Thbs4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Thbs4
Entrez Gene ID	29220
Full Name	thrombospondin 4
General protein information	Preferred Names thrombospondin 4 Names thrombospondin-4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q12
Summary	extracellular matrix protein; involved in neuronal development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017133.1	NP_058829.1	thrombospondin-4 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	THBS4	XP_003310731.1
Macaca mulatta (Rhesus monkey)	THBS4	XP_001109898.1
Mus musculus (house mouse)	Thbs4	NP_035712.1
Danio rerio (zebrafish)	thbs4b	NP_775333.1
Xenopus tropicalis (tropical clawed frog)	thbs4	NP_001072673.1
Canis lupus familiaris (dog)	THBS4	XP_005618229.1
Rattus norvegicus (Norway rat)	Thbs4	NP_058829.1
Gallus gallus (chicken)	THBS4	XP_424763.4
Homo sapiens (human)	THBS4	NP_003239.2
Bos taurus (cattle)	THBS4	NP_001029900.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons.
Guo Y, Zhang Z, Wu HE, Luo ZD, Hogan QH, Pan B
Neuropharmacology117292-304(2017 05)

Thrombospondin-4 Promotes Neuronal Differentiation of NG2 Cells via the ERK/MAPK Pathway.
Yang HJ, Ma SP, Ju F, Zhang YP, Li ZC, Zhang BB, Lian JJ, Wang L, Cheng BF, Wang M, Feng ZW
Journal of molecular neuroscience : MN60(4)517-524(2016 Dec)

Spinal Astrocytic Thrombospondin-4 Induced by Excitatory Neuronal Signaling Mediates Pain After Facet Capsule Injury.
Crosby ND, Winkelstein BA
Annals of biomedical engineering44(11)3215-3224(2016 Nov)

Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction.
Krawczyk KK, Ekman M, Rippe C, Grossi M, Nilsson BO, Albinsson S, Uvelius B, Swärd K
Scientific reports632449(2016 09)

Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling.
Brody MJ, Schips TG, Vanhoutte D, Kanisicak O, Karch J, Maliken BD, Blair NS, Sargent MA, Prasad V, Molkentin JD
Molecular and cellular biology36(1)2-12(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Thbs4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Thbs4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02977	NM_017133.1 Latest version!	Rattus norvegicus thrombospondin 4 (Thbs4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Thbs4 ( NM_017133.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058829.1 Rattus norvegicus thrombospondin 4 (Thbs4), mRNA.

