Ces1e cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ces1e
Entrez Gene ID	29225
Full Name	carboxylesterase 1E
Synonyms	Ces1,Es22
General protein information	Preferred Names carboxylesterase 1E Names carboxylesterase 1E ES-HTEL carboxyesterase ES-3 carboxylesterase 1 egasyn esterase 22 liver carboxylesterase 3 pI 5.5 esterase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p11
Summary	enzyme that hydrolyzes long-chain fatty acids; necessary for cholesterol esterification; may be important for detoxification of certain drugs [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031565.2	NP_113753.2	carboxylesterase 1E precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ces1e	NP_598421.1
Macaca mulatta (Rhesus monkey)	CES1	XP_001089981.2
Rattus norvegicus (Norway rat)	Ces1e	NP_113753.2

Gene Ontology
Bibliography

Related articles in PubMed

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.
Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ
Mammalian genome : official journal of the International Mammalian Genome Society21(9-10)427-41(2010 Oct)

Different inhibitory effects in rat and human carboxylesterases.
Takahashi S, Katoh M, Saitoh T, Nakajima M, Yokoi T
Drug metabolism and disposition: the biological fate of chemicals37(5)956-61(2009 May)

Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases.
Holmes RS, Glenn JP, VandeBerg JL, Cox LA
Journal of medical primatology38(1)27-38(2009 Feb)

Carboxylesterase in the liver and small intestine of experimental animals and human.
Taketani M, Shii M, Ohura K, Ninomiya S, Imai T
Life sciences81(11)924-32(2007 Aug)

Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1.
Langston TB, Hylemon PB, Grogan WM
Lipids40(1)31-8(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ces1e gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ces1e cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa39879	NM_031565.2 Latest version!	Rattus norvegicus carboxylesterase 1E (Ces1e), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ces1e ( NM_031565.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113753.2 Rattus norvegicus carboxylesterase 1E (Ces1e), mRNA.

