Hhip cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hhip
Entrez Gene ID	291936
Full Name	Hedgehog-interacting protein
Synonyms	RGD1564108
General protein information	Preferred Names Hedgehog-interacting protein Names hedgehog-interacting protein Hedgehog-interacting protein-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191817.1	NP_001178746.1	hedgehog-interacting protein precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	HHIP	XP_420424.4
Danio rerio (zebrafish)	hhip	NP_001073481.1
Homo sapiens (human)	HHIP	NP_071920.1
Macaca mulatta (Rhesus monkey)	HHIP	XP_001093950.1
Rattus norvegicus (Norway rat)	Hhip	NP_001178746.1
Pan troglodytes (chimpanzee)	HHIP	XP_001146476.1
Mus musculus (house mouse)	Hhip	NP_064655.4
Xenopus tropicalis (tropical clawed frog)	hhip	NP_001007191.1
Canis lupus familiaris (dog)	HHIP	XP_003639584.1
Bos taurus (cattle)	HHIP	NP_001092584.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline.
Xie J, Wu H, Xu Y, Wu X, Liu X, Shang J, Zhao J, Zhao J, Wang J, Dela Cruz CS, Xiong W, Xu Y
Respiratory research1649(2015 Apr)

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.
Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan GC, Silverman EK, Zhou X
Genome medicine7(1)12(2015)

Interactions between Hedgehog proteins and their binding partners come into view.
Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C
Genes & development24(18)2001-12(2010 Sep)

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study.
Van Durme YM, Eijgelsheim M, Joos GF, Hofman A, Uitterlinden AG, Brusselle GG, Stricker BH
The European respiratory journal36(1)89-95(2010 Jul)

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.
Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, Yang L, Sudan DL, Sicklick JK, Michelotti GA, Rojkind M, Diehl AM
American journal of physiology. Gastrointestinal and liver physiology297(6)G1093-106(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hhip gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hhip cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07740	NM_001191817.1 Latest version!	Rattus norvegicus Hedgehog-interacting protein (Hhip), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hhip ( NM_001191817.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178746.1 Rattus norvegicus Hedgehog-interacting protein (Hhip), mRNA.