Price & Availability↑

CloneID	ORa02977
Clone ID Related Accession (Same CDS sequence)	NM_017133.1
Accession Version	NM_017133.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	thrombospondin-4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07007652.1. On or before Sep 1, 2012 this sequence version replaced XM_001066338.3, XM_003753507.1, XM_342172.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689600 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTAGCCC CACGCGCGGC CGCCTTCCTC CTACTGCACC TGGTCCTGCA GCCGTGGCAG 
CGGGCGGGCG CCCAGGCCAC ACCCCAGGTC TTTGACCTTC TGCCATCCTC CAGCCAGAGG 
CTGAACCCGG CCGCCCTGCA GCCAGTCCTG ACAGACCCCA CCCTGCACGA GCTCTATGTC 
ATCTCCACCT TCAAGCTGCA GAGTAAGAGC TCAGCCACCA TCTTTGGCCT CTACTCCTCG 
AGTGACAACA GCAAATACTT TGAATTCACT GTGATGGGAC GCCTGAACAA AGCCATCCTC 
CGTTACCTAA AGGATGATGG GAAGATTCAT CTGGTGGTTT TCAACAACCT GCAGCTGGCG 
GATGGGAGGC GCCACCGGAT TCTCCTGAGA CTCAGCAATT TGCAGAGAGG GGCCGGCTCC 
GTAGAACTCT ACTTGGACTG TGTCCAGGTT GATTCAGTGA ACAACCTCCC CAGAGCCTTC 
TCTGGTCTCA CCCAGAACCC ACAGGCCATT GAATTGAGAA CATTCCAGAG GAAGCCCCAG 
GACTTCTTGG AAGAGCTGAA GCTGGTGGTG AGGGGCTCTC TGTTCCAGGT GGCCAGCCTA 
CAAGACTGTT TCCTGCAGCA GAGTGAGCCG CTGGCTGCCA CAGGCACAGG AGACTTTAAT 
CGACAGTTTT TGGGTCAAAT GACACAATTA AACCAGCTCC TTGGAGAGGT GAAAGATCTT 
CTGAGGCAGC AGGTCAAGGA AACATCATTT TTGCGAAACA CTATTGCTGA GTGCCAGGCT 
TGTGGCCCTC TCAGCTTCCA GTCCCCAACC CCAAACACGC TGGTGCCCAT AGCTCCTCCA 
GCACCCCCAA CCCGACCAAC ACGTCGCTGT GACTCCAGCC CTTGTTTCCG AGGTGTCCGA 
TGCACGGACA CCAGGGACGG CTTCCAATGT GGACCCTGCC CAGATGGCTA CACGGGGAAC 
GGGATCACCT GTTCTGACGT GGATGAGTGT AAATACCATC CCTGCTACCC TGGTGTGCGC 
TGCACAAATT TGGCTCCGGG TTTCAGATGT GATGCCTGTC CAGTAGGCTT CACGGGGCCC 
ATGGTGCAGG GCGTGGGGAT CAACTTTGCC AAAACAAACA AGCAGGTGTG CACTGATGTT 
GACGAGTGTC GGAACGGAGC GTGTGTTCTG AACTCCATCT GCATTAACAC TCTGGGCTCT 
TACCGCTGTG GGCCTTGCAA GCCAGGGTAC ACTGGTGACC AGACGAGGGG ATGCAGGACC 
GAAAGGAGCT GCCGGAACCC AGAGCAGAAC CCGTGCAGTG TGCATGCGCA GTGCATTGAG 
GAACGGCAAG GGGATGTGAC GTGTGTGTGC GGTGTTGGTT GGGCCGGCGA CGGCTATGTC 
TGTGGAAAGG ATGTGGACAT CGACAGTTAC CCCGATGAAG AACTGCCGTG CTCAGCCAGG 
AACTGCAAGA AGGATAACTG CAAGTATGTG CCAAACTCCG GCCAAGAAGA CGCAGACAGA 
GATGGCATTG GAGACGCCTG TGATGAGGAT GCGGATGGAG ACGGGATCTT GAATGAGCAG 
GACAACTGTG TCCTGACTCA CAATGTGGAC CAGAGGAACA CTGATAAAGA TATCTTTGGG 
GATGCCTGTG ACAACTGCCG GGGCGTCCTG AATAATGACC AGAAGGACAC TGACGGGGAT 
