| Gene Symbol | Polb |
| Entrez Gene ID | 29240 |
| Full Name | DNA polymerase beta |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | plays a role in DNA repair and bypass of pyrimidine dimers produced by UV-irradiation; also involved in base-excision repair [RGD, Feb 2006]. |
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Polb cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Polb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Polb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa02999 Clone ID Related Accession (Same CDS sequence) NM_017141.2 Accession Version NM_017141.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1008bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570550400000 Organism Rattus norvegicus(Norway rat) Product DNA polymerase beta Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC098668.1. On Jun 10, 2007 this sequence version replaced NM_017141.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC098668.1, U38801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961ATGAGCAAAC GCAAGGCCCC GCAGGAGACC CTCAACGGCG GCATCACGGA CATGCTCGTG
GAACTCGCAA ACTTTGAGAA GAACGTGAGC CAGGCGATCC ACAAGTACAA TGCATACAGA
AAAGCAGCAT CTGTGATAGC AAAGTACCCA CACAAAATCA AGAGTGGAGC AGAAGCTAAG
AAATTGCCAG GAGTAGGAAC AAAAATTGCT GAAAAGATTG ATGAATTTTT AGCAACTGGA
AAATTGCGTA AACTGGAAAA GATTCGTCAG GATGATACAA GTTCATCCAT CAACTTCCTG
ACTCGAGTTA CTGGCATCGG GCCATCTGCT GCAAGGAAGC TTGTAGATGA AGGAATTAAA
ACATTAGAAG ATCTCAGGAA AAATGAAGAT AAATTGAACC ACCATCAGCG AATTGGGCTG
AAATATTTTG AGGACTTTGA AAAGAGAATT CCTCGTGAGG AGATGCTGCA AATGCAGGAC
ATTGTTCTTA ATGAAGTTAA AAAGCTGGAT CCCGAGTACA TCGCTACAGT CTGCGGCAGT
TTCCGAAGAG GCGCAGAGTC CAGTGGAGAT ATGGACGTTC TGCTGACCCA CCCAAACTTC
ACGTCAGAAT CAAGCAAACA GCCAAAGTTG TTACATCGTG TTGTGGAACA GTTACAAAAA
GTCCGTTTCA TTACAGATAC TCTGTCAAAG GGTGAGACAA AGTTCATGGG TGTTTGCCAG
CTTCCCAGCG AGAATGATGA AAACGAATAT CCACACAGGA GAATCGATAT CAGGTTGATC
CCCAAAGATC AGTACTACTG TGGTGTTCTC TACTTCACTG GAAGTGACAT CTTTAATAAG
AATATGAGAG CGCATGCCCT GGAAAAGGGC TTCACAATCA ATGAGTACAC CATCCGCCCC
CTGGGGGTCA CTGGGGTTGC TGGGGAGCCC CTTCCGGTGG ACAGCGAGCA GGACATTTTC
GATTACATCC AGTGGCGCTA CCGGGAGCCC AAGGACAGGA GTGAATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_058837.2 CDS 13..1020 Translation 
Target ORF information:
RefSeq Version NM_017141.2 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus DNA polymerase beta (Polb), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_017141.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961ATGAGCAAAC GCAAGGCCCC GCAGGAGACC CTCAACGGCG GCATCACGGA CATGCTCGTG
GAACTCGCAA ACTTTGAGAA GAACGTGAGC CAGGCGATCC ACAAGTACAA TGCATACAGA
AAAGCAGCAT CTGTGATAGC AAAGTACCCA CACAAAATCA AGAGTGGAGC AGAAGCTAAG
AAATTGCCAG GAGTAGGAAC AAAAATTGCT GAAAAGATTG ATGAATTTTT AGCAACTGGA
AAATTGCGTA AACTGGAAAA GATTCGTCAG GATGATACAA GTTCATCCAT CAACTTCCTG
ACTCGAGTTA CTGGCATCGG GCCATCTGCT GCAAGGAAGC TTGTAGATGA AGGAATTAAA
ACATTAGAAG ATCTCAGGAA AAATGAAGAT AAATTGAACC ACCATCAGCG AATTGGGCTG
AAATATTTTG AGGACTTTGA AAAGAGAATT CCTCGTGAGG AGATGCTGCA AATGCAGGAC
ATTGTTCTTA ATGAAGTTAA AAAGCTGGAT CCCGAGTACA TCGCTACAGT CTGCGGCAGT
TTCCGAAGAG GCGCAGAGTC CAGTGGAGAT ATGGACGTTC TGCTGACCCA CCCAAACTTC
ACGTCAGAAT CAAGCAAACA GCCAAAGTTG TTACATCGTG TTGTGGAACA GTTACAAAAA
GTCCGTTTCA TTACAGATAC TCTGTCAAAG GGTGAGACAA AGTTCATGGG TGTTTGCCAG
CTTCCCAGCG AGAATGATGA AAACGAATAT CCACACAGGA GAATCGATAT CAGGTTGATC
CCCAAAGATC AGTACTACTG TGGTGTTCTC TACTTCACTG GAAGTGACAT CTTTAATAAG
AATATGAGAG CGCATGCCCT GGAAAAGGGC TTCACAATCA ATGAGTACAC CATCCGCCCC
CTGGGGGTCA CTGGGGTTGC TGGGGAGCCC CTTCCGGTGG ACAGCGAGCA GGACATTTTC
GATTACATCC AGTGGCGCTA CCGGGAGCCC AAGGACAGGA GTGAATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice.
Wellcome open research11(2016)
Wilson R,Geyer SH,Reissig L,Rose J,Szumska D,Hardman E,Prin F,McGuire C,Ramirez-Solis R,White J,Galli A,Tudor C,Tuck E,Mazzeo CI,Smith JC,Robertson E,Adams DJ,Mohun T,Weninger WJ
Characterization of the redox transition of the XRCC1 N-terminal domain.
Structure (London, England : 1993)22(12)1754-1763(2014 Dec)
Gabel SA,Smith CE,Cuneo MJ,Mueller GA,Kirby TW,DeRose EF,Krahn JM,London RE
Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function.
Nucleic acids research42(21)13161-73(2014 Dec)
Szczesny B,Brunyanszki A,Olah G,Mitra S,Szabo C
Mutation of POLB causes lupus in mice.
Cell reports6(1)1-8(2014 Jan)
Senejani AG,Liu Y,Kidane D,Maher SE,Zeiss CJ,Park HJ,Kashgarian M,McNiff JM,Zelterman D,Bothwell AL,Sweasy JB
Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β.
Biochemistry52(25)4422-32(2013 Jun)
Gridley CL,Rangarajan S,Firbank S,Dalal S,Sweasy JB,Jaeger J
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