Price & Availability↑

CloneID	ORa07740
Clone ID Related Accession (Same CDS sequence)	NM_001191817.1
Accession Version	NM_001191817.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2103bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527696000000
Organism	Rattus norvegicus(Norway rat)
Product	hedgehog-interacting protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07043609.1 and AABR07043611.1. On Jul 17, 2010 this sequence version replaced XM_238042.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGCTGAAGA TGCTCTCGTT TAAGCTGCTA CTGCTGGCCG TGGCTCTGGG CTTCTTTGAA 
GGAGATGCCA AGTTTGGGGA AAGGAGCGAA GGGAGCGGAG CGAGGAGGAG AAGGTGCCTG 
AATGGGAGCC CCCCAAAGCG CCTGAAAAGA AGGGACAGGA GGATGATGTC CCAGCTGGAG 
CTGCTGAGTG GAGGAGAGAT TCTGTGTGGT GGCTTCTACC CAAGAGTATC CTGCTGCCTG 
CAGAGTGACA GCCCTGGATT GGGGCGTCTG GAGAACAAGA TCTTTTCTGC CACCAACAAC 
ACAGAATGTG GGAGGCTCCT GGAGGAGATC AAATGTGCTC CTTGCTCTCC CCACTCCCAG 
AGCCTGTTCT TCTCACCTGA AAGAGATGTC CTGGATGGAG ACCTTGCACT TCCACTCCTC 
TGCAAGGACT ACTGCAAAGA ATTCTTTTAC ACTTGTCGGG GCCATATTCC AGGTCTTCTT 
CAAACAACTG CTGATGAATT TTGCTTTTAC TATGCAAGAA AAGATGCTGG GTTATGCTTT 
CCAGACTTCC CGAGAAAGCA AGTCAGAGGA CCAGCATCTA ACTATTTGGA CCAGATGGAA 
GACTATGAGA AAGTCGAAGA GATCAGCAGA AAGCACAAAC ACAACTGCTT CTGTGTCCAG 
GAGGTCATGA GTGGGCTGCG GCAGCCTGTG GGTGCTGTGC ACAGTGGGGA TGGCTCCCTT 
CGACTCTTCA TCCTAGAGAA GGAAGGCTAC GTGAAGATTC TAACCCCAGA AGGAGAAATG 
CTCAAGGAGC CTTACTTGGA CATTCACAAA CTTGTTCAGA GTGGAATAAA GGGAGGAGAC 
GAGAGGGGCC TGCTAAGCCT GGCATTCCAC CCCAATTACA AGAAAAACGG GAAGCTCTAC 
GTGTCTTACA CCACCAACCA GGAACGGTGG GCTATTGGGC CTCACGACCA CATCCTTAGG 
GTTGTGGAAT ACACAGTATC CAGGAAAAAT CCCCATCAAG TTGATGTAAG AACAGCCAGG 
GTGTTTCTGG AAGTTGCAGA GCTCCACCGG AAGCATCTTG GGGGACAGCT GCTCTTTGGT 
CCTGATGGCT TTTTGTACAT CATCCTCGGG GATGGGATGA TCACACTGGA TGACATGGAG 
GAGATGGATG GGTTAAGTGA TTTCACAGGC TCTGTGCTGA GGCTGGATGC GGACACCGAC 
ATGTGCAATG TGCCTTACTC CATTCCTCGG AGTAACCCCC ACTTCAACAG CACCAACCAG 
CCTCCAGAAG TATTTGCCCA TGGCCTCCAT GATCCAGGCA GATGTGCCGT GGATCGACAT 
CCCACTGATA TAAACATCAA TTTAACAATA CTTTGCTCAG ATTCCAATGG GAAGAACAGA 
TCGTCGGCCA GAATTCTACA GATAATAAAA GGAAGAGATT ACGAAAGCGA GCAATCTCTT 
CTAGAATTCA AGCCATTCAG TAACGGCCCT TTGGTTGGTG GATTCGTTTA CAGAGGCTGC 
CAGTCTGAAA GATTGTACGG AAGCTACGTG TTCGGAGATC GCAATGGGAA TTTCTTAACC 
CTCCAGCAAA GCCCAGTGAC TAAGCAATGG CAAGAAAAGC CACTCTGTCT GGGTGCCAGC 
GGCTCCTGTC AAGGCTACTT TTCGGGTCAC ATCTTGGGAT TTGGAGAAGA TGAATTAGGA 
GAGGTTTACA TTCTATCAAG CAGTAAGAGT ATGACCCAGA CTCACAATGG AAAACTCTAC 
AAGATCATAG ACCCAAAAAG ACCTTTGATG CCTGAGGAAT GCAGAGTCAC AGTTCAACCT 
GCCCAGACAC TGACCTCAGA TATTTCCCGG CTCTGTCGGA ACGGCTACTA CACCCCCACG 
GGCAAGTGCT GCTGCAGTCC TGGCTGGGAG GGAGACTTCT GCAGAATTGC CAAATGTGAG 
CCACCTTGTC GTCACGGAGG TGTCTGTGTC AGACCAAACA AGTGCCTCTG TAAAAAGGGC 
TATCTCGGCC CTCAGTGTGA ACGAGCGGAC AGGAGCATGC GCAGAGTGAC CAGGGCAGGT 
ATTCTTGACC AGATCATTGA CGTGACGTCT TACTTGCTGG ATCTCACAAG TTACATCGTA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178746.1
CDS	1..2103
Translation	MLKMLSFKLLLLAVALGFFEGDAKFGERSEGSGARRRRCLNGSPPKRLKRRDRRMMSQLELLSGGEILCGGFYPRVSCCLQSDSPGLGRLENKIFSATNNTECGRLLEEIKCAPCSPHSQSLFFSPERDVLDGDLALPLLCKDYCKEFFYTCRGHIPGLLQTTADEFCFYYARKDAGLCFPDFPRKQVRGPASNYLDQMEDYEKVEEISRKHKHNCFCVQEVMSGLRQPVGAVHSGDGSLRLFILEKEGYVKILTPEGEMLKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDVRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDADTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGRDYESEQSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGASGSCQGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIIDPKRPLMPEECRVTVQPAQTLTSDISRLCRNGYYTPTGKCCCSPGWEGDFCRIAKCEPPCRHGGVCVRPNKCLCKKGYLGPQCERADRSMRRVTRAGILDQIIDVTSYLLDLTSYIV

Target ORF information:

RefSeq Version	NM_001191817.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Hedgehog-interacting protein (Hhip), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191817.1

ORF Insert Sequence:

ATGCTGAAGA TGCTCTCGTT TAAGCTGCTA CTGCTGGCCG TGGCTCTGGG CTTCTTTGAA 
GGAGATGCCA AGTTTGGGGA AAGGAGCGAA GGGAGCGGAG CGAGGAGGAG AAGGTGCCTG 
AATGGGAGCC CCCCAAAGCG CCTGAAAAGA AGGGACAGGA GGATGATGTC CCAGCTGGAG 
CTGCTGAGTG GAGGAGAGAT TCTGTGTGGT GGCTTCTACC CAAGAGTATC CTGCTGCCTG 
CAGAGTGACA GCCCTGGATT GGGGCGTCTG GAGAACAAGA TCTTTTCTGC CACCAACAAC 
ACAGAATGTG GGAGGCTCCT GGAGGAGATC AAATGTGCTC CTTGCTCTCC CCACTCCCAG 
AGCCTGTTCT TCTCACCTGA AAGAGATGTC CTGGATGGAG ACCTTGCACT TCCACTCCTC 
TGCAAGGACT ACTGCAAAGA ATTCTTTTAC ACTTGTCGGG GCCATATTCC AGGTCTTCTT 
CAAACAACTG CTGATGAATT TTGCTTTTAC TATGCAAGAA AAGATGCTGG GTTATGCTTT 
CCAGACTTCC CGAGAAAGCA AGTCAGAGGA CCAGCATCTA ACTATTTGGA CCAGATGGAA 
GACTATGAGA AAGTCGAAGA GATCAGCAGA AAGCACAAAC ACAACTGCTT CTGTGTCCAG 
GAGGTCATGA GTGGGCTGCG GCAGCCTGTG GGTGCTGTGC ACAGTGGGGA TGGCTCCCTT 
CGACTCTTCA TCCTAGAGAA GGAAGGCTAC GTGAAGATTC TAACCCCAGA AGGAGAAATG 
CTCAAGGAGC CTTACTTGGA CATTCACAAA CTTGTTCAGA GTGGAATAAA GGGAGGAGAC 
GAGAGGGGCC TGCTAAGCCT GGCATTCCAC CCCAATTACA AGAAAAACGG GAAGCTCTAC 
GTGTCTTACA CCACCAACCA GGAACGGTGG GCTATTGGGC CTCACGACCA CATCCTTAGG 
GTTGTGGAAT ACACAGTATC CAGGAAAAAT CCCCATCAAG TTGATGTAAG AACAGCCAGG 
GTGTTTCTGG AAGTTGCAGA GCTCCACCGG AAGCATCTTG GGGGACAGCT GCTCTTTGGT 
CCTGATGGCT TTTTGTACAT CATCCTCGGG GATGGGATGA TCACACTGGA TGACATGGAG 
GAGATGGATG GGTTAAGTGA TTTCACAGGC TCTGTGCTGA GGCTGGATGC GGACACCGAC 
ATGTGCAATG TGCCTTACTC CATTCCTCGG AGTAACCCCC ACTTCAACAG CACCAACCAG 
CCTCCAGAAG TATTTGCCCA TGGCCTCCAT GATCCAGGCA GATGTGCCGT GGATCGACAT 
CCCACTGATA TAAACATCAA TTTAACAATA CTTTGCTCAG ATTCCAATGG GAAGAACAGA 
TCGTCGGCCA GAATTCTACA GATAATAAAA GGAAGAGATT ACGAAAGCGA GCAATCTCTT 
CTAGAATTCA AGCCATTCAG TAACGGCCCT TTGGTTGGTG GATTCGTTTA CAGAGGCTGC 
CAGTCTGAAA GATTGTACGG AAGCTACGTG TTCGGAGATC GCAATGGGAA TTTCTTAACC 
CTCCAGCAAA GCCCAGTGAC TAAGCAATGG CAAGAAAAGC CACTCTGTCT GGGTGCCAGC 
GGCTCCTGTC AAGGCTACTT TTCGGGTCAC ATCTTGGGAT TTGGAGAAGA TGAATTAGGA 
GAGGTTTACA TTCTATCAAG CAGTAAGAGT ATGACCCAGA CTCACAATGG AAAACTCTAC 
AAGATCATAG ACCCAAAAAG ACCTTTGATG CCTGAGGAAT GCAGAGTCAC AGTTCAACCT 
GCCCAGACAC TGACCTCAGA TATTTCCCGG CTCTGTCGGA ACGGCTACTA CACCCCCACG 
GGCAAGTGCT GCTGCAGTCC TGGCTGGGAG GGAGACTTCT GCAGAATTGC CAAATGTGAG 
CCACCTTGTC GTCACGGAGG TGTCTGTGTC AGACCAAACA AGTGCCTCTG TAAAAAGGGC 
TATCTCGGCC CTCAGTGTGA ACGAGCGGAC AGGAGCATGC GCAGAGTGAC CAGGGCAGGT 
ATTCTTGACC AGATCATTGA CGTGACGTCT TACTTGCTGG ATCTCACAAG TTACATCGTA 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline.
Respiratory research1649(2015 Apr)
Xie J,Wu H,Xu Y,Wu X,Liu X,Shang J,Zhao J,Zhao J,Wang J,Dela Cruz CS,Xiong W,Xu Y

Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring.
Genome medicine7(1)12(2015)
Lao T,Glass K,Qiu W,Polverino F,Gupta K,Morrow J,Mancini JD,Vuong L,Perrella MA,Hersh CP,Owen CA,Quackenbush J,Yuan GC,Silverman EK,Zhou X

Interactions between Hedgehog proteins and their binding partners come into view.
Genes & development24(18)2001-12(2010 Sep)
Beachy PA,Hymowitz SG,Lazarus RA,Leahy DJ,Siebold C

Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study.
The European respiratory journal36(1)89-95(2010 Jul)
Van Durme YM,Eijgelsheim M,Joos GF,Hofman A,Uitterlinden AG,Brusselle GG,Stricker BH

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.
American journal of physiology. Gastrointestinal and liver physiology297(6)G1093-106(2009 Dec)
Choi SS,Omenetti A,Witek RP,Moylan CA,Syn WK,Jung Y,Yang L,Sudan DL,Sicklick JK,Michelotti GA,Rojkind M,Diehl AM

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Hhip cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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