GGGAAAGGAG ACGCCTGTGA TGACGACATG GATGGAGACG GAATAAAAAA CATTTTGGAC 
AACTGTCCCC GAGTTCCCAA CCGCGACCAA CAGGATCGGG ATGGCGATGG TGTCGGAGAC 
GCCTGTGACA GCTGTCCTGA TGTCAGTAAC CCTAACCAGT CGGATGTGGA TAACGATCTG 
GTTGGGGACT CCTGTGACAC CAACCAAGAC AGTGATGGGG ATGGCCACCA GGACAGCACA 
GACAACTGCC CCACCGTCAT TAACAGCGCC CAGCTGGACA CCGACAAGGA CGGGATTGGC 
GATGAATGCG ATGACGATGA CGATAATGAC GGCATCCCAG ACCTGGTTCC CCCTGGCCCA 
GACAACTGCA GGCTTGTTCC CAACCCAGCC CAGGAAGATA GCAACAATGA TGGAGTAGGA 
GATATCTGTG AAGCTGACTT CGACCAGGAC AAGGTCATTG ATCGCATTGA TGTGTGTCCT 
GAGAATGCGG AGATCACCCT GACTGACTTC AGGGCCTATC AGACTGTGGT CCTGGACCCT 
GAAGGGGATG CCCAGATCGA CCCCAACTGG GTGGTCCTGA ACCAGGGCAT GGAGATTGTG 
CAGACCATGA ACAGTGACCC TGGCCTAGCA GTCGGGTACA CGGCATTTAA TGGAGTTGAC 
TTTGAAGGGA CCTTCCACGT AAACACCCAG ACAGATGACG ACTATGCCGG CTTTATTTTT 
GGTTACCAAG ACAGTTCCAG CTTCTATGTG GTCATGTGGA AACAGACAGA GCAGACATAC 
TGGCAGGCTA CGCCATTCCG TGCAGTAGCA GAACCTGGTA TTCAGCTCAA GGCCGTGAAG 
TCTAAAACTG GCCCAGGGGA ACATCTCCGA AACTCCCTGT GGCACACAGG GGACACCAGC 
GACCAGGTCA GGCTGCTGTG GAAGGACTCC AGGAATGTGG GCTGGAAGGA CAAGGTGTCC 
TACCGCTGGT TCCTGCAGCA TAGGCCCCAG GTGGGCTACA TCAGGGTGCG GTTTTATGAA 
GGCTCAGAGT TGGTGGCTGA CTCCGGGGTC ACTATAGACA CCACCATGCG CGGAGGCCGA 
CTGGGCGTGT TCTGCTTCTC TCAGGAAAAC ATCATCTGGT CCAACCTCAA GTACCGCTGT 
AACGACACCA TACCAGAGGA CTTCCAGGAG TTCCAGATCC AGACCTTTGA CCGCCTGGAT 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058829.1
CDS	175..3060
Translation	MLAPRAAAFLLLHLVLQPWQRAGAQATPQVFDLLPSSSQRLNPAALQPVLTDPTLHELYVISTFKLQSKSSATIFGLYSSSDNSKYFEFTVMGRLNKAILRYLKDDGKIHLVVFNNLQLADGRRHRILLRLSNLQRGAGSVELYLDCVQVDSVNNLPRAFSGLTQNPQAIELRTFQRKPQDFLEELKLVVRGSLFQVASLQDCFLQQSEPLAATGTGDFNRQFLGQMTQLNQLLGEVKDLLRQQVKETSFLRNTIAECQACGPLSFQSPTPNTLVPIAPPAPPTRPTRRCDSSPCFRGVRCTDTRDGFQCGPCPDGYTGNGITCSDVDECKYHPCYPGVRCTNLAPGFRCDACPVGFTGPMVQGVGINFAKTNKQVCTDVDECRNGACVLNSICINTLGSYRCGPCKPGYTGDQTRGCRTERSCRNPEQNPCSVHAQCIEERQGDVTCVCGVGWAGDGYVCGKDVDIDSYPDEELPCSARNCKKDNCKYVPNSGQEDADRDGIGDACDEDADGDGILNEQDNCVLTHNVDQRNTDKDIFGDACDNCRGVLNNDQKDTDGDGKGDACDDDMDGDGIKNILDNCPRVPNRDQQDRDGDGVGDACDSCPDVSNPNQSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSAQLDTDKDGIGDECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNNDGVGDICEADFDQDKVIDRIDVCPENAEITLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYEGSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFQIQTFDRLDN

Target ORF information:

RefSeq Version	NM_017133.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus thrombospondin 4 (Thbs4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017133.1

ORF Insert Sequence:

ATGCTAGCCC CACGCGCGGC CGCCTTCCTC CTACTGCACC TGGTCCTGCA GCCGTGGCAG 
CGGGCGGGCG CCCAGGCCAC ACCCCAGGTC TTTGACCTTC TGCCATCCTC CAGCCAGAGG 
CTGAACCCGG CCGCCCTGCA GCCAGTCCTG ACAGACCCCA CCCTGCACGA GCTCTATGTC 
ATCTCCACCT TCAAGCTGCA GAGTAAGAGC TCAGCCACCA TCTTTGGCCT CTACTCCTCG 
AGTGACAACA GCAAATACTT TGAATTCACT GTGATGGGAC GCCTGAACAA AGCCATCCTC 
CGTTACCTAA AGGATGATGG GAAGATTCAT CTGGTGGTTT TCAACAACCT GCAGCTGGCG 
GATGGGAGGC GCCACCGGAT TCTCCTGAGA CTCAGCAATT TGCAGAGAGG GGCCGGCTCC 
GTAGAACTCT ACTTGGACTG TGTCCAGGTT GATTCAGTGA ACAACCTCCC CAGAGCCTTC 
TCTGGTCTCA CCCAGAACCC ACAGGCCATT GAATTGAGAA CATTCCAGAG GAAGCCCCAG 
GACTTCTTGG AAGAGCTGAA GCTGGTGGTG AGGGGCTCTC TGTTCCAGGT GGCCAGCCTA 
CAAGACTGTT TCCTGCAGCA GAGTGAGCCG CTGGCTGCCA CAGGCACAGG AGACTTTAAT 
CGACAGTTTT TGGGTCAAAT GACACAATTA AACCAGCTCC TTGGAGAGGT GAAAGATCTT 
CTGAGGCAGC AGGTCAAGGA AACATCATTT TTGCGAAACA CTATTGCTGA GTGCCAGGCT 
TGTGGCCCTC TCAGCTTCCA GTCCCCAACC CCAAACACGC TGGTGCCCAT AGCTCCTCCA 
GCACCCCCAA CCCGACCAAC ACGTCGCTGT GACTCCAGCC CTTGTTTCCG AGGTGTCCGA 
TGCACGGACA CCAGGGACGG CTTCCAATGT GGACCCTGCC CAGATGGCTA CACGGGGAAC 
GGGATCACCT GTTCTGACGT GGATGAGTGT AAATACCATC CCTGCTACCC TGGTGTGCGC 
TGCACAAATT TGGCTCCGGG TTTCAGATGT GATGCCTGTC CAGTAGGCTT CACGGGGCCC 
ATGGTGCAGG GCGTGGGGAT CAACTTTGCC AAAACAAACA AGCAGGTGTG CACTGATGTT 
GACGAGTGTC GGAACGGAGC GTGTGTTCTG AACTCCATCT GCATTAACAC TCTGGGCTCT 
TACCGCTGTG GGCCTTGCAA GCCAGGGTAC ACTGGTGACC AGACGAGGGG ATGCAGGACC 
GAAAGGAGCT GCCGGAACCC AGAGCAGAAC CCGTGCAGTG TGCATGCGCA GTGCATTGAG 
GAACGGCAAG GGGATGTGAC GTGTGTGTGC GGTGTTGGTT GGGCCGGCGA CGGCTATGTC 
TGTGGAAAGG ATGTGGACAT CGACAGTTAC CCCGATGAAG AACTGCCGTG CTCAGCCAGG 
AACTGCAAGA AGGATAACTG CAAGTATGTG CCAAACTCCG GCCAAGAAGA CGCAGACAGA 
GATGGCATTG GAGACGCCTG TGATGAGGAT GCGGATGGAG ACGGGATCTT GAATGAGCAG 
GACAACTGTG TCCTGACTCA CAATGTGGAC CAGAGGAACA CTGATAAAGA TATCTTTGGG 
GATGCCTGTG ACAACTGCCG GGGCGTCCTG AATAATGACC AGAAGGACAC TGACGGGGAT 
GGGAAAGGAG ACGCCTGTGA TGACGACATG GATGGAGACG GAATAAAAAA CATTTTGGAC 
AACTGTCCCC GAGTTCCCAA CCGCGACCAA CAGGATCGGG ATGGCGATGG TGTCGGAGAC 
GCCTGTGACA GCTGTCCTGA TGTCAGTAAC CCTAACCAGT CGGATGTGGA TAACGATCTG 
