
CATCGGCTGG GATTTCTGCT GCAGAAATCA GATTCCTGTG AACATAGTTC TTCACACAGC 
AAGAAGGACA AAGTAGTAAC TTGCCAGAGG GTGAGCCAAG AAGAAGTCAA GAAATGGGCT 
GAATCGCTGG AAAACCTGAT TAACCATGAA TGTGGACTGG CAGCTTTCAA AGCTTTCCTG 
AAGTCAGAAT ACAGTGAGGA GAACATTGAC TTCTGGATCA GCTGTGAGGA GTACAAGAAA 
ATCAAATCAC CTTCTAAACT AAGTCCCAAG GCCAAGAAGA TCTACAATGA GTTCATCTCT 
GTGCAGGCAA CAAAAGAGGT GAACCTGGAT TCTTGCACCA GAGAGGAGAC AAGCCGGAAC 
ATGTTAGAGC CCACGATAAC CTGTTTTGAT GAAGCCCAGA AGAAGATTTT CAACCTGATG 
GAAAAGGATT CATACCGTCG TTTCCTCAAG TCTCGATTCT ATCTTGACCT GACCAATCCT 
TCCAGCTGCG GGGCAGAGAA GCAGAAAGGA GCCAAGAGTT CTGCAGACTG CACTTCCCTA 
GTCCCTCAGT GTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex.
Brain research1672106-112(2017 Oct)
Luessen DJ,Sun H,McGinnis MM,McCool BA,Chen R

The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat.
Journal of the neurological sciences375450-459(2017 Apr)
Namvar S,Fathollahi Y,Javan M,Zeraati M,Mohammad-Zadeh M,Shojaei A,Mirnajafi-Zadeh J

Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells.
Analytical biochemistry52210-17(2017 Apr)
Bodle CR,Hayes MP,O'Brien JB,Roman DL

A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity.
Experimental neurology2861-11(2016 Dec)
Taccola G,Doyen PJ,Damblon J,Dingu N,Ballarin B,Steyaert A,Rieux AD,Forget P,Hermans E,Bosier B,Deumens R

Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.
British journal of pharmacology172(22)5333-46(2015 Nov)
Bosier B,Doyen PJ,Brolet A,Muccioli GG,Ahmed E,Desmet N,Hermans E,Deumens R