Price & Availability↑

CloneID	ORa39879
Clone ID Related Accession (Same CDS sequence)	NM_031565.2
Accession Version	NM_031565.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1686bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1335542400000
Organism	Rattus norvegicus(Norway rat)
Product	carboxylesterase 1E precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM063764.1, EX493673.1, FM140223.1, FM062488.1, CB798951.1, AABR03115086.1 and AABR03115901.1. On Jun 17, 2010 this sequence version replaced NM_031565.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGTGCCTCT ATGCTCTGAT CCTGGTGTTT CTTGCAGCAT TCACAGCAGG GGGACACCCA 
TCGTCACTAC CCGTAGTGGA CACCCTGCAA GGCAAAGTCC TCGGGAAGTA CGTCAGCTTA 
GAAGGATTCA CACAGCCTGT GGCCGTCTTC CTGGGAGTCC CCTTTGCCAA GCCCCCTCTC 
GGATCTCTGA GGTTTGCTCC ACCACAGCCT GCAGAGCCCT GGAGCTTCGT AAAGAACACC 
ACCTCCTACC CTCCTATGTG CTCCCAAGAC CCCGTGGCAG GGCAAATAGT CAATGACCTT 
CTAACTAACC GGGAAGAGAA CATTTCTCTC CAGTTTTCTG AAGACTGTCT CTACCTAAAT 
ATTTACACGC CTGCTGACTT GACAAAACGT GATAGACTGC CGGTGATGGT GTGGATCCAT 
GGAGGTGGAC TAGTGTTAGG TGGGGCATCC ACCTATGATG GACTAGCCCT GTCTACTCAT 
GAAAATGTGG TGGTAGTGGT CATTCAATAC CGTCTGGGTA TTTGGGGATT CTTCAGCACA 
GGGGATGAAC ACAGCCGGGG CAACTGGGGT CACTTGGACC AGGTGGCTGC ACTGCACTGG 
GTCCAGGACA ACATTGACAA CTTTGGAGGG GACCCAGGCT CTGTGACCAT CTTTGGAGAG 
TCAGCAGGAG GTGAAAGTGT CTCTGTTCTT GTGTTGTCTC CCTTGGCCAA GAATCTCTTT 
CACAAGGCCA TTTCCGAAAG TGGCGTGGCC CTCACTGCAG GCCTGGTCAA GAAGAACACC 
AGGCCCTTGG CTGAGAAAAT TGCTGTTGTA TCTGGTTGTA AAAGCACAAC TTCAGCTGCC 
ATGGTTCACT GCCTTCGCCA GAAGACAGAG GAAGAGCTCT TGGAGACCAC ACTAAAATTG 
AATCTTTTTT CGCTGGATTT GCACGGAGAC TCCAGGCAGA GCTATCCGTT TGTTCCCACT 
GTGCTTGATG GAGTGGTGCT GCCAAAGATG CCTGAGGAGA TCCTGGCTGA GAAGGACTTC 
AACACTGTGC CCTACATCGT GGGAATCAAC AAGCAAGAGT TTGGCTGGAT TCTGCCAACA 
ATGATGAACT ATCCACCCTC TGATATGAAA TTGGACCCGA TGACAGCCAC ATCGCTCTTG 
AAGAAGTCTT CTTTTCTTCT TAACCTTCCT GAAGAAGCAA TTCCAGTGGC CGTTGAGAAG 
TATTTAAGAC ACACAGATGA CCCAGACAGA AATAAAGACC AACTTCTGGA ATTGATTGGG 
GATGTGATCT TCGGTGTCCC ATCAGTGATT GTCTCCCGTG GACATAGAGA TGCTGGAGCC 
CGCACATACA TGTACGAGTT TCAATATCGC CCAAGCTTCT CATCAAAAAT GAAACCAAGT 
ACGGTGGTAG GAGATCATGG AGACGAAATC TACTCTGTCT TTGGTGCTCC AATTTTAAGA 
GGTGGTACCT CAAAAGAGGA GATCAATCTC AGCAAGATGA TGATGAAATT CTGGGCAAAC 
TTTGCTAGGA ATGGGAATCC CAATGGACAG GGCCTGCCCC ATTGGCCAGA GTATGACCAA 
AAGGAAGGTT ATCTTCAGAT TGGAGCCACC ACTCAACAAG CCCAGAAGCT AAAAGAAAAA 
GAAGTGGCTT TCTGGTCTGA GCTTCTGGCT ATGAAGCCAC TGCATGCAGG ACACACTGAG 
CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113753.2
CDS	205..1890
Translation	MCLYALILVFLAAFTAGGHPSSLPVVDTLQGKVLGKYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWIHGGGLVLGGASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLVKKNTRPLAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDSRQSYPFVPTVLDGVVLPKMPEEILAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSLLKKSSFLLNLPEEAIPVAVEKYLRHTDDPDRNKDQLLELIGDVIFGVPSVIVSRGHRDAGARTYMYEFQYRPSFSSKMKPSTVVGDHGDEIYSVFGAPILRGGTSKEEINLSKMMMKFWANFARNGNPNGQGLPHWPEYDQKEGYLQIGATTQQAQKLKEKEVAFWSELLAMKPLHAGHTEL

Target ORF information:

RefSeq Version	NM_031565.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus carboxylesterase 1E (Ces1e), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031565.2

ORF Insert Sequence:

ATGTGCCTCT ATGCTCTGAT CCTGGTGTTT CTTGCAGCAT TCACAGCAGG GGGACACCCA 
TCGTCACTAC CCGTAGTGGA CACCCTGCAA GGCAAAGTCC TCGGGAAGTA CGTCAGCTTA 
GAAGGATTCA CACAGCCTGT GGCCGTCTTC CTGGGAGTCC CCTTTGCCAA GCCCCCTCTC 
GGATCTCTGA GGTTTGCTCC ACCACAGCCT GCAGAGCCCT GGAGCTTCGT AAAGAACACC 
ACCTCCTACC CTCCTATGTG CTCCCAAGAC CCCGTGGCAG GGCAAATAGT CAATGACCTT 
CTAACTAACC GGGAAGAGAA CATTTCTCTC CAGTTTTCTG AAGACTGTCT CTACCTAAAT 
ATTTACACGC CTGCTGACTT GACAAAACGT GATAGACTGC CGGTGATGGT GTGGATCCAT 
GGAGGTGGAC TAGTGTTAGG TGGGGCATCC ACCTATGATG GACTAGCCCT GTCTACTCAT 
GAAAATGTGG TGGTAGTGGT CATTCAATAC CGTCTGGGTA TTTGGGGATT CTTCAGCACA 
GGGGATGAAC ACAGCCGGGG CAACTGGGGT CACTTGGACC AGGTGGCTGC ACTGCACTGG 
GTCCAGGACA ACATTGACAA CTTTGGAGGG GACCCAGGCT CTGTGACCAT CTTTGGAGAG 
TCAGCAGGAG GTGAAAGTGT CTCTGTTCTT GTGTTGTCTC CCTTGGCCAA GAATCTCTTT 
CACAAGGCCA TTTCCGAAAG TGGCGTGGCC CTCACTGCAG GCCTGGTCAA GAAGAACACC 
AGGCCCTTGG CTGAGAAAAT TGCTGTTGTA TCTGGTTGTA AAAGCACAAC TTCAGCTGCC 
ATGGTTCACT GCCTTCGCCA GAAGACAGAG GAAGAGCTCT TGGAGACCAC ACTAAAATTG 
AATCTTTTTT CGCTGGATTT GCACGGAGAC TCCAGGCAGA GCTATCCGTT TGTTCCCACT 
GTGCTTGATG GAGTGGTGCT GCCAAAGATG CCTGAGGAGA TCCTGGCTGA GAAGGACTTC 
AACACTGTGC CCTACATCGT GGGAATCAAC AAGCAAGAGT TTGGCTGGAT TCTGCCAACA 
ATGATGAACT ATCCACCCTC TGATATGAAA TTGGACCCGA TGACAGCCAC ATCGCTCTTG 
AAGAAGTCTT CTTTTCTTCT TAACCTTCCT GAAGAAGCAA TTCCAGTGGC CGTTGAGAAG 
TATTTAAGAC ACACAGATGA CCCAGACAGA AATAAAGACC AACTTCTGGA ATTGATTGGG 
GATGTGATCT TCGGTGTCCC ATCAGTGATT GTCTCCCGTG GACATAGAGA TGCTGGAGCC 
CGCACATACA TGTACGAGTT TCAATATCGC CCAAGCTTCT CATCAAAAAT GAAACCAAGT 
ACGGTGGTAG GAGATCATGG AGACGAAATC TACTCTGTCT TTGGTGCTCC AATTTTAAGA 
GGTGGTACCT CAAAAGAGGA GATCAATCTC AGCAAGATGA TGATGAAATT CTGGGCAAAC 
TTTGCTAGGA ATGGGAATCC CAATGGACAG GGCCTGCCCC ATTGGCCAGA GTATGACCAA 
AAGGAAGGTT ATCTTCAGAT TGGAGCCACC ACTCAACAAG CCCAGAAGCT AAAAGAAAAA 
GAAGTGGCTT TCTGGTCTGA GCTTCTGGCT ATGAAGCCAC TGCATGCAGG ACACACTGAG 
CTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.
Mammalian genome : official journal of the International Mammalian Genome Society21(9-10)427-41(2010 Oct)
Holmes RS,Wright MW,Laulederkind SJ,Cox LA,Hosokawa M,Imai T,Ishibashi S,Lehner R,Miyazaki M,Perkins EJ,Potter PM,Redinbo MR,Robert J,Satoh T,Yamashita T,Yan B,Yokoi T,Zechner R,Maltais LJ

Different inhibitory effects in rat and human carboxylesterases.
Drug metabolism and disposition: the biological fate of chemicals37(5)956-61(2009 May)
Takahashi S,Katoh M,Saitoh T,Nakajima M,Yokoi T

Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases.
Journal of medical primatology38(1)27-38(2009 Feb)
Holmes RS,Glenn JP,VandeBerg JL,Cox LA

Carboxylesterase in the liver and small intestine of experimental animals and human.
Life sciences81(11)924-32(2007 Aug)
Taketani M,Shii M,Ohura K,Ninomiya S,Imai T

Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1.
Lipids40(1)31-8(2005 Jan)
Langston TB,Hylemon PB,Grogan WM