GTTGGGGACT CCTGTGACAC CAACCAAGAC AGTGATGGGG ATGGCCACCA GGACAGCACA 
GACAACTGCC CCACCGTCAT TAACAGCGCC CAGCTGGACA CCGACAAGGA CGGGATTGGC 
GATGAATGCG ATGACGATGA CGATAATGAC GGCATCCCAG ACCTGGTTCC CCCTGGCCCA 
GACAACTGCA GGCTTGTTCC CAACCCAGCC CAGGAAGATA GCAACAATGA TGGAGTAGGA 
GATATCTGTG AAGCTGACTT CGACCAGGAC AAGGTCATTG ATCGCATTGA TGTGTGTCCT 
GAGAATGCGG AGATCACCCT GACTGACTTC AGGGCCTATC AGACTGTGGT CCTGGACCCT 
GAAGGGGATG CCCAGATCGA CCCCAACTGG GTGGTCCTGA ACCAGGGCAT GGAGATTGTG 
CAGACCATGA ACAGTGACCC TGGCCTAGCA GTCGGGTACA CGGCATTTAA TGGAGTTGAC 
TTTGAAGGGA CCTTCCACGT AAACACCCAG ACAGATGACG ACTATGCCGG CTTTATTTTT 
GGTTACCAAG ACAGTTCCAG CTTCTATGTG GTCATGTGGA AACAGACAGA GCAGACATAC 
TGGCAGGCTA CGCCATTCCG TGCAGTAGCA GAACCTGGTA TTCAGCTCAA GGCCGTGAAG 
TCTAAAACTG GCCCAGGGGA ACATCTCCGA AACTCCCTGT GGCACACAGG GGACACCAGC 
GACCAGGTCA GGCTGCTGTG GAAGGACTCC AGGAATGTGG GCTGGAAGGA CAAGGTGTCC 
TACCGCTGGT TCCTGCAGCA TAGGCCCCAG GTGGGCTACA TCAGGGTGCG GTTTTATGAA 
GGCTCAGAGT TGGTGGCTGA CTCCGGGGTC ACTATAGACA CCACCATGCG CGGAGGCCGA 
CTGGGCGTGT TCTGCTTCTC TCAGGAAAAC ATCATCTGGT CCAACCTCAA GTACCGCTGT 
AACGACACCA TACCAGAGGA CTTCCAGGAG TTCCAGATCC AGACCTTTGA CCGCCTGGAT 
AATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons.
Neuropharmacology117292-304(2017 05)
Guo Y,Zhang Z,Wu HE,Luo ZD,Hogan QH,Pan B

Thrombospondin-4 Promotes Neuronal Differentiation of NG2 Cells via the ERK/MAPK Pathway.
Journal of molecular neuroscience : MN60(4)517-524(2016 Dec)
Yang HJ,Ma SP,Ju F,Zhang YP,Li ZC,Zhang BB,Lian JJ,Wang L,Cheng BF,Wang M,Feng ZW

Spinal Astrocytic Thrombospondin-4 Induced by Excitatory Neuronal Signaling Mediates Pain After Facet Capsule Injury.
Annals of biomedical engineering44(11)3215-3224(2016 Nov)
Crosby ND,Winkelstein BA

Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction.
Scientific reports632449(2016 09)
Krawczyk KK,Ekman M,Rippe C,Grossi M,Nilsson BO,Albinsson S,Uvelius B,Swärd K

Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling.
Molecular and cellular biology36(1)2-12(2016 Jan)
Brody MJ,Schips TG,Vanhoutte D,Kanisicak O,Karch J,Maliken BD,Blair NS,Sargent MA,Prasad V,Molkentin JD

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Thbs4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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